Article ; Online: Ribociclib-induced hepatotoxicity.
2023 Volume 29, Issue 5, Page(s) 1275–1277
Abstract: Introduction: Cyclin-dependent kinase (CDK) 4/6 inhibitors have shown a different adverse effect. In this case, persistent grade 3 hepatoxicity was observed after ribociclib. Therefore, ribociclib therapy was stopped, and then palbociclib was introduced. ...
Abstract | Introduction: Cyclin-dependent kinase (CDK) 4/6 inhibitors have shown a different adverse effect. In this case, persistent grade 3 hepatoxicity was observed after ribociclib. Therefore, ribociclib therapy was stopped, and then palbociclib was introduced. Transaminase levels returned to normal by switching to palbociclib therapy. Case report: 71-year-old postmenopausal female patient with luminal subtypes of metastatic breast cancer treated with ribociclib. Management & outcome: Grade 3 hepatotoxicity secondary to ribociclib developed. She was successfully treated with palbociclib 125 mg. Discussion: In our case, palbociclib was started with a full dose, to increase treatment success. Starting with a 125 mg dose was not cause any toxicity. Nevertheless, laboratory follow-up is required in terms of neutropenia and increased transaminases. |
---|---|
MeSH term(s) | Female ; Humans ; Aged ; Aminopyridines/adverse effects ; Purines/adverse effects ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Drug-Related Side Effects and Adverse Reactions/drug therapy ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/drug therapy ; Protein Kinase Inhibitors/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use |
Chemical Substances | ribociclib (TK8ERE8P56) ; Aminopyridines ; Purines ; Protein Kinase Inhibitors |
Language | English |
Publishing date | 2023-02-10 |
Publishing country | England |
Document type | Case Reports ; Journal Article |
ZDB-ID | 1330764-2 |
ISSN | 1477-092X ; 1078-1552 |
ISSN (online) | 1477-092X |
ISSN | 1078-1552 |
DOI | 10.1177/10781552231154009 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
Zs.A 4488: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.