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Article ; Online: Twenty Years' Experience in Retroperitoneal Lymph Node Dissection for Testicular Cancer in a Tertiary Referral Center.

Mottaran, Angelo / Ercolino, Amelio / Bianchi, Lorenzo / Piazza, Pietro / Manes, Francesco / Amirhassankhani, Sasan / Salvador, Marco / Chessa, Francesco / Corcioni, Beniamino / Bertaccini, Alessandro / Schiavina, Riccardo / Brunocilla, Eugenio

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 1

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Male ; Humans ; Testicular Neoplasms ; Tertiary Care Centers ; Retroperitoneal Space/surgery ; Retroperitoneal Space/pathology ; Retrospective Studies ; Lymph Node Excision/methods ; Neoplasm Staging ; Treatment Outcome
Language	English
Publishing date	2023-01-10
Publishing country	Switzerland
Document type	Review ; Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59010133
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Article ; Online: A Planned Multidisciplinary Surgical Approach to Treat Primary Pelvic Malignancies.

Sambri, Andrea / Fiore, Michele / Rottoli, Matteo / Bianchi, Giuseppe / Pignatti, Marco / Bortoli, Marta / Ercolino, Amelio / Ancetti, Stefano / Perrone, Anna Myriam / De Iaco, Pierandrea / Cipriani, Riccardo / Brunocilla, Eugenio / Donati, Davide Maria / Gargiulo, Mauro / Poggioli, Gilberto / De Paolis, Massimiliano

Current oncology (Toronto, Ont.)

2023 Volume 30, Issue 1, Page(s) 1106–1115

Abstract: The pelvic anatomy poses great challenges to orthopedic surgeons. Sarcomas are often large in size and typically enclosed in the narrow confines of the pelvis with the close proximity of vital structures. The aim of this study is to report a systematic ... ...

Abstract	The pelvic anatomy poses great challenges to orthopedic surgeons. Sarcomas are often large in size and typically enclosed in the narrow confines of the pelvis with the close proximity of vital structures. The aim of this study is to report a systematic planned multidisciplinary surgical approach to treat pelvic sarcomas. Seventeen patients affected by bone and soft tissue sarcomas of the pelvis, treated using a planned multidisciplinary surgical approach, combining the expertise of orthopedic oncology and other surgeons (colleagues from urology, vascular surgery, abdominal surgery, gynecology and plastic surgery), were included. Seven patients were treated with hindquarter amputation; 10 patients underwent excision of the tumor. Reconstruction of bone defects was conducted in six patients with a custom-made 3D-printed pelvic prosthesis. Thirteen patients experienced at least one complication. Well-organized multidisciplinary collaborations between each subspecialty are the cornerstone for the management of patients affected by pelvic sarcomas, which should be conducted in specialized centers. A multidisciplinary surgical approach is of paramount importance in order to obtain the best successful surgical results and adequate margins for achieving acceptable outcomes.
MeSH term(s)	Humans ; Pelvic Neoplasms/surgery ; Pelvic Neoplasms/pathology ; Treatment Outcome ; Pelvis/surgery ; Sarcoma/pathology
Language	English
Publishing date	2023-01-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol30010084
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Article: A case report of myoid gonadal stromal tumor treated with testis sparing surgery.

Ercolino, Amelio / Manes, Francesco / Vasuri, Francesco / Bianchi, Lorenzo / Garofalo, Marco / Piazza, Pietro / Corcioni, Beniamino / Schiavina, Riccardo / Golfieri, Rita / Fiorentino, Michelangelo / Colecchia, Maurizio / Brunocilla, Eugenio

Translational andrology and urology

2022 Volume 11, Issue 10, Page(s) 1458–1465

Abstract: Background: Myoid gonadal stromal tumors (MGST) of the testis represent a very rare finding. They are an emerging clinicopathological entity with specific features and identity. Nowadays, pathological recognition and diagnosis of MGSTs still represents ... ...

Abstract	Background: Myoid gonadal stromal tumors (MGST) of the testis represent a very rare finding. They are an emerging clinicopathological entity with specific features and identity. Nowadays, pathological recognition and diagnosis of MGSTs still represents a difficult challenge in most cases and there are no data of specific radiological features of these tumors expect for what seen by ultrasound; besides a conservative surgical approach was never performed to treat these lesions. Case description: We present the case of a 20-year-old young man patient with symptoms suspicious for left varicocele, who was incidentally diagnosed with right testicular nodule via scrotal doppler ultrasound powered with contrast enhancement infusion and subsequent multiparametric magnetic resonance imaging. Then, lesion was treated through a testis sparing surgical approach. Histopathology, which included an external revision by an experienced Center, revealed a MGST with benign features, so that no further treatment was considered. 3 and 12 months after surgery a contrast enhancement ultrasound was performed with no evidence of recurrence. Conclusions: Previous reported cases of MGST were all difficult to characterize as a specific pathological entity; treatment usually applied was radical orchiectomy and a subsequent total Body CT was performed for staging purpose. No metastatic spreading nor recurrence were ever reported. Considering the favorable behavior of this pathologic entity, testis-sparing surgery with no radiation exposure during follow-up is a safe and effective strategy.
Language	English
Publishing date	2022-11-17
Publishing country	China
Document type	Case Reports
ZDB-ID	2851630-8
ISSN	2223-4691 ; 2223-4691 ; 2223-4683
ISSN (online)	2223-4691
ISSN	2223-4691 ; 2223-4683
DOI	10.21037/tau-22-179
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Article ; Online: Multiparametric ultrasound for the diagnosis of Leydig cell tumours in non-palpable testicular lesions.

Corcioni, Beniamino / Brandi, Nicolò / Marasco, Giovanni / Gaudiano, Caterina / De Cinque, Antonio / Ciccarese, Federica / Ercolino, Amelio / Schiavina, Riccardo / Brunocilla, Eugenio / Renzulli, Matteo / Golfieri, Rita

Andrology

2022 Volume 10, Issue 7, Page(s) 1387–1397

Abstract: Background: The widespread use of ultrasonography has led to an increased number of incidentally detected small non-palpable lesions, with Leydig cell tumours representing the majority of them.: Objectives: The ultrasonography, real-time elastography ...

Abstract	Background: The widespread use of ultrasonography has led to an increased number of incidentally detected small non-palpable lesions, with Leydig cell tumours representing the majority of them. Objectives: The ultrasonography, real-time elastography and contrast-enhanced ultrasonography features of a large series of non-palpable testicular lesions were evaluated, focusing on the differences between Leydig cell tumours and other testicular masses. Materials and methods: Of the 4679 testicular ultrasonography examinations performed at the Authors' Institution between January 2009 and December 2018, 78 patients (1.7%) were incidentally diagnosed with at least one non-palpable lesion and were enrolled. Thirteen patients (16.6%) declined surgery and were thus excluded. The remaining 65 underwent surgical resection with frozen section analysis. The conventional ultrasonography, colour Doppler, real-time elastography and contrast-enhanced ultrasonography were performed by a radiologist having more than 10 years of experience. Demographic and clinical data were collected. Results: Leydig cell tumours were detected in 32 patients, being the most frequent benign tumours (49.2%); of the non-Leydig cell tumours, 25 patients had malignant tumours, five non-neoplastic lesions and three other benign tumours. The Leydig cell tumour group had mostly infertility problems whereas the non-Leydig cell tumour group frequently experienced pain (p < 0.001). Leydig cell tumours were all hypoechoic (32/32, 100%; p = 0.002), more frequently presented with well-defined margins compared to non-Leydig cell tumours (30/32, 93.8% vs. 19/33, 57.6%; p = 0.001) and tended to be smaller than non-Leydig cell tumours (5.3 mm [standard deviation 2.7 mm] vs. 10.6 mm [standard deviation 3.8 mm], respectively; p < 0.001). The vascular pattern characterised by the rapid wash-in followed by the delayed wash-out observed during contrast-enhanced ultrasonography was significantly associated with the Leydig cell tumour histological diagnosis, even at multivariate analysis (odds ratio 480.5, p < 0.001), and yielded a high diagnostic accuracy (area under the receiver operating characteristic curve 0.954, 95% confidence interval 0.903-1). Discussion: Contrast-enhanced ultrasonography demonstrated high diagnostic accuracy in identifying benign testicular lesions, such as Leydig cell tumours; they are the most common non-palpable tumours detected in infertile men and may benefit from enucleation.
MeSH term(s)	Elasticity Imaging Techniques ; Humans ; Leydig Cell Tumor/diagnostic imaging ; Leydig Cell Tumor/pathology ; Male ; Testicular Neoplasms/pathology ; Ultrasonography
Language	English
Publishing date	2022-08-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2696108-8
ISSN	2047-2927 ; 2047-2919
ISSN (online)	2047-2927
ISSN	2047-2919
DOI	10.1111/andr.13233
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Article ; Online: Diagnostic accuracy of the Novel 29 MHz micro-ultrasound "ExactVuTM" for the detection of clinically significant prostate cancer: A prospective single institutional study. A step forward in the diagnosis of prostate cancer.

Chessa, Francesco / Schiavina, Riccardo / Ercolino, Amelio / Gaudiano, Caterina / Giusti, Davide / Bianchi, Lorenzo / Pultrone, Cristian / Marcelli, Emanuela / Distefano, Concetta / Lodigiani, Luca / Brunocilla, Eugenio

Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

2021 Volume 93, Issue 2, Page(s) 132–138

Abstract: Introduction and objective: ExactVuTM is a real-time micro-ultrasound system which provides, according to the Prostate Risk Identification Using Micro-Ultrasound protocol (PRI-MUS), a 300% higher resolution compared to conventional transrectal ... ...

Abstract	Introduction and objective: ExactVuTM is a real-time micro-ultrasound system which provides, according to the Prostate Risk Identification Using Micro-Ultrasound protocol (PRI-MUS), a 300% higher resolution compared to conventional transrectal ultrasound. To evaluate the performance of ExactVuTM in the detection of Clinically significant Prostate Cancer (CsPCa). Materials and methods: Patients with Prostate Cancer diagnosed at fusion biopsy were imaged with ExactVuTM. CsPCa was defined as any Gleason Score ≥ 3+4. ExactVuTM examination was considered as positive when PRI-MUS score was ≥ 3. PRI-MUS scoring system was considered as correct when the fusion biopsy was positive for CsPCa. A transrectal fusion biopsy- proven CsPCa was considered as a gold standard. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and area under the receiver operator characteristic (ROC) curve (AUC) were calculated. Results: 57 patients out of 68 (84%) had a csPCa. PRI-MUS score was correctly assessed in 68% of cases. Regarding the detection of CsPCa, ExactVuTM 's sensitivity, specificity, PPV, and NPV was 68%, 73%, 93%, and 31%, respectively and the AUC was 0.7 (95% CI 0.5-0-8). For detecting CsPCa in the transition/ anterior zone the sensitivity, specificity, PPV, and NPV was 45%, 66%, 83% and 25% respectively ant the AUC was 0.5 (95% CI 0.2-0.9). Accounting only the CsPCa located in the peripheral zone, sensitivity, specificity, PPV, and NPV raised up to 74%, 75%, 94%, 33%, respectively with AUC 0.75 (95% CI 0.5-0-9). Conclusions: ExactVuTM provides high resolution of the prostatic peripheral zone and could represent a step forward in the detection of CsPCa as a triage tool. Further studies are needed to confirm these promising results.
MeSH term(s)	Humans ; Image-Guided Biopsy ; Male ; Multiparametric Magnetic Resonance Imaging ; Neoplasm Grading ; Prospective Studies ; Prostatic Neoplasms/diagnostic imaging
Language	English
Publishing date	2021-06-28
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1153526-x
ISSN	2282-4197 ; 1120-8538 ; 1124-3562
ISSN (online)	2282-4197
ISSN	1120-8538 ; 1124-3562
DOI	10.4081/aiua.2021.2.132
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Article ; Online: The robotic approach improves the outcomes of ERAS protocol after radical cystectomy: A prospective case-control analysis.

Schiavina, Riccardo / Droghetti, Matteo / Bianchi, Lorenzo / Ercolino, Amelio / Chessa, Francesco / Casablanca, Carlo / Piazza, Pietro / Mottaran, Angelo / Recenti, Dario / Salvador, Marco / Cacciapuoti, Crescenzo / Boschi, Sara / Giampaoli, Marco / Bertaccini, Alessandro / Romagnoli, Daniele / Porreca, Angelo

Urologic oncology

2021 Volume 39, Issue 12, Page(s) 833.e1–833.e8

Abstract: Background: Minimally-invasive approach is one of the mainstays of Enhanced Recovery After Surgery (ERAS) pathways. Robot-assisted radical cystectomy (RARC) introduction has reduced the surgical burden on patient's recovery. Accordingly, ERAS protocol ... ...

Abstract	Background: Minimally-invasive approach is one of the mainstays of Enhanced Recovery After Surgery (ERAS) pathways. Robot-assisted radical cystectomy (RARC) introduction has reduced the surgical burden on patient's recovery. Accordingly, ERAS protocol benefits may be more striking in RARC patients. We evaluated the impact of surgical approach on perioperative outcomes, Fast Track (FT) recovery steps and Trifecta success rates in patients undergoing RC followed by FT protocol. Materials and methods: We considered 147 patients who underwent RC, with open (Open radical cystectomy [ORC]; 47.6%) or robotic (RARC; 52.4%) approach at 2 tertiary centers. Urinary diversions were ileal conduit or orthotopic neobladder. All patients underwent FT protocol. We analyzed perioperative surgical and functional outcomes and Trifecta success rates (namely, defecation <5 days, in-hospital stay <10 days and no major complications). Uni and multivariable logistic regression explored the predictors for Trifecta success and the impact of surgical approach on recovery steps. Results: Patients undergoing RARC had higher FT adherence (95% vs. 61%) compared to ORCs (P < 0.01). Trifecta success rates were higher for RARC (79.2% vs 28.6%; P < 0.001). At multivariable analyses, RARC was an independent predictor for Trifecta success (OR 9.1), early mobilization (OR 5.9) and FT adherence (OR 3.33; all P < 0.001). Surgical technique was not associated with major complications or readmission within 90 days (all P > 0.05). Conclusion: RARC has more favorable perioperative outcomes compared to ORC, with higher Trifecta success rates. Accordingly, robotic approach should be ideally included in every center where ERAS protocol is applied to RC for maximizing patient's recovery.
MeSH term(s)	Aged ; Case-Control Studies ; Cystectomy/methods ; Enhanced Recovery After Surgery ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Robotic Surgical Procedures/methods ; Robotics ; Treatment Outcome
Language	English
Publishing date	2021-06-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1336505-8
ISSN	1873-2496 ; 1078-1439
ISSN (online)	1873-2496
ISSN	1078-1439
DOI	10.1016/j.urolonc.2021.04.015
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Article ; Online: Percutaneous ablation or minimally invasive partial nephrectomy for cT1a renal masses? A propensity score-matched analysis.

Bianchi, Lorenzo / Chessa, Francesco / Piazza, Pietro / Ercolino, Amelio / Mottaran, Angelo / Recenti, Dario / Serra, Carla / Gaudiano, Caterina / Cappelli, Alberta / Modestino, Francesco / Golfieri, Rita / Bertaccini, Alessandro / Marcelli, Emanuela / Porreca, Angelo / Celia, Antonio / Schiavina, Riccardo

International journal of urology : official journal of the Japanese Urological Association

2021 Volume 29, Issue 3, Page(s) 222–228

Abstract: Objective: Local tumor ablation to treat small renal mass is increasing. The aim of the present study was to compare oncologic outcomes among patients with T1 renal mass treated with partial nephrectomy and local tumor ablation.: Methods: To reduce ... ...

Abstract	Objective: Local tumor ablation to treat small renal mass is increasing. The aim of the present study was to compare oncologic outcomes among patients with T1 renal mass treated with partial nephrectomy and local tumor ablation. Methods: To reduce the inherent differences between patients undergoing laparoscopic or robot-assisted partial nephrectomy (n = 405) and local tumor ablation (n = 137), we used a 1:1 propensity score-matched analysis. Local tumor ablation consisted of radiofrequency ablation and cryoablation. Disease-free survival, overall survival and other causes mortality-free survival rates were estimated using the Kaplan-Meier method. Multivariable logistic regression and competing-risk regression models were used to identify predictors of complications, recurrence and other causes mortality, respectively. Results: Partial nephrectomy had higher disease-free survival estimates, as compared with local tumor ablation (92.8% vs 80.4% at 5 years, P = 0.02), with no significant difference between radiofrequency ablation and cryoablation (P = 0.9). Ablation showed comparable overall survival estimates to partial nephrectomy (91% vs 95.8% at 5 years, P = 0.6). The 5-year recurrence rates were 7.9% versus 23.8% for patients aged ≤70 years, and 2.5% versus 11.9% for patients aged >70 years treated with partial nephrectomy and ablation, respectively; the 5-year other causes mortality rates were 0% and 2.2% for patients treated with partial nephrectomy and ablation aged ≤70 years, and 3% versus 10.9% for patients aged >70 years treated with partial nephrectomy and ablation, respectively. At multivariable analysis, ablation was associated with fewer complications (odds ratio 0.41; P = 0.01). At competing risks analysis, age (hazard ratio 0.96) and ablation (hazard ratio 4.56) were independent predictors of disease recurrence (all P ≤ 0.008). Conclusions: Local tumor ablation showed a higher risk of recurrence and lower risk of complications compared with partial nephrectomy, with comparable overall survival rates.
MeSH term(s)	Aged ; Carcinoma, Renal Cell/pathology ; Catheter Ablation/adverse effects ; Humans ; Kidney Neoplasms/pathology ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/surgery ; Nephrectomy/adverse effects ; Nephrectomy/methods ; Propensity Score ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2021-12-11
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1328401-0
ISSN	1442-2042 ; 0919-8172
ISSN (online)	1442-2042
ISSN	0919-8172
DOI	10.1111/iju.14758
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Zs.A 4460: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Postoperative outcomes of Fast-Track-enhanced recovery protocol in open radical cystectomy: comparison with standard management in a high-volume center and Trifecta proposal.

Ercolino, Amelio / Droghetti, Matteo / Schiavina, Riccardo / Bianchi, Lorenzo / Chessa, Francesco / Mineo Bianchi, Federico / Barbaresi, Umberto / Angiolini, Andrea / Casablanca, Carlo / Mottaran, Angelo / Molinaroli, Enrico / Pultrone, Cristian / Dababneh, Hussam / Bertaccini, Alessandro / Brunocilla, Eugenio

Minerva urology and nephrology

2020 Volume 73, Issue 6, Page(s) 763–772

Abstract: Background: We aimed at comparing perioperative outcomes in patients submitted to radical cystectomy followed by Fast Track (FT) protocol or standard management, and propose a definition of Trifecta, to improve standardized quality assessment for RC.: ...

Abstract	Background: We aimed at comparing perioperative outcomes in patients submitted to radical cystectomy followed by Fast Track (FT) protocol or standard management, and propose a definition of Trifecta, to improve standardized quality assessment for RC. Methods: We considered 191 patients submitted to RC between January 2017 and January 2019. Patients followed FT or standard management according to surgeon's preference. Preoperative and intraoperative characteristics, alongside with postoperative outcomes were compared between the two groups. Trifecta was defined as follows: in-hospital stay (HS) ≤ 10 days, time to defecation (TtD) below the overall mean and no major (≥ Clavien-Dindo grade III) complications. Finally, Trifecta achievement rates were assessed in both groups. Results: Seventy-five patients (39%) followed the FT protocol and 116 (61%) standard management. The two groups were homogeneous for preoperative, intraoperative and pathological characteristics. Patients in the FT group had shorter TtD (5 vs. 6 days P=0.006), HS (12 vs. 14 days P=0.008) and lower readmission rate (8% vs. 19% P=0.04). Early complication rates and grades were similar, while less late complications were found in FT group (6.7% vs. 21.6% P=0.006). Trifecta achievement rate was higher for FT group (31% vs. 8% P<0.001). Single-item failure percentages for HS, TtD and major grade complications were respectively 90%, 60% and 19%, with no difference between the two groups. Conclusions: FT protocol can safely consent faster bowel recovery and earlier discharge after RC, plus reducing readmission rates. Using a Trifecta incorporating essential perioperative outcomes, could improve standardized quality assessment for RC.
MeSH term(s)	Cystectomy/adverse effects ; Humans ; Length of Stay ; Postoperative Period ; Urinary Bladder ; Urinary Bladder Neoplasms/surgery
Language	English
Publishing date	2020-11-17
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3062840-4
ISSN	2724-6442
ISSN (online)	2724-6442
DOI	10.23736/S2724-6051.20.03843-6
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Article ; Online: Secondary bladder amyloidosis due to Crohn's disease: a case report and literature review.

Droghetti, Matteo / Ercolino, Amelio / Piazza, Pietro / Bianchi, Lorenzo / Fabbrizio, Benedetta / Giunchi, Francesca / Mineo Bianchi, Federico / Barbaresi, Umberto / Casablanca, Carlo / Tonin, Elena / Mottaran, Angelo / Fiorentino, Michelangelo / Schiavina, Riccardo / Brunocilla, Eugenio

CEN case reports

2020 Volume 9, Issue 4, Page(s) 413–417

Abstract: The presence of amyloid deposits in bladder walls is a rare histological finding. It can be linked to primary (limited to bladder) or secondary (systemic, associated with chronic inflammatory disorders) amyloidosis. Secondary bladder involvement is very ... ...

Abstract	The presence of amyloid deposits in bladder walls is a rare histological finding. It can be linked to primary (limited to bladder) or secondary (systemic, associated with chronic inflammatory disorders) amyloidosis. Secondary bladder involvement is very uncommon; it usually presents with gross hematuria, which is challenging to manage, due to frail bladder mucosa and/or necrosis. We present a case of 54-year old man with secondary bladder amyloidosis due to Crohn's disease, that caused gross hematuria and severe anemia, which was managed conservatively by endoscopic transurethral resection, diatermocoagulation, clot evacuation and urinary drainage by bilateral percutaneous nephrostomy, with spontaneous resolution. Secondary bladder amyloidosis is a rare condition that presents with severe hematuria, difficult to control with standard management. Owing to chronic nature of the disease, treatment should be aimed to a conservative approach whenever possible. In case of failure, invasive procedures should be considered as salvage therapies.
MeSH term(s)	Amyloidosis/diagnosis ; Amyloidosis/etiology ; Amyloidosis/pathology ; Amyloidosis/therapy ; Anemia/etiology ; Crohn Disease/complications ; Endoscopy/methods ; Hematuria/etiology ; Hematuria/prevention & control ; Hematuria/surgery ; Humans ; Male ; Middle Aged ; Nephrostomy, Percutaneous/methods ; Severity of Illness Index ; Treatment Outcome ; Urinary Bladder Diseases/pathology
Language	English
Publishing date	2020-06-22
Publishing country	Japan
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2660492-9
ISSN	2192-4449 ; 2192-4449
ISSN (online)	2192-4449
ISSN	2192-4449
DOI	10.1007/s13730-020-00497-3
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Article ; Online: Predictive accuracy and clinical benefit of a nomogram aimed to predict

Bianchi, Lorenzo / Borghesi, Marco / Schiavina, Riccardo / Castellucci, Paolo / Ercolino, Amelio / Bianchi, Federico Mineo / Barbaresi, Umberto / Polverari, Giulia / Brunocilla, Eugenio / Fanti, Stefano / Ceci, Francesco

European journal of nuclear medicine and molecular imaging

2020 Volume 47, Issue 9, Page(s) 2100–2105

Abstract: Purpose: To perform an external validation of a recently published nomogram aimed to predict positive : Methods: Overall, 413 PCa patients with BCR after RP (two consecutive PSA ≥ 0.2 ng/ml) and PSA value between 0.2 and 1 ng/ml were included. A ... ...

Abstract	Purpose: To perform an external validation of a recently published nomogram aimed to predict positive Methods: Overall, 413 PCa patients with BCR after RP (two consecutive PSA ≥ 0.2 ng/ml) and PSA value between 0.2 and 1 ng/ml were included. A multivariable logistic regression model was produced to assess the predictors of positive Results: In the external cohort, the overall detection rate of Conclusion: We assessed similar suboptimal predictive accuracies in the external cohort compared to the original one. PSA and ongoing ADT were confirmed as positive predictors, and the most informative nomogram cut-off resulted 35%.
MeSH term(s)	Edetic Acid/analogs & derivatives ; Humans ; Male ; Neoplasm Recurrence, Local ; Nomograms ; Oligopeptides ; Positron Emission Tomography Computed Tomography ; Prostate-Specific Antigen ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/surgery
Chemical Substances	Oligopeptides ; gallium 68 PSMA-11 ; Edetic Acid (9G34HU7RV0) ; Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2020-01-31
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-020-04696-z
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In stock of ZB MED Cologne/Königswinter

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