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  1. AU="Erdmann, Kati"
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  1. Book ; Thesis: Immunhistochemische Analysen zur klinischen Relevanz der VEGF-A-Splicevariante VEGF-A165b als prädiktiver Biomarker für das Ansprechen auf Bevacizumab bei Patientinnen mit einem Ovarialkarzinom

    Gerber, Mara Julia / Kuhlmann, Jan Dominik / Erdmann, Kati

    2022  

    Institution Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe
    Author's details von Mara Julia Gerber aus Freiburg im Breisgau ; Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe [Dresden]
    Subject code 616.994 ; 610
    Language German
    Size XXXIII, 92 Blätter, Illustrationen, Diagramme
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2022
    HBZ-ID HT030693354
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2024 E 512 order for loan Magazin

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  2. Book ; Thesis: Cellular plasticity affects the radiosensitivity of the aldehyde dehydrogenase positive population in prostate cancer

    Schwarz, Franziska Maria / Dubrovska, Anna / Erdmann, Kati

    2022  

    Institution Zentrum für Innovationskompetenz OncoRay
    Author's details von Franziska Maria Schwarz, M.Sc. geboren in Leonberg, Deutschland ; Zentrum für Innovationskompetenz OncoRay [Dresden]
    Language English
    Size xiv, 167, F Seiten, Illustrationen, Diagramme (farbig)
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Technische Universität Dresden, Medizinische Fakultät, 2022
    HBZ-ID HT021745284
    Database Catalogue ZB MED Medicine, Health

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    2023 E 481 order for loan Magazin

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  3. Book ; Online ; Thesis: Identifizierung und Charakterisierung der regulatorischen Funktion von microRNAs innerhalb der NRP2/VEGFC-Achse im Harnblasenkarzinom

    Aldejohann-Bunk, Laura Verfasser] / [Erdmann, Kati [Gutachter] / Hoffmann, Michèle [Gutachter]

    2024  

    Author's details Laura Aldejohann-Bunk ; Gutachter: Kati Erdmann, Michèle Hoffmann
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Technische Universität Dresden
    Publishing place Dresden
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  4. Article ; Online: Early kinetics of C-reactive protein as prognosticator for survival in a real-world cohort of patients with metastatic renal cell cancer under first-line therapy with immune checkpoint inhibitors.

    Schüttke, Vayda / Kusiek, Cathrin / Fuessel, Susanne / Thomas, Christian / Buerk, Bjoern Thorben / Erdmann, Kati

    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

    2023  Volume 26, Issue 5, Page(s) 1117–1128

    Abstract: Purpose: This study investigated the prognostic potential of baseline C-reactive protein (CRP) levels and early CRP kinetics in a real-world cohort of patients with metastatic renal cell carcinoma (mRCC) under first-line (1L) therapy with immune ... ...

    Abstract Purpose: This study investigated the prognostic potential of baseline C-reactive protein (CRP) levels and early CRP kinetics in a real-world cohort of patients with metastatic renal cell carcinoma (mRCC) under first-line (1L) therapy with immune checkpoint inhibitors (CPI).
    Methods/patients: Analyses were performed retrospectively in a cohort of 61 mRCC patients under CPI-based 1L therapy. Patients were stratified based on baseline CRP (< 10 vs ≥ 10 mg/l) and CRP change within the initial three months of CPI therapy (normal: baseline < 10 mg/l, normalized: baseline ≥ 10 mg/l and nadir < 10 mg/l, non-normalized: baseline and nadir ≥ 10 mg/l). Finally, the association of baseline CRP and CRP change with progression-free (PFS) and overall survival (OS) was evaluated.
    Results: Baseline CRP was not significantly associated with both PFS (p = 0.666) and OS (p = 0.143). Following stratification according to early CRP kinetics, 23, 25 and 13 patients exhibited normal, normalized and non-normalized CRP levels, respectively. Patients with normal and normalized CRP had a markedly prolonged PFS (p = 0.091) and OS (p = 0.008) compared to patients with non-normalized CRP. Consequently, significantly better PFS (p = 0.031) and OS (p = 0.002) were observed for the combined normal-normalized group. In multivariate analysis including ECOG and IMDC risk, normalized CRP kinetics alone or in combination with the normal group was identified as significant independent risk factor for OS, whereas a statistical trend was observed for PFS.
    Conclusions: The present study emphasizes the prognostic potential of early CRP kinetics in CPI-treated mRCC. As a standard laboratory parameter, CRP can be easily implemented into clinical routine to facilitate therapy monitoring.
    MeSH term(s) Humans ; Carcinoma, Renal Cell/pathology ; C-Reactive Protein/analysis ; Immune Checkpoint Inhibitors/therapeutic use ; Kidney Neoplasms/pathology ; Retrospective Studies ; Prognosis
    Chemical Substances C-Reactive Protein (9007-41-4) ; Immune Checkpoint Inhibitors
    Language English
    Publishing date 2023-09-11
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2397359-6
    ISSN 1699-3055 ; 1699-048X
    ISSN (online) 1699-3055
    ISSN 1699-048X
    DOI 10.1007/s12094-023-03317-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6644: Show issues Location:
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  5. Book ; Online ; Thesis: Immunhistochemische Analysen zur klinischen Relevanz der VEGF-A-Splicevariante VEGF-A165b als prädiktiver Biomarker für das Ansprechen auf Bevacizumab bei Patientinnen mit einem Ovarialkarzinom

    Gerber, Mara Julia [Verfasser] / Kuhlmann, Jan Dominik [Gutachter] / Erdmann, Kati [Gutachter]

    2023  

    Author's details Mara Julia Gerber ; Gutachter: Jan Dominik Kuhlmann, Kati Erdmann
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Technische Universität Dresden
    Publishing place Dresden
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Book ; Online ; Thesis: Endothelial HIF-2alpha controls Cellular Migration in the Bone Marrow

    Gaete Alvarez, Diana Estefania [Verfasser] / Wielockx, Ben [Gutachter] / Erdmann, Kati [Gutachter]

    2023  

    Author's details Diana Estefania Gaete Alvarez ; Gutachter: Ben Wielockx, Kati Erdmann
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Technische Universität Dresden
    Publishing place Dresden
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  7. Book ; Online ; Thesis: Genetic Diversity and Treatment Resistance in Prostate Cancer Cell Lines

    Donix, Lukas [Verfasser] / Erdmann, Kati [Akademischer Betreuer] / Dahmann, Christian [Gutachter] / Taubert, Helge [Gutachter]

    2023  

    Author's details Lukas Donix ; Gutachter: Christian Dahmann, Helge Taubert ; Betreuer: Kati Erdmann
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Technische Universität Dresden
    Publishing place Dresden
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  8. Article ; Online: Identification of novel snoRNA-based biomarkers for clear cell renal cell carcinoma from urine-derived extracellular vesicles.

    Grützmann, Konrad / Salomo, Karsten / Krüger, Alexander / Lohse-Fischer, Andrea / Erdmann, Kati / Seifert, Michael / Baretton, Gustavo / Aust, Daniela / William, Doreen / Schröck, Evelin / Thomas, Christian / Füssel, Susanne

    Biology direct

    2024  Volume 19, Issue 1, Page(s) 38

    Abstract: Background: Clear cell renal cell carcinoma (ccRCC) is the most common subtype of RCC with high rates of metastasis. Targeted therapies such as tyrosine kinase and checkpoint inhibitors have improved treatment success, but therapy-related side effects ... ...

    Abstract Background: Clear cell renal cell carcinoma (ccRCC) is the most common subtype of RCC with high rates of metastasis. Targeted therapies such as tyrosine kinase and checkpoint inhibitors have improved treatment success, but therapy-related side effects and tumor recurrence remain a challenge. As a result, ccRCC still have a high mortality rate. Early detection before metastasis has great potential to improve outcomes, but no suitable biomarker specific for ccRCC is available so far. Therefore, molecular biomarkers derived from body fluids have been investigated over the past decade. Among them, RNAs from urine-derived extracellular vesicles (EVs) are very promising.
    Methods: RNA was extracted from urine-derived EVs from a cohort of 78 subjects (54 ccRCC patients, 24 urolithiasis controls). RNA-seq was performed on the discovery cohort, a subset of the whole cohort (47 ccRCC, 16 urolithiasis). Reads were then mapped to the genome, and expression was quantified based on 100 nt long contiguous genomic regions. Cluster analysis and differential region expression analysis were performed with adjustment for age and gender. The candidate biomarkers were validated by qPCR in the entire cohort. Receiver operating characteristic, area under the curve and odds ratios were used to evaluate the diagnostic potential of the models.
    Results: An initial cluster analysis of RNA-seq expression data showed separation by the subjects' gender, but not by tumor status. Therefore, the following analyses were done, adjusting for gender and age. The regions differentially expressed between ccRCC and urolithiasis patients mainly overlapped with small nucleolar RNAs (snoRNAs). The differential expression of four snoRNAs (SNORD99, SNORD22, SNORD26, SNORA50C) was validated by quantitative PCR. Confounder-adjusted regression models were then used to classify the validation cohort into ccRCC and tumor-free subjects. Corresponding accuracies ranged from 0.654 to 0.744. Models combining multiple genes and the risk factors obesity and hypertension showed improved diagnostic performance with an accuracy of up to 0.811 for SNORD99 and SNORA50C (p = 0.0091).
    Conclusions: Our study uncovered four previously unrecognized snoRNA biomarkers from urine-derived EVs, advancing the search for a robust, easy-to-use ccRCC screening method.
    MeSH term(s) Humans ; Carcinoma, Renal Cell/urine ; Carcinoma, Renal Cell/genetics ; Extracellular Vesicles/genetics ; Extracellular Vesicles/metabolism ; Biomarkers, Tumor/urine ; Biomarkers, Tumor/genetics ; Female ; Male ; Middle Aged ; Kidney Neoplasms/urine ; Kidney Neoplasms/genetics ; Aged ; RNA, Small Nucleolar/genetics ; Cohort Studies ; Adult
    Chemical Substances Biomarkers, Tumor ; RNA, Small Nucleolar
    Language English
    Publishing date 2024-05-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2221028-3
    ISSN 1745-6150 ; 1745-6150
    ISSN (online) 1745-6150
    ISSN 1745-6150
    DOI 10.1186/s13062-024-00467-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Acquired resistance to irradiation or docetaxel is not associated with cross-resistance to cisplatin in prostate cancer cell lines.

    Donix, Lukas / Erb, Holger H H / Peitzsch, Claudia / Dubrovska, Anna / Pfeifer, Manuel / Thomas, Christian / Fuessel, Susanne / Erdmann, Kati

    Journal of cancer research and clinical oncology

    2022  Volume 148, Issue 6, Page(s) 1313–1324

    Abstract: Purpose: Platinum chemotherapy can be considered to treat metastatic castration-resistant prostate cancer (mCRPC) with features of neuroendocrine differentiation. However, platinum compounds are generally only applied after the failure of multiple prior- ...

    Abstract Purpose: Platinum chemotherapy can be considered to treat metastatic castration-resistant prostate cancer (mCRPC) with features of neuroendocrine differentiation. However, platinum compounds are generally only applied after the failure of multiple prior-line treatment options. This study investigated whether acquired resistance against ionizing radiation or docetaxel chemotherapy-two commonly applied treatment modalities in prostate cancer-influences the cisplatin (CDDP) tolerance in mCRPC cell line models.
    Methods: Age-matched parental as well as radio- or docetaxel-resistant DU145 and PC-3 cell lines were treated with CDDP and their sensitivity was assessed by measurements of growth rates, viability, apoptosis, metabolic activity and colony formation ability.
    Results: The data suggest that docetaxel resistance does not influence CDDP tolerance in all tested docetaxel-resistant cell lines. Radio-resistance was associated with sensitization to CDDP in PC-3, but not in DU145 cells. In general, DU145 cells tolerated higher CDDP concentrations than PC-3 cells regardless of acquired resistances. Furthermore, non-age-matched treatment-naïve PC-3 cells exhibited significantly different CDDP tolerances.
    Conclusion: Like patients, different mCRPC cell lines exhibit significant variability regarding CDDP tolerance. The presented in vitro data suggest that previous radiation treatment may be associated with a moderate sensitization to CDDP in an isogenic and age-matched setting. Therefore, previous radiotherapy or docetaxel chemotherapy might be no contraindication against initiation of platinum chemotherapy in selected mCRPC patients.
    MeSH term(s) Cell Line ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Docetaxel/pharmacology ; Humans ; Male ; Platinum/therapeutic use ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostatic Neoplasms, Castration-Resistant/pathology ; Prostatic Neoplasms, Castration-Resistant/radiotherapy
    Chemical Substances Docetaxel (15H5577CQD) ; Platinum (49DFR088MY) ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2022-01-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-022-03914-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.10: Show issues Location:
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  10. Book ; Online ; Thesis: Antioxidative Wirkungen von schwefelhaltigen Aminosäuren und bioaktiven Peptiden

    Erdmann, Kati

    Hämoxygenase-1 und Ferritin als Mediatoren

    2006  

    Abstract: Zsfassung in engl. ... ...

    Author's details von Kati Erdmann
    Abstract Zsfassung in engl. Sprache
    Language German
    Size Online-Ressource, Text + Image (kB)
    Publisher Universitäts- und Landesbibliothek Sachsen-Anhalt
    Publishing place Halle, Saale
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., FB Pharmazie, Diss.--Halle, 2006
    Database Former special subject collection: coastal and deep sea fishing

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