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Article ; Online: The pleiotropic approach to coronavirus disease-19 pathogenesis: The impact of liver diseases associated host genetic variants.

Sahin, Eren / Dag, Ali / Eren, Fatih

Hepatology forum

2023 Volume 5, Issue 2, Page(s) 93–96

Abstract: Coronavirus disease-2019 (COVID-19) is a novel multisystemic viral disease caused pandemic. The disease impact involves liver and associated systems. Undoubtedly, host genetic background influences the predisposition and prediction of infection. Variants ...

Abstract	Coronavirus disease-2019 (COVID-19) is a novel multisystemic viral disease caused pandemic. The disease impact involves liver and associated systems. Undoubtedly, host genetic background influences the predisposition and prediction of infection. Variants among human populations might increase susceptibility or protect against severe outcomes. In this manner, rs738409 variant of patatin-like phospholipase domain-containing protein 3 gene appears to be protective in some populations in spite of its aggravating effect on non-alcoholic fatty liver diseases (NAFLDs) and steatohepatitis. DRB115:01 allele of human leukocyte antigen is associated with protective effect in European and Japanese populations. DRB103:01 contrarily increases the susceptibility of severe COVID-19 infection in European populations. rs1260326 in glucokinase regulatory protein gene, rs112875651 in tribbles homolog 1 gene, rs429358 in apolipoprotein 1, and rs58542926 in transmembrane 6 superfamily 2 alleles are found related with NAFLD and obesity; thus, hypercoagulability and severe COVID-19 outcomes. In chronic or acute liver diseases, comorbid syndromes are the key factors to explain increased severity. There might not be a direct association between the variant and severe COVID-19 infection. As it is concluded, there are genes and variants known and unknown yet to be studied to reveal the association with disease severity.
Language	English
Publishing date	2023-12-07
Publishing country	Turkey
Document type	Journal Article ; Review
ISSN	2757-7392
ISSN (online)	2757-7392
DOI	10.14744/hf.2023.2023.0018
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Analysis of microbiota profile and nutritional status in male professional football players.

Kenger, Emre B / Eren, Fatih / Ozlu, Tugce / Gunes, Fatma E

The Journal of sports medicine and physical fitness

2023 Volume 63, Issue 11, Page(s) 1235–1243

Abstract: Background: The interest in the effect of gut microbiota on athlete health has increased in recent years. Available data indicate a relationship between gut microbiota composition and physical activity, suggesting that changes in the microbiota may ... ...

Abstract	Background: The interest in the effect of gut microbiota on athlete health has increased in recent years. Available data indicate a relationship between gut microbiota composition and physical activity, suggesting that changes in the microbiota may contribute to the host's physical performance. Studies show that leaky gut syndrome is highly correlated with upper respiratory infections and gastrointestinal disorders in endurance sports. This study aims to reveal the relationship between microbiota profiles, and the nutritional status of football players who perform endurance exercises. Methods: Twenty male professional football players playing in one of the Turkish Football Federation Second League clubs participated in the study. Fecal samples were collected and stored at -86 °C, and the fecal microbiota was analyzed through 16s rRNA gene sequencing. The body composition of the football players was measured using a bioelectrical impedance analyzer. In addition, the 3-day food intake of the participants was recorded with the help of a dietitian. Results: In the microbiota of football players, four phyla, 10 genera, and four species with densities above 1% were found. Body fat percentage was observed to be negatively correlated with the species of Faecalibacterium prausnitzii and Bacteroides vulgatus and the genus of Faecalibacterium (P<0.05). Considering the nutritional status, the fat intake was found to be positively correlated with Actinobacteria and Blautia coccoides; energy and fiber intake with Prevotella and Prevotella copri (P<0.05). In addition, there was a negative correlation between carbohydrate intake and Faecalibacterium (P<0.05). Conclusions: Our study is the first to reveal the microbiota profile of professional Turkish football players. It was found that football players' nutritional status and anthropometric measurements of are significantly related to phylum, genus and species ranks in the microbiota. These results support the bidirectional interaction between microbiota and sports. The relationship between microbiota and sports health/performance is thought to be further clarified with future studies.
MeSH term(s)	Humans ; Male ; Football ; Nutritional Status ; RNA, Ribosomal, 16S ; Microbiota
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2023-07-24
Publishing country	Italy
Document type	Journal Article
ZDB-ID	410823-1
ISSN	1827-1928 ; 0022-4707
ISSN (online)	1827-1928
ISSN	0022-4707
DOI	10.23736/S0022-4707.23.15103-6
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Article ; Online: The relationship between polyphenols and miRNAs: A novel therapeutic strategy for metabolic associated fatty liver disease.

Merve Bayram, Hatice / Eren, Fatih / Esra Gunes, Fatma

Hepatology forum

2021 Volume 2, Issue 3, Page(s) 128–136

Abstract: Metabolic-associated fatty liver disease (MAFLD) is a public health problem that is increasingly recognized, currently affecting up to a quarter of the world's adult population. Although a biopsy is the current gold standard to diagnose MAFLD, there are ... ...

Abstract	Metabolic-associated fatty liver disease (MAFLD) is a public health problem that is increasingly recognized, currently affecting up to a quarter of the world's adult population. Although a biopsy is the current gold standard to diagnose MAFLD, there are potentially serious complications, making it inadequate. Thus far, noninvasive methods have not been able to determine the stage and the subtype of MAFLD. The development and prognosis of MAFLD are modulated by epigenetic factors, including microRNAs (miRNAs), which may be potential biomarkers for MAFLD. Polyphenols, found in many fruits and vegetables, may be useful, as they alter gene expression with epigenetic factors, such as miRNAs. This review presents an overview of the relationship between polyphenols and miRNAs in MAFLD. The literature suggests that miRNAs could be used as a diagnostic method for MAFLD, especially miRNA-122 and miRNA-34a. However, though it has been demonstrated that polyphenols may contribute to improving MAFLD, to our knowledge, no study to date has shown the relationship between polyphenols and miRNAs in MAFLD. The exact mechanisms of polyphenols on miRNAs in MAFLD remain unclear. Future studies may provide hope for diet therapy for MAFLD patients as well as the development of polyphenol-related foods or drugs that target miRNAs to treat MAFLD.
Language	English
Publishing date	2021-09-15
Publishing country	Turkey
Document type	Journal Article ; Review
ISSN	2757-7392
ISSN (online)	2757-7392
DOI	10.14744/hf.2021.2021.0037
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Article ; Online: Comments on "The Effect of Laparoscopic Sleeve Gastrectomy on Nonalcoholic Fatty Liver Disease".

Yilmaz, Yusuf / Eren, Fatih

Surgical laparoscopy, endoscopy & percutaneous techniques

2019 Volume 29, Issue 6, Page(s) 548

MeSH term(s)	Gastrectomy ; Humans ; Laparoscopy ; Non-alcoholic Fatty Liver Disease ; Obesity, Morbid/surgery
Language	English
Publishing date	2019-08-19
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1475108-2
ISSN	1534-4908 ; 1530-4515 ; 1051-7200
ISSN (online)	1534-4908
ISSN	1530-4515 ; 1051-7200
DOI	10.1097/SLE.0000000000000705
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Article ; Online: Transient elastography for assessing severe hepatic fibrosis in diabetic patients with nonalcoholic fatty liver disease: definitions matter.

Yilmaz, Yusuf / Eren, Fatih

European journal of gastroenterology & hepatology

2019 Volume 31, Issue 12, Page(s) 1601–1602

MeSH term(s)	Diabetes Mellitus ; Elasticity Imaging Techniques ; Humans ; Lipoproteins, LDL ; Liver ; Liver Cirrhosis ; Non-alcoholic Fatty Liver Disease
Chemical Substances	Lipoproteins, LDL
Language	English
Publishing date	2019-08-29
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	1034239-4
ISSN	1473-5687 ; 0954-691X
ISSN (online)	1473-5687
ISSN	0954-691X
DOI	10.1097/MEG.0000000000001505
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Article ; Online: NFS Is Not a Marker of Nonalcoholic Fatty Liver Disease Per Se: What Is the True Relationship With CAD Complexity?

Yilmaz, Yusuf / Eren, Fatih

Angiology

2019 Volume 71, Issue 1, Page(s) 83–84

MeSH term(s)	Biomarkers ; Coronary Artery Disease ; Fibrosis ; Humans ; Non-alcoholic Fatty Liver Disease
Chemical Substances	Biomarkers
Language	English
Publishing date	2019-07-09
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	80040-5
ISSN	1940-1574 ; 0003-3197
ISSN (online)	1940-1574
ISSN	0003-3197
DOI	10.1177/0003319719862458
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Article ; Online: Hepatic fibrosis - and not steatosis - is the main determinant of arterial stiffness in non-alcoholic fatty liver disease.

Yilmaz, Yusuf / Eren, Fatih

Atherosclerosis

2019 Volume 290, Page(s) 222–223

MeSH term(s)	Humans ; Liver Cirrhosis ; Non-alcoholic Fatty Liver Disease ; Obesity, Morbid ; Vascular Stiffness
Language	English
Publishing date	2019-07-24
Publishing country	Ireland
Document type	Letter ; Comment
ZDB-ID	80061-2
ISSN	1879-1484 ; 0021-9150
ISSN (online)	1879-1484
ISSN	0021-9150
DOI	10.1016/j.atherosclerosis.2019.07.020
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Article ; Online: Chronotype preference, sleep quality, and night-eating behaviors in patients with metabolic dysfunction-associated steatotic liver disease: Assessing the relationship with disease severity and fibrosis.

Kani, Ayse Sakalli / Ozercan, Ahmet / Kani, Haluk Tarik / Eren, Fatih / Sayar, Kemal / Yilmaz, Yusuf

Hepatology forum

2023 Volume 4, Issue 3, Page(s) 123–128

Abstract: Background and aim: Our primary objective is to examine the variance in chronotype, night-eating patterns, and sleep quality in patients with biopsy-proven metabolic dysfunction-associated steatotic liver disease. In addition, we aim to establish a ... ...

Abstract	Background and aim: Our primary objective is to examine the variance in chronotype, night-eating patterns, and sleep quality in patients with biopsy-proven metabolic dysfunction-associated steatotic liver disease. In addition, we aim to establish a correlation between these variables and the severity of the disease and fibrosis. Materials and methods: Patients who were following up with biopsy-proven metabolic dysfunction associated steatotic liver disease (MASLD) were included in the study. Histologically severe disease is characterized by a Steatosis, Activity, and Fibrosis activity score of ≥3 or the presence of advanced fibrosis (≥F3). Participants who met the inclusion criteria were given the Morningness and Evening Questionnaire (MEQ), the Pittsburgh Sleep Quality Index, and the Night Eating Questionnaire to complete. Results: A total of 93 patients were included in this study. According to the MEQ, 48 patients were morning type (51.6%), and 42 (45.2%) were neither type. Sleep quality was determined to be inferior in the non-morningness group (p=0.002). A significantly higher proportion of patients with nocturnal eating syndrome had a non-morningness chronotype preference (n=22, 23.7%), compared to those with a morningness chronotype (n=9, 9.7%) (p=0.001). In the multivariate analysis, both age and poor sleep quality had significant impacts on advanced fibrosis, with odds ratios of 1.11 and 3.81, respectively. Conclusion: Despite the non-morningness chronotype demonstrating poorer sleep quality and a higher prevalence of night-eating behavior, our findings revealed no statistically significant differences in terms of sleep quality, nocturnal eating habits, or chronotype preferences among patients with varying degrees of MASLD severity. On the other hand, advanced fibrosis was significantly impacted by poor sleep quality.
Language	English
Publishing date	2023-09-20
Publishing country	Turkey
Document type	Journal Article
ISSN	2757-7392
ISSN (online)	2757-7392
DOI	10.14744/hf.2023.2023.0034
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Article ; Online: Serum biomarkers of fibrosis and extracellular matrix remodeling in patients with nonalcoholic fatty liver disease: association with liver histology.

Yilmaz, Yusuf / Eren, Fatih

European journal of gastroenterology & hepatology

2018 Volume 31, Issue 1, Page(s) 43–46

Abstract: Background: We sought to explore the interplay of multiple serum biomarkers of fibrosis and extracellular matrix remodeling with the results of liver histology in patients with nonalcoholic fatty liver disease (NAFLD).: Patients and methods: Venous ... ...

Abstract	Background: We sought to explore the interplay of multiple serum biomarkers of fibrosis and extracellular matrix remodeling with the results of liver histology in patients with nonalcoholic fatty liver disease (NAFLD). Patients and methods: Venous blood samples were collected from 80 patients with biopsy-proven NAFLD and 59 age-matched and sex-matched healthy controls. Serum levels of transforming growth factor (TGF)-β1, TGF-β2, matrix metalloproteinases (MMP)-1, MMP-2, MMP-7, MMP-9, MMP-10, tissue inhibitors of metalloproteinase (TIMP)-1, and TIMP-2 were determined by using the Luminex MagPix technology on a MAGPIX analyzer. Results: We documented significant differences in the levels of TGF-β1, TGF-β2, MMP-2, MMP-7, MMP-9, TIMP-1, and TIMP-2 between NAFLD patients and controls. However, none of these biomarkers was able to distinguish between nonalcoholic steatohepatitis and nonalcoholic fatty liver. TIMP-1 levels were significantly higher in patients with significant fibrosis (fibrosis stage ≥2; 2624±1261 pg/ml) than in those without (fibrosis stage 0-1; 2096±906 pg/ml; P=0.03). Moreover, serum levels of TIMP-1 were identified as the only independent predictor of histological fibrosis (β=0.298, t=2.7, P=0.007). Conclusion: Our study provides insights into the association of multiple serum biomarkers of fibrosis and extracellular matrix remodeling with NAFLD histology. Notably, serum levels of TIMP-1 were identified as a clinically useful marker for distinguishing NAFLD patients with and without significant fibrosis.
MeSH term(s)	Adult ; Biomarkers/blood ; Biopsy ; Case-Control Studies ; Extracellular Matrix/metabolism ; Extracellular Matrix/pathology ; Female ; Humans ; Liver/metabolism ; Liver/pathology ; Liver Cirrhosis/blood ; Liver Cirrhosis/etiology ; Liver Cirrhosis/pathology ; Male ; Matrix Metalloproteinases/blood ; Middle Aged ; Non-alcoholic Fatty Liver Disease/blood ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/pathology ; Predictive Value of Tests ; Tissue Inhibitor of Metalloproteinase-1/blood ; Transforming Growth Factor beta/blood ; Up-Regulation
Chemical Substances	Biomarkers ; TIMP1 protein, human ; Tissue Inhibitor of Metalloproteinase-1 ; Transforming Growth Factor beta ; Matrix Metalloproteinases (EC 3.4.24.-)
Language	English
Publishing date	2018-08-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1034239-4
ISSN	1473-5687 ; 0954-691X
ISSN (online)	1473-5687
ISSN	0954-691X
DOI	10.1097/MEG.0000000000001240
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Article ; Online: The utility of noninvasive scores in non-alcoholic fatty liver disease patients with normal and elevated serum transaminases.

Kaya, Eda / Bakir, Alev / Eren, Fatih / Yilmaz, Yusuf

Hepatology forum

2020 Volume 1, Issue 1, Page(s) 8–13

Abstract: Background and aim: Noninvasive scores are developed for the estimation of advanced fibrosis, including parameters in addition to transaminases in non-alcoholic fatty liver disease (NAFLD). In this study, we aimed to investigate the diagnostic ... ...

Abstract	Background and aim: Noninvasive scores are developed for the estimation of advanced fibrosis, including parameters in addition to transaminases in non-alcoholic fatty liver disease (NAFLD). In this study, we aimed to investigate the diagnostic performances of Fibrosis-4 (FIB-4) and NAFLD Fibrosis Score (NFS) in the estimation of advanced fibrosis comparing patients with normal and elevated transaminases. Material and methods: We retrospectively analyzed the prospectively collected data of a total of 407 consecutive patients with biopsy-proven NAFLD. FIB-4 scores of <1.3 and >2.67 or <1.45 and >3.25 indicated a low and high risk for advanced fibrosis, respectively. NFS scores of <-1.455 and >0.676 were used to assess low and high risk for advanced fibrosis, respectiv. Results: FIB-4 cutoffs of <1.3 and <1.45 for low risk of advanced fibrosis had a sensitivity of 70% and 54% in patients with elevated transaminases and 70% and 52% in patients with normal transaminases, respectively. The specificities for the cutoffs of >2.67 and >3.25 were 97% and 98% in patients with elevated transaminases and 99% and 100% in patients with normal transaminases, respectively. Concerning NFS, we found similar results. Conclusion: FIB-4 and NFS showed acceptable diagnostic performance in the exclusion of advanced fibrosis in both populations with normal and elevated transaminases.
Language	English
Publishing date	2020-01-20
Publishing country	Turkey
Document type	Journal Article
ISSN	2757-7392
ISSN (online)	2757-7392
DOI	10.14744/hf.2020.0006
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