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  1. Article ; Online: Clear Cell Renal Cell Carcinoma with Prominent Micropapillary Pattern: A Case Report of a Previously Undescribed Morphology.

    Fahoum, Ibrahim / Hershkovitz, Dov / Erental, Ariel / Argani, Pedram

    International journal of surgical pathology

    2023  Volume 32, Issue 4, Page(s) 821–824

    Abstract: The classic morphology of clear cell renal cell carcinoma consists of nests of cells with clear cytoplasm. Nevertheless, other histologic patterns may be seen including cells with eosinophilic cytoplasm, bizarre multinucleated giant tumor cells and ... ...

    Abstract The classic morphology of clear cell renal cell carcinoma consists of nests of cells with clear cytoplasm. Nevertheless, other histologic patterns may be seen including cells with eosinophilic cytoplasm, bizarre multinucleated giant tumor cells and pseudopapillary structures. In this article, we present the first case of clear cell renal cell carcinoma with a prominent micropapillary pattern.
    MeSH term(s) Humans ; Carcinoma, Renal Cell/pathology ; Carcinoma, Renal Cell/diagnosis ; Carcinoma, Renal Cell/surgery ; Kidney Neoplasms/pathology ; Kidney Neoplasms/diagnosis ; Kidney Neoplasms/surgery ; Male ; Middle Aged ; Female ; Nephrectomy ; Biomarkers, Tumor/analysis
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2023-10-16
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1336393-1
    ISSN 1940-2465 ; 1066-8969
    ISSN (online) 1940-2465
    ISSN 1066-8969
    DOI 10.1177/10668969231195071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Artificial intelligence (AI) molecular analysis tool assists in rapid treatment decision in lung cancer: a case report.

    Waissengrin, Barliz / Garasimov, Alexandra / Bainhoren, Or / Merimsky, Ofer / Shamai, Sivan / Erental, Ariel / Wolf, Ido / Hershkovitz, Dov

    Journal of clinical pathology

    2023  Volume 76, Issue 11, Page(s) 790–792

    Abstract: Leptomeningeal involvement among non-small cell lung cancer (NSCLC) patients is an aggressive form of disease that requires quick and efficient treatment. In this case report, we describe a woman in her 40s with a presenting symptom of headache that ... ...

    Abstract Leptomeningeal involvement among non-small cell lung cancer (NSCLC) patients is an aggressive form of disease that requires quick and efficient treatment. In this case report, we describe a woman in her 40s with a presenting symptom of headache that ultimately was diagnosed as leptomeningeal spread from NSCLC adenocarcinoma. We identified EGFR mutation in less than 48 hours from the biopsy using imagene-artificial intelligence's real-time algorithmic solution on the pathological diagnostic slide.
    MeSH term(s) Female ; Humans ; Adenocarcinoma/genetics ; Adenocarcinoma/therapy ; Artificial Intelligence ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/therapy ; Carcinoma, Non-Small-Cell Lung/pathology ; ErbB Receptors/genetics ; Lung Neoplasms/genetics ; Lung Neoplasms/therapy ; Lung Neoplasms/diagnosis ; Mutation ; Adult
    Chemical Substances ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2023-07-18
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 80261-x
    ISSN 1472-4146 ; 0021-9746
    ISSN (online) 1472-4146
    ISSN 0021-9746
    DOI 10.1136/jcp-2023-208991
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Correction for Erental et al., "Apoptosis-Like Death, an Extreme SOS Response in Escherichia coli".

    Erental, Ariel / Kalderon, Ziva / Saada, Ann / Smith, Yoav / Engelberg-Kulka, Hanna

    mBio

    2020  Volume 11, Issue 6

    Language English
    Publishing date 2020-12-15
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.03040-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Two programmed cell death systems in Escherichia coli: an apoptotic-like death is inhibited by the mazEF-mediated death pathway.

    Erental, Ariel / Sharon, Idith / Engelberg-Kulka, Hanna

    PLoS biology

    2012  Volume 10, Issue 3, Page(s) e1001281

    Abstract: In eukaryotes, the classical form of programmed cell death (PCD) is apoptosis, which has as its specific characteristics DNA fragmentation and membrane depolarization. In Escherichia coli a different PCD system has been reported. It is mediated by the ... ...

    Abstract In eukaryotes, the classical form of programmed cell death (PCD) is apoptosis, which has as its specific characteristics DNA fragmentation and membrane depolarization. In Escherichia coli a different PCD system has been reported. It is mediated by the toxin-antitoxin system module mazEF. The E. coli mazEF module is one of the most thoroughly studied toxin-antitoxin systems. mazF encodes a stable toxin, MazF, and mazE encodes a labile antitoxin, MazE, which prevents the lethal effect of MazF. mazEF-mediated cell death is a population phenomenon requiring the quorum-sensing pentapeptide NNWNN designated Extracellular Death Factor (EDF). mazEF is triggered by several stressful conditions, including severe damage to the DNA. Here, using confocal microscopy and FACS analysis, we show that under conditions of severe DNA damage, the triggered mazEF-mediated cell death pathway leads to the inhibition of a second cell death pathway. The latter is an apoptotic-like death (ALD); ALD is mediated by recA and lexA. The mazEF-mediated pathway reduces recA mRNA levels. Based on these results, we offer a molecular model for the maintenance of an altruistic characteristic in cell populations. In our model, the ALD pathway is inhibited by the altruistic EDF-mazEF-mediated death pathway.
    MeSH term(s) Apoptosis ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Cell Membrane/genetics ; Cell Membrane/metabolism ; Cell Polarity ; DNA Damage ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Endoribonucleases/genetics ; Endoribonucleases/metabolism ; Escherichia coli/metabolism ; Escherichia coli/physiology ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Flow Cytometry ; Genes, Bacterial ; In Situ Nick-End Labeling ; Microbial Viability ; Microscopy, Confocal ; Mutation ; Plasmids/genetics ; Plasmids/metabolism ; Quorum Sensing ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rec A Recombinases/genetics ; Rec A Recombinases/metabolism ; Transcription, Genetic
    Chemical Substances Apoptosis Regulatory Proteins ; DNA-Binding Proteins ; Escherichia coli Proteins ; MazE protein, E coli ; MazF protein, E coli ; RNA, Messenger ; Rec A Recombinases (EC 2.7.7.-) ; Endoribonucleases (EC 3.1.-)
    Language English
    Publishing date 2012-03-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2126776-5
    ISSN 1545-7885 ; 1544-9173
    ISSN (online) 1545-7885
    ISSN 1544-9173
    DOI 10.1371/journal.pbio.1001281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Apoptosis-Like Death, an Extreme SOS Response in Escherichia coli

    Erental, Ariel / Kalderon, Ziva / Saada, Ann / Smith, Yoav / Engelberg-Kulka, Hanna

    mBio. 2014 Aug. 29, v. 5, no. 4

    2014  

    Abstract: In bacteria, SOS is a global response to DNA damage, mediated by the recA-lexA genes, resulting in cell cycle arrest, DNA repair, and mutagenesis. Previously, we reported that Escherichia coli responds to DNA damage via another recA-lexA -mediated ... ...

    Abstract In bacteria, SOS is a global response to DNA damage, mediated by the recA-lexA genes, resulting in cell cycle arrest, DNA repair, and mutagenesis. Previously, we reported that Escherichia coli responds to DNA damage via another recA-lexA -mediated pathway resulting in programmed cell death (PCD). We called it apoptosis-like death (ALD) because it is characterized by membrane depolarization and DNA fragmentation, which are hallmarks of eukaryotic mitochondrial apoptosis. Here, we show that ALD is an extreme SOS response that occurs only under conditions of severe DNA damage. Furthermore, we found that ALD is characterized by additional hallmarks of eukaryotic mitochondrial apoptosis, including (i) rRNA degradation by the endoribonuclease YbeY, (ii) upregulation of a unique set of genes that we called e xtensive- d amage- i n duced (Edin) genes, (iii) a decrease in the activities of complexes I and II of the electron transport chain, and (iv) the formation of high levels of OḢ through the Fenton reaction, eventually resulting in cell death. Our genetic and molecular studies on ALD provide additional insight for the evolution of mitochondria and the apoptotic pathway in eukaryotes. IMPORTANCE The SOS response is the first described and the most studied bacterial response to DNA damage. It is mediated by a set of two genes, recA-lexA , and it results in DNA repair and thereby in the survival of the bacterial culture. We have shown that Escherichia coli responds to DNA damage by an additional recA-lexA -mediated pathway resulting in an apoptosis-like death (ALD). Apoptosis is a mode of cell death that has previously been reported only in eukaryotes. We found that E. coli ALD is characterized by several hallmarks of eukaryotic mitochondrial apoptosis. Altogether, our results revealed that recA-lexA is a DNA damage response coordinator that permits two opposite responses: life, mediated by the SOS, and death, mediated by the ALD. The choice seems to be a function of the degree of DNA damage in the cell.
    Keywords DNA damage ; DNA fragmentation ; DNA repair ; Escherichia coli ; apoptosis ; bacteria ; cell cycle ; death ; electron transport chain ; evolution ; gene expression regulation ; genes ; mutagenesis ; ribosomal RNA
    Language English
    Dates of publication 2014-0829
    Size p. e01426-14.
    Publishing place American Society for Microbiology
    Document type Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.01426-14
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Apoptosis-like death, an extreme SOS response in Escherichia coli.

    Erental, Ariel / Kalderon, Ziva / Saada, Ann / Smith, Yoav / Engelberg-Kulka, Hanna

    mBio

    2014  Volume 5, Issue 4, Page(s) e01426–14

    Abstract: In bacteria, SOS is a global response to DNA damage, mediated by the recA-lexA genes, resulting in cell cycle arrest, DNA repair, and mutagenesis. Previously, we reported that Escherichia coli responds to DNA damage via another recA-lexA-mediated pathway ...

    Abstract In bacteria, SOS is a global response to DNA damage, mediated by the recA-lexA genes, resulting in cell cycle arrest, DNA repair, and mutagenesis. Previously, we reported that Escherichia coli responds to DNA damage via another recA-lexA-mediated pathway resulting in programmed cell death (PCD). We called it apoptosis-like death (ALD) because it is characterized by membrane depolarization and DNA fragmentation, which are hallmarks of eukaryotic mitochondrial apoptosis. Here, we show that ALD is an extreme SOS response that occurs only under conditions of severe DNA damage. Furthermore, we found that ALD is characterized by additional hallmarks of eukaryotic mitochondrial apoptosis, including (i) rRNA degradation by the endoribonuclease YbeY, (ii) upregulation of a unique set of genes that we called extensive-damage-induced (Edin) genes, (iii) a decrease in the activities of complexes I and II of the electron transport chain, and (iv) the formation of high levels of OH˙ through the Fenton reaction, eventually resulting in cell death. Our genetic and molecular studies on ALD provide additional insight for the evolution of mitochondria and the apoptotic pathway in eukaryotes. Importance: The SOS response is the first described and the most studied bacterial response to DNA damage. It is mediated by a set of two genes, recA-lexA, and it results in DNA repair and thereby in the survival of the bacterial culture. We have shown that Escherichia coli responds to DNA damage by an additional recA-lexA-mediated pathway resulting in an apoptosis-like death (ALD). Apoptosis is a mode of cell death that has previously been reported only in eukaryotes. We found that E. coli ALD is characterized by several hallmarks of eukaryotic mitochondrial apoptosis. Altogether, our results revealed that recA-lexA is a DNA damage response coordinator that permits two opposite responses: life, mediated by the SOS, and death, mediated by the ALD. The choice seems to be a function of the degree of DNA damage in the cell.
    MeSH term(s) Apoptosis/genetics ; Apoptosis/physiology ; DNA Damage/genetics ; Escherichia coli/cytology ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; SOS Response, Genetics/genetics ; SOS Response, Genetics/physiology
    Chemical Substances Escherichia coli Proteins
    Language English
    Publishing date 2014-07-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.01426-14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Escherichia coli extracellular death factor EDF induces the endoribonucleolytic activities of the toxins MazF and ChpBK.

    Belitsky, Maria / Avshalom, Haim / Erental, Ariel / Yelin, Idan / Kumar, Sathish / London, Nir / Sperber, Michal / Schueler-Furman, Ora / Engelberg-Kulka, Hanna

    Molecular cell

    2011  Volume 41, Issue 6, Page(s) 625–635

    Abstract: Escherichia coli (E. coli) mazEF is a toxin-antitoxin (TA) stress-induced module that mediates cell death requiring the quorum-sensing pentapeptide NNWNN designated EDF (extracellular death factor). E. coli toxin MazF is a sequence-specific ... ...

    Abstract Escherichia coli (E. coli) mazEF is a toxin-antitoxin (TA) stress-induced module that mediates cell death requiring the quorum-sensing pentapeptide NNWNN designated EDF (extracellular death factor). E. coli toxin MazF is a sequence-specific endoribonuclease cleaving single-stranded mRNAs at ACA sequences. E. coli ChpBK, a toxin homologous to MazF, is a sequence-specific endoribonuclease cleaving single-stranded mRNAs at ACA, ACG, and ACU sequences. Here we report that, in vitro, the signaling molecule EDF significantly amplifies the endoribonucleolytic activities of both MazF and ChpBK. EDF also overcomes the inhibitory activity of the antitoxins MazE over the toxin MazF and ChpBI over ChpBK. EDF sequence is important for both functions. Moreover, direct sequence-specific binding of EDF to MazF has been confirmed. Peptide-protein modeling revealed parallel contacts between EDF-MazF and MazE-MazF. These findings are intriguing, since most known quorum-sensing molecules monitor gene expression on the transcriptional level, while EDF monitors posttranscriptionally.
    MeSH term(s) Amino Acid Sequence ; Base Sequence ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Endoribonucleases/chemistry ; Endoribonucleases/genetics ; Endoribonucleases/metabolism ; Escherichia coli/enzymology ; Escherichia coli/genetics ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Molecular Sequence Data ; Molecular Structure ; Oligopeptides/chemistry ; Oligopeptides/genetics ; Oligopeptides/metabolism ; Protein Conformation
    Chemical Substances DNA-Binding Proteins ; Escherichia coli Proteins ; MazE protein, E coli ; MazF protein, E coli ; Oligopeptides ; asparagyl-aspargyl-tryptophyl-asparagyl-asparagine ; Endoribonucleases (EC 3.1.-) ; ChpBK protein, E coli (EC 3.1.27.-)
    Language English
    Publishing date 2011-03-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2011.02.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5055: Show issues Location:
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  8. Article: Escherichia coli Extracellular Death Factor EDF Induces the Endoribonucleolytic Activities of the Toxins MazF and ChpBK

    Belitsky, Maria / Avshalom, Haim / Erental, Ariel / Yelin, Idan / Kumar, Sathish / London, Nir / Sperber, Michal / Schueler-Furman, Ora / Engelberg-Kulka, Hanna

    Molecular cell

    Volume v. 41,, Issue no. 6

    Abstract: Escherichia coli (E. coli) mazEF is a toxin-antitoxin (TA) stress-induced module that mediates cell death requiring the quorum-sensing pentapeptide NNWNN designated EDF (extracellular death factor). E. coli toxin MazF is a sequence-specific ... ...

    Abstract Escherichia coli (E. coli) mazEF is a toxin-antitoxin (TA) stress-induced module that mediates cell death requiring the quorum-sensing pentapeptide NNWNN designated EDF (extracellular death factor). E. coli toxin MazF is a sequence-specific endoribonuclease cleaving single-stranded mRNAs at ACA sequences. E. coli ChpBK, a toxin homologous to MazF, is a sequence-specific endoribonuclease cleaving single-stranded mRNAs at ACA, ACG, and ACU sequences. Here we report that, in vitro, the signaling molecule EDF significantly amplifies the endoribonucleolytic activities of both MazF and ChpBK. EDF also overcomes the inhibitory activity of the antitoxins MazE over the toxin MazF and ChpBI over ChpBK. EDF sequence is important for both functions. Moreover, direct sequence-specific binding of EDF to MazF has been confirmed. Peptide-protein modeling revealed parallel contacts between EDF-MazF and MazE-MazF. These findings are intriguing, since most known quorum-sensing molecules monitor gene expression on the transcriptional level, while EDF monitors posttranscriptionally.
    Keywords cell death ; models ; messenger RNA ; toxins ; antitoxins ; death ; quorum sensing ; Escherichia coli ; gene expression ; transcription (genetics)
    Language English
    Document type Article
    ISSN 1097-2765
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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