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Article: The Effect of University Students' Levels of Knowledge about HPV Infection and the HPV Vaccine on Their Health Beliefs: Health Sciences Students.

Ergün, Sibel

2023 Volume 11, Issue 6

Abstract: The aim of this study was to determine health sciences students' levels of knowledge about HPV infection and the vaccine and their health beliefs, to compare them in terms of individual characteristics, and to examine the relationship between their ... ...

Abstract	The aim of this study was to determine health sciences students' levels of knowledge about HPV infection and the vaccine and their health beliefs, to compare them in terms of individual characteristics, and to examine the relationship between their knowledge of the HPV infection/vaccine and their health beliefs. The data of the study were collected from Health Sciences Faculty students through a face-to-face setting (n: 824). The data tools used in the study were the identification form, the health belief model scale for human papillomavirus infection and vaccination, and the human papillomavirus knowledge scale. The results showed that (1) although the students' levels of knowledge about HPV infection and the vaccine were low, (2) they did perceive HPV infection to be a severe problem. According to the multilinear regression analysis performed, the main predictor of the perceived severity (β = 0.29; 95% Cl: 0.04, 0.07), obstacle (β = 0.21; 95% Cl: 0.01, 0.04), and sensitivity (β = 0.22; 95% Cl: 0.02, 0.06) subscales of the HBMS-HPVV was general HPV knowledge. It was also determined that as the students' knowledge about HPV increased, their health belief levels regarding HPV infection and the vaccine increased as well (n: 824). In conclusion, for nurses and other healthcare professionals to be effective in informing individuals, they should have knowledge of HPV infection and the vaccine. In this context, the necessary education and advice about the importance of HPV infection and the vaccine should be provided to students receiving education in the field of healthcare.
Language	English
Publishing date	2023-06-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines11061126
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Article ; Online: The relationship between caregiver burden and self-care agency of pregnant women with 0-6-year-old children.

Ergün, Sibel

Nursing open

2021 Volume 9, Issue 2, Page(s) 1052–1059

Abstract: Aim: This study aims to determine the relationship between the burden of care and self-care abilities of pregnant women with 0-6-year-old children and the factors affecting them.: Design: A cross-sectional questionnaire survey.: Methods: This ... ...

Abstract	Aim: This study aims to determine the relationship between the burden of care and self-care abilities of pregnant women with 0-6-year-old children and the factors affecting them. Design: A cross-sectional questionnaire survey. Methods: This study consisted of 348 pregnant women over the age of 18, with children between the ages of 0-6. Results: The study determined that the self-care ability mean scores of mothers who have two or more children between the ages of 0-6 were low and the caregiver burden mean scores were high. The researcher found a negative correlation between the self-care ability scale scores and caregiver burden scale scores of pregnant women included in the study. These results are statistically significant and valuable in terms of revealing information about the caregiver burden and self-care ability of pregnant women with 0-6-year-old children.
MeSH term(s)	Adult ; Caregiver Burden ; Caregivers ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Humans ; Infant ; Infant, Newborn ; Pregnancy ; Pregnant Women ; Self Care
Language	English
Publishing date	2021-11-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2809556-X
ISSN	2054-1058 ; 2054-1058
ISSN (online)	2054-1058
ISSN	2054-1058
DOI	10.1002/nop2.1142
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Article ; Online: Repair of eyelid margin defects with diagonal tarsal suture technique.

Berk Ergun, Şule

International ophthalmology

2023 Volume 43, Issue 9, Page(s) 3373–3376

Abstract: Purpose: Evaluation of the results of diagonal suture technique in full-thickness eyelid margin repair in the early recovery period.: Materials and methods: In this study, full-thickness eyelid margin repair cases using a diagonal suture technique ... ...

Abstract	Purpose: Evaluation of the results of diagonal suture technique in full-thickness eyelid margin repair in the early recovery period. Materials and methods: In this study, full-thickness eyelid margin repair cases using a diagonal suture technique between February 2016 and March 2020 were reviewed retrospectively. Cases due to trauma were not included in the study. Patients were evaluated on the 1st, 6th and 30th day following surgery. The demographic information of the patients, the surgery performed, the level of the lid margin (normal healing, notching), and the presence of tissue reaction (edema, redness, tissue separation, abscess formation) were recorded. Results: Nine (47.4%) out of 19 patients were female and 10 (52.6%) were male. Their ages ranged from 56 to 83 (median: 66). Of the 19 surgeries performed, 14 were Quickert, 3 were pentagon excision, and 2 were Lazy-T. Edema was observed in 3 cases (15.8%) on the first day. Tissue reaction was not observed in any of the cases in neither the first week nor the first month. Although the lid margin healed properly in each case, notching was observed on the inner surface of the lid margin on the 1st and 6th postoperative days in 1 (5.3%) patient. During the 30th-day follow-up visit, it was observed that the notching had decreased. Conclusion: The advantages of diagonal suture technique are having no sutures that may touch the cornea at the lid margin and resulting in a better cosmetic appearance in the early postoperative period. It is an easy, effective and reliable method to apply.
MeSH term(s)	Humans ; Male ; Female ; Retrospective Studies ; Eyelids/surgery ; Blepharoplasty/methods ; Suture Techniques ; Sutures
Language	English
Publishing date	2023-05-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	800087-6
ISSN	1573-2630 ; 0165-5701
ISSN (online)	1573-2630
ISSN	0165-5701
DOI	10.1007/s10792-023-02744-9
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Article ; Online: Development of a calculation software for 4πβ-γ digital coincidence counting and its application to

Şahin, N K / Ergün, Ş

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

2021 Volume 172, Page(s) 109686

Abstract: A unique calculation software has been developed for 4πβ-γ coincidence counting system that has been recently set up. The combination of the software and the hardware constitutes the measurement system. The developed coincidence counting software uses ... ...

Abstract	A unique calculation software has been developed for 4πβ-γ coincidence counting system that has been recently set up. The combination of the software and the hardware constitutes the measurement system. The developed coincidence counting software uses both of coincidence and anticoincidence methods. Activity calculations have been performed using unique algorithms generated for these methods. The main processing modules of the software are the raw data reading-writing module, energy spectrum composing module, energy filtering module, deadtime application module, coincidence and anticoincidence calculation modules and efficiency extrapolation module. The known activities of
Language	English
Publishing date	2021-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1142596-9
ISSN	1872-9800 ; 0883-2889 ; 0969-8043
ISSN (online)	1872-9800
ISSN	0883-2889 ; 0969-8043
DOI	10.1016/j.apradiso.2021.109686
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Article ; Online: Cross-Kingdom Gene regulation via miRNAs of Hypericum perforatum (St. John's wort) flower dietetically absorbed: An in silico approach to define potential biomarkers for prostate cancer.

Ergün, Sercan

Computational biology and chemistry

2019 Volume 80, Page(s) 16–22

Abstract: Prostate cancer (PCa) is the most frequent type of cancer in men. Hypericum perforatum (H. Perforatum) extract (HPE) administration provides remarkable decrease of PCa development. H. perforatum contains 7 conserved miRNAs (Hyp-miR-156a, Hyp-miR-156b, ... ...

Abstract	Prostate cancer (PCa) is the most frequent type of cancer in men. Hypericum perforatum (H. Perforatum) extract (HPE) administration provides remarkable decrease of PCa development. H. perforatum contains 7 conserved miRNAs (Hyp-miR-156a, Hyp-miR-156b, Hyp-miR-166, Hyp-miR-390, Hyp-miR-394, Hyp-miR-396 and Hyp-miR-414) with different targets. In this study, we aimed to investigate cross-kingdom gene regulation via miRNAs of H. perforatum flower dietetically absorbed in manner of an in silico approach to define potential biomarkers for PCa. psRNATarget database was used to find human genes targeted by 7 pre-defined H. perforatum miRNAs. We defined the mostly affected gene families from these miRNAs as ZNF, TMEM, SLC and FAM gene families. GeneMANIA database was used to define the most affected genes (TMEM41B and SLC4A7) from these 7 miRNAs. cBioPortal database was used to define alteration frequencies of TMEM41B and SLC4A7 on different types of PCa and to measure the mutual interaction potency and significance of co-occurence in PCa. This analysis showed that neuroendocrine prostate cancer (NEPC) had the highest total mutation frequency (22%) of TMEM41B and SLC4A7 genes. Also, TMEM41B and SLC4A7 genes had an average 2.1% pathway change potential among all different types of PCa. Moreover, TMEM41B and SLC4A7 gene pair was found significantly co-occurrent in PCa (p < 0.001). Finally, via GEPIA database, we used Spearman correlation analysis to measure the correlation degree of TMEM41B and SLC4A7 genes in PCa and found their significant correlation with PCa (p = 1.2 × 10
MeSH term(s)	Biomarkers ; Computer Simulation ; Flowers/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Hypericum/genetics ; Male ; Membrane Proteins/genetics ; MicroRNAs/genetics ; Mutation ; Prostatic Neoplasms/genetics ; RNA, Plant/genetics ; Sodium-Bicarbonate Symporters/genetics ; Software
Chemical Substances	Biomarkers ; Membrane Proteins ; MicroRNAs ; RNA, Plant ; SLC4A7 protein, human ; Sodium-Bicarbonate Symporters ; TMEM41B protein, human
Language	English
Publishing date	2019-02-28
Publishing country	England
Document type	Journal Article
ISSN	1476-928X
ISSN (online)	1476-928X
DOI	10.1016/j.compbiolchem.2019.02.010
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Article ; Online: The relationship between DNA mismatch repair gene and other prognostic parameters in pancreatic adenocarcinoma.

Urganci, Nil / Kepil, Nuray / Ergun, Sefa / Bakkaloglu, Oguz Kaan

Journal of surgical oncology

2024 Volume 129, Issue 5, Page(s) 876–884

Abstract: The aim of the study was to determine DNA mismatch repair (MMR) proteins by immunohistochemically using MLH1, MSH2, MSH6, and PMS2 antibodies in patients diagnosed as pancreatic ductal adenocarcinoma and to assess its relationship with histopathological ... ...

Abstract	The aim of the study was to determine DNA mismatch repair (MMR) proteins by immunohistochemically using MLH1, MSH2, MSH6, and PMS2 antibodies in patients diagnosed as pancreatic ductal adenocarcinoma and to assess its relationship with histopathological and clinical prognostic parameters. Fifty cases with a diagnosis of pancreatic ductal adenocarcinoma who underwent surgical resection, were included in the study. Demographic and histopathological features of the patients were collected from the medical records. The relationships between microsatellite status and prognostic parameters were determined. The mean age of the patients was 66.5 ± 9.5 years (range: 47-87) and male/female ratio was 1.63 (31/19). No errors were detected in DNA MMR proteins in any of the cases, and were classified as microsatellite stable. The mean tumor diameter was 4.01 ± 1.77 cm and 74% of the tumors were localized in the pancreatic head. All of the cases had lymphatic invasion, whereas vascular invasion was detected in only 78% and perineural invasion in 98% of the patients. When the relationship between prognostic parameters and survival was evaluated, statistically significant correlation was observed in patient age and histopathological parameters such as tumor diameter, status of surgical margins, and vascular invasion (p < 0.05). Age, tumor size, presence of tumor at surgical margins, vascular invasion, and adjuvant treatment were correlated with survival. Although microsatellite instability was not detected in our cases, it is important to determine the microsatellite status by immunohistochemistry for predicting the chemotherapy response and determining the immunotherapy option in pancreatic adenocarcinomas.
MeSH term(s)	Humans ; Male ; Female ; Middle Aged ; Aged ; Aged, 80 and over ; Adenocarcinoma/genetics ; Adenocarcinoma/therapy ; Adenocarcinoma/metabolism ; Prognosis ; DNA Mismatch Repair ; Margins of Excision ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/therapy ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/therapy ; MutL Protein Homolog 1/genetics ; MutL Protein Homolog 1/metabolism ; MutS Homolog 2 Protein/genetics ; MutS Homolog 2 Protein/metabolism
Chemical Substances	MutL Protein Homolog 1 (EC 3.6.1.3) ; MutS Homolog 2 Protein (EC 3.6.1.3)
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	82063-5
ISSN	1096-9098 ; 0022-4790
ISSN (online)	1096-9098
ISSN	0022-4790
DOI	10.1002/jso.27579
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Article: Characteristics of Bacterial Biofilm Formation in Nasolacrimal Silicone Tubes Post-dacryocystorhinostomy.

Berk Ergun, Şule / Has, Elif G / Akçelik, Nefise / Akçelik, Mustafa

Cureus

2024 Volume 16, Issue 3, Page(s) e56112

Abstract: Purpose: To examine the biofilm formation characteristics of bacteria identified at the genus level in samples obtained from silicone tubes after dacryocystorhinostomy surgery.: Methods: In the study involving consecutive patients who underwent ... ...

Abstract	Purpose: To examine the biofilm formation characteristics of bacteria identified at the genus level in samples obtained from silicone tubes after dacryocystorhinostomy surgery. Methods: In the study involving consecutive patients who underwent dacryocystorhinostomy surgery at Ankara Bilkent City Hospital and whose silicone tubes were removed six months after surgery, between January 2023 and May 2023; the tubes were placed in glycerol-PBS (phosphate buffered saline) solution and cultured on descriptive selective media at the genus level. The biofilm-forming properties of the obtained isolates were examined in solid-air and liquid-air interphases. Results: As a result of the analysis of the samples taken from the patients, Conclusion: Since biofilms are considered potential factors in the pathogenesis of infectious and inflammatory diseases, they are a subject that needs to be thoroughly investigated. In our study, although there were no clinical infections in any of the patients, biofilm formation was detected in the patient samples. The fact that the bacteria exhibited moderate to strong biofilm formation characteristics suggests that these microorganisms could be persistent infectious agents.
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.56112
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Article ; Online: Understanding the link between neurotropic viruses, BBB permeability, and MS pathogenesis.

Rani, Annu / Ergün, Süleyman / Karnati, Srikanth / Jha, Hem Chandra

Journal of neurovirology

2024 Volume 30, Issue 1, Page(s) 22–38

Abstract: Neurotropic viruses can infiltrate the CNS by crossing the blood-brain barrier (BBB) through various mechanisms including paracellular, transcellular, and "Trojan horse" mechanisms during leukocyte diapedesis. These viruses belong to several families, ... ...

Abstract	Neurotropic viruses can infiltrate the CNS by crossing the blood-brain barrier (BBB) through various mechanisms including paracellular, transcellular, and "Trojan horse" mechanisms during leukocyte diapedesis. These viruses belong to several families, including retroviruses; human immunodeficiency virus type 1 (HIV-1), flaviviruses; Japanese encephalitis (JEV); and herpesviruses; herpes simplex virus type 1 (HSV-1), Epstein-Barr virus (EBV), and mouse adenovirus 1 (MAV-1). For entering the brain, viral proteins act upon the tight junctions (TJs) between the brain microvascular endothelial cells (BMECs). For instance, HIV-1 proteins, such as glycoprotein 120, Nef, Vpr, and Tat, disrupt the BBB and generate a neurotoxic effect. Recombinant-Tat triggers amendments in the BBB by decreasing expression of the TJ proteins such as claudin-1, claudin-5, and zona occludens-1 (ZO-1). Thus, the breaching of BBB has been reported in myriad of neurological diseases including multiple sclerosis (MS). Neurotropic viruses also exhibit molecular mimicry with several myelin sheath proteins, i.e., antibodies against EBV nuclear antigen 1 (EBNA1) aa411-426 cross-react with MBP and EBNA1 aa385-420 was found to be associated with MS risk haplotype HLA-DRB1*150. Notably, myelin protein epitopes (PLP
MeSH term(s)	Blood-Brain Barrier/virology ; Blood-Brain Barrier/metabolism ; Blood-Brain Barrier/pathology ; Humans ; Animals ; Multiple Sclerosis/virology ; Multiple Sclerosis/metabolism ; Multiple Sclerosis/pathology ; Mice ; Tight Junctions/virology ; Tight Junctions/metabolism ; Capillary Permeability ; Endothelial Cells/virology ; Endothelial Cells/metabolism ; Endothelial Cells/pathology
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1283265-0
ISSN	1538-2443 ; 1355-0284
ISSN (online)	1538-2443
ISSN	1355-0284
DOI	10.1007/s13365-023-01190-8
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Article ; Online: Direct Stochastic Optical Reconstruction Microscopy (dSTORM) of Peroxisomes.

Klein, Teresa / Sauer, Markus / Ergün, Süleyman / Karnati, Srikanth

Methods in molecular biology (Clifton, N.J.)

2023 Volume 2643, Page(s) 85–92

Abstract: Peroxisomes are central metabolic organelles whose maturation and function depend on efficient and accurate targeting of peroxisomal membrane proteins (PMPs). Ultrastructural imaging of the PMPs is a quite difficult task as it requires high spatial and ... ...

Abstract	Peroxisomes are central metabolic organelles whose maturation and function depend on efficient and accurate targeting of peroxisomal membrane proteins (PMPs). Ultrastructural imaging of the PMPs is a quite difficult task as it requires high spatial and temporal resolution. Further, the spatial resolution of conventional light microscopy is limited due to the diffraction of light. However, recent methodological developments in super resolution microscopy showed us to access the nanoscale regimes spatially allowing to elucidate the membrane structures of cell organelles. In this chapter, we present protocols used in our laboratory for the super-resolution imaging of the peroxisomal membrane protein 14 (PEX14p) by direct stochastic optical reconstruction microscopy (dSTORM).
MeSH term(s)	Microscopy/methods ; Peroxisomes ; Intracellular Membranes ; Membrane Proteins
Chemical Substances	Membrane Proteins
Language	English
Publishing date	2023-03-23
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3048-8_6
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Article ; Online: Clinically informative microRNAs for SARS-CoV-2 infection.

Ergün, Sercan / Sankaranarayanan, Ramamoorthy / Petrović, Nina

Epigenomics

2023 Volume 15, Issue 13, Page(s) 705–716

Abstract: COVID-19 is a viral respiratory infection induced by the newly discovered coronavirus SARS-CoV-2. miRNA is an example of a strong and direct regulator of a gene's transcriptional activity. The interaction between miRNAs and their target molecules is ... ...

Abstract	COVID-19 is a viral respiratory infection induced by the newly discovered coronavirus SARS-CoV-2. miRNA is an example of a strong and direct regulator of a gene's transcriptional activity. The interaction between miRNAs and their target molecules is responsible for homeostasis. Virus-derived and host-derived miRNAs are involved in the activity of hiding from immune system cells, inducing the inflammatory reaction through interplay with associated genes, during SARS-COV-2 infection. Interest in miRNAs has raised the comprehension of the machinery and pathophysiology of SARS-COV-2 infection. In this review, the effects and biological roles of miRNAs on SARS-CoV-2 pathogenicity and life cycle are described. The therapeutic potential of miRNAs against SARS-CoV-2 infection are also mentioned.
MeSH term(s)	Humans ; MicroRNAs/genetics ; COVID-19/genetics ; SARS-CoV-2/genetics ; Inflammation
Chemical Substances	MicroRNAs
Language	English
Publishing date	2023-09-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2537199-X
ISSN	1750-192X ; 1750-1911
ISSN (online)	1750-192X
ISSN	1750-1911
DOI	10.2217/epi-2023-0179
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