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  1. AU="Erhart, Stephen"
  2. AU="Glenn Smith"
  3. AU="Shillingford, Shanelle R"
  4. AU="Ahn, Sung Soo"
  5. AU="Salih, Harith M"
  6. AU="Clayton, Philip A"
  7. AU="Soto, A. Garcia"
  8. AU="Jones, Daniel OB"
  9. AU="Chen, Maosheng"
  10. AU="Li, Zhengxi"
  11. AU="Toshiya Takahashi"
  12. AU=Hickey Chelsea L.
  13. AU="Badhrinarayanan, Shreya"
  14. AU="Milani, Liliana"
  15. AU="Reinhardt, Klaus"
  16. AU="Caudillo-Flores, Uriel"
  17. AU="Yin, Yizhen"
  18. AU=Kaushansky Kenneth
  19. AU="Golla, Jaya Prakash"
  20. AU="Penn, Marc S"
  21. AU="Montero, Vincent"
  22. AU="Etevenon, Pierre"
  23. AU="Hyseni, Agon"
  24. AU="Seitzman, Natalie"
  25. AU="Loukil, Abdelhalim"
  26. AU="Giammusso, Bruno"
  27. AU="Kaplan, Jonathan E"
  28. AU=Francolini Giulio
  29. AU="Yuhu Li"
  30. AU=Kim Moojung
  31. AU="Vise, Luciana M"
  32. AU="Marcinowska, Zuzanna"
  33. AU="Graff, Pablo"

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Treffer 1 - 7 von insgesamt 7

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  1. Artikel: Treatment of schizophrenia negative symptoms: future prospects.

    Erhart, Stephen M / Marder, Stephen R / Carpenter, William T

    Schizophrenia bulletin

    2006  Band 32, Heft 2, Seite(n) 234–237

    Abstract: New findings from neuroscience, genetics, and experimental psychology have emerged that provide alternative explanations of many negative symptoms. We review the continuing limitations in treatment and discuss possible sources of heterogeneity among ... ...

    Abstract New findings from neuroscience, genetics, and experimental psychology have emerged that provide alternative explanations of many negative symptoms. We review the continuing limitations in treatment and discuss possible sources of heterogeneity among negative symptoms. We also anticipate conceptual uncertainties that may arise with forthcoming treatment developments.
    Mesh-Begriff(e) Antipsychotic Agents/pharmacology ; Antipsychotic Agents/therapeutic use ; Drug Therapy/trends ; Forecasting ; Frontal Lobe/physiopathology ; Humans ; Receptors, Dopamine D4/drug effects ; Receptors, Dopamine D4/genetics ; Schizophrenia/drug therapy ; Schizophrenia/genetics ; Schizophrenia/physiopathology ; Schizophrenic Psychology ; Surveys and Questionnaires
    Chemische Substanzen Antipsychotic Agents ; Receptors, Dopamine D4 (137750-34-6)
    Sprache Englisch
    Erscheinungsdatum 2006-04
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 439173-1
    ISSN 1745-1701 ; 0586-7614
    ISSN (online) 1745-1701
    ISSN 0586-7614
    DOI 10.1093/schbul/sbj055
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Social Cognition and Neurocognition: Effects of Risperidone, Olanzapine, and Haloperidol.

    Sergi, Mark / Green, Michael / Widmark, Clifford / Reist, Christopher / Erhart, Stephen / Braff, David / Kee, Kimmy / Marder, Stephen / Mintz, Jim

    The American journal of psychiatry

    2012  Band 164, Heft 10, Seite(n) 1585–1592

    Abstract: Objective: This study examined the short-term effects of first- and second-generation antipsychotic medications on social cognition and basic cognition. Method: One hundred patients with schizophrenia or schizoaffective disorder participated in an 8 week, ...

    Abstract Objective: This study examined the short-term effects of first- and second-generation antipsychotic medications on social cognition and basic cognition. Method: One hundred patients with schizophrenia or schizoaffective disorder participated in an 8 week, double-blind study of risperidone, olanzapine, and haloperidol. Participants were administered multiple measures of social cognition, basic cognition, and clinical symptoms at baseline, the end of week 4, and the end of week 8. Seventy-three patients completed the baseline assessment and at least one other assessment. Data were analyzed with mixed-effects analyses of covariance. For data reduction, the social cognitive measures were clustered into a summary score, and the cognitive measures were clustered into two summary scores: general cognitive ability and processing speed. (The effects on thinking of risperidone and olanzapine can be found at NCT00108368, www.clinicaltrials.gov.) Results: There were no treatment-related differences on any of the three summary scores. Social cognition did not show within-group changes over time either by itself or after control for the cognitive clusters. One cognitive score (general cognitive ability) increased during the study period for all three medication groups. Conclusions: The present study included a rather thorough assessment of social cognition and did not find any evidence of between-group or within-group effects of antipsychotic medication on social cognition.
    Sprache Englisch
    Erscheinungsdatum 2012-06-06
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    DOI 10.1176/appi.ajp.2007.06091515
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Clinical utility of magnetic resonance imaging radiographs for suspected organic syndromes in adult psychiatry.

    Erhart, Stephen M / Young, Alexander S / Marder, Stephen R / Mintz, Jim

    The Journal of clinical psychiatry

    2005  Band 66, Heft 8, Seite(n) 968–973

    Abstract: Objective: In psychiatric practice, adult patients are most commonly referred for magnetic resonance imaging (MRI) to screen for suspected organic medical diseases of the central nervous system that can mimic psychiatric syndromes. We identified the ... ...

    Abstract Objective: In psychiatric practice, adult patients are most commonly referred for magnetic resonance imaging (MRI) to screen for suspected organic medical diseases of the central nervous system that can mimic psychiatric syndromes. We identified the most common signs and symptoms prompting MRIs to establish the predictive value of these signs and symptoms for clinically pertinent organic syndromes.
    Method: This study was a retrospective chart review of psychiatric patients at the Veterans Affairs Greater Los Angeles Health Care Center (Los Angeles, Calif.) who were referred for MRI of the brain between 1996 and 2002. Patients referred for evaluation of dementia were excluded. The specific indications leading clinicians to obtain MRI were identified and grouped. In order to offset the uncertain significance of many MRI findings, for this study, the predictive value of each indication was calculated based on the percentage of patients in whom clinical management changed in response to MRI findings rather than on the percentage with any abnormal MRI results.
    Results: Of 253 patients who had MRIs, 38 (15%) incurred some degree of treatment modification as a result of MRI findings, including 6 patients in whom MRI identified a medical condition that became the focus of treatment. Six indications appeared most likely to prompt clinicians to obtain MRIs. Because pertinent results were associated with each of these indications, statistical evaluation did not reveal significant differences in their predictive values (chi(2) = 4.32, df = 5, p = .505).
    Conclusions: Unlike prior studies showing no value to screening radioimaging, this study shows MRI can be a useful screening test among patients suspected of having organic psychiatric disorders and that the common indications for MRI employed at one institution were predictive.
    Mesh-Begriff(e) Adult ; Aged ; Cognition Disorders/diagnosis ; Cognition Disorders/epidemiology ; Female ; Humans ; Incidence ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Imaging/statistics & numerical data ; Male ; Middle Aged ; Neurocognitive Disorders/diagnosis ; Neurocognitive Disorders/epidemiology ; Neurocognitive Disorders/therapy ; Patient Care Management/methods ; Predictive Value of Tests ; Psychiatry/methods ; Referral and Consultation/statistics & numerical data ; Retrospective Studies
    Sprache Englisch
    Erscheinungsdatum 2005-05-05
    Erscheinungsland United States
    Dokumenttyp Evaluation Studies ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    DOI 10.4088/jcp.v66n0802
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Understanding the new and evolving profile of adverse drug effects in schizophrenia.

    Wirshing, Donna A / Pierre, Joseph M / Erhart, Stephen M / Boyd, Jennifer A

    The Psychiatric clinics of North America

    2003  Band 26, Heft 1, Seite(n) 165–190

    Abstract: This article has reviewed the emerging side-effect profiles of second-generation antipsychotic medications. Although these medications have favorable extrapyramidal side-effect profiles, clinicians must be aware of their propensity to cause weight gain, ... ...

    Abstract This article has reviewed the emerging side-effect profiles of second-generation antipsychotic medications. Although these medications have favorable extrapyramidal side-effect profiles, clinicians must be aware of their propensity to cause weight gain, glucose and lipid abnormalities, and cardiac and sexual side effects. If clinicians are proactive about warning patients about these side effects and appropriately monitoring them, further morbidity and mortality may be prevented in this patient population. Initial choices of medication should be made based on the relative side-effect profiles in light of a particular patient's medical status. In the future, new treatments may be developed, with even fewer side effects.
    Mesh-Begriff(e) Antipsychotic Agents/adverse effects ; Diabetes Mellitus/chemically induced ; Female ; Glucose/metabolism ; Humans ; Hyperlipidemias/chemically induced ; Long QT Syndrome/chemically induced ; Male ; Prolactin/metabolism ; Schizophrenia/classification ; Schizophrenia/drug therapy ; Sexual Dysfunction, Physiological/chemically induced ; Weight Gain/drug effects
    Chemische Substanzen Antipsychotic Agents ; Prolactin (9002-62-4) ; Glucose (IY9XDZ35W2)
    Sprache Englisch
    Erscheinungsdatum 2003-02-27
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 431518-2
    ISSN 1558-3147 ; 0193-953X
    ISSN (online) 1558-3147
    ISSN 0193-953X
    DOI 10.1016/s0193-953x(02)00035-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Social cognition in schizophrenia: relationships with neurocognition and negative symptoms.

    Sergi, Mark J / Rassovsky, Yuri / Widmark, Clifford / Reist, Christopher / Erhart, Stephen / Braff, David L / Marder, Stephen R / Green, Michael F

    Schizophrenia research

    2007  Band 90, Heft 1-3, Seite(n) 316–324

    Abstract: Despite the growing importance of social cognition in schizophrenia, fundamental issues concerning the nature of social cognition in schizophrenia remain unanswered. One issue concerns the strength of the relationships between social cognition and key ... ...

    Abstract Despite the growing importance of social cognition in schizophrenia, fundamental issues concerning the nature of social cognition in schizophrenia remain unanswered. One issue concerns the strength of the relationships between social cognition and key features of the disorder such as neurocognitive deficits and negative symptoms. The current study employed structural equation modeling to examine three key questions regarding the nature of social cognition in schizophrenia: 1) Are social cognition and neurocognition in schizophrenia better modeled as one or two separate constructs? 2) Are social cognition and negative symptoms in schizophrenia better modeled as one or two separate constructs?, and 3) When social cognition, neurocognition, and negative symptoms are included in a single model, is social cognition more closely related to neurocognition or to negative symptoms? In this cross sectional study, one hundred outpatients with schizophrenia or schizoaffective disorder were administered measures of social cognition, neurocognition, and negative symptoms. A two-factor model that represented social cognition and neurocognition as separate constructs fit the data significantly better than a one-factor model, suggesting that social cognition and neurocognition are distinct, yet highly related, constructs. Likewise, a two-factor model that represented social cognition and negative symptoms as separate constructs fit the data significantly better than a one-factor model, suggesting that social cognition and negative symptoms are distinct constructs. A three-factor model revealed that the relationship between social cognition and neurocognition was stronger than the relationship between social cognition and negative symptoms. The current findings start to provide insights into the structure of social cognition, neurocognition, and negative symptoms in schizophrenia.
    Mesh-Begriff(e) Adult ; Awareness ; Cognition Disorders/diagnosis ; Cognition Disorders/psychology ; Depression/diagnosis ; Depression/psychology ; Emotions ; Female ; Humans ; Interpersonal Relations ; Male ; Middle Aged ; Neuropsychological Tests ; Pattern Recognition, Visual ; Personal Construct Theory ; Psychotic Disorders/diagnosis ; Psychotic Disorders/psychology ; Schizophrenia/diagnosis ; Schizophrenic Psychology ; Social Behavior ; Social Perception ; Statistics as Topic
    Sprache Englisch
    Erscheinungsdatum 2007-02
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2006.09.028
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Social cognition [corrected] and neurocognition: effects of risperidone, olanzapine, and haloperidol.

    Sergi, Mark J / Green, Michael F / Widmark, Clifford / Reist, Christopher / Erhart, Stephen / Braff, David L / Kee, Kimmy S / Marder, Stephen R / Mintz, Jim

    The American journal of psychiatry

    2007  Band 164, Heft 10, Seite(n) 1585–1592

    Abstract: Objective: This study examined the short-term effects of first- and second-generation antipsychotic medications on social cognition and basic cognition.: Method: One hundred patients with schizophrenia or schizoaffective disorder participated in an 8 ...

    Abstract Objective: This study examined the short-term effects of first- and second-generation antipsychotic medications on social cognition and basic cognition.
    Method: One hundred patients with schizophrenia or schizoaffective disorder participated in an 8 week, double-blind study of risperidone, olanzapine, and haloperidol. Participants were administered multiple measures of social cognition, basic cognition, and clinical symptoms at baseline, the end of week 4, and the end of week 8. Seventy-three patients completed the baseline assessment and at least one other assessment. Data were analyzed with mixed-effects analyses of covariance. For data reduction, the social cognitive measures were clustered into a summary score, and the cognitive measures were clustered into two summary scores: general cognitive ability and processing speed.
    Results: There were no treatment-related differences on any of the three summary scores. Social cognition did not show within-group changes over time either by itself or after control for the cognitive clusters. One cognitive score (general cognitive ability) increased during the study period for all three medication groups.
    Conclusions: The present study included a rather thorough assessment of social cognition and did not find any evidence of between-group or within-group effects of antipsychotic medication on social cognition.
    Mesh-Begriff(e) Ambulatory Care ; Antipsychotic Agents/pharmacology ; Antipsychotic Agents/therapeutic use ; Benzodiazepines/pharmacology ; Benzodiazepines/therapeutic use ; Cognition/drug effects ; Cognition Disorders/diagnosis ; Cognition Disorders/drug therapy ; Cognition Disorders/psychology ; Emotions ; Facial Expression ; Female ; Haloperidol/pharmacology ; Haloperidol/therapeutic use ; Humans ; Male ; Middle Aged ; Neuropsychological Tests/statistics & numerical data ; Psychotic Disorders/drug therapy ; Psychotic Disorders/psychology ; Risperidone/pharmacology ; Risperidone/therapeutic use ; Schizophrenia/drug therapy ; Schizophrenic Psychology ; Social Perception ; Treatment Outcome
    Chemische Substanzen Antipsychotic Agents ; Benzodiazepines (12794-10-4) ; Haloperidol (J6292F8L3D) ; Risperidone (L6UH7ZF8HC) ; olanzapine (N7U69T4SZR)
    Sprache Englisch
    Erscheinungsdatum 2007-10
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    DOI 10.1176/appi.ajp.2007.06091515
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Effects of olanzapine, risperidone and haloperidol on prepulse inhibition in schizophrenia patients: a double-blind, randomized controlled trial.

    Wynn, Jonathan K / Green, Michael F / Sprock, Joyce / Light, Gregory A / Widmark, Clifford / Reist, Christopher / Erhart, Stephen / Marder, Stephen R / Mintz, Jim / Braff, David L

    Schizophrenia research

    2007  Band 95, Heft 1-3, Seite(n) 134–142

    Abstract: Prepulse inhibition (PPI), whereby the startle eyeblink response is inhibited by a relatively weak non-startling stimulus preceding the powerful startle eliciting stimulus, is a measure of sensorimotor gating and has been shown to be deficient in ... ...

    Abstract Prepulse inhibition (PPI), whereby the startle eyeblink response is inhibited by a relatively weak non-startling stimulus preceding the powerful startle eliciting stimulus, is a measure of sensorimotor gating and has been shown to be deficient in schizophrenia patients. There is considerable interest in whether conventional and/or atypical antipsychotic medications can "normalize" PPI deficits in schizophrenia patients. 51 schizophrenia patients participated in a randomized, double-blind controlled trial on the effects of three commonly-prescribed antipsychotic medications (risperidone, olanzapine, or haloperidol) on PPI, startle habituation, and startle reactivity. Patients were tested at baseline, Week 4 and Week 8. Mixed model regression analyses revealed that olanzapine significantly improved PPI from Week 4 to Week 8, and that at Week 8 patients receiving olanzapine produced significantly greater PPI than those receiving risperidone, but not haloperidol. There were no effects of medication on startle habituation or startle reactivity. These results support the conclusion that olanzapine effectively increased PPI in schizophrenia patients, but that risperidone and haloperidol had no such effects. The results are discussed in terms of animal models, neural substrates, and treatment implications.
    Mesh-Begriff(e) Acoustic Stimulation ; Antipsychotic Agents/therapeutic use ; Benzodiazepines/pharmacology ; Benzodiazepines/therapeutic use ; Double-Blind Method ; Electromyography ; Female ; Habituation, Psychophysiologic/drug effects ; Haloperidol/pharmacology ; Haloperidol/therapeutic use ; Humans ; Male ; Middle Aged ; Psychotic Disorders/drug therapy ; Psychotic Disorders/psychology ; Reflex, Startle/drug effects ; Risperidone/pharmacology ; Risperidone/therapeutic use ; Schizophrenia/drug therapy ; Schizophrenic Psychology ; Treatment Outcome
    Chemische Substanzen Antipsychotic Agents ; Benzodiazepines (12794-10-4) ; Haloperidol (J6292F8L3D) ; Risperidone (L6UH7ZF8HC) ; olanzapine (N7U69T4SZR)
    Sprache Englisch
    Erscheinungsdatum 2007-09
    Erscheinungsland Netherlands
    Dokumenttyp Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2007.05.039
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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