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  1. AU="Eric Woode"
  2. AU="Zybina O"
  3. AU="Reynolds, Cecil R"
  4. AU="Shahidul Khan"
  5. AU="Vasisth, Rashi"
  6. AU="Raju Mandal"
  7. AU="Owen, Noel L"
  8. AU=Liu Xiaolei
  9. AU="Fırıncıoğluları, Ali"
  10. AU="Piepel, Christiane"
  11. AU="Saremi, Saeid"
  12. AU="Dunxian She"

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  1. Artikel ; Online: Ceiba pentandra (L.) Gaertn hydroethanolic leaf extract exhibits anticonvulsant properties in mouse models

    Anthony Sarfo / Wonder Kofi Mensah Abotsi / Edmund Ekuadzi / Eric Woode

    Phytomedicine Plus, Vol 2, Iss 2, Pp 100263- (2022)

    2022  

    Abstract: Background: Ceiba pentandra (L.) Gaertn. (Malvaceae) is a plant documented folklorically to be used in the management of epilepsy but with no scientific evidence to support its efficacy. Aim: The aim of this study was to evaluate the anticonvulsant ... ...

    Abstract Background: Ceiba pentandra (L.) Gaertn. (Malvaceae) is a plant documented folklorically to be used in the management of epilepsy but with no scientific evidence to support its efficacy. Aim: The aim of this study was to evaluate the anticonvulsant properties of a hydroethanolic leaf extract of Ceiba pentandra (CPLE). Methods: Mouse models of acute seizures [maximal electroshock (MES)-, 4-aminopyridine (4-AP)-, pentylenetetrazole (PTZ)-, strychnine- and picrotoxin (PIC)- induced seizure tests)] and status epilepticus (lithium/pilocarpine test) were employed to investigate the anticonvulsant properties of CPLE (30–300 mg/kg, p.o.). The effects of CPLE on motor coordination (rotarod test) and spontaneous locomotor activity (open field test) were also examined. The study further investigated the possible involvement of GABAergic mechanisms in the actions of the extract. Results: CPLE, given orally, delayed the onset and reduced the frequency and duration of PTZ- and PIC-induced convulsions. Additionally, CPLE delayed the onset of convulsions and prolonged survival in the 4-aminopyridine test. The extract also prolonged survival in the MES test. CPLE, however, failed to attenuate strychnine-induced convulsions. The extract reduced severity of convulsions and increased the latency to status epilepticus in the lithium-pilocarpine test. Pre-treatment of the animals with flumazenil (1 mg/kg, i.p.) reversed the anticonvulsant effect of the extract (100 mg/kg) against PTZ-induced convulsions. The extract (at 300 mg/kg) impaired motor coordination in the rotarod test and reduced locomotor activity in the open field arena. Conclusion: The present findings indicate that Ceiba pentandra leaf extract has significant anticonvulsant properties in mouse models. These observations justify the traditional use of Ceiba pentandra for the management of seizure conditions.
    Schlagwörter Epilepsy ; Seizure ; Picrotoxin ; Ceiba pentandra ; GABAergic ; Pentylenetetrazole ; Other systems of medicine ; RZ201-999
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2022-05-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
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  2. Artikel ; Online: Medicinal Plants with Prospective Benefits in the Management of Peptic Ulcer Diseases in Ghana

    Mavis Boakye-Yiadom / Doris Kumadoh / Emmanuel Adase / Eric Woode

    BioMed Research International, Vol

    2021  Band 2021

    Abstract: Background. The growth or multiplication of harmful microorganisms in addition to harmful human activities has led to many disorders in humans. Consequently, there is a search for medications to treat these disorders. Interestingly, medicines of plant ... ...

    Abstract Background. The growth or multiplication of harmful microorganisms in addition to harmful human activities has led to many disorders in humans. Consequently, there is a search for medications to treat these disorders. Interestingly, medicines of plant origin are known to be among the most attractive sources of new drugs and have shown promising results in the treatment of various diseases including peptic ulcers. This review, therefore, is aimed at obtaining knowledge on some Ghanaian ethnomedicinal plants used to treat peptic ulcers, their folkloric uses, their phytochemicals, and their antiulcer and related pharmacological activities as well as finding areas for prospective studies.Methods. Published peer-reviewed articles on ethnomedicinal plants used for the management of peptic ulcers in Ghana from 1967 to 2020 were sourced and used for the study. Results. In this review, 13 plants were identified which belong to 10 different families including Sapindaceae, Apocynaceae, and Bignoniaceae. The parts most often used for most preparations were the leaves (53%), followed by stem bark and roots (both having the same percentage of use of 17.6%), the whole plant (5.9%), and the rhizomes (5.9%). Azadirachta indica was the only plant that had undergone some patient studies in addition to animal studies. Conclusion. A discussion of various antiulcer activity studies using ulcer models carried out on selected medicinal plants used for the management of peptic ulcer disease in addition to brief information on their folkloric uses and their phytochemical and other pharmacological properties is presented. These medicinal plants may be used in developing herbal products for the management of peptic ulcer disease.
    Schlagwörter Medicine ; R
    Thema/Rubrik (Code) 580
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Patterns in protein consumption in Ghanaian cities

    Cheetham Lawrence Mingle / Godfred Darko / Noah Kyame Asare-Donkor / Lawrence Sheringham Borquaye / Eric Woode

    Scientific African, Vol 11, Iss , Pp e00684- (2021)

    2021  

    Abstract: Consumption of food of animal origin or animal proteins has been associated with many perceptions about the quantity and quality consumed and the related health effects on the consumer. Several investigative methods including a food frequency ... ...

    Abstract Consumption of food of animal origin or animal proteins has been associated with many perceptions about the quantity and quality consumed and the related health effects on the consumer. Several investigative methods including a food frequency questionnaire have been used to confirm or disprove these perceptions. This study investigated the consumption patterns of animal proteins (beef, chicken, fish, egg, offal, sausage, and pork) of some residents in major cities in Ghana. A total of 688 participants were involved in this survey with an average age of 38.7±16; having religious makeup of 89.1% Christians, 10.32% Muslims, 0.44% non-religious, and 0.15% Traditionalists. The Akan ethnicity accounted for 55% of all participants followed by Ga-Adangbe, and Ewe with 20% and 12% respectively. The estimated protein consumptions were 657 g/person/day chicken, 412 g/person/day pork, 477 g/person/day fish, 410 g/person/day beef, 211 g/person/day egg and 148 g/person/day sausage. While boiled eggs were the most preferred protein form, the fried type was the most preferred for the other protein sources.
    Schlagwörter Food frequency questionnaire ; Foods of animal origin ; Animal protein sources ; Red meat consumption ; Science ; Q
    Thema/Rubrik (Code) 390
    Sprache Englisch
    Erscheinungsdatum 2021-03-01T00:00:00Z
    Verlag Elsevier
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  4. Artikel ; Online: Neuropharmacological Assessment of the Hydroethanolic Leaf Extract of Calotropis procera (Ait). R. Br. (Apocynaceae) in Mice

    Ernest Obese / Elvis Ofori Ameyaw / Robert Peter Biney / Emmanuel Awintiig Adakudugu / Eric Woode

    Scientifica, Vol

    2021  Band 2021

    Abstract: Background. Calotropis procera has been widely used traditionally for its analgesic and anti-inflammatory effects. It is also reportedly used in ethnomedicine for mental health disorders including epilepsy even in the absence of supporting scientific ... ...

    Abstract Background. Calotropis procera has been widely used traditionally for its analgesic and anti-inflammatory effects. It is also reportedly used in ethnomedicine for mental health disorders including epilepsy even in the absence of supporting scientific data. Thus, the potential of the plant to affect neurological functions was evaluated. Methods. Irwin’s test was performed to determine the effect of the oral administration of the extract (30–3000 mg kg−1) on gross behaviour and physiological function. The activity meter, rotarod, pentylenetetrazol- (PTZ-) induced convulsion, pentobarbitone-induced sleep test, and the tail immersion tests were used to evaluate the spontaneous activity, neuromuscular function, convulsive threshold, sedation, and analgesic effects of the Calotropis procera extract (30–1000 mg/kg), respectively, in mice. Results. Calotropis procera extract (CPE) exhibited significant (p<0.0001) anticonvulsant and analgesic effects. There was a significant increase in withdrawal latency of the CPE-treated animals in the tail immersion test for analgesia (p<0.0001), while latency and duration of PTZ-induced convulsions were positively modulated. Calotropis procera extract showed significant (p<0.0001) central nervous system depressant effects in pentobarbitone-induced hypnosis at 100–1000 mg/kg and spontaneous activity test (30–1000 mg/kg). The extract also depicted impaired motor coordination at 100–1000 mg/kg dose levels. LD50 was estimated to be above 1000 mg kg−1. Conclusions. Calotropis procera extract has significant central nervous system depressant and analgesic effects in mice.
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
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  5. Artikel ; Online: Antinociceptive effects of a hydroethanolic stem bark extract of Burkea africana

    Yakubu Jibira / Eric Boakye-Gyasi / Wonder Kofi Mensah Abotsi / Isaac Kingsley Amponsah / Peter Duah / Frederick Kwadwo Baah / Eric Woode

    Heliyon, Vol 8, Iss 2, Pp e08917- (2022)

    2022  

    Abstract: Introduction: Pain is a major symptom of many clinical disorders and its relief has long been a concern for individuals across the globe. There is therefore an unmet need to search for new efficacious agents for the effective management of pain. The stem ...

    Abstract Introduction: Pain is a major symptom of many clinical disorders and its relief has long been a concern for individuals across the globe. There is therefore an unmet need to search for new efficacious agents for the effective management of pain. The stem bark of the savanna tree Burkea africana (Hook) (Family: Leguminosae) is used in the Ghanaian traditional medicine for the treatment and management of various pain-related diseases. Method: An acute oral toxicity study in mice was conducted by administering BAE (50–5000 mg kg−1 p.o.). Antinociceptive effect of BAE (50–1000 mg kg−1 p.o.) was evaluated using the acetic acid-induced abdominal constriction, acidic saline-induced muscle pain and formalin-induced pain models. The antinociceptive mechanism of BAE was also assessed using the formalin-induced pain model. Results: The LD50 of BAE was thus estimated to be above 5000 mg kg−1 since none of the animals died in the acute toxicity study. Pretreatment with BAE (50–1000 mg kg−1 p.o.) significantly reduced the number of writhes after acetic-acid administration compared to the vehicle treated group. BAE also produced a significant and dose-dependent reversal of mechanical hyperalgesia induced by the injection of the acidic saline. Administration of BAE was able to significantly suppress both phases of the formalin test. This effect of the extract was however reversed by pretreatment with naloxone and granisetron. Conclusions: BAE exhibits antinociceptive effects in rodent pain models with a possible involvement of 5-HT3 receptors and opioidergic pathways.
    Schlagwörter Burkea africana ; Acidic-saline ; Acetic acid ; Hyperalgesia ; Formalin ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag Elsevier
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  6. Artikel ; Online: Effect of Trichilia monadelpha (Thonn.) J. J. de Wilde (Meliaceae) extracts on C-reactive proteins levels and acute inflammation

    Inemesit Okon Ben / Lydia Ewurabena Gamey / Benjamin Kingsley Harley / Phyllis Elsie Owusu Agyei / Eric Woode

    Scientific African, Vol 16, Iss , Pp e01119- (2022)

    2022  

    Abstract: Trichilia monadelpha is reported to have acute anti-inflammatory effects. This study sought to establish the possible effects of the petroleum ether, ethyl acetate, and ethanolic extracts of Trichilia monadelpha stem bark (i.e., PEE, EAE, and EthE, ... ...

    Abstract Trichilia monadelpha is reported to have acute anti-inflammatory effects. This study sought to establish the possible effects of the petroleum ether, ethyl acetate, and ethanolic extracts of Trichilia monadelpha stem bark (i.e., PEE, EAE, and EthE, respectively) on C-reactive proteins, using various acute inflammatory models. Changes in hind paw volume of Sprague-Dawley rats were measured before and after intraplantar injection of; 50 μL of 0.5% λ-carrageenan, 0.1 ml of 0.1% histamine, 0.1 ml of 0.02% serotonin, 1 nmol Prostaglandin E2, or 10 nmol bradykinin, to induce paw oedema, and during treatment with 10, 30, or 100 mgkg−1 PEE, EAE, or EthE, or various reference drugs. Changes in rectal temperature, and plasma C-reactive protein levels were also measured after injecting, intraperitoneally, 0.1 mgkg−1 Lipopolysaccharide (Escherichia coli) to induce pyrexia.PEE, EAE, and EthE reduced significantly (P ≤ 0.01–0.001; maximum inhibition at 100 mgkg−1 (imax) = 55.0–76.7%) paw oedema induced by carrageenan; comparable to diclofenac (P ≤ 0.0001; imax = 93.1%). PEE, EAE and chlorpheniramine prevented significantly (P ≤ 0.0001; imax = 115–144%) or reduced significantly (P ≤ 0.0001; imax = 80–85%) histamine-induced paw oedema. PEE, EAE and ondansetron significantly decreased (curative: P ≤ 0.01–0.001, imax = 51–82%; prophylactic: P ≤ 0.01–0.001, imax = 56–77%) serotonin-induced inflammation. In prostaglandin E2 –induced inflammation PEE and EAE significantly reduced (curative: P ≤ 0.05–0.01, imax = 60–70%; prophylactic: P ≤ 0.0001, imax = 86–332%) oedema; PEE and EAE also significantly decreased (curative: P ≤ 0.050–0001, imax = 46–98%; prophylactic: P ≤ 0.01–0.001 imax = 62–78%) in bradykinin-induced inflammation. PEE, EAE, Diclofenac and Dexamethasone significantly reduced (P ≤ 0.05–0.001) plasma C-reactive protein levels. PEE, EthE, EAE and Aspirin significantly reduced (P ≤ 0.05–0.001) febrile response.Trichilia monadelpha stem bark extracts had anti-inflammatory and anti-pyretic properties and significantly ...
    Schlagwörter λ-carrageenan ; Histamine ; Serotonin ; Prostaglandin E2 ; Bradykinin ; C-reactive protein ; Science ; Q
    Thema/Rubrik (Code) 572
    Sprache Englisch
    Erscheinungsdatum 2022-07-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Anticonvulsant effects of antiaris toxicaria aqueous extract

    Priscilla Kolibea Mante / Donatus Wewura Adongo / Eric Woode

    BMC Research Notes, Vol 10, Iss 1, Pp 1-

    investigation using animal models of temporal lobe epilepsy

    2017  Band 9

    Abstract: Abstract Background Antiaris toxicaria has previously shown anticonvulsant activity in acute animal models of epilepsy. The aqueous extract (AAE) was further investigated for activity in kindling with pentylenetetrazole and administration of pilocarpine ... ...

    Abstract Abstract Background Antiaris toxicaria has previously shown anticonvulsant activity in acute animal models of epilepsy. The aqueous extract (AAE) was further investigated for activity in kindling with pentylenetetrazole and administration of pilocarpine and kainic acid which mimic temporal lobe epilepsy in various animal species. Results ICR mice and Sprague–Dawley rats were pre-treated with AAE (200–800 mg kg−1) and convulsive episodes induced using pentylenetetrazole, pilocarpine and kainic acid. The potential of AAE to prevent or delay onset and alter duration of seizures were measured. In addition, damage to hippocampal cells was assessed in kainic acid-induced status epilepticus test. 800 mg kg−1 of the extract suppressed the kindled seizure significantly (P < 0.05) as did diazepam. AAE also produced significant effect (P < 0.01) on latency to first myoclonic jerks and on total duration of seizures. The latency to onset of wet dog shakes was increased significantly (P < 0.05) by AAE on kainic acid administration. Carbamazepine and Nifedipine (30 mg kg−1) also delayed the onset. Histopathological examination of brain sections showed no protective effect on hippocampal cells by AAE and nifedipine. Carbamazepine offered better preservation of hippocampal cells in the CA1, CA2 and CA3 regions. Conclusion Antiaris toxicaria may be effective in controlling temporal lobe seizures in rodents.
    Schlagwörter Hippocampus ; Kainic acid ; Pentylenetetrazole ; Pilocarpine ; Kindling ; Medicine ; R ; Biology (General) ; QH301-705.5 ; Science (General) ; Q1-390
    Sprache Englisch
    Erscheinungsdatum 2017-04-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Protective effects of andrographolide against diclofenac-induced gastric damage

    Augustine Tandoh / Cynthia Amaning Danquah / Paul Poku Sampene Ossei / Charles Kwaku Benneh / William Gilbert Ayibor / Eric Woode

    Scientific African, Vol 13, Iss , Pp e00944- (2021)

    2021  

    Abstract: The use diclofenac in pain management is limited by the development of gastric ulcers. Andrographolide is a clinically approved medicinal plant extract that has been found to possess among others, a gastro protective effect and may therefore be useful in ...

    Abstract The use diclofenac in pain management is limited by the development of gastric ulcers. Andrographolide is a clinically approved medicinal plant extract that has been found to possess among others, a gastro protective effect and may therefore be useful in protecting against damaging effects of diclofenac. The research study aimed at determining the gastro-protective effect of andrographolide in the presence of diclofenac. Two rodent models of gastro-protection were used in this study. In the mouse pyloric ligation model, effect of andrographolide alone and in combination with diclofenac on secretion of gastric contents was determined. In the acute gastritis model, effects of andrographolide on diclofenac induced ulcers in rats was evaluated. Haematoxylin and Eosin (H&E) stain was used in histopathological examination in the acute gastritis model. All statistical analysis was done using one way analysis of variance.In the mouse pyloric ligation model, diclofenac treatment significantly lowered the pH (1.46 ± 0.1453 compared to ligated controls 3.30 ± 0.0577, p < 0.05), and co-administration of diclofenac with andrographolide raised it significantly (pH of 4.80 ±0.3512 in combination compared to diclofenac only treated groups with pH of 1.46 ± 0.1453, p < 0.001). The standard anti-ulcer drug, esomeprazole also produced a similar elevation in pH (3.87 ± 0.2848 for esomeprazole compared to diclofenac only treated groups with pH of 1.46 ±0.1453, p < 0.01). Esomeprazole and andrographolide also reduced the mucosal damaging effects of diclofenac in the acute gastritis model in rats with a reduction in the number of ulcers produced (esomeprazole 50 mg/kg, 1.0 ± 0.6000, p < 0.0001 and andrographolide 100 mg kg/kg, 2.0 ± 0.6000, p < 0.001 compared to vehicle treated groups, 10.0 ± 1.095). Histopathological examination showed reduction in damaging effects of diclofenac after andrographolide and esomeprazole administration.Results show andrographolide possesses gastro-protective effect in the presence of ...
    Schlagwörter Andrographolide ; Diclofenac ; Ulcer ; Gastritis ; Science ; Q
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2021-09-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel: Anticonvulsant effect of the hydroethanolic leaf extract of Psydrax subcordata (DC.) Bridson in murine models

    Daanaa, Samuel / Eric Boakye-Gyasi / Eric Woode / Wonder Kofi Mensah Abotsi

    Journal of ethnopharmacology. 2018 Mar. 01, v. 213

    2018  

    Abstract: Psydrax subcordata (DC.) Bridson is a tropical medicinal plant used traditionally for the management of epilepsy. However, there is little scientific evidence to support its use.The current study investigated the anticonvulsant properties of the ... ...

    Abstract Psydrax subcordata (DC.) Bridson is a tropical medicinal plant used traditionally for the management of epilepsy. However, there is little scientific evidence to support its use.The current study investigated the anticonvulsant properties of the hydroethanolic leaf extract of Psydrax subcordata (PSE) in animal models.The anticonvulsant effects were evaluated in mouse models of acute seizures (pentylenetetrazole-, picrotoxin-, 4-aminopyridine-, strychnine- and maximal electroshock-induced seizure tests) and status epilepticus (Lithium/pilocarpine-induced SE). The role of GABAergic mechanisms in the actions of the extract was also examined by pre-treatment of animals with flumazenil in the pentylenetetrazole test.The extract (30, 100 and 300mg/kg, p.o.) significantly delayed the onset and decreased the duration and frequency of pentylenetetrazole- and picrotoxin-convulsions. PSE also reduced the duration of tonic hind limb extensions in the maximal electroshock-induced seizure test. Furthermore, PSE pre-treatment significantly delayed the onset of seizures and improved survival in the 4-aminopyridine-induced seizure test. In the strychnine-induced seizure test, PSE treatment did not significantly affect the latency to convulsions and time until death when compared to controls. PSE exhibited anticonvulsant effects in the lithium/pilocarpine test by delaying the onset of seizures and status epilepticus as well as reducing the severity of seizures and mortality of mice. Again, the anticonvulsant effect of PSE (100mg/kg, p.o.) was blocked by pre-treatment with flumazenil in the PTZ test.PSE has anticonvulsant activity in animal models, and this effect may be mediated, at least partly, through GABAergic mechanisms.
    Schlagwörter animal models ; anticonvulsants ; death ; epilepsy ; hindlimbs ; leaf extracts ; lithium ; medicinal plants ; mice ; mortality ; pilocarpine ; Psydrax subcordata ; seizures ; traditional medicine
    Sprache Englisch
    Erscheinungsverlauf 2018-0301
    Umfang p. 384-394.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2017.11.028
    Datenquelle NAL Katalog (AGRICOLA)

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  10. Artikel ; Online: Formulation and evaluation of sustained release matrix tablets of capparis erythrocarpos roots extract to improve patient compliance in management of arthritis

    Frederick W.A. Owusu / Mariam E. Boakye-Gyasi / Priscilla K. Mante / Edmund Ekuadzi / Kwabena Ofori-Kwakye / Eric Woode

    Scientific African, Vol 6, Iss , Pp - (2019)

    2019  

    Abstract: Capparis erythrocarpos is used in the management of arthritis in Ghana and some other African countries. In Ghana, the powdered form of Capparis erythrocarpos is prescribed and dispensed to patients for the management of arthritis. In the present study, ... ...

    Abstract Capparis erythrocarpos is used in the management of arthritis in Ghana and some other African countries. In Ghana, the powdered form of Capparis erythrocarpos is prescribed and dispensed to patients for the management of arthritis. In the present study, Capparis erythrocarpos controlled release tablets were successfully prepared by wet granulation method. Hydroxypropyl methyl cellulose and Xanthan gum were used as drug release modifying polymers in varying ratios of (1;1), (1;2) and (1;3) respectively. The formulated tablets passed the uniformity of weight, friability, uniformity of thickness and uniformity of diameter tests respectively. The formulated tablets had crushing strength ranging from 73.39 to 78.42 N and good tensile strength. Ratios of 1:1 and 1:2 (F1 and F2) combinations of HPMC and Xanthan gum respectively are able to provide the desired drug release over a twenty-four (24) hour period. Higher proportions of Xanthan gum in combination with HPMC (3:1) retarded the release of Capparis erythrocarpos and did not provide the desired drug release after 24 h. Keywords: Capparis erythrocarpos, Hydroxypropyl methylcellulose (HPMC), Xanthan gum, Matrix tablets, Sustained-release tablets, Polymer ratio
    Schlagwörter Science ; Q
    Thema/Rubrik (Code) 660
    Sprache Englisch
    Erscheinungsdatum 2019-11-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
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