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  1. AU="Erminia Donnarumma"
  2. AU="Albores-Figueroa, Rosenberg"
  3. AU="Squillace, Lino"
  4. AU="Laufs, Sebastian"
  5. AU="McCanny, Suzette"
  6. AU="McHardy, John Alexander"
  7. AU="Erdal, Ranya"
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  1. Article ; Online: Mitochondrial Fission Process 1 controls inner membrane integrity and protects against heart failure

    Erminia Donnarumma / Michael Kohlhaas / Elodie Vimont / Etienne Kornobis / Thibault Chaze / Quentin Giai Gianetto / Mariette Matondo / Maryse Moya-Nilges / Christoph Maack / Timothy Wai

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 24

    Abstract: Mitochondria power the beating heart. Here, Donnarumma et al. show that loss of the inner mitochondrial membrane protein MTFP1 in cardiomyocytes reduces bioenergetic efficiency and cell death resistance leading to heart failure in mice. ...

    Abstract Mitochondria power the beating heart. Here, Donnarumma et al. show that loss of the inner mitochondrial membrane protein MTFP1 in cardiomyocytes reduces bioenergetic efficiency and cell death resistance leading to heart failure in mice.
    Keywords Science ; Q
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: PO-20 A HYDROGEN SULFIDE PRODRUG AUGMENTS ANGIOGENESIS IN A SWINE MODEL OF CRITICAL LIMB ISCHEMIA VIA A NITRIC OXIDE DEPENDENT MECHANISM

    Amanda M. Rushing / Amy L. Scarborough / Sarah F. Boisvert / Erminia Donnarumma / Rishi Trivedi / David J. Polhemus / David J. Lefer / Traci T. Goodchild

    Artery Research, Vol

    2016  Volume 16

    Abstract: Introduction: Despite advances in revascularization, treatments for critical limb ischemia (CLI) have been largely unsuccessful. Hydrogen sulfide (H2S) and nitric oxide (NO), are endogenous gasotransmitters which exert potent vasodilatory and ... ...

    Abstract Introduction: Despite advances in revascularization, treatments for critical limb ischemia (CLI) have been largely unsuccessful. Hydrogen sulfide (H2S) and nitric oxide (NO), are endogenous gasotransmitters which exert potent vasodilatory and proangiogenic effects. Recent experimental evidence suggest that the proangiogenic effects of H2S are medicated in part through the NO pathway. We sought to determine whether a novel H2S prodrug, SG-1002 (Sulfagenix, Inc. Cleveland OH), increases NO production and promotes peripheral revascularization. Methods: CLI was generated in Yucatan miniswine (n=17) via carotid cutdown and placement of an Amplatzer vascular plug deployed within a Viabahn stent positioned proximally in the external iliac artery. At day 7 post-CLI pigs, received daily placebo or SG-1002 (1600 mg PO). Cuff-pressures were measured weekly by ankle/brachial index (ABI). Plasma H2S, H2S metabolite sulfane sulfur (SS), and NO metabolite, nitrite (NO2) were measured. At day 42 post-CLI, digital subtraction angiography (DSA) was performed and opacified vessels quantitated. Results: ABI was reduced to 0 following CLI induction. ABI improved in both groups but continued to demonstrate persistent ischemia with values below 0.25 at day 42 and showed no difference between groups. Circulating H2S levels were similar between groups. SS levels were increased from baseline to day 42 in SG-1002 treated pigs (p < 0.001) but remained unchanged in placebo treated animals. At day 42, SG-1002 treatment increase circulating NO2 levels (p < 0.05) compared to placebo. There was an increase in NO2 levels from baseline to day 42 in SG-1002 treated pigs (p < 0.05). DSA revealed an increase of CLI limb vessel number in SG-1002 treated pigs compared to placebo (p < 0.05). Conclusions: Treatment with the H2S prodrug, SG-1002, results in increased metabolites of H2S and NO signaling. H2S treatment increased vascular density in the setting of severe CLI in a clinical relevant swine model.
    Keywords Specialties of internal medicine ; RC581-951 ; Diseases of the circulatory (Cardiovascular) system ; RC666-701
    Subject code 630
    Language English
    Publishing date 2016-11-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: A new therapeutic approach to erectile dysfunction

    Roberta d'Emmanuele di Villa Bianca / Emma Mitidieri / Erminia Donnarumma / Ferdinando Fusco / Nicola Longo / Giuseppe De Rosa / Ettore Novellino / Paolo Grieco / Vincenzo Mirone / Giuseppe Cirino / Raffaella Sorrentino

    Asian Journal of Andrology, Vol 17, Iss 1, Pp 81-

    urotensin-II receptor high affinity agonist ligands

    2015  Volume 85

    Abstract: Urotensin-II (U-II) is a cyclic peptide that acts through a G protein-coupled receptor (urotensin-II receptor [UTR]) mainly involved in cardiovascular function in humans. The urotensinergic system is also implicated in the urogenital tract. Indeed, U-II ... ...

    Abstract Urotensin-II (U-II) is a cyclic peptide that acts through a G protein-coupled receptor (urotensin-II receptor [UTR]) mainly involved in cardiovascular function in humans. The urotensinergic system is also implicated in the urogenital tract. Indeed, U-II relaxes human corpus cavernosum strips and causes an increase in intracavernous pressure (ICP) in rats. In light of this, the U-II/UTR pathway can be considered a new target for the treatment of erectile dysfunction. On this hypothesis, herein we report on two new UTR high affinity-agonists, P5U (H-Asp-c[Pen-Phe-Trp-Lys-Tyr-Cys]-Val-OH) and UPG84(H-Asp-c[Pen-Phe-DTrp-Orn-(pNH 2 ) Phe-Cys]-Val-OH). The effects of P5U and UPG84 were each compared separately with U-II by monitoring the ICP in anesthetized rats. Intracavernous injection of U-II (0.03-1 nmol), P5U (0.03-1 nmol) or UPG84 (0.03-1 nmol) caused an increase in ICP. P5U, in particular, elicited a significant increase in ICP as compared to U-II. The observed effect by using P5U at a dose of 0.1 nmol per rat was comparable to the effect elicited by U-II at a dose of 0.3 nmol. Moreover, UPG84 at the lowest dose (0.03 nmol) showed an effect similar to the highest dose of U-II (1 nmol). Furthermore, UPG84 was found to be more effective than P5U. Indeed, while the lowest dose of P5U (0.03 nmol) did not affect the ICP, UPG84, at the same dose, induced a prominent penile erection in rat. These compounds did not modify the blood pressure, which indicates a good safety profile. In conclusion, UPG84 and P5U may open new perspectives for the management of erectile dysfunction.
    Keywords erectile dysfunction; intracavernous pressure; rat; urotensin-II; urotensin-II ligands ; Medicine ; R ; Diseases of the genitourinary system. Urology ; RC870-923
    Subject code 616
    Language English
    Publishing date 2015-02-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Human Cystathionine-β-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium.

    Roberta d'Emmanuele di Villa Bianca / Emma Mitidieri / Davide Esposito / Erminia Donnarumma / Annapina Russo / Ferdinando Fusco / Angela Ianaro / Vincenzo Mirone / Giuseppe Cirino / Giulia Russo / Raffaella Sorrentino

    PLoS ONE, Vol 10, Iss 9, p e

    2015  Volume 0136859

    Abstract: Urothelium, the epithelial lining the inner surface of human bladder, plays a key role in bladder physiology and pathology. It responds to chemical, mechanical and thermal stimuli by releasing several factors and mediators. Recently it has been shown ... ...

    Abstract Urothelium, the epithelial lining the inner surface of human bladder, plays a key role in bladder physiology and pathology. It responds to chemical, mechanical and thermal stimuli by releasing several factors and mediators. Recently it has been shown that hydrogen sulfide contributes to human bladder homeostasis. Hydrogen sulfide is mainly produced in human bladder by the action of cystathionine-β-synthase. Here, we demonstrate that human cystathionine-β-synthase activity is regulated in a cGMP/PKG-dependent manner through phosphorylation at serine 227. Incubation of human urothelium or T24 cell line with 8-Bromo-cyclic-guanosine monophosphate (8-Br-cGMP) but not dibutyryl-cyclic-adenosine monophosphate (d-cAMP) causes an increase in hydrogen sulfide production. This result is congruous with the finding that PKG is robustly expressed but PKA only weakly present in human urothelium as well as in T24 cells. The cGMP/PKG-dependent phosphorylation elicited by 8-Br-cGMP is selectively reverted by KT5823, a specific PKG inhibitor. Moreover, the silencing of cystathionine-β-synthase in T24 cells leads to a marked decrease in hydrogen sulfide production either in basal condition or following 8-Br-cGMP challenge. In order to identify the phosphorylation site, recombinant mutant proteins of cystathionine-β-synthase in which Ser32, Ser227 or Ser525 was mutated in Ala were generated. The Ser227Ala mutant cystathionine-β-synthase shows a notable reduction in basal biosynthesis of hydrogen sulfide becoming unresponsive to the 8-Br-cGMP challenge. A specific antibody that recognizes the phosphorylated form of cystathionine-β-synthase has been produced and validated by using T24 cells and human urothelium. In conclusion, human cystathionine-β-synthase can be phosphorylated in a PKG-dependent manner at Ser227 leading to an increased catalytic activity.
    Keywords Medicine ; R ; Science ; Q
    Subject code 571
    Language English
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Correction

    Roberta d'Emmanuele di Villa Bianca / Emma Mitidieri / Davide Esposito / Erminia Donnarumma / Annapina Russo / Ferdinando Fusco / Angela Ianaro / Vincenzo Mirone / Giuseppe Cirino / Giulia Russo / Raffaella Sorrentino

    PLoS ONE, Vol 10, Iss 10, p e

    Human Cystathionine-β-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium.

    2015  Volume 0141027

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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