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  1. Article ; Online: Glycoprotein 2 as a gut gate keeper for mucosal equilibrium between inflammation and immunity.

    Zhang, Zhongwei / Tanaka, Izumi / Nakahashi-Ouchida, Rika / Ernst, Peter B / Kiyono, Hiroshi / Kurashima, Yosuke

    Seminars in immunopathology

    2024  

    Abstract: Glycoprotein 2 (GP2) is a widely distributed protein in the digestive tract, contributing to mucosal barrier maintenance, immune homeostasis, and antigen-specific immune response, while also being linked to inflammatory bowel disease (IBD) pathogenesis. ... ...

    Abstract Glycoprotein 2 (GP2) is a widely distributed protein in the digestive tract, contributing to mucosal barrier maintenance, immune homeostasis, and antigen-specific immune response, while also being linked to inflammatory bowel disease (IBD) pathogenesis. This review sheds light on the extensive distribution of GP2 within the gastrointestinal tract and its intricate interplay with the immune system. Furthermore, the significance of GP2 autoantibodies in diagnosing and categorizing IBD is underscored, alongside the promising therapeutic avenues for modulating GP2 to regulate immunity and maintain mucosal balance.
    Language English
    Publishing date 2024-01-03
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2316828-6
    ISSN 1863-2300 ; 1863-2297
    ISSN (online) 1863-2300
    ISSN 1863-2297
    DOI 10.1007/s00281-023-00999-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correction: Glycoprotein 2 as a gut gate keeper for mucosal equilibrium between inflammation and immunity.

    Zhang, Zhongwei / Tanaka, Izumi / Nakahashi-Ouchida, Rika / Ernst, Peter B / Kiyono, Hiroshi / Kurashima, Yosuke

    Seminars in immunopathology

    2024  

    Language English
    Publishing date 2024-04-22
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 2316828-6
    ISSN 1863-2300 ; 1863-2297
    ISSN (online) 1863-2300
    ISSN 1863-2297
    DOI 10.1007/s00281-024-01002-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: The immunobiology of H. pylori

    Ernst, Peter B.

    from pathogenesis to prevention

    1997  

    Author's details ed. Peter B. Ernst
    Keywords Helicobacter pylori / immunology ; Helicobacter Infections / immunology ; Gastrointestinal Diseases / immunology ; Helicobacter pylori ; Immunbiologie
    Subject Immunobiologie ; Campylobacter pylori ; Campylobacter pyloridis
    Language English
    Size XIX, 328 S. : Ill., graph. Darst.
    Publisher Lippincott-Raven
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT008165578
    ISBN 0-397-58765-1 ; 978-0-397-58765-0
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1998 A 1361 order for loan Magazin

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  4. Article ; Online: Our New President- Sheila E. Crowe, MD.

    Ernst, Peter B

    Gastroenterology

    2017  Volume 152, Issue 6, Page(s) 1599–1604

    Language English
    Publishing date 2017-05
    Publishing country United States
    Document type Editorial
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2017.03.028
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  5. Article ; Online: Utilizing mast cells in a positive manner to overcome inflammatory and allergic diseases.

    Zhang, Zhongwei / Ernst, Peter B / Kiyono, Hiroshi / Kurashima, Yosuke

    Frontiers in immunology

    2022  Volume 13, Page(s) 937120

    Abstract: Mast cells (MCs) are immune cells widely distributed in the body, accompanied by diverse phenotypes and functions. Committed mast cell precursors (MCPs) leave the bone marrow and enter the blood circulation, homing to peripheral sites under the control ... ...

    Abstract Mast cells (MCs) are immune cells widely distributed in the body, accompanied by diverse phenotypes and functions. Committed mast cell precursors (MCPs) leave the bone marrow and enter the blood circulation, homing to peripheral sites under the control of various molecules from different microenvironments, where they eventually differentiate and mature. Partly attributable to the unique maturation mechanism, MCs display high functional heterogeneity and potentially plastic phenotypes. High plasticity also means that MCs can exhibit different subtypes to cope with different microenvironments, which we call "the peripheral immune education system". Under the peripheral immune education system, MCs showed a new character from previous cognition in some cases, namely regulation of allergy and inflammation. In this review, we focus on the mucosal tissues, such as the gastrointestinal tract, to gain insights into the mechanism underlying the migration of MCs to the gut or other organs and their heterogeneity, which is driven by different microenvironments. In particular, the immunosuppressive properties of MCs let us consider that positively utilizing MCs may be a new way to overcome inflammatory and allergic disorders.
    MeSH term(s) Cell Differentiation ; Humans ; Hypersensitivity ; Mast Cells ; Phenotype ; Plastics
    Chemical Substances Plastics
    Language English
    Publishing date 2022-09-14
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.937120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Of mice, men and immunity: a case for evolutionary systems biology.

    Ernst, Peter B / Carvunis, Anne-Ruxandra

    Nature immunology

    2018  Volume 19, Issue 5, Page(s) 421–425

    MeSH term(s) Allergy and Immunology ; Animals ; Biological Evolution ; Disease Models, Animal ; Humans ; Mice ; Systems Biology ; Translational Research, Biomedical
    Language English
    Publishing date 2018-03-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-018-0084-4
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  7. Article ; Online: Intestinal homeostasis and inflammation: Gut microbiota at the crossroads of pancreas-intestinal barrier axis.

    Zhang, Zhongwei / Tanaka, Izumi / Pan, Zhen / Ernst, Peter B / Kiyono, Hiroshi / Kurashima, Yosuke

    European journal of immunology

    2022  Volume 52, Issue 7, Page(s) 1035–1046

    Abstract: The pancreas contains exocrine glands, which release enzymes (e.g., amylase, trypsin, and lipase) that are important for digestion and islets, which produce hormones. Digestive enzymes and hormones are secreted from the pancreas into the duodenum and ... ...

    Abstract The pancreas contains exocrine glands, which release enzymes (e.g., amylase, trypsin, and lipase) that are important for digestion and islets, which produce hormones. Digestive enzymes and hormones are secreted from the pancreas into the duodenum and bloodstream, respectively. Growing evidence suggests that the roles of the pancreas extend to not only the secretion of digestive enzymes and hormones but also to the regulation of intestinal homeostasis and inflammation (e.g., mucosal defense to pathogens and pathobionts). Organ crosstalk between the pancreas and intestine is linked to a range of physiological, immunological, and pathological activities, such as the regulation of the gut microbiota by the pancreatic proteins and lipids, the retroaction of the gut microbiota on the pancreas, the relationship between inflammatory bowel disease, and pancreatic diseases. We herein discuss the current understanding of the pancreas-intestinal barrier axis and the control of commensal bacteria in intestinal inflammation.
    MeSH term(s) Gastrointestinal Microbiome/physiology ; Homeostasis ; Hormones ; Humans ; Inflammation ; Intestinal Mucosa ; Intestines ; Pancreas
    Chemical Substances Hormones
    Language English
    Publishing date 2022-05-15
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202149532
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Microbial-Driven Immunological Memory and Its Potential Role in Microbiome Editing for the Prevention of Colorectal Cancer.

    Campillo-Gimenez, Laure / Rios-Covian, David / Rivera-Nieves, Jesus / Kiyono, Hiroshi / Chu, Hiutung / Ernst, Peter B

    Frontiers in cellular and infection microbiology

    2021  Volume 11, Page(s) 752304

    Abstract: Over the last several years, many advances have been made in understanding the role of bacteria in the pathogenesis of gastrointestinal cancers. Beginning ... ...

    Abstract Over the last several years, many advances have been made in understanding the role of bacteria in the pathogenesis of gastrointestinal cancers. Beginning with
    MeSH term(s) Colorectal Neoplasms/prevention & control ; Gastrointestinal Microbiome ; Helicobacter pylori ; Humans ; Immunologic Memory ; Stomach
    Language English
    Publishing date 2021-11-12
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2021.752304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cationic-nanogel nasal vaccine containing the ectodomain of RSV-small hydrophobic protein induces protective immunity in rodents.

    Umemoto, Shingo / Nakahashi-Ouchida, Rika / Yuki, Yoshikazu / Kurokawa, Shiho / Machita, Tomonori / Uchida, Yohei / Mori, Hiromi / Yamanoue, Tomoyuki / Shibata, Takehiko / Sawada, Shin-Ichi / Ishige, Kazuya / Hirano, Takashi / Fujihashi, Kohtaro / Akiyoshi, Kazunari / Kurashima, Yosuke / Tokuhara, Daisuke / Ernst, Peter B / Suzuki, Masashi / Kiyono, Hiroshi

    NPJ vaccines

    2023  Volume 8, Issue 1, Page(s) 106

    Abstract: Respiratory syncytial virus (RSV) is a leading cause of upper and lower respiratory tract infection, especially in children and the elderly. Various vaccines containing the major transmembrane surface proteins of RSV (proteins F and G) have been tested; ... ...

    Abstract Respiratory syncytial virus (RSV) is a leading cause of upper and lower respiratory tract infection, especially in children and the elderly. Various vaccines containing the major transmembrane surface proteins of RSV (proteins F and G) have been tested; however, they have either afforded inadequate protection or are associated with the risk of vaccine-enhanced disease (VED). Recently, F protein-based maternal immunization and vaccines for elderly patients have shown promising results in phase III clinical trials, however, these vaccines have been administered by injection. Here, we examined the potential of using the ectodomain of small hydrophobic protein (SHe), also an RSV transmembrane surface protein, as a nasal vaccine antigen. A vaccine was formulated using our previously developed cationic cholesteryl-group-bearing pullulan nanogel as the delivery system, and SHe was linked in triplicate to pneumococcal surface protein A as a carrier protein. Nasal immunization of mice and cotton rats induced both SHe-specific serum IgG and mucosal IgA antibodies, preventing viral invasion in both the upper and lower respiratory tracts without inducing VED. Moreover, nasal immunization induced greater protective immunity against RSV in the upper respiratory tract than did systemic immunization, suggesting a critical role for mucosal RSV-specific IgA responses in viral elimination at the airway epithelium. Thus, our nasal vaccine induced effective protection against RSV infection in the airway mucosa and is therefore a promising vaccine candidate for further development.
    Language English
    Publishing date 2023-07-24
    Publishing country England
    Document type Journal Article
    ISSN 2059-0105
    ISSN (online) 2059-0105
    DOI 10.1038/s41541-023-00700-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Understanding immunity to Helicobacter pylori: unraveling the riddle, wrapped in a mystery, inside an enigma.

    Ernst, Peter B

    Gastroenterology

    2005  Volume 129, Issue 1, Page(s) 380–383

    MeSH term(s) Animals ; Gastritis/immunology ; Gastritis/microbiology ; Helicobacter Infections/immunology ; Helicobacter pylori
    Language English
    Publishing date 2005-07
    Publishing country United States
    Document type Comment ; Editorial ; Review
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2005.05.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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