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  1. AU="Ersin Akinci"
  2. AU="Lale Say"
  3. AU="Nada, Khaled M"
  4. AU="Letesson, Gaetan"
  5. AU="Łukasik, Sylwia"
  6. AU="Van Der Meer, Peter J."
  7. AU="Jojoa Jojoa, Ruby Isabel"
  8. AU="Tan, Qingshan" AU="Tan, Qingshan"
  9. AU="Pennington, R Toby"
  10. AU="Bou Sanayeh, Elie"
  11. AU="Yun, Hwa Young"
  12. AU="C. Maridith Arthur"
  13. AU="Kunze, Ursula"
  14. AU="Adam Bienenstock"
  15. AU="Laviolette, M"
  16. AU="Mama, Khursheed R"
  17. AU="Sachse, Katharina" AU="Sachse, Katharina"
  18. AU="Skrlin, Branimir"
  19. AU="Mathais, Quentin"
  20. AU=Armstrong Ehrin J
  21. AU="Bahadi, Abdelaali"
  22. AU="Qin, Shuhui"
  23. AU="Huaraca-Quispe, Lidia P"
  24. AU=Petrovan Vlad AU=Petrovan Vlad AU=Petrovan Vlad
  25. AU="Elaina M Blair"
  26. AU="Hui Ram Kim"
  27. AU="Litvak, Yael"
  28. AU="Chen, Xiang-Yan"
  29. AU="Honorio Coronado, Eurídice N."
  30. AU="Garny, Hella"
  31. AU="Idris, Zamzuri"
  32. AU="Gao, Xinyu"
  33. AU="Tewari, Srishti"
  34. AU="Behrendt, Ulrike" AU="Behrendt, Ulrike"
  35. AU="Margenthaler, Julie A"
  36. AU="Si, Lian-Jing"
  37. AU="Strand, Torbjørn"
  38. AU=Abdoli Amir

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  1. Artikel ; Online: A Plant-Produced in vivo deglycosylated full-length Pfs48/45 as a Transmission-Blocking Vaccine Candidate against malaria

    Tarlan Mamedov / Kader Cicek / Kazutoyo Miura / Burcu Gulec / Ersin Akinci / Gunay Mammadova / Gulnara Hasanova

    Scientific Reports, Vol 9, Iss 1, Pp 1-

    2019  Band 12

    Abstract: Abstract Pfs48/45 is a leading antigen candidate for a transmission blocking (TB) vaccine. However, efforts to produce affordable, safe and correctly folded full-length Pfs48/45 using different protein expression systems have not produced an antigen with ...

    Abstract Abstract Pfs48/45 is a leading antigen candidate for a transmission blocking (TB) vaccine. However, efforts to produce affordable, safe and correctly folded full-length Pfs48/45 using different protein expression systems have not produced an antigen with satisfactory TB activity. Pfs48/45 has 16 cysteines involved in disulfide bond formation, and the correct formation is critical for proper folding and induction of TB antibodies. Moreover, Pfs48⁄45 is not a glycoprotein in the native hosts, but contains potential glycosylation sites, which are aberrantly glycosylated during expression in eukaryotic systems. Here, we demonstrate for the first time that full length, Endo H in vivo enzymatic deglycosylated Pfs48/45 antigen is produced at a high level in plants and is structurally stable at elevated temperatures. Sera from mice immunized with this antigen showed strong inhibition in SMFA. Thus, Endo H in vivo enzymatic deglycosylated Pfs48/45 is a promising candidate for the development of an affordable TB vaccine, which may have the potential to save millions.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2019-07-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Peptide fusion improves prime editing efficiency

    Minja Velimirovic / Larissa C. Zanetti / Max W. Shen / James D. Fife / Lin Lin / Minsun Cha / Ersin Akinci / Danielle Barnum / Tian Yu / Richard I. Sherwood

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Band 8

    Abstract: Prime editing enables search-and-replace genome editing but is limited by low editing efficiency. Here the authors present PepSEq, a high-throughput method for screening a large library of peptides that influence prime editing efficiency. ...

    Abstract Prime editing enables search-and-replace genome editing but is limited by low editing efficiency. Here the authors present PepSEq, a high-throughput method for screening a large library of peptides that influence prime editing efficiency.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2022-06-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Estimating Time of Weed Emergence in Cucumber (Cucumis sativus L.)

    Nihat Tursun / İrfan Ersin Akıncı / Mustafa Şahin / Ahmet Uludağ

    Turkish Journal of Agriculture: Food Science and Technology, Vol 3, Iss 5, Pp 271-

    2015  Band 278

    Abstract: Modelling is carried out for eleven major weeds in cucumber to develop estimated models for weed emergence time. Weed species were grouped according to their emergence patterns. Amaranthus retroflexus, Chenopodium album, Heliotropium europaeum, Polygonum ...

    Abstract Modelling is carried out for eleven major weeds in cucumber to develop estimated models for weed emergence time. Weed species were grouped according to their emergence patterns. Amaranthus retroflexus, Chenopodium album, Heliotropium europaeum, Polygonum aviculare and Solanum nigrum were early emerging, Convolvulus arvensis, Cyperus rotundus, Cynodon dactylon, Portulaca oleracea and Sorghum halepense were season long emerging Tribulus terrestris was the late emerging weed species. Different non-linear growth curves (Chapman-Richard, Weibull, logistic, Gompertz and cubic spline) fitted to the data of cumulative percent emergence for the different species and years. Cubic spline seemed the best model for many species.
    Schlagwörter Hıyar ; Çıkış modelleri ERI ; MET ; Büyüme gün derece (GDD) ; Yabancı otlar ; Agriculture ; S ; Agriculture (General) ; S1-972
    Sprache Englisch
    Erscheinungsdatum 2015-01-01T00:00:00Z
    Verlag Turkish Science and Technology Publishing (TURSTEP)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Ameliorative Effects of Potassium and Calcium on the Salinity Stress in Embryo Culture of Cucumber ( Cucumis sativus L.)

    Irfan Ersin Akinci / Murat Simsek

    Journal of Biological Sciences, Vol 4, Iss 3, Pp 361-

    2004  Band 365

    Abstract: The effect of varying potassium (0-control, 5, 10, 18 and 28 mM as potassium nitrate) and calcium (0-control, 5, 10, 18 and 28 mM as calcium nitrate) supply on growth of NaCl stressed (0-control, 100 and 150 mM) mature embryos of cucumber ( Cucumis ... ...

    Abstract The effect of varying potassium (0-control, 5, 10, 18 and 28 mM as potassium nitrate) and calcium (0-control, 5, 10, 18 and 28 mM as calcium nitrate) supply on growth of NaCl stressed (0-control, 100 and 150 mM) mature embryos of cucumber ( Cucumis sativus L.) in vitro condition. NaCl caused decrease root (rooting percent, root number, root length and root fresh weight) and shoot (shoot length, shoot FW, leaf FW, whole plant FW) growth. Root/shoot length index and root/plant FW index was generally lower in the 100 and 150 mM NaCl concentrations than control (absence of NaCl). There was an increase in callus induction of NaCl treated cucumber embryos. Callus induction was decreased by K + and Ca 2+ applications at both NaCl concentrations In general, root and shoot growth of cucumber embryos was improved by supplemental potassium (10 mM potassium nitrate) and calcium (20 mM calcium nitrate).
    Schlagwörter Salt stress ; ca2+ ; K+ ; cucumber ; embryo culture ; Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
    Thema/Rubrik (Code) 580
    Sprache Englisch
    Erscheinungsdatum 2004-01-01T00:00:00Z
    Verlag Asian Network for Scientific Information
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Evaluation of Red Pepper for Spice ( Capsicum annuum L.) Germplasm Resource of Kahramanmaras Region (Turkey)

    Sermin Akinci / Irfan Ersin Akinci

    Pakistan Journal of Biological Sciences, Vol 7, Iss 5, Pp 703-

    2004  Band 710

    Abstract: Red hot pepper production for spices is very important for Kahramanmaras City located in Eastern Mediterranean Region of Turkey as around the world. However, there are major production problems. One of the biggest problems is absence of improved variety ... ...

    Abstract Red hot pepper production for spices is very important for Kahramanmaras City located in Eastern Mediterranean Region of Turkey as around the world. However, there are major production problems. One of the biggest problems is absence of improved variety yet inside of cultivated peppers and low quality of seed material in region. In experiment, 115 red hot pepper accessions for spice production originally collected from region were evaluated based on quantitative and qualitative characters. When accessions were evaluated based on each one character, successful of accessions varied. Therefore accessions were evaluated with weighed grade method and 17, 122, 43 and 140 (elongate), 52, 135 and 51 (triangular), 118 (campanulate) and 123, 26 and 65 (blocky) accessions were selected as use in breeding research of red hot spice pepper in Kahramanmaras.
    Schlagwörter Red peper (capsicum annuum L.) ; germplasm ; selection ; Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
    Sprache Englisch
    Erscheinungsdatum 2004-01-01T00:00:00Z
    Verlag Asian Network for Scientific Information
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Effect of Salt Stress on Growth and Na, K Contents of Pepper (C apsicum annuum L.) In Germination and Seedling Stages

    Kadir Yilmaz / Irfan Ersin Akinci / Sermin Akinci

    Pakistan Journal of Biological Sciences, Vol 7, Iss 4, Pp 606-

    2004  Band 610

    Abstract: The effects of NaCl concentration (0, 50, 100 and 150 mM NaCl) on the growth and development of pepper varieties, Demre, �etinel 150 and Ilica 256, were investigated for germination and seedling growth. The parameters measured were germination (speed and ...

    Abstract The effects of NaCl concentration (0, 50, 100 and 150 mM NaCl) on the growth and development of pepper varieties, Demre, �etinel 150 and Ilica 256, were investigated for germination and seedling growth. The parameters measured were germination (speed and germination rate), radicle length, hypocotyl length, radicle fresh weight, hypocotyl fresh weight and the ratio of hypocotyls to radicle fresh weight in the germination stage. High NaCl had a negative effect on plant growth and development. In the seedling stage, the negative effects were relative growth rate for root and shoot length; Relative growth rate for fresh and dry weights of roots, shoots and whole plant; fresh and dry weight of shoot to root indices, relative growth rate for leaf number and area. Leaf content of K + and Na + and K + /Na + were negatively affected by increased NaCl concentrations. It was found that the Na + concentration increased whereas the K + and K + /Na + values decreased in leaves. Ilica 256 showed better NaCl tolerance in the germination stage and Demre was the most tolerant at the seedling stage than other varieties. This research demonstrated different NaCl tolerances for the varieties tested based on growth and development ability at germination and seedling development
    Schlagwörter Relative growth rate ; NaCI ; salt stress ; peper (capsicum annuum L.) ; K ; Na ; growth ; development ; Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
    Thema/Rubrik (Code) 333 ; 630
    Sprache Englisch
    Erscheinungsdatum 2004-01-01T00:00:00Z
    Verlag Asian Network for Scientific Information
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Reprogramming of various cell types to a beta-like state by Pdx1, Ngn3 and MafA.

    Ersin Akinci / Anannya Banga / Katie Tungatt / Joanna Segal / Daniel Eberhard / James R Dutton / Jonathan M W Slack

    PLoS ONE, Vol 8, Iss 11, p e

    2013  Band 82424

    Abstract: The three transcription factors, PDX1, NGN3 and MAFA, are very important in pancreatic development. Overexpression of these three factors can reprogram both pancreatic exocrine cells and SOX9-positive cells of the liver into cells resembling pancreatic ... ...

    Abstract The three transcription factors, PDX1, NGN3 and MAFA, are very important in pancreatic development. Overexpression of these three factors can reprogram both pancreatic exocrine cells and SOX9-positive cells of the liver into cells resembling pancreatic beta cells. In this study we investigate whether other cell types can be reprogrammed. Eight cell types are compared and the results are consistent with the idea that reprogramming occurs to a greater degree for developmentally related cells (pancreas, liver) than for other types, such as fibroblasts. Using a line of mouse hepatocyte-derived cells we screened 13 compounds for the ability to increase the yield of reprogrammed cells. Three are active and when used in combination they can increase the yield of insulin-immunopositive cells by a factor of six. These results should contribute to the eventual ability to develop a new cure for diabetes based on the ability to reprogram other cells in the body to a beta cell phenotype.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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