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Article ; Online: Relationship between hand hygiene and cutaneous findings during COVID-19 pandemic.

Altunisik Toplu, Sibel / Altunisik, Nihal / Turkmen, Dursun / Ersoy, Yasemin

2020 Volume 19, Issue 10, Page(s) 2468–2473

Abstract: Background: In the current situation of the COVID-19 pandemic, healthcare workers (HCWs) have to comply with hygiene conditions and use gloves more frequently and for a longer period of time than they would previously to avoid infection and prevent ... ...

Abstract	Background: In the current situation of the COVID-19 pandemic, healthcare workers (HCWs) have to comply with hygiene conditions and use gloves more frequently and for a longer period of time than they would previously to avoid infection and prevent transmission. Aims: We aimed to characterize the adverse skin reactions occurring after hand hygiene and glove use in HCWs in a tertiary university hospital to determine the possible causative factors and whether the use of these measures is affected. Methods: Between April 15 and May 1, 2020, a cross-sectional survey was conducted, using online questionnaire, answered by HCWs in a tertiary university hospital. Results: The increase in general hand-skin problems during the pandemic period was statistically significant (P = .004). The most common symptom was dryness. During the pandemic period, 67 (24.3%) HCWs thought that the conditions were caused by glove use, and 197 (71.4%) thought that they were due to alcohol-based hand antiseptics. The incidence of other hand-skin conditions except for vesicles was statistically higher in women than in men (P < .001). Conclusions: Increased number of hand-skin conditions during the pandemic should not be ignored, since hand hygiene and glove use are expected to increase.
MeSH term(s)	Adult ; COVID-19/prevention & control ; Cross-Sectional Studies ; Dermatitis, Occupational/epidemiology ; Dermatitis, Occupational/etiology ; Female ; Gloves, Protective/adverse effects ; Hand Dermatoses/epidemiology ; Hand Dermatoses/etiology ; Hand Hygiene ; Health Personnel ; Humans ; Male
Keywords	covid19
Language	English
Publishing date	2020-08-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.13656
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Article: Multisystem Inflammatory Syndrome in Adults (MIS-A) Associated with SARS-CoV-2 Infection in a Young Adult Case from Turkey.

Altunisik Toplu, Sibel / Ersoy, Yasemin / Bayindir, Yasar / Kilic, Talat / Bayazit, Volkan

Medeniyet medical journal

2021 Volume 36, Issue 2, Page(s) 180–184

Abstract: Weeks and even months after recovering from the SARS-CoV-2 infection, clinically more severe cases are being reported, which are suggestive of COVID-19- related multisystemic inflammatory syndromes (MIS). Firstly on March 2020, this condition was ... ...

Abstract	Weeks and even months after recovering from the SARS-CoV-2 infection, clinically more severe cases are being reported, which are suggestive of COVID-19- related multisystemic inflammatory syndromes (MIS). Firstly on March 2020, this condition was reported to be COVID-19 related to children (MIS-C). Since June 2020, a syndrome similar to multisystem inflammatory syndrome in adults (MIS-A) came to be noticed in adults as well. We reported here a case of 24-year-old young woman who had gone to a hospital with abdominal pain and later developed a severe cough, followed by development of subconjunctival bleeding, pericardial effusion, pleural effusion, and intra-abdominal fluid that we deemed them to be acute multisystemic clinical symptoms, 47 days after she had undergone a COVID-19 infection of mild clinical severity. It should be kept in mind that a multisystemic inflammatory syndrome along with a delayed immune response during COVID-19 disease can be seen not only in children but also in young adults, and seemingly severe clinical and laboratory findings can improve by controlling the inflammatory process.
Language	English
Publishing date	2021-06-18
Publishing country	Turkey
Document type	Case Reports
ZDB-ID	3035195-9
ISSN	2149-4606 ; 2149-2042
ISSN (online)	2149-4606
ISSN	2149-2042
DOI	10.5222/MMJ.2021.95422
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Article ; Online: Investigation of SARS-CoV-2 RNA in milk produced by women with COVID-19 and follow-up of their infants: A preliminary study.

Kilic, Talat / Kilic, Sebnem / Berber, Nurcan Kırıcı / Gunduz, Ayten / Ersoy, Yasemin

International journal of clinical practice

2021 Volume 75, Issue 7, Page(s) e14175

Abstract: Objectives: Studies have shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is primarily transmitted from person to person via airborne droplets. It is unclear whether it can be shed into human milk and transmitted to a child via ... ...

Abstract	Objectives: Studies have shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is primarily transmitted from person to person via airborne droplets. It is unclear whether it can be shed into human milk and transmitted to a child via breastfeeding. We investigated the presence of SARS-CoV-2 RNA in human milk samples of 15 mothers with coronavirus disease 19 (COVID-19) and in the throat swab samples of their infants. Methods: This is a prospective observational study in which breast milk samples were collected from 15 mothers with COVID-19. The presence of SARS-CoV-2 RNA in the whole human milk samples of the patients was investigated using RT-qPCR. All of the infants underwent a clinical follow-up during their 14-day isolation and their throat swab samples were tested for SARS-CoV-2 RNA. Results: Of 15 mothers with COVID-19, SARS-CoV-2 RNA was detected in milk samples from 4 mothers. The throat swab samples from these mothers' infants were found to be positive for SARS-CoV-2 RNA. Three of the four mothers were breastfeeding. In addition, during the 14-day isolation, all but three of the mothers breastfed their infants. Of the 12 breastfed infants, while the test for SARS-CoV-2 RNA in throat swab samples was negative in 6 of the infants, the other 6 infants, who had mild COVID-19 symptoms, tested positive for SARS-CoV-2 RNA. Clinical outcomes of all mothers and infants were uneventful. Conclusion: To our knowledge, this is the first case series with the largest number of cases with SARS-CoV-2 RNA positivity in human milk samples of mothers with COVID-19. However, we believe that the benefits of breastfeeding may outweigh the risk of SARS-CoV-2 infection in infants.
MeSH term(s)	COVID-19 ; Child ; Female ; Follow-Up Studies ; Humans ; Infant ; Infectious Disease Transmission, Vertical ; RNA, Viral ; SARS-CoV-2
Chemical Substances	RNA, Viral
Language	English
Publishing date	2021-04-17
Publishing country	India
Document type	Journal Article ; Observational Study
ZDB-ID	1386246-7
ISSN	1742-1241 ; 1368-5031
ISSN (online)	1742-1241
ISSN	1368-5031
DOI	10.1111/ijcp.14175
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Article ; Online: Hydrocortisone may act through the angiotensin II receptor-2 level in patients with catecholamine-resistant septic shock.

Baykan, Seyma / Bicakcioglu, Murat / Bulut, Nilüfer / Yucel, Neslihan / Ersoy, Yasemin / Kibrislioglu Uysal, Nermin / Ozer, Ayse B

Minerva anestesiologica

2022 Volume 89, Issue 4, Page(s) 298–305

Abstract: Background: This study aimed to compare the serum angiotensin II and its receptor levels (AT1, AT2) in septic patients with catecholamine-responsive or resistant. The effect of hydrocortisone treatment on angiotensin II levels in the catecholamine- ... ...

Abstract	Background: This study aimed to compare the serum angiotensin II and its receptor levels (AT1, AT2) in septic patients with catecholamine-responsive or resistant. The effect of hydrocortisone treatment on angiotensin II levels in the catecholamine-resistant septic patients was evaluated. Methods: This prospective observational study enrolled 40 patients diagnosed with septic shock based on sepsis-3 criteria. Patients were divided into two groups according to the noradrenalin infusion rate required to keep the mean arterial pressure above 65 mmHg: control group and hydrocortisone group (control group: below 0.5 µg/kg/min, hydrocortisone group: above 0.5 µg/kg/min). Serum angiotensin II, AT1, AT2 levels were measured at the time of diagnosis (A), one hour after hydrocortisone treatment (B), and three days later (C). Results: In the catecholamine-resistant group, angiotensin II and AT1 levels were higher than the catecholamine-responder group in all periods. The sensitivity and specificity of AT-1 was observed to be high in all periods. AT2 levels decreased after hydrocortisone treatment in the catecholamine-resistant group and cut-off value was found 11%. Conclusions: It was concluded that angiotensin II and AT1 can be used as a biomarker of refractory septic shock and hydrocortisone may provide their blood pressure correcting effect by reducing AT2 level in these patients. AT2 can be a therapeutic target in the catecholamine-resistant septic shock patients.
MeSH term(s)	Humans ; Hydrocortisone/therapeutic use ; Shock, Septic ; Catecholamines/therapeutic use ; Angiotensin II/therapeutic use ; Sepsis/drug therapy
Chemical Substances	Hydrocortisone (WI4X0X7BPJ) ; Catecholamines ; Angiotensin II (11128-99-7)
Language	English
Publishing date	2022-10-26
Publishing country	Italy
Document type	Observational Study ; Journal Article
ZDB-ID	123584-9
ISSN	1827-1596 ; 0026-4717 ; 0375-9393
ISSN (online)	1827-1596
ISSN	0026-4717 ; 0375-9393
DOI	10.23736/S0375-9393.22.16766-0
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Article: A silent outbreak due to

Duman, Yucel / Ersoy, Yasemin / Gursoy, Nafia Canan / Altunisik Toplu, Sibel / Otlu, Baris

Iranian journal of basic medical sciences

2020 Volume 23, Issue 1, Page(s) 46–50

Abstract: Objectives: Infections due to carbapenemase-producing : Materials and methods: Once an outbreak was suspected at the end of December 2017 in our intensive care unit (ICU), carbapenem resistance : Results: We investigate 21 carbapenem-resistant : ...

Abstract	Objectives: Infections due to carbapenemase-producing Materials and methods: Once an outbreak was suspected at the end of December 2017 in our intensive care unit (ICU), carbapenem resistance Results: We investigate 21 carbapenem-resistant Conclusion: The interventions that successfully controlled this outbreak were hand hygiene, tight contact prevention, good clean-up of the hospital environment and medical devices. As a result, we believe that it would be beneficial to take infection control measures to prevent the spread of these strains to the community and hospital settings.
Language	English
Publishing date	2020-04-25
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2500485-2
ISSN	2008-3874 ; 2008-3866
ISSN (online)	2008-3874
ISSN	2008-3866
DOI	10.22038/IJBMS.2019.35269.8400
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Article: Relationship between hand hygiene and cutaneous findings during COVID-19 pandemic

Altunisik Toplu, Sibel / Altunisik, Nihal / Turkmen, Dursun / Ersoy, Yasemin

Abstract: BACKGROUND: In the current situation of the COVID-19 pandemic, healthcare workers (HCWs) have to comply with hygiene conditions and use gloves more frequently and for a longer period of time than they would previously to avoid infection and prevent ... ...

Abstract	BACKGROUND: In the current situation of the COVID-19 pandemic, healthcare workers (HCWs) have to comply with hygiene conditions and use gloves more frequently and for a longer period of time than they would previously to avoid infection and prevent transmission. AIMS: We aimed to characterize the adverse skin reactions occurring after hand hygiene and glove use in HCWs in a tertiary university hospital to determine the possible causative factors and whether the use of these measures is affected. METHODS: Between April 15 and May 1, 2020, a cross-sectional survey was conducted, using online questionnaire, answered by HCWs in a tertiary university hospital. RESULTS: The increase in general hand-skin problems during the pandemic period was statistically significant (P = .004). The most common symptom was dryness. During the pandemic period, 67 (24.3%) HCWs thought that the conditions were caused by glove use, and 197 (71.4%) thought that they were due to alcohol-based hand antiseptics. The incidence of other hand-skin conditions except for vesicles was statistically higher in women than in men (P < .001). CONCLUSIONS: Increased number of hand-skin conditions during the pandemic should not be ignored, since hand hygiene and glove use are expected to increase.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #693686
Database	COVID19

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Article ; Online: Relationship between hand hygiene and cutaneous findings during COVID‐19 pandemic

Altunisik Toplu, Sibel / Altunisik, Nihal / Turkmen, Dursun / Ersoy, Yasemin

Journal of Cosmetic Dermatology

2020 Volume 19, Issue 10, Page(s) 2468–2473

Keywords	Dermatology ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
ZDB-ID	2280551-5
ISSN	1473-2130
ISSN	1473-2130
DOI	10.1111/jocd.13656
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Article ; Online: The safety profile of favipiravir in COVID-19 patients with severe renal impairment.

Gök, Selim / Bahçecioğlu, Ömer Faruk / Durmuş, Mefküre / Gün, Zeynep Ülkü / Ersoy, Yasemin / Aytemur, Zeynep Ayfer / Ulutaş, Özkan

International journal of clinical practice

2021 Volume 75, Issue 12, Page(s) e14938

Abstract: Objective: The safety profile of favipiravir in patients with severe renal impairment has not been investigated and available data are insufficient. The study aimed to compare the incidence of favipiravir-associated adverse events amongst patients with ... ...

Abstract	Objective: The safety profile of favipiravir in patients with severe renal impairment has not been investigated and available data are insufficient. The study aimed to compare the incidence of favipiravir-associated adverse events amongst patients with varying renal function statuses. Methods: Records of 921 patients who were hospitalised for COVID-19 and had received at least 5 days of favipiravir treatment were retrospectively evaluated and 228 patients were included in the study. Patients' age, sex, comorbidities, estimated glomerular filtration rate (eGFR) and haematological and biochemical values were recorded. The incidence of adverse events was compared with the age, sex, comorbidities and eGFR of the patients. Results: The mean age of the patients was 59.3 ± 15.6 years, and 38.2% of the patients were women. One hundred and thirty-one (57.5%) patients had experienced adverse events. These adverse effects consisted of ALT elevation (35.5%), AST elevation (21.5%), anaemia (16.2%), hyperuricaemia (10.5%), hepatocellular injury (9.2%), neutropenia (3.5%) and thrombocytopenia (2.6%). The incidence of adverse events was not significantly different when patients had eGFR >60 mL/min/1.73 m Conclusion: Even though favipiravir appeared to be well tolerated in the individuals with renal failure in this study, its use in this population remains a challenge that requires more research and analysis.
MeSH term(s)	Adult ; Aged ; Amides/adverse effects ; Amides/therapeutic use ; COVID-19/drug therapy ; Female ; Glomerular Filtration Rate ; Humans ; Male ; Middle Aged ; Pyrazines/adverse effects ; Pyrazines/therapeutic use ; Renal Insufficiency ; Retrospective Studies
Chemical Substances	Amides ; Pyrazines ; favipiravir (EW5GL2X7E0)
Language	English
Publishing date	2021-10-10
Publishing country	India
Document type	Journal Article
ZDB-ID	1386246-7
ISSN	1742-1241 ; 1368-5031
ISSN (online)	1742-1241
ISSN	1368-5031
DOI	10.1111/ijcp.14938
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Article: Oral colonization of

Duman, Yucel / Ersoy, Yasemin / Tanriverdi, Elif Seren / Otlu, Barıs / Toplu, Sibel Altunisik / Gözükara Bağ, Harika Gözde / Tekerekoglu, Mehmet Sait / Bulam, Nazire / Canturk, Elif Kaplan / Parmaksiz, Nalan

Iranian journal of basic medical sciences

2022 Volume 25, Issue 2, Page(s) 239–244

Abstract: Objectives: Oral colonization of : Materials and methods: The study began in February 2021. Oral cultures were taken. The microorganisms were identified by a Maldi-tof MS mass spectrometry device. Colistin resistance genes were investigated by ... ...

Abstract	Objectives: Oral colonization of Materials and methods: The study began in February 2021. Oral cultures were taken. The microorganisms were identified by a Maldi-tof MS mass spectrometry device. Colistin resistance genes were investigated by polymerase chain reaction. Clonal relationships were determined by pulsed-field gel electrophoresis. Results: A. baumannii Conclusion: Oral colonization of
Language	English
Publishing date	2022-04-23
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2500485-2
ISSN	2008-3874 ; 2008-3866
ISSN (online)	2008-3874
ISSN	2008-3866
DOI	10.22038/IJBMS.2022.59713.13243
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Article ; Online: Angiotensin II and angiotensin II receptor 2 levels can predict shock and mortality in septic patients.

Ozer, Ayse B / Bicakcioglu, Murat / Baykan, Seyma / Bulut, Nilüfer / Kalkan, Serkan / Demircan, Selcuk / Korkmaz Disli, Zeliha / Duzenci, Deccane / Aydogan, Mustafa S / Yucel, Aytac / Yucel, Neslihan / Ersoy, Yasemin / Kibrislioglu Uysal, Nermin / Dogan, Zafer

Minerva anestesiologica

2022 Volume 88, Issue 12, Page(s) 1021–1029

Abstract: Background: The aim of this study was to evaluate the place of angiotensin II and its receptors in the prognosis of septic patients.: Methods: Patients with sepsis and septic shock were included in the study group. The control group consisted of ... ...

Abstract	Background: The aim of this study was to evaluate the place of angiotensin II and its receptors in the prognosis of septic patients. Methods: Patients with sepsis and septic shock were included in the study group. The control group consisted of patients who were followed up in the ICU and had no sepsis/septic shock. Plasma angiotensin II, angiotensin receptor-1 and 2 (AT-1, AT-2) levels were evaluated first and third days. Results: Angiotensin II levels were significantly lower in the septic shock and non-survivor. AT-1 levels were lower in all septic patients on the first day compared to the control. While AT-1 levels on the third day decreased in the septic shock group, it increased in the sepsis group. AT-2 levels were significantly higher in sepsis, and lower in septic shock compared to controls on the first day. Angiotensin II (95%, 82%) and AT-2 levels (100%, 87%) were observed to have high sensitivity and specificity in demonstrating the presence of shock in septic patients. Angiotensin II and AT-1/AT-2 ratios were observed to have high sensitivity and low specificity in the development of mortality. Conclusions: In septic patients, angiotensin II, AT-2 and AT-1/AT-2 levels can predict the probability of shock development and mortality.
MeSH term(s)	Humans ; Shock, Septic ; Angiotensin II ; Sepsis ; Prognosis ; Receptors, Angiotensin
Chemical Substances	Angiotensin II (11128-99-7) ; Receptors, Angiotensin
Language	English
Publishing date	2022-06-15
Publishing country	Italy
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123584-9
ISSN	1827-1596 ; 0026-4717 ; 0375-9393
ISSN (online)	1827-1596
ISSN	0026-4717 ; 0375-9393
DOI	10.23736/S0375-9393.22.16566-1
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