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  1. Article: Hydrochemical and isotopic studies to understand quality problems in groundwater of the Niğde Province, Central Turkey

    Lermi, Abdurrahman / Ertan, Gökhan

    Environmental earth sciences. 2019 June, v. 78, no. 12

    2019  

    Abstract: This study seeks to decipher the hydrochemistry, recharge sources, and the possible factors controlling the chemistry of groundwater in Niğde Province of central Turkey. This was done by conducting hydrochemical, multivariate statistical, and stable ... ...

    Abstract This study seeks to decipher the hydrochemistry, recharge sources, and the possible factors controlling the chemistry of groundwater in Niğde Province of central Turkey. This was done by conducting hydrochemical, multivariate statistical, and stable isotope analysis on 37 well and spring water samples collected in the wet and dry seasons of 2016. The major ion abundance in the groundwater is in the order Ca2+ > Na+ > Mg2+ > K+ and HCO3− > SO42− > Cl−. This accounted for the dominance of Ca–SO4–HCO3 water type with other mixed water types, reflecting the geology of the area, which is predominated by carbonate lithologies. All the physico-chemical parameters generally comply with the WHO and Turkish national guideline values for drinking water except TDS, Ca2+, SO42−, NO3−, and As. The elevated amounts of TDS, SO42−, and NO3− were largely from anthropogenic sources. The studied well and spring water samples are suitable for irrigation purposes in terms of their sodium hazard, but with regard to salinity hazard, the well water samples are not suitable for irrigation purposes due to their high salinity values. Three factors that explain 85.2% of the total variance of the data point to water–rock interaction and mixing with thermal waters as the principal factors controlling the chemistry of the groundwater. Metal pollution load was significantly higher in the wet season than in the dry season with arsenic as the key contaminant (0.69–391.14 μg/L and 0.29–43.6 μg/L in the wet and dry seasons, respectively). The tritium concentrations reveal that the well waters have longer residence time and water–rock interaction than the spring waters and are thus recharged from older groundwater sources.
    Keywords anthropogenic activities ; arsenic ; bicarbonates ; calcium ; carbonates ; chlorides ; drinking water ; dry season ; geology ; groundwater ; guidelines ; hydrochemistry ; irrigation ; magnesium ; mixing ; nitrates ; pollution load ; potassium ; salinity ; sodium ; stable isotopes ; sulfates ; tritium ; variance ; wet season ; World Health Organization ; Turkey (country)
    Language English
    Dates of publication 2019-06
    Size p. 365.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    ZDB-ID 2493699-6
    ISSN 1866-6299 ; 1866-6280
    ISSN (online) 1866-6299
    ISSN 1866-6280
    DOI 10.1007/s12665-019-8365-2
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  2. Article ; Online: Firat Üniversitesi Çalişanlarinin Süt ve Süt Ürünleri Satin Alma Tercihleri

    Emin Ertan GÖKHAN / Mehmet Saltuk ARIKAN

    Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi, Vol 3, Iss 2, Pp 125-

    2018  Volume 129

    Abstract: Bu çalışmada Fırat Üniversitesi çalışanlarının süt ve süt ürünleri tüketim yapısının ve bu ürünleri satın almada tercihlerinin belirlenmesi amaçlanmıştır. Çalışma materyalini 2015-2016 eğitim-öğretim yılında Fırat Üniversitesi’nde görev yapan ve ... ...

    Abstract Bu çalışmada Fırat Üniversitesi çalışanlarının süt ve süt ürünleri tüketim yapısının ve bu ürünleri satın almada tercihlerinin belirlenmesi amaçlanmıştır. Çalışma materyalini 2015-2016 eğitim-öğretim yılında Fırat Üniversitesi’nde görev yapan ve araştırmaya katılmayı kabul eden 128 akademik ve personelle yüz yüze yapılan anket uygulamasından elde edilen veriler oluşturmuştur. Gruplar arasında yapılan istatistiksel karşılaştırmalarda tek yönlü varyans analizi ve gruplar arası farkın önem kontrolünde post hoc test olarak Scheffe testinden yararlanılmıştır. Çalışmaya katılanların .25’i haftada bir kez süt ve süt ürünleri satın aldığı, .94’ü sütü üreticiden satın aldığı tespit edilmiştir. Süt ve süt ürünlerini satın almada; güvenirlik, katkısız olması, ambalaj ve üretim yerinin bilinmesi kriterleri ile eğitim düzeyi arasında ve süt ve süt ürünleri satın almada göz önünde bulundurulan tüm kriterler ile aylık gelir düzeyi arasında istatistiksel farklılık olduğu belirlenmiştir (P<0.05). Sonuç olarak katılımcıların işlenmiş ambalajlı markalı süt ve süt ürünlerini, günlük açık süt ve süt ürünlerine göre daha cazip bulduğu diğer taraftan süt ve süt ürünleri tüketim tercihlerinde üniversite çalışanlarında eğitim ve gelir düzeyinin etkili olduğu tespit edilmiştir.
    Keywords Milk products ; income ; education ; Fırat University ; buyingpreferences ; Süt ürünleri ; gelir ; eğitim ; Fırat Üniversitesi ; satın alma tercihleri ; Veterinary medicine ; SF600-1100
    Language English
    Publishing date 2018-12-01T00:00:00Z
    Publisher Mehmet Akif Ersoy University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Enhanced delivery of naproxen to the viable epidermis from an activated poly N-isopropylacrylamide (PNIPAM) Nanogel: Skin penetration, modulation of COX-2 expression and rat paw oedema.

    Yurdasiper, Aysu / Ertan, Gokhan / Heard, Charles M

    Nanomedicine : nanotechnology, biology, and medicine

    2018  Volume 14, Issue 7, Page(s) 2051–2059

    Abstract: Stimulus-responsive drug-loaded poly (N-isopropylacrylamide) nanogels were examined as a means of enhancing the delivery of naproxen into skin ex vivo. Following massaging into skin, the epidermis was probed (with and without base activation) for depth ... ...

    Abstract Stimulus-responsive drug-loaded poly (N-isopropylacrylamide) nanogels were examined as a means of enhancing the delivery of naproxen into skin ex vivo. Following massaging into skin, the epidermis was probed (with and without base activation) for depth penetration and transdermal delivery of drug, and anti-inflammatory activity in the relative levels of COX-2 expression. Rat paw oedema testing was used to determine anti-inflammatory effects in vivo. When activated by sodium carbonate, particle size reduced by 19%. Tape stripping revealed significantly greater delivery of naproxen into the epidermis for the activated nanogel and the steady state flux was enhanced 2.8-fold. With base-activation COX-2 was 50% lower than non-activated, and this trend was confirmed by immunostaining, and by the reduction of rat paw swelling which provided ex vivo - in vivo corroboration. A mechanism of action is proposed. In conclusion, stimulus-responsive nanogels have potential for enhancing dermal drug delivery and therapeutic outcomes in inflammatory skin diseases.
    MeSH term(s) Acrylamides/chemistry ; Administration, Cutaneous ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Carrageenan/toxicity ; Cyclooxygenase 2/genetics ; Cyclooxygenase 2/metabolism ; Drug Delivery Systems ; Edema/chemically induced ; Edema/drug therapy ; Epidermal Cells ; Epidermis/drug effects ; Epidermis/metabolism ; Gene Expression Regulation/drug effects ; Male ; Naproxen/administration & dosage ; Naproxen/chemistry ; Naproxen/pharmacology ; Polyethylene Glycols/administration & dosage ; Polyethylene Glycols/chemistry ; Polyethyleneimine/administration & dosage ; Polyethyleneimine/chemistry ; Polymers/chemistry ; Rats ; Rats, Wistar ; Skin/cytology ; Skin/drug effects ; Skin/metabolism
    Chemical Substances Acrylamides ; Anti-Inflammatory Agents, Non-Steroidal ; NanoGel ; Polymers ; Polyethylene Glycols (3WJQ0SDW1A) ; Naproxen (57Y76R9ATQ) ; Carrageenan (9000-07-1) ; Polyethyleneimine (9002-98-6) ; N-isopropylacrylamide (B7GFF17L9U) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Ptgs2 protein, rat (EC 1.14.99.1)
    Language English
    Publishing date 2018-06-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2183417-9
    ISSN 1549-9642 ; 1549-9634
    ISSN (online) 1549-9642
    ISSN 1549-9634
    DOI 10.1016/j.nano.2018.05.017
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  4. Article ; Online: Improved Method for Solid Lipid Nanoparticle Preparation Based on Hot Microemulsions: Preparation, Characterization, Cytotoxicity, and Hemocompatibility Evaluation.

    Kotmakçı, Mustafa / Akbaba, Hasan / Erel, Gülşah / Ertan, Gökhan / Kantarcı, Gülten

    AAPS PharmSciTech

    2017  Volume 18, Issue 4, Page(s) 1355–1365

    Abstract: The ease of application and no requirement of extra energy input make the microemulsion method favorable for solid lipid nanoparticles (SLNs) production. Very limited data are available to date on preparation of SLNs from pre-screened microemulsion phase ...

    Abstract The ease of application and no requirement of extra energy input make the microemulsion method favorable for solid lipid nanoparticles (SLNs) production. Very limited data are available to date on preparation of SLNs from pre-screened microemulsion phase diagrams. The purpose of this study was to investigate the microemulsion formation area with solid lipids using hot ternary phase diagrams at elevated temperatures and to use selected microemulsions for SLN production. Also, we aimed to characterize obtained SLNs in terms of physicochemical properties, in vitro cell toxicity, and hemolysis. Phase diagrams of solid lipids were screened at elevated temperatures and oil-in-water microemulsion regions were determined. Microemulsions were selected, and SLNs were produced by modification of the microemulsion dilution method and characterized in terms of visual appearance, turbidity, particle size, and zeta potential. Cytotoxicity of nanoparticles was tested on L929 mouse skin fibroblast cells. Hemolytic potential was assessed in vitro using freshly isolated erythrocytes. The phase diagram screening and the modified hot microemulsion dilution method enabled production of SLNs with particle size below 100 nm. We found evidence that the solid lipids in the SLNs produced by the new method remain in supercooled liquid state. Nanoparticles prepared by the new method exhibit lower toxicity on L929 cells and have lower hemolytic potential than the formulations prepared by direct mixing of the components. The method can be used to prepare SLNs with controllable composition and small particle size below 100 nm. These SLNs are low toxic and can be used for drug delivery purposes.
    Language English
    Publishing date 2017-05
    Publishing country United States
    Document type Journal Article
    ISSN 1530-9932
    ISSN (online) 1530-9932
    DOI 10.1208/s12249-016-0606-z
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  5. Article: In vitro-in vivo evaluation of in situ gelling and thermosensitive ketoprofen liquid suppositories.

    Ozgüney, Işık / Kardhiqi, Anita / Yıldız, Gülbeyaz / Ertan, Gökhan

    European journal of drug metabolism and pharmacokinetics

    2013  Volume 39, Issue 4, Page(s) 283–291

    Abstract: The main objective of this study was to investigate the release and pharmacokinetic profiles of ketoprofen (KP) from developed thermosensitive and mucoadhesive liquid suppositories. Thermosensitive liquid suppositories were prepared using KP, poloxamer ... ...

    Abstract The main objective of this study was to investigate the release and pharmacokinetic profiles of ketoprofen (KP) from developed thermosensitive and mucoadhesive liquid suppositories. Thermosensitive liquid suppositories were prepared using KP, poloxamer 407 (P 407), poloxamer 188 (P 188) and various amounts of different mucoadhesive polymers. In vitro release studies was monitored by the USP XXVI paddle method. The results thus obtained were evaluated kinetically and mechanism of release was analyzed. Identification of poloxamer gel localization in vivo was conducted using white male rabbits by adding 1 % methylene blue. For in vivo studies, twenty-four white male rabbits were randomly divided into three groups. The rabbits in each group were administered with liquid suppository F1 [P407/P188/KP (4/20/2.5 %)], F5 [P407/P188/KP/C (4/20/2.5/0.8 %)] or conventional suppository (F-C) into the rectum. The plasma concentration of KP was analyzed by high performance liquid chromatography (HPLC). C max, AUC, MRT and T max were evaluated. The release of KP was variously affected by the mucoadhesive polymers. In vitro release studies showed that Carbopol 934 P(C) has significant effect on release rate among the mucoadhesive polymers. When the formulations were evaluated kinetically, different kinetic models were obtained. Formulation F6 [P407/P188/KP/C (4/20/2.5/1.6 %)] which contains the highest C concentration and very high viscosity, shows a significantly better fit with Higuchi kinetic model. n value of this formulation was also found approximately 0.5. n exponent results of the other formulations showed that KP might be released from the suppositories by non-Fickian diffusion. Identification of poloxamer gel localization in vivo showed that the suppositories remain in the rectum without leakage after administration. With regard to the results of in vivo studies, the AUC6→14 values of KP in liquid suppository containing C are significantly higher than those in liquid suppository without C. MRT0→24 and MRT0→∞ values of liquid suppository containing C are significantly higher than those in liquid suppository without C and conventional suppository. Conventional suppository and liquid suppository without C significantly gave faster time to reach the maximum plasma concentrations of KP. With regard to the in vitro and in vivo experiments, liquid suppository formulation F5 might be a promising formulation for the development of an effective rectal dosage form.
    MeSH term(s) Animals ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Area Under Curve ; Gels ; Ketoprofen/administration & dosage ; Ketoprofen/chemistry ; Ketoprofen/pharmacokinetics ; Male ; Rabbits ; Solubility ; Suppositories/administration & dosage
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Gels ; Suppositories ; Ketoprofen (90Y4QC304K)
    Language English
    Publishing date 2013-10-06
    Publishing country France
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 196729-0
    ISSN 2107-0180 ; 0378-7966 ; 0398-7639
    ISSN (online) 2107-0180
    ISSN 0378-7966 ; 0398-7639
    DOI 10.1007/s13318-013-0157-6
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  6. Article ; Online: Preparation of

    İlem-Özdemir, Derya / Yararbas, Ulkem / Zengel, Baha / Ertan, Gökhan / Asikoglu, Makbule

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

    2016  Volume 118, Page(s) 338–342

    Abstract: The sentinel lymph node (SLN) is defined as the first regional lymph node to receive lymphatic drainage from a malignant tumor. Therefore, this node is a "sentinel" for second metastatic lymph node stations and for labeling regional tumor spread. For SLN ...

    Abstract The sentinel lymph node (SLN) is defined as the first regional lymph node to receive lymphatic drainage from a malignant tumor. Therefore, this node is a "sentinel" for second metastatic lymph node stations and for labeling regional tumor spread. For SLN detection, many surgeons preferred a combination of a preoperative injection of radiolabeled colloid and the intraoperative injection of blue dye. Under this combination protocol, nodes are considered to be "sentinel nodes" if they are radioactive and blue. The aim of this study is to develop a new single agent that combines both detection methods. For this purpose Isosulfan Blue (ISB) was radiolabeled by
    Language English
    Publishing date 2016-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1142596-9
    ISSN 1872-9800 ; 0883-2889 ; 0969-8043
    ISSN (online) 1872-9800
    ISSN 0883-2889 ; 0969-8043
    DOI 10.1016/j.apradiso.2016.10.007
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  7. Article ; Online: Determination of in vivo behavior of mitomycin C-loaded o/w soybean oil microemulsion and mitomycin C solution via gamma camera imaging.

    Kotmakçı, Mustafa / Kantarcı, Gülten / Aşıkoğlu, Makbule / Ozkılıç, Hayal / Ertan, Gökhan

    Cancer biotherapy & radiopharmaceuticals

    2013  Volume 28, Issue 7, Page(s) 530–533

    Abstract: In this study, a microemulsion system was evaluated for delivery of mitomycin C (MMC). To track the distribution of the formulated drug after intravenous administration, radiochemical labeling and gamma scintigraphy imaging were used. The aim was to ... ...

    Abstract In this study, a microemulsion system was evaluated for delivery of mitomycin C (MMC). To track the distribution of the formulated drug after intravenous administration, radiochemical labeling and gamma scintigraphy imaging were used. The aim was to evaluate a microemulsion system for intravenous delivery of MMC and to compare its in vivo behavior with that of the MMC solution. For microemulsion formulation, soybean oil was used as the oil phase. Lecithin and Tween 80 were surfactants and ethanol was the cosurfactant. To understand the whole body localization of MMC-loaded microemulsion, MMC was labeled with radioactive technetium and gamma scintigraphy was applied for visualization of drug distribution. Radioactivity in the bladder 30 minutes after injection of the MMC solution was observed, according to static gamma camera images. This shows that urinary excretion of the latter starts very soon. On the other hand, no radioactivity appeared in the urinary bladder during the 90 minutes following the administration of MMC-loaded microemulsion. The unabated radioactivity in the liver during the experiment shows that the localization of microemulsion formulation in the liver is stable. In the light of the foregoing, it is suggested that this microemulsion formulation may be an appropriate carrier system for anticancer agents by intravenous delivery in hepatic cancer chemotherapy.
    MeSH term(s) Administration, Intravenous ; Animals ; Emulsions/administration & dosage ; Emulsions/chemistry ; Gamma Cameras ; Humans ; Male ; Mitomycin/administration & dosage ; Mitomycin/chemistry ; Mitomycin/pharmacokinetics ; Rabbits ; Radionuclide Imaging/methods ; Sodium Pertechnetate Tc 99m/administration & dosage ; Sodium Pertechnetate Tc 99m/chemistry ; Soybean Oil/administration & dosage ; Soybean Oil/chemistry ; Soybean Oil/pharmacokinetics ; Surface-Active Agents/administration & dosage ; Surface-Active Agents/chemistry ; Surface-Active Agents/pharmacokinetics
    Chemical Substances Emulsions ; Surface-Active Agents ; Mitomycin (50SG953SK6) ; Soybean Oil (8001-22-7) ; Sodium Pertechnetate Tc 99m (A0730CX801)
    Language English
    Publishing date 2013-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1315649-4
    ISSN 1557-8852 ; 1084-9785
    ISSN (online) 1557-8852
    ISSN 1084-9785
    DOI 10.1089/cbr.2012.1428
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  8. Article ; Online: Novel nanostructured lipid carrier-based inserts for controlled ocular drug delivery: evaluation of corneal bioavailability and treatment efficacy in bacterial keratitis.

    Üstündağ-Okur, Neslihan / Gökçe, Evren Homan / Bozbıyık, Duygu İnci / Eğrilmez, Sait / Ertan, Gökhan / Özer, Özgen

    Expert opinion on drug delivery

    2015  Volume 12, Issue 11, Page(s) 1791–1807

    Abstract: Objectives: The aim of the present study was to develop novel ofloxacin (OFX)-loaded nanostructured lipid carrier (NLC)-based inserts for ocular application for treatment of bacterial keratitis.: Methods: NLC loaded with 0.3% OFX was prepared by ... ...

    Abstract Objectives: The aim of the present study was to develop novel ofloxacin (OFX)-loaded nanostructured lipid carrier (NLC)-based inserts for ocular application for treatment of bacterial keratitis.
    Methods: NLC loaded with 0.3% OFX was prepared by means of high shear homogenization and 0.75% chitosan oligosaccharide lactate (COL) was added. Glycerin or PEG 400 at the range of 1 - 15% was added to NLCs as plasticizers and inserts were developed by solvent casting evaporation. Characterization, in vitro release, microbiological, ex vivo and in vivo studies were performed.
    Results: The inserts developed with the addition of glycerin (Ins3OFX) was found as optimal. The kinetic studies revealed that the release of Ins3OFX was a combination of diffusion and swelling. Ins3OFX was more bioadhesive in texture profile analysis studies. In the in vivo studies performed with rabbits, the pre-ocular retention time was enhanced up to 24 h and Cmax was increased almost six times in comparison with commercial. The rabbits were infected with Staphylococcus aureus and keratitis was confirmed. This group was treated with Ins3OFX and they recovered in 7 days with no significant sign of conjunctival redness and corneal opacity.
    Conclusion: NLC-based inserts developed with COL and glycerin may be offered as appropriate vehicles for ocular delivery.
    MeSH term(s) Animals ; Biological Availability ; Cornea/metabolism ; Drug Delivery Systems ; Excipients/chemistry ; Eye Infections, Bacterial/drug therapy ; Keratitis/drug therapy ; Lipids/chemistry ; Nanostructures ; Ofloxacin/administration & dosage ; Polyethylene Glycols/chemistry ; Rabbits ; Staphylococcus aureus/drug effects ; Treatment Outcome
    Chemical Substances Excipients ; Lipids ; Polyethylene Glycols (30IQX730WE) ; Ofloxacin (A4P49JAZ9H)
    Language English
    Publishing date 2015
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2167286-6
    ISSN 1744-7593 ; 1742-5247
    ISSN (online) 1744-7593
    ISSN 1742-5247
    DOI 10.1517/17425247.2015.1059419
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  9. Article: The effect of geometric shape on the release properties of metronidazole from lipid matrix tablets.

    Gökçe, Evren H / Ozyazici, Mine / Ertan, Gokhan

    Journal of biomedical nanotechnology

    2010  Volume 5, Issue 4, Page(s) 421–427

    Abstract: In this study, the lipophilic matrix tablets of metronidazole were prepared with Cutina HR (hydrogenated castor oil), stearic acid, Compritol ATO 888 (glyceryl behenate) and Precirol ATO 5 (glycerol palmitostearate) in two different shapes; cylinder and ... ...

    Abstract In this study, the lipophilic matrix tablets of metronidazole were prepared with Cutina HR (hydrogenated castor oil), stearic acid, Compritol ATO 888 (glyceryl behenate) and Precirol ATO 5 (glycerol palmitostearate) in two different shapes; cylinder and hexagonal. Our first aim was to investigate the influence of the lipid excipients and geometric shape on the release behavior of metronidazole, and the second aim was to investigate the influence of tablet surface area/volume (SA/V) ratio on drug release from controlled release matrix tablets. In vitro release test was performed using a standard USP dissolution apparatus I. Hardness, surface/volume ratio and friability were determined. The hexagonal tablets were harder than the cylinder tablets. Stearic acid showed the highest release rates for both geometric shapes reflecting the highest surface area and the lowest SA/V ratio. According to power law analysis, the diffusion mechanism was expressed as a Fickian diffusion for all lipid matrix tablets. The square root of time relationship was operative for all tablets. Higuchi kinetic constants obtained with hexagonal tablets were higher than the cylinder tablets. As the type of lipid matrix, the geometric shape of the tablets was also effective on the diffusion and release kinetics. From the present study, it was shown that surface area and volume ratio may be used as parameters for the evaluation of the drug release profile.
    MeSH term(s) Body Fluids/chemistry ; Crystallization/methods ; Diffusion ; Drug Carriers/chemistry ; Lipids/chemistry ; Liposomes/chemistry ; Macromolecular Substances/chemistry ; Materials Testing ; Metronidazole/chemistry ; Molecular Conformation ; Nanostructures/chemistry ; Nanostructures/ultrastructure ; Particle Size ; Surface Properties
    Chemical Substances Drug Carriers ; Lipids ; Liposomes ; Macromolecular Substances ; Metronidazole (140QMO216E)
    Language English
    Publishing date 2010-01-01
    Publishing country United States
    Document type Journal Article
    ISSN 1550-7033
    ISSN 1550-7033
    DOI 10.1166/jbn.2009.1052
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  10. Article ; Online: Preparation and in vitro-in vivo evaluation of ofloxacin loaded ophthalmic nano structured lipid carriers modified with chitosan oligosaccharide lactate for the treatment of bacterial keratitis.

    Ustündağ-Okur, Neslihan / Gökçe, Evren Homan / Bozbıyık, Duygu İnci / Eğrilmez, Sait / Ozer, Ozgen / Ertan, Gökhan

    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

    2014  Volume 63, Page(s) 204–215

    Abstract: The objective of this study was to explore the potential of the nanostructured lipid carriers (NLCs) modified with chitosan oligosaccharide lactate (COL) for topical ocular application. Ofloxacin (OFX) loaded NLCs were prepared by microemulsion or high ... ...

    Abstract The objective of this study was to explore the potential of the nanostructured lipid carriers (NLCs) modified with chitosan oligosaccharide lactate (COL) for topical ocular application. Ofloxacin (OFX) loaded NLCs were prepared by microemulsion or high shear homogenization methods. For combination of NLCs Compritol HD5 ATO was used as solid lipid, oleic acid as liquid lipid, Tween 80 as surfactant, ethanol as co-surfactant. The optimum NLCs was modified with 0.75% COL. The properties of NLCs in the absence or presence of OFX (0.3%) were characterized as zeta potential, particle size, viscosity and pH, TEM, drug loading, encapsulation efficiency and anti-microbial properties. Ex-vivo penetration/permeation studies were performed with rabbit cornea in Franz-diffusion cells. The penetration rate of OFX from NM-COL4OFX and NH-COL4OFX were significantly higher than commercial solution. Based on the selected formulations, in vivo tests were carried out by eye-drop instillation of NLCs in rabbit. The addition of COL improved the preocular residence time, controlled the drug release and enhanced the corneal bioavailability. In conclusion, OFX COL modified NLCs prepared by high shear homogenization method could be offered as a promising strategy for ocular drug delivery.
    MeSH term(s) Animals ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Chitosan/chemistry ; Drug Carriers/chemistry ; Escherichia coli/drug effects ; Hydrogen-Ion Concentration ; Keratitis/drug therapy ; Lactates/chemistry ; Lipids/chemistry ; Male ; Microbial Sensitivity Tests ; Nanoparticles/chemistry ; Ofloxacin/chemistry ; Ofloxacin/pharmacology ; Particle Size ; Rabbits ; Staphylococcus aureus/drug effects ; Surface Properties ; Viscosity
    Chemical Substances Anti-Bacterial Agents ; Drug Carriers ; Lactates ; Lipids ; Chitosan (9012-76-4) ; Ofloxacin (A4P49JAZ9H)
    Language English
    Publishing date 2014-10-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1154366-8
    ISSN 1879-0720 ; 0928-0987
    ISSN (online) 1879-0720
    ISSN 0928-0987
    DOI 10.1016/j.ejps.2014.07.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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