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Article ; Online: The recent use of Swietenia mahagoni (L.) Jacq. as antidiabetes type 2 phytomedicine: A systematic review

Sukardiman / Ervina, Martha

Heliyon. 2020 Mar., v. 6, no. 3 p.e03536-

2020

Abstract: Natural resources provide more efficient and safer alternatives in managing diabetes compare to the synthetic oral anti diabetes (OAD). The plants not only have hypoglycemic effect, but also prevent its complications; in which no synthetic drugs provide ... ...

Abstract	Natural resources provide more efficient and safer alternatives in managing diabetes compare to the synthetic oral anti diabetes (OAD). The plants not only have hypoglycemic effect, but also prevent its complications; in which no synthetic drugs provide of both properties. Among antidiabetes plants, mahogany seed (Swietenia macrophylla) has been used as traditional medicine in Indonesia and India, though most popular utilized as timber wood. The present study was performed of chemotaxonomic approach to review its phytochemical and anti-diabetic properties of Swietenia mahagoni (L.) Jacq seed/bark/leaves. The qualitative systematic review (SR) was carried out by analysing indexed journals and peer reviewed of Swietenia and Swietenia spp from Scopus, PubMed, Medline, Google Scholar, and Research Gate. Data selection criteria are accordance to botany, phytochemistry, in vitro, in vivo, and clinical test of related subject. The keywords used for the search in the databases were Swietenia, Swietenia mahagony, diabetes, and diabetes plants. Swietenia mahagoni (L.) Jacq. extracts have shown in vitro, in vivo and limited clinically test of its anti-diabetic properties. Ethanolic/methanolic/aqueous/petroleum/n-hexane extracts of mahagonis's seed/bark or leaves have anti-diabetic activities comparable to the synthetic drug and observed no to relatively mild toxic effect. The hypoglycemic mechanism suggested via reducing blood glucose level, restoring liver and β-cells islet function (might) blocking epinephrine function, inhibiting of α-amylase and β-glucosidase, antioxidant and antihiperlipidemia. Phytochemical compounds of S. mahagoni consist of the phenolics (flavonoids (swietemacrophyllanin, catechins and epichatechins) and tannins), triterpenoids and tetranortriterpenoids (limonoids: mahonin, secomahoganin, swietmanins, swiemahogins, swietenine and swietenolide), saponins and alkaloids which are known as anti-diabetic bioactive principles. S. mahagoni was potentially used and developed as an antidiabetes source. To use it as an antidiabetic further, more extensive clinical trials and biomarkers of active compounds determination are needed.
Keywords	Swietenia macrophylla ; Swietenia mahagoni ; alpha-amylase ; antioxidants ; bark ; biomarkers ; blood glucose ; chemotaxonomy ; diabetes ; drugs ; epinephrine ; flavanols ; glycemic effect ; limonoids ; liver ; phenolic compounds ; saponins ; systematic review ; toxicity ; traditional medicine ; wood ; India ; Indonesia ; Toxicology ; Hypoglycemic ; Mahogany ; Meliaceae ; Swietenia sp
Language	English
Dates of publication	2020-03
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2020.e03536
Database	NAL-Catalogue (AGRICOLA)

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Article: The recent use of

Sukardiman / Ervina, Martha

Heliyon

2020 Volume 6, Issue 3, Page(s) e03536

Abstract: Background: Natural resources provide more efficient and safer alternatives in managing diabetes compare to the synthetic oral anti diabetes (OAD). The plants not only have hypoglycemic effect, but also prevent its complications; in which no synthetic ... ...

Abstract	Background: Natural resources provide more efficient and safer alternatives in managing diabetes compare to the synthetic oral anti diabetes (OAD). The plants not only have hypoglycemic effect, but also prevent its complications; in which no synthetic drugs provide of both properties. Among antidiabetes plants, mahogany seed ( Methods: The present study was performed of chemotaxonomic approach to review its phytochemical and anti-diabetic properties of Results: Swietenia mahagoni Conclusion: S. mahagoni
Language	English
Publishing date	2020-03-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2020.e03536
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Solvent preextraction influenced to coumarin and glucose binding capacity of cinnamomi's extracts.

Ervina, Martha / Wea, Virgiana Kristin Coco / Oktaviani, Annisah / Hartanti, Lanny / Sinansari, Restry / Wilianto, Yufita Ratnasari / Steven / Caroline

Journal of advanced pharmaceutical technology & research

2023 Volume 14, Issue 2, Page(s) 69–74

Abstract: Cinnamon is one of the world's oldest spices that is also widely used as medicine for antimicrobe, anti-inflammation, and immune stimulant to now developed as an antidiabetic herbal medicine. Among its bioactive contents, the coumarin must have been ... ...

Abstract	Cinnamon is one of the world's oldest spices that is also widely used as medicine for antimicrobe, anti-inflammation, and immune stimulant to now developed as an antidiabetic herbal medicine. Among its bioactive contents, the coumarin must have been controlled; since of its toxicities. Therefore, in this study aimed to reduce the amount of coumarin in the extracts by chloroform preextraction to dried powdered cinnamons and determine their glucose binding capacity. The extractions were used two methods by water infusion and ethanol soxhletation. To measure the coumarin's was used validated thin-layer chromatography (TLC)-densitometry, while for the chemical profiling of the extract was examined with liquid chromatography-mass spectrometry. The activity antidiabetic of the extracts was obtained by glucose binding. The TLC-densitometry method has been validated with silica gel 60F
Language	English
Publishing date	2023-04-13
Publishing country	India
Document type	Journal Article
ISSN	2231-4040
ISSN	2231-4040
DOI	10.4103/japtr.japtr_671_22
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Bio-selective hormonal breast cancer cytotoxic and antioxidant potencies of

Ervina, Martha / Poerwono, Hadi / Widyowati, Retno / Matsunami, Katsuyoshi / Sukardiman

Biotechnology reports (Amsterdam, Netherlands)

2020 Volume 25, Page(s) e00437

Abstract: ... Melia ... ...

Abstract	Melia azedarach
Language	English
Publishing date	2020-02-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2801018-8
ISSN	2215-017X
ISSN	2215-017X
DOI	10.1016/j.btre.2020.e00437
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: In silico

Ervina, Martha / Pratama, Mohammad Rizki Fadhil / Poerwono, Hadi / Ekowati, Juni / Widyowati, Retno / Matsunami, Katsuyoshi / Sukardiman

Journal of advanced pharmaceutical technology & research

2021 Volume 12, Issue 3, Page(s) 236–241

Abstract: The estrogen hormone dependent accounts for a major cause in the incidence of women breast cancer. Thus, their receptor, especially the estrogen receptor α (ER-α), is becoming a target in endocrine treatment. These ligand-inducible nuclear functions are ... ...

Abstract	The estrogen hormone dependent accounts for a major cause in the incidence of women breast cancer. Thus, their receptor, especially the estrogen receptor α (ER-α), is becoming a target in endocrine treatment. These ligand-inducible nuclear functions are regulated by an array of phytochemical and synthetic compounds, such as 17 β-estradiol and tamoxifen (4-hydroxytamoxifen [4OHT]). The Chinaberry (
Language	English
Publishing date	2021-07-16
Publishing country	India
Document type	Journal Article
ISSN	2231-4040
ISSN	2231-4040
DOI	10.4103/japtr.JAPTR_198_21
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Pregnane Steroids from the Leaves of Melia Azedarach and Apoptotic Activity against T47D Cells.

Ervina, Martha / Poerwono, Hadi / Widyowati, Retno / Otsuka, Hideaki / Matsunami, Katsuyoshi / Sukardiman, Sukardiman

Asian Pacific journal of cancer prevention : APJCP

2021 Volume 22, Issue 6, Page(s) 1967–1973

Abstract: Objective: Nature has provided us with many pharmaceutical resources so far. Breast cancer shows an increasing trend in the world for the last decade and becomes one of five leading causes of death. Among the plants, Melia azedarach L. has been used ... ...

Abstract	Objective: Nature has provided us with many pharmaceutical resources so far. Breast cancer shows an increasing trend in the world for the last decade and becomes one of five leading causes of death. Among the plants, Melia azedarach L. has been used widely in traditional medicine for many ailments including breast cancer. Following our previous findings that the ethyl acetate fraction was the most active cytotoxic fraction against T47D cells, we aimed to isolate the cytotoxic compounds and further elucidate their apoptotic mechanisms. Methods: The compounds were isolated through a series of chromatography with cytotoxicity evaluations. Identification of the isolated compounds was achieved by intensive spectroscopic analysis such as NMR, MS, and IR spectra. Cytotoxicity was evaluated by MTT method using doxorubicin as a reference compound. The expression of apoptosis-related factors was quantified by flow cytometry and immunocytochemistry. Results: Two isomers of pregnane steroids with molecular weight 330.2087 (C21H30O3) were isolated from the EtOAc extract. Spectroscopic analysis revealed the structures as 17-ethylene-3,4-dihydroxy-14-methyl-18-norandrostene-16-one (1) and 17-ethylene-3,4-dihydroxy-5-pregnene-16-one (2), respectively. These compounds showed moderate cytotoxicity (IC50 172.9 and 62.2 µg/mL, respectively) comparable to doxorubicin (IC50 3.08 µg/mL). The execution of apoptosis may be related to the increase of the ratio of BAX/bcl-2 of the cells. Conclusion: The EtOAc fraction of Melia azedarach L. leaves and the isolated 5-pregnene-16-one steroids are promising reagents for breast cancer treatment by introducing apoptosis to tumor cells. However, further researches are required to highlight its safety and usage in vivo. .
MeSH term(s)	Apoptosis/drug effects ; Breast Neoplasms/drug therapy ; Doxorubicin/pharmacology ; Female ; Humans ; Melia azedarach/chemistry ; Molecular Structure ; Molecular Weight ; Plant Leaves/chemistry ; Pregnanes/pharmacology ; Steroids/pharmacology ; Tumor Cells, Cultured
Chemical Substances	Pregnanes ; Steroids ; Doxorubicin (80168379AG)
Language	English
Publishing date	2021-06-01
Publishing country	Thailand
Document type	Journal Article
ZDB-ID	2218955-5
ISSN	2476-762X ; 1513-7368
ISSN (online)	2476-762X
ISSN	1513-7368
DOI	10.31557/APJCP.2021.22.6.1967
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The coronavirus disease 2019 main protease inhibitor from Andrographis paniculata (Burm.f) Ness

Sukardiman, Ervina Martha Fadhil Pratama Mohammad Poerwono Hadi Siswodihardjo Siswandono

Journal of Advanced Pharmaceutical Technology & Research

Abstract: The coronavirus disease 2019 (COVID-19) pandemic has attracted worldwide attention Andrographis paniculata (Burm f) Ness (AP) is naturally used to treat various diseases, including infectious diseases Its Andrographolide has been clinically observed for ... ...

Abstract	The coronavirus disease 2019 (COVID-19) pandemic has attracted worldwide attention Andrographis paniculata (Burm f) Ness (AP) is naturally used to treat various diseases, including infectious diseases Its Andrographolide has been clinically observed for anti-HIV and has also in silico tested for COVID-19 main protease inhibitors Meanwhile, the AP phytochemicals content also provides insight into the molecular structures diversity for the bioactive discovery This study aims to find COVID-19 main protease inhibitor from AP by the molecular docking method and determine the toxicity profile of the compounds The results obtained two compounds consisting of flavonoid glycosides 5,4'-dihydroxy-7-O-β -D-pyran-glycuronate butyl ester and andrographolide glycoside 3-O-β-D-glucopyranosyl-andrographolide have lower free binding energy and highest similarity in types of interaction with amino acid residues compared to its co-crystal ligands (6LU7) and Indinavir or Remdesivir The toxicity prediction of the compounds also reveals their safety These results confirm the probability of using AP phytochemical compounds as COVID-19 main protease inhibitors, although further research must be carried out [ABSTRACT FROM AUTHOR] Copyright of Journal of Advanced Pharmaceutical Technology & Research is the property of Wolters Kluwer India Pvt Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission However, users may print, download, or email articles for individual use This abstract may be abridged No warranty is given about the accuracy of the copy Users should refer to the original published version of the material for the full abstract (Copyright applies to all Abstracts )
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #886254
Database	COVID19

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Article: The coronavirus disease 2019 main protease inhibitor from

Sukardiman / Ervina, Martha / Fadhil Pratama, Mohammad Rizki / Poerwono, Hadi / Siswodihardjo, Siswandono

Journal of advanced pharmaceutical technology & research

2020 Volume 11, Issue 4, Page(s) 157–162

Abstract: The coronavirus disease 2019 (COVID-19) pandemic has attracted worldwide attention. ...

Abstract	The coronavirus disease 2019 (COVID-19) pandemic has attracted worldwide attention.
Language	English
Publishing date	2020-10-10
Publishing country	India
Document type	Journal Article
ISSN	2231-4040
ISSN	2231-4040
DOI	10.4103/japtr.JAPTR_84_20
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Optimization of water extract of Cinnamomum burmannii bark to ascertain its in vitro antidiabetic and antioxidant activities

Ervina, Martha / Caroline / Diva, Jesslyn / Lie, Han Sanjaya / Tewfik, Ihab / Tewfik, Sundus

Biocatalysis and agricultural biotechnology. 2019 May, v. 19

2019

Abstract: The antidiabetic and antioxidant activity of water extract of Cinnamomum burmannii bark is well documented. This research aimed to optimize cinnamon water extraction process and verify active components instigating its in vitro antidiabetic activity. The ...

Abstract	The antidiabetic and antioxidant activity of water extract of Cinnamomum burmannii bark is well documented. This research aimed to optimize cinnamon water extraction process and verify active components instigating its in vitro antidiabetic activity. The study employed a Design Expert 7.0 program to derive factorial design and optimization conditions. The extraction step comprised of three factors (temperature, concentration and time of extraction) and two levels (low and high), with four responses observed (yield, total phenolic content, IC50DPPH antioxidant activity, and IC50 α-glucosidase inhibition). The polynomial equations revealed influence and interaction among the selected factors to the responses and obtained overlay optimization of factors to responses. The results indicated that optimal temperature, concentration, and extraction time were 98 °C, 30% and 20 min, respectively. Corresponding DPPH, α-glucosidase, TPC, and yield values were 3.45 μg/mL, 0.50 μg/mL, 259.08 μg GAE/mg of sample, 6.28%, respectively. LCMS analysis of the optimum extract confirmed typical characteristic of C. burmannii contents (coumarins, polymers of proanthocyanidins A-type and protonated heterodimer of flavan-3-ol group). The optimized water extract of C.burmannii has the potency to assist in complementary therapy to modulate diabetes mellitus.
Keywords	2,2-diphenyl-1-picrylhydrazyl ; alpha-glucosidase ; antioxidant activity ; bark ; Cinnamomum burmanni ; cinnamon ; coumarins ; diabetes mellitus ; enzyme inhibition ; equations ; glycemic effect ; inhibitory concentration 50 ; polymers ; proanthocyanidins ; temperature ; therapeutics
Language	English
Dates of publication	2019-05
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2642052-1
ISSN	1878-8181
ISSN	1878-8181
DOI	10.1016/j.bcab.2019.101152
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Phytochemical screening and preliminary clinical trials of the aqueous extract mixture of Andrographis paniculata (Burm. f.) Wall. ex Nees and Syzygium polyanthum (Wight.) Walp leaves in metformin treated patients with type 2 diabetes.

Widjajakusuma, Elisabeth Catherina / Jonosewojo, Arijanto / Hendriati, Lucia / Wijaya, Sumi / Ferawati / Surjadhana, Adrianta / Sastrowardoyo, Widayat / Monita, Nadia / Muna, Nafdsu Makhmudatul / Fajarwati, Rachma Pantja / Ervina, Martha / Esar, Senny Yesery / Soegianto, Lisa / Lang, Tirza / Heriyanti, Cindy

Phytomedicine : international journal of phytotherapy and phytopharmacology

2018 Volume 55, Page(s) 137–147

Abstract: Background: Our previous preclinical study showed that the extract mixture (EM) of Andrographis paniculata (Burm. f.) Wall. ex Nees (AP) and Syzygium polyanthum (Wight.) Walp (SP) leaves had antidiabetic effects and were beneficial on alloxan-induced ... ...

Abstract	Background: Our previous preclinical study showed that the extract mixture (EM) of Andrographis paniculata (Burm. f.) Wall. ex Nees (AP) and Syzygium polyanthum (Wight.) Walp (SP) leaves had antidiabetic effects and were beneficial on alloxan-induced diabetic rats. Purpose: The objectives of this study were to: 1) identify the phytochemical compounds present in aqueous extract of AP and SP and 2) examine the benefits of the EM of AP and SP leaves in lowering blood glucose in the presence of standard antidiabetic treatment using metformin in type 2 diabetic patients in Indonesian Traditional Medicine Polyclinic of Dr. Soetomo General Hospital in Surabaya. Methods: Phytochemical analysis of aqueous leaf extract of AP and SP was performed using standard chemical tests, TLC, and GC-MS. Furthermore, a total of 54 subjects with T2DM participated in this study and were randomly assigned to either the intervention group supplemented with the extract mixture of AP and SP at a dose 900  mg/day for 8 weeks, or the control group which received placebo tablets in a randomized placebo-controlled double-blinded parallel clinical trial. Both groups received metformin at dose 1000  mg/day. Body weight, blood pressure, fasting blood glucose, postprandial glucose, haemoglobin A1c, triglycerides, total cholesterol, low density lipoprotein, high density lipoprotein, and markers of liver and kidney damage were measured. Results: The results of phytochemical analysis showed that the glycosides, terpenoids, alkaloids, flavonoids, saponins, and tannins were found to be present in the extract mixture. GC-MS analyses of AP and SP showed the presence of 19 and 12 peaks, respectively. Methyl ester of 9-octadecenoic and eicosanoic acid were determined as the main constituents of both species. Moreover, the results of clinical study suggested that the extract mixture improved the decrease of fasting blood glucose and postprandial glucose, significantly lowered body mass index compared with the control group. The EM appeared beneficial for SGPT values and uric acid levels. Conclusion: Overall, the results of this study suggested the potential beneficial effects of the extract mixture for use as complementary medicine alongside conventional treatment of metformin. The extract mixture contained many highly potent compounds for treating T2DM and preventing short- and long-term risk complications of diabetes.
MeSH term(s)	Adult ; Andrographis/chemistry ; Blood Glucose/drug effects ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Double-Blind Method ; Female ; Humans ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Male ; Medicine, Traditional ; Metformin/therapeutic use ; Middle Aged ; Phytochemicals/analysis ; Phytochemicals/therapeutic use ; Plant Extracts/analysis ; Plant Extracts/pharmacology ; Plant Leaves/chemistry ; Syzygium/chemistry
Chemical Substances	Blood Glucose ; Hypoglycemic Agents ; Phytochemicals ; Plant Extracts ; Metformin (9100L32L2N)
Language	English
Publishing date	2018-07-21
Publishing country	Germany
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2018.07.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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