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Article ; Online: Quality of life in mothers of children with psoriasis.

Elgamal, EmadEldin Abd Elmoneim / Aboelwafa, Hany Othman / Ibrahim, Ayman Ahmed Mahmoud / Elshafey, Mai Esam Mohamed

2023 Volume 22, Issue 9, Page(s) 2560–2564

Abstract: Background: Patients' and their mothers' quality of life is severely affected by childhood psoriasis. Almost all children have a chronic illness that lasts until adulthood, which puts them at risk for lifelong difficulties like stigma, psychiatric ... ...

Abstract	Background: Patients' and their mothers' quality of life is severely affected by childhood psoriasis. Almost all children have a chronic illness that lasts until adulthood, which puts them at risk for lifelong difficulties like stigma, psychiatric comorbidity, and suicide. Objective: Evaluation of the effects of childhood psoriasis on the mothers' quality of life was the project's primary objective. Subjects and methods: 100 mothers of children with various kinds of psoriasis participated in the study. The Family Dermatology Life Quality Index (FDLQI) was used to evaluate the mothers' quality of life. Results: The mother's FDLQI score was between 3 and 25, with a mean of 13. In terms of how the FDLQI was interpreted, 8 moms had an incredibly enormous impact, 63 mothers had a very significant impact, 26 mothers had a moderate impact, and 3 mothers had a modest impact. We discovered a substantial direct link between the mother's FDLQI and the children's PASI scores. Furthermore, we discovered that scalp and pustular psoriasis had the highest FDLQI scores, indicating a poor quality of life. Conclusion: Both the quality of life for affected children and their cares may be negatively impacted by childhood psoriasis. Age of the children, PASI score, and kind of psoriasis can all have an impact on how psoriasis in childhood affects the mother.
MeSH term(s)	Female ; Humans ; Child ; Adult ; Quality of Life/psychology ; Mothers/psychology ; Surveys and Questionnaires ; Psoriasis ; Suicide ; Severity of Illness Index
Language	English
Publishing date	2023-03-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.15737
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Article: Capsaicin ameliorate pulmonary fibrosis via antioxidant Nrf-2/ PPAR- γ pathway activation and inflammatory TGF-β1/ NF-κB/COX II pathway inhibition.

Abdulaal, Wesam H / Asfour, Hani Z / Helmi, Nawal / Al Sadoun, Hadeel / Eldakhakhny, Basmah / Alhakamy, Nabil A / Alqarni, Hani Mohammed / Alzahrani, Saeed Ali Mohammed / El-Moselhy, Mohamed A / Sharkawi, Sara S / Aboubakr, Esam Mohamed

Frontiers in pharmacology

2024 Volume 15, Page(s) 1333715

Abstract: Bleomycin is an effective antibiotic with a significant anticancer properties, but its use is limited due to its potential to induce dose-dependent pulmonary fibrosis. Therefore, this study aimed to assess the therapeutic potential of Capsaicin as an ... ...

Abstract	Bleomycin is an effective antibiotic with a significant anticancer properties, but its use is limited due to its potential to induce dose-dependent pulmonary fibrosis. Therefore, this study aimed to assess the therapeutic potential of Capsaicin as an additional treatment to enhance patient tolerance to Bleomycin compared to the antifibrotic drug Pirfenidone. Pulmonary fibrosis was induced in rats through by a single intratracheal Bleomycin administration in day zero, followed by either Capsaicin or Pirfenidone treatment for 7 days. After the animals were sacrificed, their lungs were dissected and examined using various stains for macroscopic and histopathological evaluation. Additionally, the study assessed various antioxidant, anti-inflammatory, and antifibrotic parameters were assessed. Rats exposed to Bleomycin exhibited visible signs of fibrosis, histopathological alterations, increased collagen deposition, and elevated mucin content. Bleomycin also led to heightened increased inflammatory cells infiltration in the bronchoalveolar lavage, elevated fibrosis biomarkers such as hydroxyproline, alpha-smooth muscle actin (α-SMA) and transforming growth factor-beta (TGF-β1), increased inflammatory markers including tumor necrosis factor-alpha (TNF-α), interlukine-6 (Il-6), interlukine-1β (Il-1β) nuclear factor-kappa B (NF-κB), and Cyclooxygenase-2 (COX-2), and transforming growth factor-beta (TGF-β1),. Furthermore, it reduced the expression of peroxisome proliferator-activated receptor-gamma (PPAR-γ), increased oxidative stress biomarkers like nitric oxide (NO), malondialdehyde (MDA), myeloperoxidase (MPO) and protein carbonyl. Bleomycin also decreased the expression of nuclear factor erythroid 2-related factor 2 (Nrf-2), reduced glutathione (GSH), total antioxidant capacity, and the activities of catalase and superoxide dismutase (SOD). Treating the animals with Capsaicin and Pirfenidone following Bleomycin exposure resulted in improved lung macroscopic and microscopic characteristics, reduced collagen deposition (collagen I and collagen III) and mucin content, decreased inflammatory cell infiltration, lowered levels of hydroxyproline, α-SMA, and TGF-β1, decreased TNF-α, Il-6, Il-1β, NF-κB, and COX-2, increased PPAR-γ and Nrf-2 expression, and improvement improved in all oxidative stress biomarkers. In summary, Capsaicin demonstrates significant antifibrotic activity against Bleomycin-induced lung injury that may be attributed, at least in part, to the antioxidant and anti-inflammatory activities of Capsaicin mediated by upregulation of PPAR-γ and Nrf-2 expression and decreasing. TGF-β1, NF-κB and COX II proteins concentrations.
Language	English
Publishing date	2024-02-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1333715
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Article: Ion-Triggered In Situ Gelling Nanoemulgel as a Platform for Nose-to-Brain Delivery of Small Lipophilic Molecules.

Nagaraja, Sreeharsha / Basavarajappa, Girish Meravanige / Karnati, Ranjith Kumar / Bakir, Esam Mohamed / Pund, Swati

Pharmaceutics

2021 Volume 13, Issue 8

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-08-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics13081216
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Article ; Online: Early-Onset Colorectal Cancer in Egypt: Pathological Characters, Patterns of Care, and Survival Compared to Average-Age Onset Colorectal Cancer: A Retrospective Multicenter Study.

Rashad, Noha / Eid Salem, Salem / Meheissen, Mohamed A M / Refaat, Ghada / Mahmoud Sami, Heba / Temerik, Abdelsalam / Kordy, Nashwa / Daniel, Mina A / El-Kaffas, Mohamed / Esam, Mohamed / El Mansy, Hazem / Elkerm, Yasser / Abdelaziz Elsaid, Amr / Attia Ismail, Abdelsalam / Saber Abdelhalim, Mohyeldin / Moustafa Ahmad, Lamiaa / Akram Mahmoud, Mai / El Desouky, Eman D

JCO global oncology

2024 Volume 10, Page(s) e2300372

Abstract: Purpose: Early-onset colorectal cancer (EOCRC) is a rising health problem. The incidence of EOCRC has increased over the past 2 decades all over the world. Reports from Egypt since the 1990s have reported a higher incidence among young populations with ... ...

Abstract	Purpose: Early-onset colorectal cancer (EOCRC) is a rising health problem. The incidence of EOCRC has increased over the past 2 decades all over the world. Reports from Egypt since the 1990s have reported a higher incidence among young populations with no identifiable risk factors. The aim of this study was to assess EOCRC in Egypt regarding incidence, characteristics, treatment pattern, and survival compared with average age onset and elderly patients. Materials and methods: This was a retrospective, record-based, cohort study combining data from four different cancer centers in Egypt. We grouped patients according to age into three categories: the EOCRC group for patients age ≤45 years and the average age onset and elderly cancer group (for patients age ≥65 years). Results: The study included 1,310 patients with histopathologically proven colorectal cancer, representing four different geographical areas in Egypt. Patients with EOCRC represented 42.4% of the study population. Female patients were 50.6% among the EOCRC group and 52.5% among the average age group. Rectal tumors were significantly higher in EOCRC (54.7% Conclusion: A comprehensive framework for the study of EOCRC is required in Egypt as well as a genomic analysis to identify possible underlying genetic alterations responsible for the high incidence of EOCRC.
MeSH term(s)	Aged ; Humans ; Female ; Middle Aged ; Cohort Studies ; Egypt/epidemiology ; Retrospective Studies ; Disease-Free Survival ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/therapy
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ISSN	2687-8941
ISSN (online)	2687-8941
DOI	10.1200/GO.23.00372
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Article ; Online: Relation between Soluble CD14 Levels, Inflammation, Subclinical Atherosclerosis and Mortality in Hemodialysis Patients.

Abdallah, Amany Mohamed / Elhakeem, Heba / Yahia, Mohamed Basiouny / Youssef, Eman Mohy Ibrahim / El-Khouly, Nashwa / Elmohaseb, Ghada Fathy / Awad, Eman Abu-Elnasr / Hassan, Marwa Mohamed / Ghamry, Esam Mohamed / Abdelhamed, Mohamed Rashed / Kotb, Essam / Mahmoud, Tamer Mohamed

Endocrine, metabolic & immune disorders drug targets

2022 Volume 23, Issue 6, Page(s) 843–849

Abstract: Background and aim: Chronic kidney disease (CKD) is characterized by persistent lowgrade inflammation. Soluble CD14 (sCD14) is involved in many pathological conditions, including inflammation and atherosclerosis. The present study aimed to assess the ... ...

Abstract	Background and aim: Chronic kidney disease (CKD) is characterized by persistent lowgrade inflammation. Soluble CD14 (sCD14) is involved in many pathological conditions, including inflammation and atherosclerosis. The present study aimed to assess the relationship between sCD14 levels, subclinical atherosclerosis (SCA), inflammation and mortality in Egyptian hemodialysis (HD) patients. Patients and methods: The present longitudinal study included 62 HD patients. All patients were submitted to careful history taking, thorough clinical examination and laboratory assessment for high-sensitivity C-reactive protein (hsCRP) and sCD14. Carotid intima-media thickness (CIMT) was also assessed. Patients were followed for a maximum of 18 months. The primary outcome is patients' mortality. Data were statistically analyzed using standard descriptive, comparative, correlative and regression methods. Results: The present study was conducted on 62 HD patients. They comprised 34 males and 28 females with an age of 54.6 ± 9.0 years. At the end of follow-up, 12 patients (19.4 %) died. It was shown that survivors had significantly lower hsCRP levels (104.2 ± 38.2 versus 134.1 ± 15.3 mg/dL, p < 0.001), lower sCD14 levels (32.7 ± 10.3 versus 47.4 ± 18.4 μg/mL, p = 0.02) and lower CIMT (1.32 ± 0.5 versus 1.5 ± 0.2 mm, p = 0.049). sCD14 levels were significantly correlated with hsCRP (r = 0.4, p = 0.001) and CIMT (r = 0.31, p = 0.013). Multivariate analysis identified HD duration [HR (95% CI): 1.02 (1.0-1.04), p = 0.021] and sCD14 levels [HR (95% CI): 1.06 (1.0-1.12), p = 0.026] as significant predictors of patients' survival. Conclusions: sCD14 levels in this cohort of HD patients are well-correlated with hsCRP levels and CIMT. In addition, they are significant predictors of patients' mortality.
MeSH term(s)	Male ; Female ; Humans ; Middle Aged ; Lipopolysaccharide Receptors ; C-Reactive Protein/metabolism ; Longitudinal Studies ; Carotid Intima-Media Thickness ; Biomarkers ; Inflammation ; Renal Dialysis/adverse effects ; Atherosclerosis/diagnosis
Chemical Substances	Lipopolysaccharide Receptors ; C-Reactive Protein (9007-41-4) ; Biomarkers
Language	English
Publishing date	2022-10-11
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2228325-0
ISSN	2212-3873 ; 1871-5303
ISSN (online)	2212-3873
ISSN	1871-5303
DOI	10.2174/1871530322666221011091606
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Article ; Online: The suggested system for health insurance Application based on Smart Cards

Esam Mohamed El Gohary / Mohamed El-Sayed Waheed

International Journal of Computer Science Issues, Vol 10, Iss 1, Pp 729-

2013 Volume 748

Abstract: This paper concentrates on designing a system for Health insurance using smart card technology .The system is called HISS (Health insurance system using smart card).As we will see the system is web based application based on central database ,uses smart ... ...

Abstract	This paper concentrates on designing a system for Health insurance using smart card technology .The system is called HISS (Health insurance system using smart card).As we will see the system is web based application based on central database ,uses smart card for two reasons first, as a data carrier for patient and professionals. Second reason is for authentication purposes. There are some figures that describe system architecture and processes then each component well be explained.
Keywords	smart cards ; e-government ; Health insuranc ; IJCSI ; Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q ; DOAJ:Computer Science ; DOAJ:Technology and Engineering
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	IJCSI Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Salvadora persica protects mouse intestine from eimeriosis.

Al-Quraishy, Saleh / Thagfan, Felwa Abdullah / Al-Shaebi, Esam Mohamed / Qasem, Mahmood / Abdel-Gaber, Rewaida / Dkhil, Mohamed Abdel Monam

Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria

2019 Volume 28, Issue 4, Page(s) 605–612

Abstract: Eimeriosis is a global poultry health problem. In the current study, we investigated the role of Salvadora persica leaf extracts (SE) against murine eimeriosis induced by Eimeria papillata. The infection induced an oocyst output of 6242 ± 731 oocysts/g ... ...

Abstract	Eimeriosis is a global poultry health problem. In the current study, we investigated the role of Salvadora persica leaf extracts (SE) against murine eimeriosis induced by Eimeria papillata. The infection induced an oocyst output of 6242 ± 731 oocysts/g feces. After treatment with 300 mg⁄kg SE, the oocysts expelled in feces decreased by approximately 3-fold. In addition, the total number of E. papillata in the parasitic stage decreased in the jejunum of mice after treatment with SE. In addition, SE significantly reduced the number of apoptotic cells by approximately 2-fold in the infected jejunum. SE ameliorated the changes in glutathione, malondialdehyde, and catalase due to E. papillata infection. Finally, SE regulated the cytokine genes, interleukin (IL)-1β, IL-6, interferon-γ, and tumor necrosis factor-α, and the apoptotic genes, B-cell lymphoma-2, Bax, and Caspase-3. SE protects the jejunum from E. papillata induced injury and may have potential therapeutic value as a food additive during eimeriosis.
MeSH term(s)	Animals ; Antiprotozoal Agents/isolation & purification ; Antiprotozoal Agents/pharmacology ; Coccidiosis/parasitology ; Disease Models, Animal ; Eimeria/drug effects ; Feces/parasitology ; Male ; Mice ; Mice, Inbred C57BL ; Parasite Egg Count ; Plant Extracts/pharmacology ; Salvadoraceae/chemistry
Chemical Substances	Antiprotozoal Agents ; Plant Extracts
Language	English
Publishing date	2019-11-13
Publishing country	Brazil
Document type	Journal Article
ISSN	1984-2961
ISSN (online)	1984-2961
DOI	10.1590/S1984-29612019068
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Article ; Online: Screening the bio-safety of wheat produced from pretreated grains to enhance tolerance against drought using physiological and spectroscopic methods.

Abdelkader, Amal Fadl / Hassanein, Raifa Ahmed / Abo-Aly, Mohamed Mahmoud / Attia, Mohamed Said / Bakir, Esam Mohamed

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2010 Volume 48, Issue 7, Page(s) 1827–1835

Abstract: Drought is a serious abiotic stress, causes worldwide intensive reduction in crop growth and productivity. Plants in contrast to other organisms, do not enjoy the luxury of being able to change their environment or seeking shelters. In this investigation, ...

Abstract	Drought is a serious abiotic stress, causes worldwide intensive reduction in crop growth and productivity. Plants in contrast to other organisms, do not enjoy the luxury of being able to change their environment or seeking shelters. In this investigation, wheat grains were pre-soaked for 12h in salicylic acid (SA) and/or thiourea (ThU) prior they were left to grow in dry land (40% field water capacity) until harvest. The bio-safety of the harvested wheat was deduced using technical physiological and spectral methods. The pretreatment using SA up to ( approximately 1.5mmol) viewed homologous protein profile and less flag leaf proline in comparison to the non-stressed wheat. In addition, SA-pretreatment has maintained 70% of the emission intensity of yielded grain. The spectra of FTIR were more or less similar in yielded grain and flag leaf in SA-pretreatment. On the other hand, ThU pretreatment induced varied protein profile, higher proline than normal, reduced the fluorescence emission intensity by 52%, and induced varied FTIR spectra. Pretreatment of SA not only has enhanced wheat productivity but also increased yield and straw productions even above the non-treated-non-stressed wheat plant. In contrast to ThU SA was considered safe for drought-stress alleviation in crop plant agriculture.
MeSH term(s)	Droughts ; Electrophoresis, Polyacrylamide Gel ; Germination/drug effects ; Germination/physiology ; Indicators and Reagents ; Pigments, Biological/analysis ; Plant Leaves/chemistry ; Plant Proteins/chemistry ; Proline/chemistry ; Salicylic Acid/chemistry ; Seeds/chemistry ; Seeds/toxicity ; Spectrometry, Fluorescence ; Spectrophotometry, Ultraviolet ; Spectroscopy, Fourier Transform Infrared ; Thiourea/chemistry ; Triticum/chemistry ; Triticum/growth & development ; Triticum/toxicity
Chemical Substances	Indicators and Reagents ; Pigments, Biological ; Plant Proteins ; Proline (9DLQ4CIU6V) ; Thiourea (GYV9AM2QAG) ; Salicylic Acid (O414PZ4LPZ)
Language	English
Publishing date	2010-07
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2010.04.015
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Article: Screening the bio-safety of wheat produced from pretreated grains to enhance tolerance against drought using physiological and spectroscopic methods

Abdelkader, Amal Fadl / Hassanein, Raifa Ahmed / Abo-Aly, Mohamed Mahmoud / Attia, Mohamed Said / Bakir, Esam Mohamed

Food and chemical toxicology. 2010 July, v. 48, no. 7

2010

Abstract	Drought is a serious abiotic stress, causes worldwide intensive reduction in crop growth and productivity. Plants in contrast to other organisms, do not enjoy the luxury of being able to change their environment or seeking shelters. In this investigation, wheat grains were pre-soaked for 12 h in salicylic acid (SA) and/or thiourea (ThU) prior they were left to grow in dry land (40% field water capacity) until harvest. The bio-safety of the harvested wheat was deduced using technical physiological and spectral methods. The pretreatment using SA up to (∼1.5 mmol) viewed homologous protein profile and less flag leaf proline in comparison to the non-stressed wheat. In addition, SA-pretreatment has maintained 70% of the emission intensity of yielded grain. The spectra of FTIR were more or less similar in yielded grain and flag leaf in SA-pretreatment. On the other hand, ThU pretreatment induced varied protein profile, higher proline than normal, reduced the fluorescence emission intensity by 52%, and induced varied FTIR spectra. Pretreatment of SA not only has enhanced wheat productivity but also increased yield and straw productions even above the non-treated-non-stressed wheat plant. In contrast to ThU SA was considered safe for drought-stress alleviation in crop plant agriculture.
Keywords	Fourier transform infrared spectroscopy ; abiotic stress ; arid lands ; crops ; drought ; emissions factor ; fluorescence ; leaves ; proline ; salicylic acid ; screening ; straw ; thiourea ; toxicology ; wheat
Language	English
Size	p. 1827-1835.
Document type	Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2010.04.015
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: [Sexual concepts and behaviors affecting AIDS prevalence in Southern Sudan]

Ahmed, Ebtisam Mahmoud / Ibrahim, Somaya Hasan / Magzoub, Mohyeddine / El Khidir, Esam Mohamed

1998

Abstract: ... 370- ... ...

Abstract	370-375
Keywords	Acquired Immunodeficiency Syndrome ; Prevalence ; Questionnaires ; Socioeconomic Factors ; Health Education ; Sexual Behavior
Language	Arabic
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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