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  1. Article ; Online: Vibrio fischeri

    Fung, Brittany L / Esin, Jeremy J / Visick, Karen L

    Journal of bacteriology

    2024  Volume 206, Issue 2, Page(s) e0037023

    Abstract: Multicellular communities of adherent bacteria known as biofilms are often detrimental in the context of a human host, making it important to study their formation and dispersal, especially in animal models. One such model is the symbiosis between the ... ...

    Abstract Multicellular communities of adherent bacteria known as biofilms are often detrimental in the context of a human host, making it important to study their formation and dispersal, especially in animal models. One such model is the symbiosis between the squid
    MeSH term(s) Animals ; Humans ; Aliivibrio fischeri/metabolism ; Biofilms ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Adhesins, Bacterial ; Decapodiformes/microbiology ; Symbiosis ; Polysaccharides
    Chemical Substances Bacterial Proteins ; Adhesins, Bacterial ; Polysaccharides
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/jb.00370-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Corrected and republished from: "

    Fidopiastis, Pat M / Childs, Chaz / Esin, Jeremy J / Stellern, Jordan / Darin, Anna / Lorenzo, Andrea / Mariscal, Vanessa T / Lorenz, Jason / Gopan, Vinay / McAnulty, Sarah / Visick, Karen L

    Applied and environmental microbiology

    2024  , Page(s) e0032824

    Abstract: ... Cells ... ...

    Abstract Cells of
    Language English
    Publishing date 2024-05-07
    Publishing country United States
    Document type Journal Article ; Corrected and Republished Article
    ZDB-ID 223011-2
    ISSN 1098-5336 ; 0099-2240
    ISSN (online) 1098-5336
    ISSN 0099-2240
    DOI 10.1128/aem.00328-24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Correction for Fidopiastis et al., "

    Fidopiastis, Pat M / Childs, Chaz / Esin, Jeremy J / Stellern, Jordan / Darin, Anna / Lorenzo, Andrea / Mariscal, Vanessa T / Lorenz, Jason / Gopan, Vinay / McAnulty, Sarah / Visick, Karen L

    Applied and environmental microbiology

    2024  , Page(s) e0032724

    Language English
    Publishing date 2024-05-07
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 223011-2
    ISSN 1098-5336 ; 0099-2240
    ISSN (online) 1098-5336
    ISSN 0099-2240
    DOI 10.1128/aem.00327-24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Polyamine Depletion Abrogates Enterovirus Cellular Attachment.

    Kicmal, Thomas M / Tate, Patrick M / Dial, Courtney N / Esin, Jeremy J / Mounce, Bryan C

    Journal of virology

    2019  Volume 93, Issue 20

    Abstract: Polyamines are small polycationic molecules with flexible carbon chains that are found in all eukaryotic cells. Polyamines are involved in the regulation of many host processes and have been shown to be implicated in viral replication. Depletion of ... ...

    Abstract Polyamines are small polycationic molecules with flexible carbon chains that are found in all eukaryotic cells. Polyamines are involved in the regulation of many host processes and have been shown to be implicated in viral replication. Depletion of polyamine pools in cells treated with FDA-approved drugs restricts replication of diverse RNA viruses. Viruses can exploit host polyamines to facilitate nucleic acid packaging, transcription, and translation, but other mechanisms remain largely unknown. Picornaviruses, including Coxsackievirus B3 (CVB3), are sensitive to the depletion of polyamines and remain a significant public health threat. We employed CVB3 as a model system to investigate a potential proviral role for polyamines using a forward screen. Passaging CVB3 in polyamine-depleted cells generated a mutation in capsid protein VP3 at residue 234. We show that this mutation confers resistance to polyamine depletion. Through attachment assays, we demonstrate that polyamine depletion limits CVB3 attachment to susceptible cells, which is rescued by incubating virus with polyamines. Furthermore, the capsid mutant rescues this inhibition in polyamine-depleted cells. More divergent viruses also exhibited reduced attachment to polyamine-depleted cells, suggesting that polyamines may facilitate attachment of diverse RNA viruses. These studies inform additional mechanisms of action for polyamine-depleting pharmaceuticals, with implications for potential antiviral therapies.
    MeSH term(s) Animals ; Capsid Proteins/genetics ; Capsid Proteins/metabolism ; Chlorocebus aethiops ; Enterovirus/physiology ; Enterovirus Infections/metabolism ; Enterovirus Infections/virology ; Humans ; Mutation ; Polyamines/metabolism ; Vero Cells ; Virus Attachment ; Virus Replication
    Chemical Substances Capsid Proteins ; Polyamines
    Language English
    Publishing date 2019-09-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.01054-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Vibrio fischeri Possesses Xds and Dns Nucleases That Differentially Influence Phosphate Scavenging, Aggregation, Competence, and Symbiotic Colonization of Squid.

    Fidopiastis, Pat M / Childs, Chaz / Esin, Jeremy J / Stellern, Jordan / Darin, Anna / Lorenzo, Andrea / Mariscal, Vanessa T / Lorenz, Jason / Gopan, Vinay / McAnulty, Sarah / Visick, Karen L

    Applied and environmental microbiology

    2022  Volume 88, Issue 22, Page(s) e0163522

    Abstract: Cells of Vibrio fischeri colonize the light organ of Euprymna scolopes, providing the squid bioluminescence in exchange for nutrients and protection. The bacteria encounter DNA-rich mucus throughout their transition to a symbiotic lifestyle, leading us ... ...

    Abstract Cells of Vibrio fischeri colonize the light organ of Euprymna scolopes, providing the squid bioluminescence in exchange for nutrients and protection. The bacteria encounter DNA-rich mucus throughout their transition to a symbiotic lifestyle, leading us to hypothesize a role for nuclease activity in the colonization process. In support of this, we detected abundant extracellular nuclease activity in growing cells of V. fischeri. To discover the gene(s) responsible for this activity, we screened a V. fischeri transposon mutant library for nuclease-deficient strains. Interestingly, only one strain, whose transposon insertion mapped to nuclease gene
    MeSH term(s) Animals ; Aliivibrio fischeri/genetics ; Decapodiformes/microbiology ; Symbiosis ; Phosphates ; Biofilms
    Chemical Substances Phosphates
    Language English
    Publishing date 2022-11-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 223011-2
    ISSN 1098-5336 ; 0099-2240
    ISSN (online) 1098-5336
    ISSN 0099-2240
    DOI 10.1128/aem.01635-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Virion-Associated Polyamines Transmit with Bunyaviruses to Maintain Infectivity and Promote Entry.

    Mastrodomenico, Vincent / Esin, Jeremy J / Qazi, Shefah / Khomutov, Maxim A / Ivanov, Alexander V / Mukhopadhyay, Suchetana / Mounce, Bryan C

    ACS infectious diseases

    2020  Volume 6, Issue 9, Page(s) 2490–2501

    Abstract: Viruses require host cell metabolites to productively infect, and the mechanisms by which viruses usurp these molecules are diverse. One group of cellular metabolites important in virus infection is the polyamines, small positively charged molecules ... ...

    Abstract Viruses require host cell metabolites to productively infect, and the mechanisms by which viruses usurp these molecules are diverse. One group of cellular metabolites important in virus infection is the polyamines, small positively charged molecules involved in cell cycle, translation, and nucleic acid metabolism, among other cellular functions. Polyamines support replication of diverse viruses, and they are important for processes such as transcription, translation, and viral protein enzymatic activity. Rift Valley fever virus (RVFV) is a negative and ambisense RNA virus that requires polyamines to produce infectious particles. In polyamine depleted conditions, noninfectious particles are produced that interfere with virus replication and stimulate immune signaling. Here, we find that RVFV relies on virion-associated polyamines to maintain infectivity and enhance viral entry. We show that RVFV replication is facilitated by a limited set of polyamines and that spermidine and closely related molecules associate with purified virions and transmit from cell to cell during infection. Virion-associated spermidine maintains virion infectivity, as virions devoid of polyamines rapidly lose infectivity and are temperature sensitive. Further, virions without polyamines bind to cells but exhibit a defect in entry, requiring more acidic conditions than virions containing spermidine. These data highlight a unique role for polyamines, and spermidine particularly, to maintain virus infectivity. Further, these studies are the first to identify polyamines associated with RVFV virions. Targeting polyamines represents a promising antiviral strategy, and this work highlights a new mechanism by which we can inhibit virus replication through FDA-approved polyamine depleting pharmaceuticals.
    MeSH term(s) Animals ; Polyamines ; Rift Valley fever virus ; Viral Proteins ; Virion ; Virus Replication
    Chemical Substances Polyamines ; Viral Proteins
    Language English
    Publishing date 2020-08-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.0c00402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Polyamine Depletion Inhibits Bunyavirus Infection via Generation of Noninfectious Interfering Virions.

    Mastrodomenico, Vincent / Esin, Jeremy J / Graham, Marion L / Tate, Patrick M / Hawkins, Grant M / Sandler, Zachary J / Rademacher, David J / Kicmal, Thomas M / Dial, Courtney N / Mounce, Bryan C

    Journal of virology

    2019  Volume 93, Issue 14

    Abstract: Several host and viral processes contribute to forming infectious virions. Polyamines are small host molecules that play diverse roles in viral replication. We previously demonstrated that polyamines are crucial for RNA viruses; however, the mechanisms ... ...

    Abstract Several host and viral processes contribute to forming infectious virions. Polyamines are small host molecules that play diverse roles in viral replication. We previously demonstrated that polyamines are crucial for RNA viruses; however, the mechanisms by which polyamines function remain unknown. Here, we investigated the role of polyamines in the replication of the bunyaviruses Rift Valley fever virus (vaccine strain MP-12) and La Crosse virus (LACV). We found that polyamine depletion did not impact viral RNA or protein accumulation, despite significant decreases in titer. Viral particles demonstrated no change in morphology, size, or density. Thus, polyamine depletion promotes the formation of noninfectious particles. These particles interfere with virus replication and stimulate innate immune responses. We extended this phenotype to Zika virus; however, coxsackievirus did not similarly produce noninfectious particles. In sum, polyamine depletion results in the accumulation of noninfectious particles that interfere with replication and stimulate immune signaling, with important implications for targeting polyamines therapeutically, as well as for vaccine strategies.
    MeSH term(s) Biogenic Polyamines/immunology ; Bunyaviridae Infections/genetics ; Bunyaviridae Infections/immunology ; Bunyaviridae Infections/pathology ; Cell Line, Tumor ; Defective Viruses/physiology ; Encephalitis Virus, California/physiology ; Humans ; Rift Valley fever virus/physiology ; Virion/physiology ; Virus Replication/immunology
    Chemical Substances Biogenic Polyamines
    Language English
    Publishing date 2019-06-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.00530-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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