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  1. Article ; Online: Snabbtest för covid-19-antikroppar bör utföras av utbildad personal.

    Stackelberg, Otto / Esmaeilzadeh, Mouna / Olsen, Björn / Lundkvist, Åke

    Lakartidningen

    2020  Volume 117

    Abstract: Increasing evidence indicates immunity against severe acute respiratory syndrome coronavirus 2 (sars-cov-2) after covid-19, but it remains unclear for how long the protection remains. Serology testing seems to have a higher sensitivity than molecular ... ...

    Title translation Rapid point-of-care serology testing for sars-cov-2.
    Abstract Increasing evidence indicates immunity against severe acute respiratory syndrome coronavirus 2 (sars-cov-2) after covid-19, but it remains unclear for how long the protection remains. Serology testing seems to have a higher sensitivity than molecular diagnostics from 8 days after onset of symtoms, and should be part of risk assessment and epidemiological studies of COVID-19. The performance of commercial serological point-of-care (POC) lateral flow tests are highly manufacturer-dependant. Low sensitivity increases the risk of false negative results and could result in unnecessary quarantine of test persons with developed antibodies. Low specificity increases the risk of false positive results and could lead to false assumptions of immunity. Carefully selected serological POC tests for sars-cov-2 can be used in large scale testing but should only be used by licensed medical staff able to understand their limitations and interpret the results.
    MeSH term(s) Betacoronavirus/immunology ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/standards ; Coronavirus Infections/diagnosis ; Coronavirus Infections/immunology ; Epidemiologic Studies ; Humans ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/immunology ; Point-of-Care Systems/standards ; SARS-CoV-2 ; Sensitivity and Specificity ; Time
    Keywords covid19
    Language Swedish
    Publishing date 2020-05-27
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 391010-6
    ISSN 1652-7518 ; 0023-7205
    ISSN (online) 1652-7518
    ISSN 0023-7205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Rapid point-of-care serology testing for sars-cov-2 TT - Snabbtest for covid-19-antikroppar bor utforas av utbildad personal

    Stackelberg, Otto / Esmaeilzadeh, Mouna / Olsen, Bjorn / Lundkvist, Ake

    Lakartidningen

    Abstract: Increasing evidence indicates immunity against severe acute respiratory syndrome coronavirus 2 (sars-cov-2) after covid-19, but it remains unclear for how long the protection remains Serology testing seems to have a higher sensitivity than molecular ... ...

    Abstract Increasing evidence indicates immunity against severe acute respiratory syndrome coronavirus 2 (sars-cov-2) after covid-19, but it remains unclear for how long the protection remains Serology testing seems to have a higher sensitivity than molecular diagnostics from 8 days after onset of symtoms, and should be part of risk assessment and epidemiological studies of COVID-19 The performance of commercial serological point-of-care (POC) lateral flow tests are highly manufacturer-dependant Low sensitivity increases the risk of false negative results and could result in unnecessary quarantine of test persons with developed antibodies Low specificity increases the risk of false positive results and could lead to false assumptions of immunity Carefully selected serological POC tests for sars-cov-2 can be used in large scale testing but should only be used by licensed medical staff able to understand their limitations and interpret the results
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #436775
    Database COVID19

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  3. Article: Rapid point-of-care serology testing for sars-cov-2/ Snabbtest for covid-19-antikroppar bor utforas av utbildad personal

    Stackelberg, Otto / Esmaeilzadeh, Mouna / Olsen, Bjorn / Lundkvist, Ake

    Lakartidningen

    Abstract: Increasing evidence indicates immunity against severe acute respiratory syndrome coronavirus 2 (sars-cov-2) after covid-19, but it remains unclear for how long the protection remains Serology testing seems to have a higher sensitivity than molecular ... ...

    Abstract Increasing evidence indicates immunity against severe acute respiratory syndrome coronavirus 2 (sars-cov-2) after covid-19, but it remains unclear for how long the protection remains Serology testing seems to have a higher sensitivity than molecular diagnostics from 8 days after onset of symtoms, and should be part of risk assessment and epidemiological studies of COVID-19 The performance of commercial serological point-of-care (POC) lateral flow tests are highly manufacturer-dependant Low sensitivity increases the risk of false negative results and could result in unnecessary quarantine of test persons with developed antibodies Low specificity increases the risk of false positive results and could lead to false assumptions of immunity Carefully selected serological POC tests for sars-cov-2 can be used in large scale testing but should only be used by licensed medical staff able to understand their limitations and interpret the results
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #436775
    Database COVID19

    Kategorien

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  4. Article: Snabbtest för covid-19-antikroppar bör utföras av utbildad personal./ [Rapid point-of-care serology testing for sars-cov-2]

    Stackelberg, Otto / Esmaeilzadeh, Mouna / Olsen, Björn / Lundkvist, Åke

    Lakartidningen

    Abstract: Increasing evidence indicates immunity against severe acute respiratory syndrome coronavirus 2 (sars-cov-2) after covid-19, but it remains unclear for how long the protection remains. Serology testing seems to have a higher sensitivity than molecular ... ...

    Abstract Increasing evidence indicates immunity against severe acute respiratory syndrome coronavirus 2 (sars-cov-2) after covid-19, but it remains unclear for how long the protection remains. Serology testing seems to have a higher sensitivity than molecular diagnostics from 8 days after onset of symtoms, and should be part of risk assessment and epidemiological studies of COVID-19. The performance of commercial serological point-of-care (POC) lateral flow tests are highly manufacturer-dependant. Low sensitivity increases the risk of false negative results and could result in unnecessary quarantine of test persons with developed antibodies. Low specificity increases the risk of false positive results and could lead to false assumptions of immunity. Carefully selected serological POC tests for sars-cov-2 can be used in large scale testing but should only be used by licensed medical staff able to understand their limitations and interpret the results.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #432276
    Database COVID19

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  5. Article: High seroprevalence of SARS-CoV-2 in elderly care employees in Sweden.

    Lindahl, Johanna F / Hoffman, Tove / Esmaeilzadeh, Mouna / Olsen, Björn / Winter, Reidar / Amer, Stefan / Molnár, Christian / Svalberg, Ann / Lundkvist, Åke

    Infection ecology & epidemiology

    2020  Volume 10, Issue 1, Page(s) 1789036

    Abstract: The COVID-19 pandemic is growing and spread in the Swedish elderly care system during April 2020. The increasing number of employees on sick-leave due to COVID-19 created severe logistic problems. Some elderly care homes therefore started to screen their ...

    Abstract The COVID-19 pandemic is growing and spread in the Swedish elderly care system during April 2020. The increasing number of employees on sick-leave due to COVID-19 created severe logistic problems. Some elderly care homes therefore started to screen their personnel to secure the safety of the elderly and to avoid unnecessary quarantine of potentially immune employees. Secondary data from a screening with a COVID-19 rapid test for detection of SARS-CoV-2-specific IgM and IgG of 1,005 employees in 22 elderly care homes in Stockholm, Sweden, were analyzed. Seropositive employees were found in 21 out of the 22 care homes. In total, 23% (231/1,005) of the employees tested positive for antibodies against SARS-CoV-2, and 14.3% (144/1,005) were found positive for IgM (either alone or combined with IgG), indicating recent or present infection. Of those that tested seropositive, 46.5% did not report any clinical symptoms, indicating pre- or asymptomatic infections. Reported symptoms with the highest correlation with seropositivity were fever and loss of smell and taste. These results suggest that antibody testing of employees in elderly care homes is valuable for surveillance of disease development and a crucial screening tool in the effort to decrease the death toll in this pandemic.
    Keywords covid19
    Language English
    Publishing date 2020-08-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2627673-2
    ISSN 2000-8686
    ISSN 2000-8686
    DOI 10.1080/20008686.2020.1789036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Evaluation of a COVID-19 IgM and IgG rapid test; an efficient tool for assessment of past exposure to SARS-CoV-2.

    Hoffman, Tove / Nissen, Karolina / Krambrich, Janina / Rönnberg, Bengt / Akaberi, Dario / Esmaeilzadeh, Mouna / Salaneck, Erik / Lindahl, Johanna / Lundkvist, Åke

    Infection ecology & epidemiology

    2020  Volume 10, Issue 1, Page(s) 1754538

    Abstract: COVID-19 is the most rapidly growing pandemic in modern time, and the need for serological testing is most urgent. Although the diagnostics of acute patients by RT-PCR is both efficient and specific, we are also crucially in need of serological tools for ...

    Abstract COVID-19 is the most rapidly growing pandemic in modern time, and the need for serological testing is most urgent. Although the diagnostics of acute patients by RT-PCR is both efficient and specific, we are also crucially in need of serological tools for investigating antibody responses and assessing individual and potential herd immunity. We evaluated a commercially available test developed for rapid (within 15 minutes) detection of SARS-CoV-2-specific IgM and IgG by 29 PCR-confirmed COVID-19 cases and 124 negative controls. The results revealed a sensitivity of 69% and 93.1% for IgM and IgG, respectively, based solely on PCR-positivity due to the absence of a serological gold standard. The assay specificities were shown to be 100% for IgM and 99.2% for IgG. This indicates that the test is suitable for assessing previous virus exposure, although negative results may be unreliable during the first weeks after infection. More detailed studies on antibody responses during and post infection are urgently needed.
    Keywords covid19
    Language English
    Publishing date 2020-04-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2627673-2
    ISSN 2000-8686
    ISSN 2000-8686
    DOI 10.1080/20008686.2020.1754538
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Caudate glucose hypometabolism in a subject carrying an unstable allele of intermediate CAG(33) repeat length in the Huntington's disease gene.

    Squitieri, Ferdinando / Esmaeilzadeh, Mouna / Ciarmiello, Andrea / Jankovic, Joseph

    Movement disorders : official journal of the Movement Disorder Society

    2011  Volume 26, Issue 5, Page(s) 925–927

    MeSH term(s) Aged ; Caudate Nucleus/diagnostic imaging ; Caudate Nucleus/metabolism ; Fluorodeoxyglucose F18 ; Glucose/metabolism ; Humans ; Huntingtin Protein ; Huntington Disease/diagnostic imaging ; Huntington Disease/genetics ; Huntington Disease/pathology ; Male ; Nerve Tissue Proteins/genetics ; Nuclear Proteins/genetics ; Positron-Emission Tomography/methods ; Trinucleotide Repeats/genetics
    Chemical Substances HTT protein, human ; Huntingtin Protein ; Nerve Tissue Proteins ; Nuclear Proteins ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2011-04
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.23623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2555: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 238: Show issues

    Order via subito

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  8. Article: Evaluation of a COVID-19 IgM and IgG rapid test; an efficient tool for assessment of past exposure to SARS-CoV-2

    Hoffman, Tove / Nissen, Karolina / Krambrich, Janina / Rönnberg, Bengt / Akaberi, Dario / Esmaeilzadeh, Mouna / Salaneck, Erik / Lindahl, Johanna / Lundkvist, Åke

    Infect. Ecol. Epidemiol.

    Abstract: COVID-19 is the most rapidly growing pandemic in modern time, and the need for serological testing is most urgent. Although the diagnostics of acute patients by RT-PCR is both efficient and specific, we are also crucially in need of serological tools for ...

    Abstract COVID-19 is the most rapidly growing pandemic in modern time, and the need for serological testing is most urgent. Although the diagnostics of acute patients by RT-PCR is both efficient and specific, we are also crucially in need of serological tools for investigating antibody responses and assessing individual and potential herd immunity. We evaluated a commercially available test developed for rapid (within 15 minutes) detection of SARS-CoV-2-specific IgM and IgG by 29 PCR-confirmed COVID-19 cases and 124 negative controls. The results revealed a sensitivity of 69% and 93.1% for IgM and IgG, respectively, based solely on PCR-positivity due to the absence of a serological gold standard. The assay specificities were shown to be 100% for IgM and 99.2% for IgG. This indicates that the test is suitable for assessing previous virus exposure, although negative results may be unreliable during the first weeks after infection. More detailed studies on antibody responses during and post infection are urgently needed.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #142390
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article: High seroprevalence of SARS-CoV-2 in elderly care employees in Sweden

    Lindahl, Johanna F. / Hoffman, Tove / Esmaeilzadeh, Mouna / Olsen, Björn / Winter, Reidar / Amer, Stefan / Molnár, Christian / Svalberg, Ann / Lundkvist, Åke

    Infect. Ecol. Epidemiol.

    Abstract: The COVID-19 pandemic is growing and spread in the Swedish elderly care system during April 2020. The increasing number of employees on sick-leave due to COVID-19 creates severe logistic problems. Some elderly care homes therefore started to screen their ...

    Abstract The COVID-19 pandemic is growing and spread in the Swedish elderly care system during April 2020. The increasing number of employees on sick-leave due to COVID-19 creates severe logistic problems. Some elderly care homes therefore started to screen their personnel to secure the safety of the elderly and to avoid unnecessary quarantine of potentially immune employees. Secondary data from a screening with a COVID-19 rapid test for detection of SARS-CoV-2-specific IgM and IgG of 1,500 employees in 22 elderly care homes in Stockholm, Sweden, were analyzed. Seropositive employees were found in 21 out of the 22 care homes. In total, 23% (231/1,005) of the employees tested positive for antibodies against SARS-CoV-2, and 14.3% (144/1,005) were found positive for IgM (either alone or combined with IgG), indicating recent or present infection. Of those that tested seropositive, 46.5% did not report any clinical symptoms, indicating pre- or asymptomatic infections. Reported symptoms with the highest correlation with seropositivity were fever and loss of smell and taste. These results suggest that antibody testing of employees in elderly care homes is valuable for surveillance of disease development and a crucial screening tool in the effort to decrease the death toll in this pandemic.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #706068
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Evaluation of a COVID-19 IgM and IgG rapid test; an efficient tool for assessment of past exposure to SARS-CoV-2

    Hoffman, Tove / Nissen, Karolina / Krambrich, Janina / Ronnberg, Bengt / Akaberi, Dario / Esmaeilzadeh, Mouna / Salaneck, Erik / Lindahl, Johanna / Lundkvist, Ake

    Infection ecology & epidemiology, 10:1

    2020  

    Abstract: COVID-19 is the most rapidly growing pandemic in modern time, and the need for serological testing is most urgent. Although the diagnostics of acute patients by RT-PCR is both efficient and specific, we are also crucially in need of serological tools for ...

    Abstract COVID-19 is the most rapidly growing pandemic in modern time, and the need for serological testing is most urgent. Although the diagnostics of acute patients by RT-PCR is both efficient and specific, we are also crucially in need of serological tools for investigating antibody responses and assessing individual and potential herd immunity. We evaluated a commercially available test developed for rapid (within 15 minutes) detection of SARS-CoV-2-specific IgM and IgG by 29 PCR-confirmed COVID-19 cases and 124 negative controls. The results revealed a sensitivity of 69% and 93.1% for IgM and IgG, respectively, based solely on PCR-positivity due to the absence of a serological gold standard. The assay specificities were shown to be 100% for IgM and 99.2% for IgG. This indicates that the test is suitable for assessing previous virus exposure, although negative results may be unreliable during the first weeks after infection. More detailed studies on antibody responses during and post infection are urgently needed.
    Keywords IgG ; IgM ; COVID-19 ; rapid test ; sars-CoV-2 ; diagnostics ; covid19
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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