LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 399

Search options

  1. Book ; Online ; E-Book: Precision medicine in neurodegenerative disorders / Part 1

    Espay, Alberto J.

    (Handbook of clinical neurology ; volume 192)

    2023  

    Author's details volume editor Alberto J. Espay
    Series title Handbook of clinical neurology ; volume 192
    Precision medicine in neurodegenerative disorders
    Collection Precision medicine in neurodegenerative disorders
    Keywords Nervous system/Degeneration
    Subject code 616.8
    Language English
    Size 1 Online-Ressource (xvii, 269 Seiten), Illustrationen
    Publishing country Netherlands
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021730573
    ISBN 978-0-323-90064-5 ; 9780323855389 ; 0-323-90064-X ; 0323855385
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Book ; Online: Precision medicine in neurodegenerative disorders

    Espay, Alberto J.

    (Handbook of clinical neurology ; ...)

    2023  

    Author's details volume editor Alberto J. Espay
    Series title Handbook of clinical neurology
    ...
    Keywords Nervous system/Degeneration
    Subject code 616.8
    Language English
    Size Online-Ressource
    Publisher Elsevier
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book ; Online
    HBZ-ID HT021730565
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Book ; Online ; E-Book: Precision medicine in neurodegenerative disorders / Part 2

    Espay, Alberto J.

    (Handbook of clinical neurology ; volume 193)

    2023  

    Author's details volume editor Alberto J. Espay
    Series title Handbook of clinical neurology ; volume 193
    Precision medicine in neurodegenerative disorders
    Collection Precision medicine in neurodegenerative disorders
    Keywords Nervous system/Degeneration
    Subject code 616.8
    Language English
    Size 1 Online-Ressource (xx, 371 Seiten), Illustrationen
    Publishing country Netherlands
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021730607
    ISBN 978-0-323-90065-2 ; 9780323855556 ; 0-323-90065-8 ; 0323855555
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Book ; Online ; E-Book: Brain fables

    Espay, Alberto J. / Stecher, Benjamin

    the hidden history of neurodegenerative diseases and a blueprint to conquer them

    2020  

    Abstract: An estimated 80 million people live with a neurodegenerative disease. That number is expected to increase rapidly as populations age, lifespans increase, and exposure to toxins rises. Despite decades of research and billions in funding, there are no ... ...

    Author's details Alberto Espay and Benjamin Stecher
    Abstract An estimated 80 million people live with a neurodegenerative disease. That number is expected to increase rapidly as populations age, lifespans increase, and exposure to toxins rises. Despite decades of research and billions in funding, there are no medications that can slow, much less stop, the progress of these diseases. This is because diseases such as Parkinson's and Alzheimer's do not exist in biology. Yet, hundreds of clinical trials around the world are examining the potential of single therapies in thousands of people sharing one of these labels. Compounding the problem, these therapies were developed on evidence from models that do not come close to capturing the complexity of these diseases in the affected humans. These practices must end. Brain Fables is a call to refocus on understanding living and aging to create the personalized treatments each affected individual desperately needs.
    Keywords Nervous system/Degeneration ; Nervous system/Aging
    Subject code 616.8
    Language English
    Size 1 online resource (xiv, 162 pages) :, digital, PDF file(s).
    Publisher Cambridge University Press
    Publishing place Cambridge, UK
    Document type Book ; Online ; E-Book
    Note Title from publisher's bibliographic system (viewed on 29 Jun 2020).
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-108-89976-5 ; 1-108-88820-8 ; 1-108-74462-1 ; 978-1-108-89976-5 ; 978-1-108-88820-2 ; 978-1-108-74462-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Abandoning the Proteinopathy Paradigm in Parkinson Disease-Not So Fast-Reply.

    Espay, Alberto J

    JAMA neurology

    2023  Volume 80, Issue 8, Page(s) 872–873

    MeSH term(s) Humans ; Parkinson Disease ; Proteostasis Deficiencies
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2023.1697
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.191: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Preface.

    Espay, Alberto J

    Handbook of clinical neurology

    2023  Volume 193, Page(s) xiii–xiv

    Language English
    Publishing date 2023-02-18
    Publishing country Netherlands
    Document type Editorial
    ISSN 0072-9752
    ISSN 0072-9752
    DOI 10.1016/B978-0-323-85555-6.00022-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Preface.

    Espay, Alberto J

    Handbook of clinical neurology

    2023  Volume 192, Page(s) xiii–xiv

    Language English
    Publishing date 2023-01-06
    Publishing country Netherlands
    Document type Editorial
    ISSN 0072-9752
    ISSN 0072-9752
    DOI 10.1016/B978-0-323-85538-9.00017-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Models of precision medicine for neurodegeneration.

    Espay, Alberto J

    Handbook of clinical neurology

    2023  Volume 192, Page(s) 21–34

    Abstract: The clinicopathologic model that defines neurodegenerative disorders has remained unchanged for over a century. According to it, clinical manifestations are defined and explained by a given pathology, that is, by the burden and distribution of selected ... ...

    Abstract The clinicopathologic model that defines neurodegenerative disorders has remained unchanged for over a century. According to it, clinical manifestations are defined and explained by a given pathology, that is, by the burden and distribution of selected proteins aggregated into insoluble amyloids. There are two logical consequences from this model: (1) a measurement of the disease-defining pathology represents a biomarker of that disease in everyone affected, and (2) the targeted elimination of that pathology should end that disease. But success in disease modification guided by this model has remained elusive. New technologies to probe living biology have been used to validate rather than question the clinicopathologic model, despite three important observations: (1) a disease-defining pathology in isolation (without other pathologies) is an exceptional autopsy finding; (2) many genetic and molecular pathways converge on the same pathology; (3) the presence of pathology without neurological disease is more common than expected by chance. We here discuss the rationale for abandoning the clinicopathologic model, review the competing biological model of neurodegeneration, and propose developmental pathways for biomarker development and disease-modifying efforts. Further, in justifying future disease-modifying trials testing putative neuroprotective molecules, a key inclusion criterion must be the deployment of a bioassay of the mechanism corrected by the therapy of interest. No improvements in trial design or execution can overcome the fundamental deficit created by testing experimental therapies in clinically defined recipients unselected for their biologically suitability. Biological subtyping is the key developmental milestone needed to launch precision medicine for patients living with neurodegenerative disorders.
    MeSH term(s) Humans ; Parkinson Disease/pathology ; alpha-Synuclein/metabolism ; Precision Medicine ; Neurodegenerative Diseases ; Biomarkers
    Chemical Substances alpha-Synuclein ; Biomarkers
    Language English
    Publishing date 2023-01-29
    Publishing country Netherlands
    Document type Review ; Journal Article
    ISSN 0072-9752
    ISSN 0072-9752
    DOI 10.1016/B978-0-323-85538-9.00009-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Is Pathology Always the Diagnostic Gold Standard in Neurodegeneration?

    Espay, Alberto J

    Movement disorders clinical practice

    2022  Volume 9, Issue 8, Page(s) 1152–1153

    Language English
    Publishing date 2022-10-03
    Publishing country United States
    Document type Journal Article
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13570
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Your After-Visit Summary-May 29, 2042.

    Espay, Alberto J

    The Lancet. Neurology

    2022  Volume 21, Issue 5, Page(s) 412–413

    Language English
    Publishing date 2022-04-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(22)00129-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5955: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top