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Article ; Online: Should we integrate the gut microbiota composition to manage idiopathic nephrotic syndrome?

Espi, Maxime / Soulage, Christophe O / Koppe, Laetitia

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2023 Volume 38, Issue 9, Page(s) 1927–1930

MeSH term(s)	Child ; Humans ; Nephrotic Syndrome ; Gastrointestinal Microbiome ; Glucocorticoids ; Syndrome ; Nephrosis, Lipoid ; Recurrence
Chemical Substances	Glucocorticoids
Language	English
Publishing date	2023-06-13
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfad126
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Zs.A 2198: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 329: Show issues

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Article ; Online: Chronic Kidney Disease-Associated Immune Dysfunctions: Impact of Protein-Bound Uremic Retention Solutes on Immune Cells.

Espi, Maxime / Koppe, Laetitia / Fouque, Denis / Thaunat, Olivier

Toxins

2020 Volume 12, Issue 5

Abstract: Regardless of the primary disease responsible for kidney failure, patients suffering from chronic kidney disease (CKD) have in common multiple impairments of both the innate and adaptive immune systems, the pathophysiology of which has long remained ... ...

Abstract	Regardless of the primary disease responsible for kidney failure, patients suffering from chronic kidney disease (CKD) have in common multiple impairments of both the innate and adaptive immune systems, the pathophysiology of which has long remained enigmatic. CKD-associated immune dysfunction includes chronic low-grade activation of monocytes and neutrophils, which induces endothelial damage and increases cardiovascular risk. Although innate immune effectors are activated during CKD, their anti-bacterial capacity is impaired, leading to increased susceptibility to extracellular bacterial infections. Finally, CKD patients are also characterized by profound alterations of cellular and humoral adaptive immune responses, which account for an increased risk for malignancies and viral infections. This review summarizes the recent emerging data that link the pathophysiology of CKD-associated immune dysfunctions with the accumulation of microbiota-derived metabolites, including indoxyl sulfate and p-cresyl sulfate, the two best characterized protein-bound uremic retention solutes.
MeSH term(s)	Animals ; Cresols/blood ; Humans ; Immune System/immunology ; Immune System/metabolism ; Immune System/physiopathology ; Immunity, Cellular ; Immunity, Humoral ; Immunity, Innate ; Indican/blood ; Kidney/immunology ; Kidney/metabolism ; Kidney/physiopathology ; Protein Binding ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/immunology ; Renal Insufficiency, Chronic/physiopathology ; Sulfuric Acid Esters/blood ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Uremia/blood ; Uremia/immunology ; Uremia/physiopathology
Chemical Substances	Cresols ; Sulfuric Acid Esters ; 4-cresol sulfate (56M34ZQY1S) ; Indican (N187WK1Y1J)
Keywords	covid19
Language	English
Publishing date	2020-05-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518395-3
ISSN	2072-6651 ; 2072-6651
ISSN (online)	2072-6651
ISSN	2072-6651
DOI	10.3390/toxins12050300
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Article ; Online: Predictive factors of a viral neutralizing humoral response after a third dose of COVID-19 mRNA vaccine.

Charmetant, Xavier / Espi, Maxime / Barba, Thomas / Ovize, Anne / Morelon, Emmanuel / Mathieu, Cyrille / Thaunat, Olivier

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2022 Volume 22, Issue 5, Page(s) 1442–1450

Abstract: Kidney transplant recipients (KTRs) have reduced ability to mount adequate antibody response after two doses of the COVID-19 mRNA vaccine. French health authorities have allowed a third booster dose (D3) for KTRs, but their response is heterogeneous and ... ...

Abstract	Kidney transplant recipients (KTRs) have reduced ability to mount adequate antibody response after two doses of the COVID-19 mRNA vaccine. French health authorities have allowed a third booster dose (D3) for KTRs, but their response is heterogeneous and tools able to discriminate the responders are lacking. Anti-RBD IgG titers (chemiluminescence immunoassay), spike-specific cellular responses (IFN-γ-releasing assay, IGRA), and in vitro serum neutralization of the virus (the best available correlate of protection), were evaluated 7-14 days after the second dose (D2) of BNT162b2 vaccine in 93 KTRs. Among the 73 KTRs, whose serum did not neutralize SARS-CoV-2 in vitro after D2, 14 (19%) acquired this capacity after D3, and were considered as "responders." Exploratory univariate analysis identified short time from transplantation and high maintenance immunosuppression as detrimental factors for the response to D3. In addition, any of the presence of anti-RBD IgGs and/or positive IGRA after D2 was predictive of response to D3. By contrast, none of the KTRs with both a negative serology and IGRA responded to D3. In summary, routinely available bioassays performed after D2 allow identifying KTRs that will respond to a booster D3. These results pave the way for the personalization of vaccination strategy in KTRs.
MeSH term(s)	Antibodies, Neutralizing ; Antibodies, Viral ; BNT162 Vaccine ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Kidney Transplantation ; SARS-CoV-2 ; Vaccines, Synthetic ; mRNA Vaccines
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Vaccines, Synthetic ; mRNA Vaccines ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2022-02-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1111/ajt.16990
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Zs.A 5542: Show issues

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Article ; Online: Improved cell signaling analysis by biofunctionalized nanospheres and imaging flow cytometry.

Koenig, Alice / Charmetant, Xavier / Barba, Thomas / Sicard, Antoine / Espi, Maxime / Dussurgey, Sébastien / Thaunat, Olivier

Cytometry. Part A : the journal of the International Society for Analytical Cytology

2021 Volume 99, Issue 11, Page(s) 1079–1090

Abstract: The analysis of immune cell signaling is critical for the understanding of the biology and pathology of the immune system, and thus a mandatory step for the development of efficient biomarkers and targeted therapies. Phosflow, which has progressively ... ...

Abstract	The analysis of immune cell signaling is critical for the understanding of the biology and pathology of the immune system, and thus a mandatory step for the development of efficient biomarkers and targeted therapies. Phosflow, which has progressively replaced the traditional western blot approach, relies on flow cytometry to analyze various signaling pathways at a single-cell level. This technique however suffers a lack of sensitivity largely due to the low signal/noise ratio that characterizes cell signaling analysis. In this study, we describe a new technique, which combines the use of biofunctionalized nanospheres (i.e., synthetic particulate antigens, SPAg) to stimulate the immune cells in suspension and imaging flow cytometry to identify homogenously-stimulated cells and quantify the activity of the chosen signaling pathway in selected subcellular regions of interest. Using BCR signaling as model, we demonstrate that SIBERIAN (SPAg-assIsted suB-cEllulaR sIgnaling ANalysis) allows assessing immune cell signaling with unprecedented sensitivity and specificity.
MeSH term(s)	Flow Cytometry ; Nanospheres ; Phosphorylation ; Signal Transduction
Language	English
Publishing date	2021-04-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2099868-5
ISSN	1552-4930 ; 0196-4763 ; 1552-4922
ISSN (online)	1552-4930
ISSN	0196-4763 ; 1552-4922
DOI	10.1002/cyto.a.24354
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Zs.A 1688: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 68: Show issues

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Article ; Online: Rapid Waning of Immune Memory Against SARS-CoV-2 in Maintenance Hemodialysis Patients After mRNA Vaccination and Impact of a Booster Dose.

Espi, Maxime / Charmetant, Xavier / Mathieu, Cyrille / Lalande, Alexandre / Decimo, Didier / Koppe, Laetitia / Pelletier, Caroline / Ovize, Anne / Barbry, Alexia / Morelon, Emmanuel / Kalbacher, Emilie / Fouque, Denis / Thaunat, Olivier

Kidney international reports

2023 Volume 8, Issue 4, Page(s) 907–911

Language	English
Publishing date	2023-01-09
Publishing country	United States
Document type	Journal Article
ISSN	2468-0249
ISSN (online)	2468-0249
DOI	10.1016/j.ekir.2023.01.004
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Article ; Online: Predictive factors of response to 3rd dose of COVID-19 mRNA vaccine in kidney transplant recipients

Charmetant, Xavier / ESPI, Maxime / Barba, Thomas / Ovize, Anne / Morelon, Emmanuel / Thaunat, Olivier

medRxiv

Abstract: Only a minority of kidney transplant recipients (KTRs) develop protective neutralizing titers of anti-receptor binding domain of spike protein (RBD) IgG after two doses of mRNA COVID-19 vaccine. Administration of a third dose of mRNA vaccine to KTRs with ...

Abstract	Only a minority of kidney transplant recipients (KTRs) develop protective neutralizing titers of anti-receptor binding domain of spike protein (RBD) IgG after two doses of mRNA COVID-19 vaccine. Administration of a third dose of mRNA vaccine to KTRs with sub-optimal response increase anti-RBD IgG titers but with high inter-individual variability. Patients with the higher response rate to the third dose of vaccine can be identified by the presence of low anti-RBD IgG titers and spike-specific CD4+ T cells in their circulation 14 days after the second dose.
Keywords	covid19
Language	English
Publishing date	2021-08-30
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2021.08.23.21262293
Database	COVID19

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Article: Hamster organotypic kidney culture model of early-stage SARS-CoV-2 infection highlights a two-step renal susceptibility.

Shyfrin, Sophie R / Ferren, Marion / Perrin-Cocon, Laure / Espi, Maxime / Charmetant, Xavier / Brailly, Manon / Decimo, Didier / Iampietro, Mathieu / Canus, Lola / Horvat, Branka / Lotteau, Vincent / Vidalain, Pierre-Olivier / Thaunat, Olivier / Mathieu, Cyrille

Journal of tissue engineering

2022 Volume 13, Page(s) 20417314221122130

Abstract: Kidney pathology is frequently reported in patients hospitalized with COVID-19, the pandemic disease caused by the Severe acute respiratory coronavirus 2 (SARS-CoV-2). However, due to a lack of suitable study models, the events occurring in the kidney ... ...

Abstract	Kidney pathology is frequently reported in patients hospitalized with COVID-19, the pandemic disease caused by the Severe acute respiratory coronavirus 2 (SARS-CoV-2). However, due to a lack of suitable study models, the events occurring in the kidney during the earliest stages of infection remain unknown. We have developed hamster organotypic kidney cultures (OKCs) to study the early stages of direct renal infection. OKCs maintained key renal structures in their native three-dimensional arrangement. SARS-CoV-2 productively replicated in hamster OKCs, initially targeting endothelial cells and later disseminating into proximal tubules. We observed a delayed interferon response, markers of necroptosis and pyroptosis, and an early repression of pro-inflammatory cytokines transcription followed by a strong later upregulation. While it remains an open question whether an active replication of SARS-CoV-2 takes place in the kidneys of COVID-19 patients with AKI, our model provides new insights into the kinetics of SARS-CoV-2 kidney infection and can serve as a powerful tool for studying kidney infection by other pathogens and testing the renal toxicity of drugs.
Language	English
Publishing date	2022-09-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2573915-3
ISSN	2041-7314
ISSN	2041-7314
DOI	10.1177/20417314221122130
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Article ; Online: A prospective observational study for justification, safety, and efficacy of a third dose of mRNA vaccine in patients receiving maintenance hemodialysis.

Espi, Maxime / Charmetant, Xavier / Barba, Thomas / Mathieu, Cyrille / Pelletier, Caroline / Koppe, Laetitia / Chalencon, Elodie / Kalbacher, Emilie / Mathias, Virginie / Ovize, Anne / Cart-Tanneur, Emmanuelle / Bouz, Christine / Pellegrina, Laurence / Morelon, Emmanuel / Juillard, Laurent / Fouque, Denis / Couchoud, Cécile / Thaunat, Olivier

Kidney international

2021 Volume 101, Issue 2, Page(s) 390–402

Abstract: The level of protection achieved by the standard two doses of COVID-19 mRNA vaccines in patients receiving maintenance hemodialysis (MHD) remains unclear. To study this we used the French Renal Epidemiology and Information Network (REIN) Registry to ... ...

Abstract	The level of protection achieved by the standard two doses of COVID-19 mRNA vaccines in patients receiving maintenance hemodialysis (MHD) remains unclear. To study this we used the French Renal Epidemiology and Information Network (REIN) Registry to compare the incidence and severity of 1474 cases of COVID-19 diagnosed in patients receiving MHD after none, one or two doses of vaccine. Vaccination significantly reduce COVID-19 incidence and severity, but 11% of patients infected after two doses still died. Lack of vaccinal protection in patients naïve for SARS-CoV-2 could be due to defective Tfh response [38% of patients with negative spike-specific CD4
MeSH term(s)	Antibodies, Viral ; BNT162 Vaccine ; COVID-19 ; Humans ; Renal Dialysis/adverse effects ; SARS-CoV-2 ; Vaccines, Synthetic ; mRNA Vaccines
Chemical Substances	Antibodies, Viral ; Vaccines, Synthetic ; mRNA Vaccines ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2021-11-29
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2021.10.040
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Zs.A 797: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: The ROMANOV study found impaired humoral and cellular immune responses to SARS-CoV-2 mRNA vaccine in virus-unexposed patients receiving maintenance hemodialysis.

Espi, Maxime / Charmetant, Xavier / Barba, Thomas / Koppe, Laetitia / Pelletier, Caroline / Kalbacher, Emilie / Chalencon, Elodie / Mathias, Virginie / Ovize, Anne / Cart-Tanneur, Emmanuelle / Bouz, Christine / Pellegrina, Laurence / Morelon, Emmanuel / Fouque, Denis / Juillard, Laurent / Thaunat, Olivier

Kidney international

2021 Volume 100, Issue 4, Page(s) 928–936

Abstract: Patients on maintenance hemodialysis (MHD), which are at high risk of infection by SARS-CoV-2 virus and death due to COVID-19, have been prioritized for vaccination. However, because they were excluded from pivotal studies and have weakened immune ... ...

Abstract	Patients on maintenance hemodialysis (MHD), which are at high risk of infection by SARS-CoV-2 virus and death due to COVID-19, have been prioritized for vaccination. However, because they were excluded from pivotal studies and have weakened immune responses, it is not known whether these patients are protected after the "standard" two doses of mRNA vaccines. To answer this, anti-spike receptor binding domain (RBD) IgG and interferon gamma-producing CD4
MeSH term(s)	Antibodies, Viral ; CD8-Positive T-Lymphocytes ; COVID-19 ; COVID-19 Vaccines ; Humans ; Immunity, Cellular ; RNA, Messenger ; Renal Dialysis/adverse effects ; SARS-CoV-2
Chemical Substances	Antibodies, Viral ; COVID-19 Vaccines ; RNA, Messenger ; BNT162 vaccine (N38TVC63NU)
Language	English
Publishing date	2021-07-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2021.07.005
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Zs.A 797: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Infection or a third dose of mRNA vaccine elicits neutralizing antibody responses against SARS-CoV-2 in kidney transplant recipients.

Science translational medicine

2022 Volume 14, Issue 636, Page(s) eabl6141

Abstract: Transplant recipients, who receive therapeutic immunosuppression to prevent graft rejection, are characterized by high coronavirus disease 2019 (COVID-19)-related mortality and defective response to vaccines. We observed that previous infection with ... ...

Abstract	Transplant recipients, who receive therapeutic immunosuppression to prevent graft rejection, are characterized by high coronavirus disease 2019 (COVID-19)-related mortality and defective response to vaccines. We observed that previous infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but not the standard two-dose regimen of vaccination, provided protection against symptomatic COVID-19 in kidney transplant recipients. We therefore compared the cellular and humoral immune responses of these two groups of patients. Neutralizing anti-receptor-binding domain (RBD) immunoglobulin G (IgG) antibodies were identified as the primary correlate of protection for transplant recipients. Analysis of virus-specific B and T cell responses suggested that the generation of neutralizing anti-RBD IgG may have depended on cognate T-B cell interactions that took place in germinal center, potentially acting as a limiting checkpoint. High-dose mycophenolate mofetil, an immunosuppressive drug, was associated with fewer antigen-specific B and T follicular helper (T
MeSH term(s)	Antibodies, Neutralizing ; Antibodies, Viral ; BNT162 Vaccine ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Kidney Transplantation ; Prospective Studies ; SARS-CoV-2 ; Transplant Recipients ; Vaccines, Synthetic ; mRNA Vaccines
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Vaccines, Synthetic ; mRNA Vaccines ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2022-03-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2518854-9
ISSN	1946-6242 ; 1946-6234
ISSN (online)	1946-6242
ISSN	1946-6234
DOI	10.1126/scitranslmed.abl6141
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Zs.A 6941: Show issues

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