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Article: An approach to the phenomenology of the disease.

Espinosa, Carlos Alva

2017 Volume 153, Issue 5, Page(s) 641–644

Abstract: Modern medicine has undergone technological progress, undoubtedly with better results, but the doctor-patient relationship has been undermined in its most important aspect, human contact. The patient experiences and confronts in solitude his adverse ... ...

Title translation	Una aproximación a la fenomenología de la enfermedad.
Abstract	Modern medicine has undergone technological progress, undoubtedly with better results, but the doctor-patient relationship has been undermined in its most important aspect, human contact. The patient experiences and confronts in solitude his adverse experience. This experience is complex, not only are the symptoms of the disease, they also include disability, isolation, fear, dependence and sometimes guilt. Phenomenology attaches a paramount importance to the data in the consciousness of the patient, as facts given with absolute value. The purpose of this paper is to deepen the experience of the healthy adult individual who is ill. The better understanding of this phenomenology of the patient by the physician and the health personnel, can favor a better efficiency, empathy and compassion in their care.
Language	Spanish
Publishing date	2017
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	425456-9
ISSN	0016-3813
ISSN	0016-3813
DOI	10.24875/GMM.17003009
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Article ; Online: Recommender system for ablation lines to treat complex atrial tachycardia.

Vila, Muhamed / Rivolta, Massimo W / Barrios Espinosa, Cristian A / Unger, Laura A / Luik, Armin / Loewe, Axel / Sassi, Roberto

Computer methods and programs in biomedicine

2023 Volume 231, Page(s) 107406

Abstract: Background and objective: Planning the optimal ablation strategy for the treatment of complex atrial tachycardia (CAT) is a time consuming task and is error-prone. Recently, directed network mapping, a technology based on graph theory, proved to ... ...

Abstract	Background and objective: Planning the optimal ablation strategy for the treatment of complex atrial tachycardia (CAT) is a time consuming task and is error-prone. Recently, directed network mapping, a technology based on graph theory, proved to efficiently identify CAT based solely on data of clinical interventions. Briefly, a directed network was used to model the atrial electrical propagation and reentrant activities were identified by looking for closed-loop paths in the network. In this study, we propose a recommender system, built as an optimization problem, able to suggest the optimal ablation strategy for the treatment of CAT. Methods: The optimization problem modeled the optimal ablation strategy as that one interrupting all reentrant mechanisms while minimizing the ablated atrial surface. The problem was designed on top of directed network mapping. Considering the exponential complexity of finding the optimal solution of the problem, we introduced a heuristic algorithm with polynomial complexity. The proposed algorithm was applied to the data of i) 6 simulated scenarios including both left and right atrial flutter; and ii) 10 subjects that underwent a clinical routine. Results: The recommender system suggested the optimal strategy in 4 out of 6 simulated scenarios. On clinical data, the recommended ablation lines were found satisfactory on 67% of the cases according to the clinician's opinion, while they were correctly located in 89%. The algorithm made use of only data collected during mapping and was able to process them nearly real-time. Conclusions: The first recommender system for the identification of the optimal ablation lines for CAT, based solely on the data collected during the intervention, is presented. The study may open up interesting scenarios for the application of graph theory for the treatment of CAT.
MeSH term(s)	Humans ; Catheter Ablation ; Tachycardia, Supraventricular ; Atrial Flutter/surgery ; Heart Atria/surgery ; Treatment Outcome
Language	English
Publishing date	2023-02-05
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632564-6
ISSN	1872-7565 ; 0169-2607
ISSN (online)	1872-7565
ISSN	0169-2607
DOI	10.1016/j.cmpb.2023.107406
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Article ; Online: Metatranscriptome Profiling of a Specialized Microbial Consortium during the Degradation of Nixtamalized Maize Pericarp.

Serrano-Gamboa, José Germán / Fócil-Espinosa, Carlos Abraham / Cabello-Yeves, Pedro J / Coutinho, Felipe H / Rojas-Herrera, Rafael Antonio / Sánchez-González, Mónica Noel

Microbiology spectrum

2022 Volume 10, Issue 1, Page(s) e0231821

Abstract: Lignocellulose degradation by microbial consortia is multifactorial; hence, it must be analyzed from a holistic perspective. In this study, the temporal transcriptional activity of consortium PM-06, a nixtamalized maize pericarp (NMP) degrader, was ... ...

Abstract	Lignocellulose degradation by microbial consortia is multifactorial; hence, it must be analyzed from a holistic perspective. In this study, the temporal transcriptional activity of consortium PM-06, a nixtamalized maize pericarp (NMP) degrader, was determined and related to structural and physicochemical data to give insights into the mechanism used to degrade this substrate. Transcripts were described in terms of metabolic profile, carbohydrate-active enzyme (CAZyme) annotation, and taxonomic affiliation. The PM-06 gene expression pattern was closely related to the differential rates of degradation. The environmental and physiological conditions preceding high-degradation periods were crucial for CAZyme expression. The onset of degradation preceded the period with the highest degradation rate in the whole process, and in this time, several CAZymes were upregulated. Functional analysis of expressed CAZymes indicated that PM-06 overcomes NMP recalcitrance through modular enzymes operating at the proximity of the insoluble substrate. Increments in the diversity of expressed modular CAZymes occurred in the last stages of degradation where the substrate is more recalcitrant and environmental conditions are stressing. Taxonomic affiliation of CAZyme transcripts indicated that Paenibacillus macerans was fundamental for degradation. This microorganism established synergistic relationships with Bacillus thuringiensis for the degradation of cellulose and hemicellulose and with
MeSH term(s)	Bacteria/classification ; Bacteria/genetics ; Bacteria/isolation & purification ; Bacteria/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Biodegradation, Environmental ; Cellulose/metabolism ; Gene Expression Profiling ; Lignin/metabolism ; Microbial Consortia ; Polysaccharides/metabolism ; Transcriptome ; Zea mays/metabolism ; Zea mays/microbiology
Chemical Substances	Bacterial Proteins ; Polysaccharides ; lignocellulose (11132-73-3) ; hemicellulose (8024-50-8) ; Cellulose (9004-34-6) ; Lignin (9005-53-2)
Language	English
Publishing date	2022-01-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.02318-21
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Article ; Online: A three-criteria performance score for rats exercising on a running treadmill.

Ríos-Kristjánsson, Juan Gabriel / Rizo-Roca, David / Kristjánsdóttir, Karen Mist / Núñez-Espinosa, Cristian Andrés / Torrella, Joan Ramon / Pagès, Teresa / Viscor, Ginés

PloS one

2019 Volume 14, Issue 7, Page(s) e0219167

Abstract: In this study, we propose a novel three-criteria performance score to semiquantitatively classify the running style, the degree of involvement and compliance and the validity of electric shock count for rats exercising on a treadmill. Each score ... ...

Abstract	In this study, we propose a novel three-criteria performance score to semiquantitatively classify the running style, the degree of involvement and compliance and the validity of electric shock count for rats exercising on a treadmill. Each score criterion has several style-marks that are based on the observational registry of male Sprague-Dawley rats running for 4-7 weeks. Each mark was given a score value that was averaged throughout a session-registry and resulting in a session score for each criterion, ranging from "0" score for a hypothetical "worst runner", to score "1" for a hypothetical "perfect runner" rat. We found significant differences throughout a training program, thus providing evidence of sufficient sensitivity of this score to reflect the individual evolution of performance improvement in exercise capacity due to training. We hypothesize that this score could be correlated with other physiological or metabolic parameters, thus refining research results and further helping researchers to reduce the number of experimental subjects.
MeSH term(s)	Animals ; Male ; Physical Conditioning, Animal/methods ; Physical Conditioning, Animal/physiology ; Physical Conditioning, Animal/statistics & numerical data ; Rats ; Rats, Sprague-Dawley ; Running/physiology ; Running/statistics & numerical data
Language	English
Publishing date	2019-07-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0219167
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Article ; Online: Clinicopathologic and Surgical Study of Pleomorphic Adenoma of the Parotid Gland: Analysis of Risk Factors for Recurrence and Facial Nerve Dysfunction.

Espinosa, Carlos A / Fernández-Valle, Álvaro / Lequerica-Fernández, Paloma / de Villalaín, Lucas / de Vicente, Juan Carlos

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

2017 Volume 76, Issue 2, Page(s) 347–354

Abstract: Purpose: To determine whether clinicopathologic or surgical features are risk factors for recurrence and facial nerve dysfunction in pleomorphic adenoma (PA) of the parotid gland.: Patients and methods: The records of 198 patients surgically treated ... ...

Abstract	Purpose: To determine whether clinicopathologic or surgical features are risk factors for recurrence and facial nerve dysfunction in pleomorphic adenoma (PA) of the parotid gland. Patients and methods: The records of 198 patients surgically treated for a PA of the parotid gland from 1999 through 2013 were retrospectively reviewed to identify patients who developed a tumor recurrence. The Fisher exact test and Mann-Whitney U test were used to analyze patient characteristics between recurrent and non-recurrent PAs. Logistic regression was used to determine the risks of recurrence and facial nerve dysfunction. Results: Twenty-three patients (11.6%) developed a recurrence. Patients with tumor recurrence were notably younger than patients without recurrence. Of the 14 patients who underwent enucleation, 11 (78.6%) developed residual disease, as did 10 of 165 patients (6%) managed by a superficial parotidectomy (P < .0005). Furthermore, the risk of residual disease was 9.3 to 21.6 times higher in patients who underwent enucleation than in those who underwent a total or superficial parotidectomy. For tumor histology, recurrence was observed in 3 (15.8%) of the 19 cellular types, 18 (11.5%) of 157 classic cases, and 1 (4.8%) of 21 myxoid cases (P = .5). The risk of recurrence with positive resection margins was 49 times higher than with negative margins (P = .001). Conclusion: Young age, enucleation, and positive margins are risk factors for residual pleomorphic adenoma, and surgical technique and histomorphologic features are associated with increased facial nerve dysfunction.
MeSH term(s)	Adenoma, Pleomorphic/pathology ; Adenoma, Pleomorphic/surgery ; Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Facial Nerve/pathology ; Female ; Humans ; Male ; Margins of Excision ; Middle Aged ; Neoplasm Recurrence, Local/pathology ; Parotid Neoplasms/pathology ; Parotid Neoplasms/surgery ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2017-08-03
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	392404-x
ISSN	1531-5053 ; 0278-2391
ISSN (online)	1531-5053
ISSN	0278-2391
DOI	10.1016/j.joms.2017.07.171
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Article ; Online: Sclerosing Polycystic Adenosis of the Parotid Gland: A Systematic Review and Report of 2 New Cases.

Espinosa, Carlos A / Rua, Laura / Torres, Héctor E / Fernández Del Valle, Álvaro / Fernandes, Rui P / Devicente, Juan C

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

2017 Volume 75, Issue 5, Page(s) 984–993

Abstract: Purpose: We sought to evaluate clinical-epidemiologic aspects, pathologic characteristics, and treatment of sclerosing polycystic adenosis (SPA) of the parotid gland and to report 2 new cases.: Materials and methods: We conducted a systematic review ... ...

Abstract	Purpose: We sought to evaluate clinical-epidemiologic aspects, pathologic characteristics, and treatment of sclerosing polycystic adenosis (SPA) of the parotid gland and to report 2 new cases. Materials and methods: We conducted a systematic review following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for studies published in or before June 2016. The inclusion criteria were as follows: final diagnosis of SPA affecting the parotid gland and articles published in Spanish or English. The exclusion criteria were as follows: unclear diagnosis after pathologic analysis and patients affected by other conditions in the major salivary glands. We added 2 new cases. Results: Our review ultimately included 21 articles and 45 cases. The mean patient age was 41 years (range, 7-84 years). The female-to-male ratio was 2:1. In all patients the tumor showed progressive growth. The evolution range was 7 days to 11 years. In 17.7% of cases, the tumor was associated with pain. The average tumor size was 30.3 mm (range, 12-60 mm). Fine needle aspiration biopsy (FNAB) was unable to diagnose 30 cases. Benign tumors comprised 58% of tumors (18), whereas malignancy was present in 25.8% (8). Thirty-five tumors were well circumscribed. There were 8 multinodular or lobed cases. The tumor was described as encapsulated in 1 case, partially encapsulated or pseudo-encapsulated in 16, and not encapsulated in 12. Five cases showed different degrees of degenerative changes, ranging from dysplasia to invasive carcinoma. All cases underwent surgical treatment. Superficial parotidectomy with preservation of the facial nerve was performed in 22 cases (61.1%), total parotidectomy in 8 (22.2%), and tumor enucleation in 6 (16.6%). The mean follow-up period was 51.5 months (range, 5-276 months). Of documented cases, 74.2% had 2 or more years of follow-up. Recurrences occurred in 6 cases (16.6%). Conclusions: We consider SPA a benign tumor with progressive growth, which is occasionally painful. It occurs around age 40 years and occurs more often in female patients. Fine needle aspiration biopsy does not provide an adequate preoperative diagnosis. Recurrences are infrequent. Follow-up should be customized according to the pathologic findings. Malignant transformation may occur. Superficial parotidectomy with facial nerve preservation is the treatment of choice.
MeSH term(s)	Aged ; Female ; Humans ; Middle Aged ; Parotid Gland/pathology ; Salivary Gland Diseases/diagnosis ; Salivary Gland Diseases/surgery ; Sclerosis
Language	English
Publishing date	2017-05
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	392404-x
ISSN	1531-5053 ; 0278-2391
ISSN (online)	1531-5053
ISSN	0278-2391
DOI	10.1016/j.joms.2016.10.031
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Article ; Online: Design and construction of a quadruple-resonance MAS NMR probe for investigation of extensively deuterated biomolecules.

Collier, Kelsey A / Sengupta, Suvrajit / Espinosa, Catalina A / Kelly, John E / Kelz, Jessica I / Martin, Rachel W

Journal of magnetic resonance (San Diego, Calif. : 1997)

2017 Volume 285, Page(s) 8–17

Abstract: Extensive deuteration is frequently used in solid-state NMR studies of biomolecules because it dramatically reduces both homonuclear ( ...

Abstract	Extensive deuteration is frequently used in solid-state NMR studies of biomolecules because it dramatically reduces both homonuclear (
MeSH term(s)	Algorithms ; Carbon Isotopes ; Deuterium/chemistry ; Electromagnetic Fields ; Nitrogen Isotopes ; Nuclear Magnetic Resonance, Biomolecular/instrumentation ; Protons
Chemical Substances	Carbon Isotopes ; Nitrogen Isotopes ; Protons ; Deuterium (AR09D82C7G)
Language	English
Publishing date	2017-10-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1469665-4
ISSN	1096-0856 ; 1557-8968 ; 1090-7807 ; 0022-2364
ISSN (online)	1096-0856 ; 1557-8968
ISSN	1090-7807 ; 0022-2364
DOI	10.1016/j.jmr.2017.10.002
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Article: Modulation of cross polarization in motionally averaged solids by Variable Angle Spinning NMR.

Espinosa, Catalina A / Thureau, Pierre / Shapiro, Rebecca A / Litvak, Ilya M / Martin, Rachel W

Chemical physics letters

2011 Volume 508, Issue 4-6, Page(s) 314–319

Abstract: In systems where the dipolar couplings are partially averaged by molecular motion, cross-polarization is modulated by sample spinning. The cross-polariation efficiency in Variable Angle Spinning (VAS) and Switched Angle Spinning (SAS) experiments on ... ...

Abstract	In systems where the dipolar couplings are partially averaged by molecular motion, cross-polarization is modulated by sample spinning. The cross-polariation efficiency in Variable Angle Spinning (VAS) and Switched Angle Spinning (SAS) experiments on mobile samples is therefore strongly dependent on the spinning angle. We describe simulations and experimental measurements of these effects over a range of spinning angles from 0° to 90°.
Language	English
Publishing date	2011-07-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1466293-0
ISSN	0009-2614
ISSN	0009-2614
DOI	10.1016/j.cplett.2011.04.043
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Article ; Online: Multiomic signals associated with maternal epidemiological factors contributing to preterm birth in low- and middle-income countries.

Espinosa, Camilo A / Khan, Waqasuddin / Khanam, Rasheda / Das, Sayan / Khalid, Javairia / Pervin, Jesmin / Kasaro, Margaret P / Contrepois, Kévin / Chang, Alan L / Phongpreecha, Thanaphong / Michael, Basil / Ellenberger, Mathew / Mehmood, Usma / Hotwani, Aneeta / Nizar, Ambreen / Kabir, Furqan / Wong, Ronald J / Becker, Martin / Berson, Eloise /

Culos, Anthony / De Francesco, Davide / Mataraso, Samson / Ravindra, Neal / Thuraiappah, Melan / Xenochristou, Maria / Stelzer, Ina A / Marić, Ivana / Dutta, Arup / Raqib, Rubhana / Ahmed, Salahuddin / Rahman, Sayedur / Hasan, A S M Tarik / Ali, Said M / Juma, Mohamed H / Rahman, Monjur / Aktar, Shaki / Deb, Saikat / Price, Joan T / Wise, Paul H / Winn, Virginia D / Druzin, Maurice L / Gibbs, Ronald S / Darmstadt, Gary L / Murray, Jeffrey C / Stringer, Jeffrey S A / Gaudilliere, Brice / Snyder, Michael P / Angst, Martin S / Rahman, Anisur / Baqui, Abdullah H / Jehan, Fyezah / Nisar, Muhammad Imran / Vwalika, Bellington / Sazawal, Sunil / Shaw, Gary M / Stevenson, David K / Aghaeepour, Nima

Science advances

2023 Volume 9, Issue 21, Page(s) eade7692

Abstract: Preterm birth (PTB) is the leading cause of death in children under five, yet comprehensive studies are hindered by its multiple complex etiologies. Epidemiological associations between PTB and maternal characteristics have been previously described. ... ...

Abstract	Preterm birth (PTB) is the leading cause of death in children under five, yet comprehensive studies are hindered by its multiple complex etiologies. Epidemiological associations between PTB and maternal characteristics have been previously described. This work used multiomic profiling and multivariate modeling to investigate the biological signatures of these characteristics. Maternal covariates were collected during pregnancy from 13,841 pregnant women across five sites. Plasma samples from 231 participants were analyzed to generate proteomic, metabolomic, and lipidomic datasets. Machine learning models showed robust performance for the prediction of PTB (AUROC = 0.70), time-to-delivery (
MeSH term(s)	Infant, Newborn ; Pregnancy ; Child ; Humans ; Female ; Premature Birth/epidemiology ; Developing Countries ; Multiomics ; Proteomics ; Chemokines, CC
Chemical Substances	Chemokines, CC
Language	English
Publishing date	2023-05-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.ade7692
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Article ; Online: Circadian and Sex Differences After Acute High-Altitude Exposure: Are Early Acclimation Responses Improved by Blue Light?

Silva-Urra, Juan A / Núñez-Espinosa, Cristian A / Niño-Mendez, Oscar A / Gaitán-Peñas, Héctor / Altavilla, Cesare / Toro-Salinas, Andrés / Torrella, Joan R / Pagès, Teresa / Javierre, Casimiro F / Behn, Claus / Viscor, Ginés

Wilderness & environmental medicine

2015 Volume 26, Issue 4, Page(s) 459–471

Abstract: Objective: The possible effects of blue light during acute hypoxia and the circadian rhythm on several physiological and cognitive parameters were studied.: Methods: Fifty-seven volunteers were randomly assigned to 2 groups: nocturnal (2200-0230 ... ...

Abstract	Objective: The possible effects of blue light during acute hypoxia and the circadian rhythm on several physiological and cognitive parameters were studied. Methods: Fifty-seven volunteers were randomly assigned to 2 groups: nocturnal (2200-0230 hours) or diurnal (0900-1330 hours) and exposed to acute hypoxia (4000 m simulated altitude) in a hypobaric chamber. The participants were illuminated by blue LEDs or common artificial light on 2 different days. During each session, arterial oxygen saturation (Spo2), blood pressure, heart rate variability, and cognitive parameters were measured at sea level, after reaching the simulated altitude of 4000 m, and after 3 hours at this altitude. Results: The circadian rhythm caused significant differences in blood pressure and heart rate variability. A 4% to 9% decrease in waking nocturnal Spo2 under acute hypoxia was observed. Acute hypoxia also induced a significant reduction (4%-8%) in systolic pressure, slightly more marked (up to 13%) under blue lighting. Women had significantly increased systolic (4%) and diastolic (12%) pressures under acute hypoxia at night compared with daytime pressure; this was not observed in men. Some tendencies toward better cognitive performance (d2 attention test) were seen under blue illumination, although when considered together with physiological parameters and reaction time, there was no conclusive favorable effect of blue light on cognitive fatigue suppression after 3 hours of acute hypobaric hypoxia. Conclusions: It remains to be seen whether longer exposure to blue light under hypobaric hypoxic conditions would induce favorable effects against fatigue.
MeSH term(s)	Acclimatization/physiology ; Adult ; Altitude ; Altitude Sickness/physiopathology ; Altitude Sickness/psychology ; Attention/physiology ; Circadian Rhythm/physiology ; Female ; Heart Rate/physiology ; Humans ; Hypoxia/physiopathology ; Light ; Male
Language	English
Publishing date	2015-12
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1238909-2
ISSN	1545-1534 ; 1080-6032
ISSN (online)	1545-1534
ISSN	1080-6032
DOI	10.1016/j.wem.2015.06.009
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