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Article ; Online: The untold story of cyanoacrylate adhesive closure: Addressing the challenges of reporting and analyzing adverse events in medical device studies.

Esponda, Omar L

2024 , Page(s) 2683555241239555

Language	English
Publishing date	2024-03-25
Publishing country	England
Document type	Letter
ZDB-ID	645172-x
ISSN	1758-1125 ; 0268-3555
ISSN (online)	1758-1125
ISSN	0268-3555
DOI	10.1177/02683555241239555
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Zs.A 2538: Show issues

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Article ; Online: A Call to Leadership: New VTE Treatment and Prevention Guidelines.

Esponda, Omar L / Tafur, Alfonso J

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

2024 Volume 30, Page(s) 10760296241243079

MeSH term(s)	Humans ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/prevention & control ; Leadership ; Anticoagulants/therapeutic use ; Guideline Adherence
Chemical Substances	Anticoagulants
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Editorial
ZDB-ID	1237357-6
ISSN	1938-2723 ; 1076-0296
ISSN (online)	1938-2723
ISSN	1076-0296
DOI	10.1177/10760296241243079
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Zs.A 4370: Show issues

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Article ; Online: SVM Communications: Venous Taskforce update and Society announcements.

Ahsan, Syed T / Esponda, Omar / Li, Wenzhu / Amini, Reza / Shaydakov, Maxim / Wheeler, Jason / Fukaya, Eri

Vascular medicine (London, England)

2023 Volume 28, Issue 5, Page(s) 493–495

MeSH term(s)	Humans ; Support Vector Machine ; Veins/diagnostic imaging
Language	English
Publishing date	2023-09-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1311628-9
ISSN	1477-0377 ; 1358-863X
ISSN (online)	1477-0377
ISSN	1358-863X
DOI	10.1177/1358863X231195630
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Zs.A 4409: Show issues

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Article ; Online: Platelet biology of the rapidly failing lung.

Washington, A Valance / Esponda, Omar / Gibson, Angelia

British journal of haematology

2019 Volume 188, Issue 5, Page(s) 641–651

Abstract: Acute respiratory distress syndrome (ARDS) is characterized by a rapid-onset respiratory failure with a mortality rate of approximately 40%. This physiologic inflammatory process is mediated by disruption of the alveolar-vascular interface, leading to ... ...

Abstract	Acute respiratory distress syndrome (ARDS) is characterized by a rapid-onset respiratory failure with a mortality rate of approximately 40%. This physiologic inflammatory process is mediated by disruption of the alveolar-vascular interface, leading to pulmonary oedema and impaired oxygen exchange, which often warrants mechanical ventilation to increase survival in the acute setting. One of the least understood aspects of ARDS is the role of the platelets in this process. Platelets, which protect vascular integrity, play a pivotal role in the progression and resolution of ARDS. The recent substantiation of the age-old theory that megakaryocytes are found in the lungs has rejuvenated interest in and raised new questions about the importance of platelets for pulmonary function. In addition to primary haemostasis, platelets provide a myriad of inflammatory functions that are poised to aid the innate immune system. This review focuses on the evidence for regulatory roles of platelets in pulmonary inflammation, with an emphasis on two receptors, CLEC-2 and TLT-1. Studies of these receptors identify novel pathways through which platelets may regulate vascular integrity and inflammation in the lungs, thereby influencing the development of ARDS.
MeSH term(s)	Animals ; Blood Platelets/metabolism ; Blood Platelets/pathology ; Humans ; Inflammation/metabolism ; Inflammation/pathology ; Lectins, C-Type/metabolism ; Lung/metabolism ; Lung/pathology ; Megakaryocytes/metabolism ; Megakaryocytes/pathology ; Membrane Glycoproteins/metabolism ; Receptors, Immunologic/metabolism ; Respiratory Distress Syndrome, Adult/metabolism ; Signal Transduction
Chemical Substances	CLEC2B protein, human ; Lectins, C-Type ; Membrane Glycoproteins ; Receptors, Immunologic ; TREML1 protein, human
Language	English
Publishing date	2019-11-07
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.16315
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Uh III Zs.182: Show issues

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Article: Management of pulmonary embolism: state of the art treatment and emerging research.

Esponda, Omar / Tafur, Alfonso

Current treatment options in cardiovascular medicine

2013 Volume 15, Issue 2, Page(s) 137–152

Abstract: Opinion statement: Pulmonary embolism is one of the most important causes of morbidity and mortality in cardiovascular medicine and demands a circumscribed algorithmic treatment approach (Fig. 1). Anticoagulation should be triggered by a high clinical ... ...

Abstract	Opinion statement: Pulmonary embolism is one of the most important causes of morbidity and mortality in cardiovascular medicine and demands a circumscribed algorithmic treatment approach (Fig. 1). Anticoagulation should be triggered by a high clinical probability and continued based on urgent definitive imaging. Our assessment then continues with evaluation of the clinical severity of the pulmonary embolism to determine whether the patient will benefit from thrombolysis or not. We usually reserve this option for cases of massive pulmonary embolism (sustained hypotension, pulselessness, or persistent profound bradycardia) or patients with a low cardiopulmonary reserve and categorical signs of right ventricle failure. At this juncture, renal function, a diagnosis of active cancer, calculated bleeding risk, and estimated patient compliance will help us gravitate toward specific agent selection for subsequent anticoagulation management. While rivaroxaban is an attractive oral therapy option, it is not an appropriate choice for patients with significant renal disease; patients with cancer are better treated with low molecular weight heparin when possible. Warfarin anticoagulation continues to be a well-known, valid, and cost-effective treatment option. At the end of the primary treatment we assess each patient for the likelihood of thromboembolism recurrence, which will be highest among those patients with idiopathic events or those with cancer-associated thrombosis. We favor prolonged anticoagulation in these scenarios. In addition, we strongly advocate periodic scheduled follow up of patients on long-term anticoagulation for secondary prophylaxis to re-evaluate their bleeding and recurrence risk. We understand both of these extremes are in a dynamic balance, and likewise so should be the anticoagulation directives. As we learn more about recurrence and bleeding prediction, we foresee a personalized approach in which the anticoagulant agent for each patient will be narrowly chosen based on their specific performance.
Language	English
Publishing date	2013-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2057337-6
ISSN	1534-3189 ; 1092-8464
ISSN (online)	1534-3189
ISSN	1092-8464
DOI	10.1007/s11936-013-0229-6
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Zs.A 5529: Show issues

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Article ; Online: International Union of Angiology Position Statement on perioperative drug and hemostasis management in vascular surgery.

Troisi, Nicola / Baccellieri, Domenico / Biscetti, Federico / D'Oria, Mario / Esponda, Omar / Lainez Rube, Rocio / Lecuona, Nora / Oller Grau, Mar / Peinado Cebrian, Javier / Pandey, Sandeep R / Zlatanovic, Petar / Fareed, Jawed / Antignani, Pier L

International angiology : a journal of the International Union of Angiology

2022 Volume 41, Issue 5, Page(s) 420–432

Abstract: This position paper, written by members of International Union of Angiology (IUA) Youth Committee, shows an overview of coagulation system and laboratory tests, analysis of medical therapies (older and newer), medication discontinuation/restart ... ...

Abstract	This position paper, written by members of International Union of Angiology (IUA) Youth Committee, shows an overview of coagulation system and laboratory tests, analysis of medical therapies (older and newer), medication discontinuation/restart recommendations, bridging therapy recommendations, and an overview of hemostatic agents used in the operating room.
MeSH term(s)	Adolescent ; Humans ; Cardiology ; Hemostasis ; Hemostatics ; Vascular Surgical Procedures/adverse effects
Chemical Substances	Hemostatics
Language	English
Publishing date	2022-06-15
Publishing country	Italy
Document type	Journal Article ; Practice Guideline
ZDB-ID	604910-2
ISSN	1827-1839 ; 0392-9590
ISSN (online)	1827-1839
ISSN	0392-9590
DOI	10.23736/S0392-9590.22.04861-1
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Zs.A 1833: Show issues

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Article ; Online: Treatment of superficial venous incompetence.

Esponda, Omar / Sadek, Mikel / Kabnick, Lowell S

Seminars in vascular surgery

2015 Volume 28, Issue 1, Page(s) 29–38

Abstract: Superficial venous incompetence is a common lower limb vascular condition, with venous ulceration representing the most severe sequela of the disease. The treatment of superficial venous incompetence can aid in ulcer healing, and a variety of modalities ... ...

Abstract	Superficial venous incompetence is a common lower limb vascular condition, with venous ulceration representing the most severe sequela of the disease. The treatment of superficial venous incompetence can aid in ulcer healing, and a variety of modalities are available. Successful treatment requires attention to appropriate patient selection and procedural technique.
MeSH term(s)	Catheter Ablation/adverse effects ; Catheter Ablation/methods ; Endovascular Procedures/adverse effects ; Endovascular Procedures/methods ; Evidence-Based Medicine ; Female ; Humans ; Laser Therapy/adverse effects ; Laser Therapy/methods ; Lower Extremity/blood supply ; Male ; Prognosis ; Risk Assessment ; Sclerotherapy/adverse effects ; Sclerotherapy/methods ; Severity of Illness Index ; Varicose Ulcer/diagnosis ; Varicose Ulcer/therapy ; Vascular Surgical Procedures/methods ; Venous Insufficiency/diagnosis ; Venous Insufficiency/therapy ; Wound Healing/physiology
Language	English
Publishing date	2015-03
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Review
ZDB-ID	645131-7
ISSN	1558-4518 ; 0895-7967
ISSN (online)	1558-4518
ISSN	0895-7967
DOI	10.1053/j.semvascsurg.2015.05.001
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Zs.A 2503: Show issues

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Article ; Online: Daily Step Counts in Participants With and Without Peripheral Artery Disease.

Gardner, Andrew W / Montgomery, Polly S / Wang, Ming / Shen, Biyi / Casanegra, Ana I / Silva-Palacios, Federico / Zhang, Shangming / Pomilla, William A / Esponda, Omar L / Kuroki, Marcos

Journal of cardiopulmonary rehabilitation and prevention

2020 Volume 41, Issue 3, Page(s) 182–187

Abstract: Purpose: We compared the prevalence of participants with and without symptomatic peripheral artery disease (PAD) who met the goals of attaining >7000 and 10 000 steps/d, and we determined whether PAD status was significantly associated with meeting the ... ...

Abstract	Purpose: We compared the prevalence of participants with and without symptomatic peripheral artery disease (PAD) who met the goals of attaining >7000 and 10 000 steps/d, and we determined whether PAD status was significantly associated with meeting the daily step count goals before and after adjusting for demographic variables, comorbid conditions, and cardiovascular risk factors. Methods: Participants with PAD (n = 396) and without PAD (n = 396) were assessed on their walking for 7 consecutive days with a step activity monitor. Results: The PAD group took significantly fewer steps/d than the non-PAD control group (6722 ± 3393 vs. 9475 ± 4110 steps/d; P < .001). Only 37.6% and 15.7% of the PAD group attained the goals of walking >7000 and 10 000 steps/d, respectively, whereas 67.9% and 37.4% of the control group attained these goals (P < .001 for each goal). Having PAD was associated with a 62% lower chance of attaining 7000 steps/d than compared with the control group (OR = 0.383; 95% CI, 0.259-0.565; P < .001), and a 55% lower chance of attaining 10 000 steps/d (OR = 0.449; 95% CI, 0.282-0.709; P < .001). Significant covariates (P < .01) included age, current smoking, diabetes, and body mass index. Conclusions: Participants with symptomatic PAD had a 29% lower daily step count compared with age- and sex-matched controls, and were less likely to attain the 7000 and 10 000 steps/d goals. Additionally, participants who were least likely to meet the 7000 and 10 000 daily step count recommendations included those who were older, currently smoked, had diabetes, and had higher body mass index.
MeSH term(s)	Body Mass Index ; Humans ; Peripheral Arterial Disease/complications ; Peripheral Arterial Disease/epidemiology ; Prevalence ; Walking
Language	English
Publishing date	2020-11-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2272063-7
ISSN	1932-751X ; 1932-7501
ISSN (online)	1932-751X
ISSN	1932-7501
DOI	10.1097/HCR.0000000000000554
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Zs.A 1998: Show issues

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Article ; Online: Levels of soluble TREM-like transcript 1 in patients presenting to the emergency department with chest pain.

Esponda, Omar L / Hunter, Robert / Del Río, José R Rivera / Washington, A Valance

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

2014 Volume 21, Issue 1, Page(s) 30–34

Abstract: Objective: Recent studies suggest that the soluble triggering receptor expressed on myeloid cells-like transcript 1 (sTLT-1) facilitate atherothrombosis. Therefore, we evaluated sTLT-1 as a functional measure of atherothrombosis in acute coronary ... ...

Abstract	Objective: Recent studies suggest that the soluble triggering receptor expressed on myeloid cells-like transcript 1 (sTLT-1) facilitate atherothrombosis. Therefore, we evaluated sTLT-1 as a functional measure of atherothrombosis in acute coronary syndrome (ACS). Methods: Levels of sTLT-1 were determined by enzyme-linked immunosorbent assay on plasma from patients with potential ACS and compared with an age-matched control group with similar risk factors for cardiovascular disease. Results: Of 53 patients enrolled, 19 patients were undergoing ACS (15 unstable angina, 2 non-ST-segment elevated myocardial infarction, and 2 ST-segment elevated myocardial infarction), 5 patients were found with noncardiac chest pain, and 29 were in the control group. The mean plasma sTLT-1 values in the ACS group were 4.644 ng/mL ± 1.277 standard error of the mean (SEM), in the noncardiac chest pain group were 0.708 ng/mL ± 0.427 SEM, and in the control group were 1.007 ng/mL ± 0.098 SEM. Conclusion: A statistically significant difference exists between patients experiencing cardiogenic chest pain versus controls (P < .05), suggesting sTLT-1 as a potential tool for understanding atherothrombosis in ACS.
MeSH term(s)	Acute Coronary Syndrome/blood ; Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/etiology ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Blood Platelets/physiology ; Case-Control Studies ; Chest Pain/blood ; Chest Pain/etiology ; Coronary Artery Disease/blood ; Coronary Artery Disease/complications ; Emergency Service, Hospital ; Female ; Humans ; Inflammation Mediators/blood ; Male ; Middle Aged ; Receptors, Immunologic/blood ; Risk Factors ; Solubility
Chemical Substances	Biomarkers ; Inflammation Mediators ; Receptors, Immunologic ; TREML1 protein, human
Language	English
Publishing date	2014-08-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1237357-6
ISSN	1938-2723 ; 1076-0296
ISSN (online)	1938-2723
ISSN	1076-0296
DOI	10.1177/1076029614547298
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Zs.A 4370: Show issues

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Article: Clinical studies support a role for trem-like transcript-1 during the progression of sepsis.

Esponda, Omar / Morales, Jessica / Aguilar, Alexandra / Gomez, Michael / Washington, A Valance

Boletin de la Asociacion Medica de Puerto Rico

2013 Volume 102, Issue 3, Page(s) 59–61

Abstract: Sepsis is a multi-factorial disease that kills an estimated 1,400 people a day worldwide. The Triggering Receptor Expressed in Myeloid (TREM) cells Like Transcript (TLT)-1 is a platelet receptor expressed on activated platelets. Translational studies of ... ...

Abstract	Sepsis is a multi-factorial disease that kills an estimated 1,400 people a day worldwide. The Triggering Receptor Expressed in Myeloid (TREM) cells Like Transcript (TLT)-1 is a platelet receptor expressed on activated platelets. Translational studies of TLT-1 suggest that TLT-1 affects hemostatic and immunological parameters that lead to the formation of disseminated intravascular coagulation (DIC). Evaluation of mice suffering from endotoxic shock shows a dramatic increase of soluble TLT-1 (sTLT-1) in their blood. Accordingly, when we evaluated the blood of septic patients we find increased levels of sTLT-1 that correlate with the presence of DIC in humans. Based on current data we hypothesize that TLT-1 plays an important role in maintaining vascular integrity during sepsis; perhaps by modulation of both the immune and hemostatic systems, and that TLT-1 makes an attractive target not only for better understanding of sepsis, but also as a point of therapeutic intervention as well.
MeSH term(s)	Animals ; Disease Progression ; Mice ; Receptors, Immunologic/physiology ; Sepsis/etiology
Chemical Substances	Receptors, Immunologic ; Treml1 protein, mouse
Language	English
Publishing date	2013-07-23
Publishing country	Puerto Rico
Document type	Journal Article ; Review
ZDB-ID	730428-6
ISSN	0004-4849
ISSN	0004-4849
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