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  1. Article ; Online: Cell type specific long non-coding RNA targets identified by integrative analysis of single-cell and bulk colorectal cancer transcriptomes.

    Mihaljevic, Ante / Rubin, Philip D / Chouvardas, Panagiotis / Esposito, Roberta

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 10939

    Abstract: Long non-coding RNAs (lncRNAs) represent an emerging class of genes which play significant and diverse roles in human cancers. Nevertheless, the functional repertoires of lncRNAs in cancer cell subtypes remains unknown since most studies are focused on ... ...

    Abstract Long non-coding RNAs (lncRNAs) represent an emerging class of genes which play significant and diverse roles in human cancers. Nevertheless, the functional repertoires of lncRNAs in cancer cell subtypes remains unknown since most studies are focused on protein coding genes. Here, we explored the contribution of lncRNAs in Colorectal Cancer (CRC) heterogeneity. We analyzed 49'436 single-cells from 29 CRC patients and showed that lncRNAs are significantly more cell type specific compared to protein-coding genes. We identified 996 lncRNAs strongly enriched in epithelial cells. Among these, 98 were found to be differentially expressed in tumor samples compared to normal controls, when integrating 270 bulk CRC profiles. We validated the upregulation of two of them (CASC19 and LINC00460) in CRC cell lines and showed their involvement in CRC proliferation by CRISPR-Cas9 knock down experiments. This study highlights a list of novel RNA targets for potential CRC therapeutics, substantiated through experimental validation.
    MeSH term(s) Humans ; RNA, Long Noncoding/genetics ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Gene Expression Regulation, Neoplastic ; Transcriptome ; Single-Cell Analysis/methods ; Cell Line, Tumor ; Gene Expression Profiling ; Cell Proliferation/genetics
    Chemical Substances RNA, Long Noncoding
    Language English
    Publishing date 2024-05-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-61430-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Bioactive Molecules from Marine Diatoms and Their Value for the Nutraceutical Industry.

    Nieri, Paola / Carpi, Sara / Esposito, Roberta / Costantini, Maria / Zupo, Valerio

    Nutrients

    2023  Volume 15, Issue 2

    Abstract: The search for novel sources of nutrients is among the basic goals for achievement of sustainable progress. In this context, microalgae are relevant organisms, being rich in high-value compounds and able to grow in open ponds or photobioreactors, thus ... ...

    Abstract The search for novel sources of nutrients is among the basic goals for achievement of sustainable progress. In this context, microalgae are relevant organisms, being rich in high-value compounds and able to grow in open ponds or photobioreactors, thus enabling profitable exploitation of aquatic resources. Microalgae, a huge taxon containing photosynthetic microorganisms living in freshwater, as well as in brackish and marine waters, typically unicellular and eukaryotic, include green algae (
    MeSH term(s) Humans ; Diatoms ; Chlorophyta ; Dietary Supplements ; Phaeophyceae ; Microalgae
    Language English
    Publishing date 2023-01-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15020464
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Preliminary Results of a Double-Blind Randomized Controlled Trial Evaluating the Cardiometabolic Effects of Levothyroxine and Liothyronine Compared to Levothyroxine with Placebo in Athyreotic Low-Risk Thyroid Cancer Patients.

    Biondi, Bernadette / Pucci, Martina / Pontieri, Gilda / Formisano, Pietro / Esposito, Roberta

    Thyroid : official journal of the American Thyroid Association

    2023  Volume 33, Issue 12, Page(s) 1402–1413

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Hypothyroidism/drug therapy ; Thyroid Neoplasms/epidemiology ; Thyroxine/pharmacology ; Triiodothyronine/pharmacology ; Cardiometabolic Risk Factors
    Chemical Substances Thyroxine (Q51BO43MG4) ; Triiodothyronine (06LU7C9H1V)
    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1086044-7
    ISSN 1557-9077 ; 1050-7256
    ISSN (online) 1557-9077
    ISSN 1050-7256
    DOI 10.1089/thy.2023.0135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3307: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 106: Show issues

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  4. Article ; Online: Metataxonomic Analysis of Bacterial Diversity Associated with Marine Organisms.

    Ruocco, Nadia / Esposito, Roberta / Zupo, Valerio / Costantini, Maria

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2498, Page(s) 253–264

    Abstract: In the present era marine biotechnologies are dominating the world of scientific research assisted by great advances in molecular biology techniques, and microbial community analysis provides useful tool to investigate their diversity and their potential ...

    Abstract In the present era marine biotechnologies are dominating the world of scientific research assisted by great advances in molecular biology techniques, and microbial community analysis provides useful tool to investigate their diversity and their potential for biotechnological applications. In fact, several marine organisms harbor diverse microbial associated communities, which play key roles for their host functioning and are rich sources of bioactive natural compounds. Here, we describe the fundamental steps of metataxonomic analysis of microbial communities associated with marine organisms.
    MeSH term(s) Aquatic Organisms/genetics ; Bacteria/genetics ; Biotechnology/methods
    Language English
    Publishing date 2022-06-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2313-8_12
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: De Novo

    Costantini, Maria / Esposito, Roberta / Ruocco, Nadia / Caramiello, Davide / Cordella, Angela / Ventola, Giovanna Maria / Zupo, Valerio

    International journal of molecular sciences

    2024  Volume 25, Issue 3

    Abstract: The Mediterranean purple sea ... ...

    Abstract The Mediterranean purple sea urchin
    MeSH term(s) Humans ; Animals ; Paracentrotus/genetics ; Paracentrotus/metabolism ; Immunity, Innate ; Evolution, Molecular
    Language English
    Publishing date 2024-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25031685
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Marine Demospongiae: A Challenging Treasure of Bioactive Compounds.

    Esposito, Roberta / Federico, Serena / Bertolino, Marco / Zupo, Valerio / Costantini, Maria

    Marine drugs

    2022  Volume 20, Issue 4

    Abstract: In the last decades, it has been demonstrated that marine organisms are a substantial source of bioactive compounds with possible biotechnological applications. Marine sponges, in particular those belonging to the class of Demospongiae, have been ... ...

    Abstract In the last decades, it has been demonstrated that marine organisms are a substantial source of bioactive compounds with possible biotechnological applications. Marine sponges, in particular those belonging to the class of Demospongiae, have been considered among the most interesting invertebrates for their biotechnological potential. In this review, particular attention is devoted to natural compounds/extracts isolated from Demospongiae and their associated microorganisms with important biological activities for pharmacological applications such as antiviral, anticancer, antifouling, antimicrobial, antiplasmodial, antifungal and antioxidant. The data here presented show that this class of sponges is an exciting source of compounds, which are worth developing into new drugs, such as avarol, a hydroquinone isolated from the marine sponge
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents/pharmacology ; Aquatic Organisms ; Biological Products/pharmacology ; Biotechnology ; Porifera/microbiology
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; Biological Products
    Language English
    Publishing date 2022-03-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md20040244
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Fulminant myocarditis in the time of coronavirus.

    Cuomo, Vittoria / Esposito, Roberta / Santoro, Ciro

    European heart journal

    2020  Volume 41, Issue 22, Page(s) 2121

    MeSH term(s) Coronavirus ; Electrocardiography ; Glucocorticoids ; Humans ; Immunoglobulins ; Myocarditis
    Chemical Substances Glucocorticoids ; Immunoglobulins
    Keywords covid19
    Language English
    Publishing date 2020-05-04
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehaa354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 640: Show issues

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  8. Article ; Online: Genome Mining as New Challenge in Natural Products Discovery.

    Albarano, Luisa / Esposito, Roberta / Ruocco, Nadia / Costantini, Maria

    Marine drugs

    2020  Volume 18, Issue 4

    Abstract: Drug discovery is based on bioactivity screening of natural sources, traditionally represented by bacteria fungi and plants. Bioactive natural products and their secondary metabolites have represented the main source for new therapeutic agents, used as ... ...

    Abstract Drug discovery is based on bioactivity screening of natural sources, traditionally represented by bacteria fungi and plants. Bioactive natural products and their secondary metabolites have represented the main source for new therapeutic agents, used as drug leads for new antibiotics and anticancer agents. After the discovery of the first biosynthetic genes in the last decades, the researchers had in their hands the tool to understand the biosynthetic logic and genetic basis leading to the production of these compounds. Furthermore, in the genomic era, in which the number of available genomes is increasing, genome mining joined to synthetic biology are offering a significant help in drug discovery. In the present review we discuss the importance of genome mining and synthetic biology approaches to identify new natural products, also underlining considering the possible advantages and disadvantages of this technique. Moreover, we debate the associated techniques that can be applied following to genome mining for validation of data. Finally, we review on the literature describing all novel natural drugs isolated from bacteria, fungi, and other living organisms, not only from the marine environment, by a genome-mining approach, focusing on the literature available in the last ten years.
    MeSH term(s) Animals ; Biological Products ; Computational Biology ; Drug Discovery/methods ; Gene Expression ; Genomics/methods ; Humans ; Molecular Biology ; Synthetic Biology
    Chemical Substances Biological Products
    Language English
    Publishing date 2020-04-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md18040199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Bioactive Compounds from Marine Sponges and Algae: Effects on Cancer Cell Metabolome and Chemical Structures.

    Esposito, Roberta / Federico, Serena / Glaviano, Francesca / Somma, Emanuele / Zupo, Valerio / Costantini, Maria

    International journal of molecular sciences

    2022  Volume 23, Issue 18

    Abstract: Metabolomics represent the set of small organic molecules generally called metabolites, which are located within cells, tissues or organisms. This new "omic" technology, together with other similar technologies (genomics, transcriptomics and proteomics) ... ...

    Abstract Metabolomics represent the set of small organic molecules generally called metabolites, which are located within cells, tissues or organisms. This new "omic" technology, together with other similar technologies (genomics, transcriptomics and proteomics) is becoming a widely used tool in cancer research, aiming at the understanding of global biology systems in their physiologic or altered conditions. Cancer is among the most alarming human diseases and it causes a considerable number of deaths each year. Cancer research is one of the most important fields in life sciences. In fact, several scientific advances have been made in recent years, aiming to illuminate the metabolism of cancer cells, which is different from that of healthy cells, as suggested by Otto Warburg in the 1950s. Studies on sponges and algae revealed that these organisms are the main sources of the marine bioactive compounds involved in drug discovery for cancer treatment and prevention. In this review, we analyzed these two promising groups of marine organisms to focus on new metabolomics approaches for the study of metabolic changes in cancer cell lines treated with chemical extracts from sponges and algae, and for the classification of the chemical structures of bioactive compounds that may potentially prove useful for specific biotechnological applications.
    MeSH term(s) Animals ; Aquatic Organisms/chemistry ; Biotechnology ; Humans ; Metabolome ; Neoplasms/drug therapy ; Plant Extracts ; Porifera/chemistry
    Chemical Substances Plant Extracts
    Language English
    Publishing date 2022-09-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms231810680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: SARS-CoV-2 Lysate Stimulation Impairs the Release of Platelet-like Particles and Megakaryopoiesis in the MEG-01 Cell Line.

    Lopardo, Valentina / Montella, Francesco / Esposito, Roberta Maria / Zannella, Carla / Aliberti, Silvana Mirella / Capunzo, Mario / Franci, Gianluigi / Puca, Annibale Alessandro / Ciaglia, Elena

    International journal of molecular sciences

    2023  Volume 24, Issue 5

    Abstract: SARS-CoV-2 infection causes a considerable inflammatory response coupled with impaired platelet reactivity, which can lead to platelet disorders recognized as negative prognostic factors in COVID-19 patients. The virus may cause thrombocytopenia or ... ...

    Abstract SARS-CoV-2 infection causes a considerable inflammatory response coupled with impaired platelet reactivity, which can lead to platelet disorders recognized as negative prognostic factors in COVID-19 patients. The virus may cause thrombocytopenia or thrombocytosis during the different disease stages by destroying or activating platelets and influencing platelet production. While it is known that several viruses can impair megakaryopoiesis by generating an improper production and activation of platelets, the potential involvement of SARS-CoV-2 in affecting megakaryopoiesis is poorly understood. To this purpose, we explored, in vitro, the impact of SARS-CoV-2 stimulation in the MEG-01 cell line, a human megakaryoblastic leukemia cell line, considering its spontaneous capacity of releasing platelet-like particles (PLPs). We interrogated the effect of heat-inactivated SARS-CoV-2 lysate in the release of PLPs and activation from MEG-01, the signaling pathway influenced by SARS-CoV-2, and the functional effect on macrophagic skewing. The results highlight the potential influence of SARS-CoV-2 in the early stages of megakaryopoiesis by enhancing the production and activation of platelets, very likely due to the impairment of STATs signaling and AMPK activity. Overall, these findings provide new insight into the role of SARS-CoV-2 in affecting megakaryocyte-platelet compartment, possibly unlocking another avenue by which SARS-CoV-2 moves.
    MeSH term(s) Humans ; Blood Platelets/metabolism ; SARS-CoV-2 ; COVID-19/metabolism ; Megakaryocytes/metabolism ; Cell Line
    Language English
    Publishing date 2023-03-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24054723
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