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Article ; Online: The positioning of ceftobiprole in Staphylococcus aureus bacteremia.

Membrillo de Novales, Francisco Javier / Bravo de Pablo, Olga / Estella García, Ángel / Morata Ruiz, Laura / Oltra Sempere, Maria Rosa / Salavert Lleti, Miguel / Estébanez Muñoz, Miriam / Hidalgo-Tenorio, Carmen

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2024

Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciae123
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Article: The Impact of Antibiotic Prophylaxis on a Retrospective Cohort of Hospitalized Patients with COVID-19 Treated with a Combination of Steroids and Tocilizumab.

Membrillo de Novales, Francisco Javier / Ramírez-Olivencia, Germán / Mata Forte, Maj Tatiana / Zamora Cintas, María Isabel / Simón Sacristán, Maj María / Sánchez de Castro, María / Estébanez Muñoz, Miriam

Antibiotics (Basel, Switzerland)

2023 Volume 12, Issue 10

Abstract: Objectives: In the context of COVID-19, patients with a severe or critical illness may be more susceptible to developing secondary bacterial infections. This study aims to investigate the relationship between the use of prophylactic antibiotic therapy ... ...

Abstract	Objectives: In the context of COVID-19, patients with a severe or critical illness may be more susceptible to developing secondary bacterial infections. This study aims to investigate the relationship between the use of prophylactic antibiotic therapy and the occurrence of bacterial or fungal isolates following the administration of tocilizumab in hospitalized COVID-19 patients who had previously received steroids during the first and second waves of the pandemic in Spain. Methods: This retrospective observational study included 70 patients hospitalized with COVID-19 who received tocilizumab and steroids between January and December 2020. Data on demographics, comorbidities, laboratory tests, microbiologic results, treatment, and outcomes were collected from electronic health records. The patients were divided into two groups based on the use of antibiotic prophylaxis, and the incidence of bacterial and fungal colonizations/infections was analyzed. Results: Among the included patients, 45 patients received antibiotic prophylaxis. No significant clinical differences were observed between the patients based on prophylaxis use regarding the number of clinically diagnosed infections, ICU admissions, or mortality rates. However, the patients who received antibiotic prophylaxis showed a higher incidence of colonization by multidrug-resistant bacteria compared to that of the subgroup that did not receive prophylaxis. The most commonly isolated microorganisms were
Language	English
Publishing date	2023-10-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12101515
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Article ; Online: Treatment and prevention of monkeypox.

de la Calle-Prieto, Fernando / Estébanez Muñoz, Miriam / Ramírez, Germán / Díaz-Menéndez, Marta / Velasco, María / Azkune Galparsoro, Harkaitz / Salavert Lletí, Miguel / Mata Forte, Tatiana / Blanco, José Luis / Mora-Rillo, Marta / Arsuaga, Marta / de Miguel Buckley, Rosa / Arribas, Jose Ramón / Membrillo, Francisco Javier

Enfermedades infecciosas y microbiologia clinica (English ed.)

2023 Volume 41, Issue 10, Page(s) 629–634

Abstract: Monkeypox is a zoonosis that is spread mainly through direct contact with fluids and skin lesions of infected people with vesicles still active. Although the virus was isolated for the first time in 1958 and the first human case was identified in a child ...

Abstract	Monkeypox is a zoonosis that is spread mainly through direct contact with fluids and skin lesions of infected people with vesicles still active. Although the virus was isolated for the first time in 1958 and the first human case was identified in a child in 1970, in the Democratic Republic of the Congo, the disease has progressively increased its incidence in Africa reaching in May 2022 sustained transmission outside this continent. As it is a newly introduced virus in our health system, it is necessary to learn the epidemiological pattern in a different environment from that of traditionally endemic areas and to know the available antiviral treatments, as well as the prophylactic measures that could be considered, knowing that as a virus emerging in our regions, scientific evidence is still limited. There are antivirals that have been shown, in animal models, to effectively combat the disease with very good clinical tolerance. This disease has also forced us to review the characteristics of smallpox vaccines, because they have shown a protective effect against monkeypox. For this reason, it is important to have a document that compiles all the scientific information published in this regard.
MeSH term(s)	Child ; Animals ; Humans ; Mpox (monkeypox)/drug therapy ; Mpox (monkeypox)/epidemiology ; Mpox (monkeypox)/prevention & control ; Monkeypox virus ; Smallpox Vaccine/therapeutic use ; Africa ; Incidence
Chemical Substances	Smallpox Vaccine
Language	English
Publishing date	2023-01-07
Publishing country	Spain
Document type	Journal Article ; Review
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimce.2022.12.010
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Article ; Online: Tratamiento y prevención de la viruela del mono.

Enfermedades infecciosas y microbiologia clinica

2022

Title translation	Treatment and prevention of monkeypox.
Abstract	Monkeypox is a zoonosis that is spread mainly through direct contact with fluids and skin lesions of infected people with vesicles still active. Although the virus was isolated for the first time in 1958 and the first human case was identified in a child in 1970, in the Democratic Republic of the Congo, the disease has progressively increased its incidence in Africa reaching in May 2022 sustained transmission outside this continent. As it is a newly introduced virus in our health system, it is necessary to learn the epidemiological pattern in a different environment from that of traditionally endemic areas and to know the available antiviral treatments, as well as the prophylactic measures that could be considered, knowing that as a virus emerging in our regions, scientific evidence is still limited. There are antivirals that have been shown, in animal models, to effectively combat the disease with very good clinical tolerance. This disease has also forced us to review the characteristics of smallpox vaccines, because they have shown a protective effect against monkeypox. For this reason, it is important to have a document that compiles all the scientific information published in this regard.
Language	Spanish
Publishing date	2022-09-22
Publishing country	Spain
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1070941-1
ISSN	1578-1852 ; 0213-005X
ISSN (online)	1578-1852
ISSN	0213-005X
DOI	10.1016/j.eimc.2022.08.001
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Article ; Online: Infección por el virus de la inmunodeficiencia humana tipo 1 e inflamación persistente: ¿es la traslocación bacteriana la causa oculta?

Estébanez-Muñoz, Miriam / Stella, Natalia / Bernardino, Jose I

Medicina clinica

2012 Volume 138, Issue 15, Page(s) 673–677

Abstract: Currently, non-AIDS comorbidities (cardiovascular disease, non-AIDS-related cancers, liver disease, osteoporosis, etc.) have become an important cause of morbimortality in patients with human immunodeficiency virus type 1 (HIV-1) infection. The elevation ...

Title translation	HIV infection and chronic inflammation: is the bacterial translocation the underlying cause?.
Abstract	Currently, non-AIDS comorbidities (cardiovascular disease, non-AIDS-related cancers, liver disease, osteoporosis, etc.) have become an important cause of morbimortality in patients with human immunodeficiency virus type 1 (HIV-1) infection. The elevation of plasma markers of inflammation has been associated with the development of cardiovascular disease and death from all causes. Therefore, there is great interest in elucidating the underlying causes responsible for this persistent inflammatory status. The intestinal barrier disruption associated with HIV-1 infection may favor the passage of gut microbial products into the blood, resulting in immune stimulation. In this article we review the pathogenesis of bacterial translocation and its relevance to HIV-1 infection.
MeSH term(s)	Antiretroviral Therapy, Highly Active ; Bacterial Translocation/immunology ; Biomarkers/metabolism ; Chronic Disease ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV-1 ; Humans ; Inflammation/etiology ; Inflammation/immunology ; Inflammation/metabolism ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/pathology
Chemical Substances	Biomarkers
Language	Spanish
Publishing date	2012-05-26
Publishing country	Spain
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2011.11.010
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Article ; Online: Aspectos cardiológicos relevantes en la infección COVID-19

Martí Sánchez, David / Fernández Pascual, Concepción / Marschall, Alexander Felix / Delgado Calva, Freddy Andrés / Estébanez Muñoz, Miriam / Álvarez Antón, Salvador

2020

Abstract: Durante el mes de diciembre de 2019 se comunicaron en Wuhan, la capital de la provincia de Hubei, China, los primeros casos de neumonía asociada a la nueva variante de coronavirus 2 del síndrome respiratorio agudo grave (SARS-CoV-2). Durante el primer ... ...

Abstract	Durante el mes de diciembre de 2019 se comunicaron en Wuhan, la capital de la provincia de Hubei, China, los primeros casos de neumonía asociada a la nueva variante de coronavirus 2 del síndrome respiratorio agudo grave (SARS-CoV-2). Durante el primer trimestre de 2020, la enfermedad por coronavirus de 2019 (COVID-19) experimentó una rápida expansión global, poniendo a prueba los sistemas sanitarios y financieros de las principales potencias del mundo. Paralelamente, el extraordinario esfuerzo en investigación ha permitido ampliar el conocimiento de la enfermedad, y en concreto de la afectación de otros órganos y sistemas más allá del aparato respiratorio. En la presente revisión se enumeran los aspectos clínicos más importantes en el manejo de los pacientes con COVID-19 desde el punto de vista cardiológico, desde la afectación miocárdica, al manejo de procesos cardiológicos específicos. During December 2019, the first cases of pneumonia associated with the new variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were reported in Wuhan, the capital of Hubei province, China. During the first quarter of 2020, the 2019 coronavirus disease (COVID-19) underwent rapid global expansion, testing the health and financial systems of the world's leading powers. At the same time, the extraordinary research effort has allowed us to expand our knowledge of the disease, and specifically of the involvement of other organs and systems beyond the respiratory system. This review lists the most important clinical aspects in the management of patients with COVID-19 from the cardiological viewpoint, from myocardial injury to the management of specific cardiological procedures.
Keywords	COVID-19 ; Troponina ; Miocarditis ; Arritmia ; Troponin ; Myocarditis ; Arrhythmia ; Medicina ; Enfermería ; Fisioterapia ; Deportes ; Medicine ; Nursery ; Sports ; Physical therapy ; covid19
Language	Spanish
Publisher	Facultad de Medicina y Ciencias de la Salud, Universidad de Alcalá
Publishing country	es
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Motivos de consulta de pacientes con enfermedades autoinmunes sistémicas en el servicio de urgencias de un hospital terciario.

Rivera Núñez, María Angélica / Martínez Caballero, Carlos / Estébanez Muñoz, Miriam / Calvin García, María Elena / Robles M, Ángel / Quintana Díaz, Manuel

Revista medica de Chile

2015 Volume 143, Issue 12, Page(s) 1546–1551

Abstract: Background: The causes of acute decompensations of patients with systemic autoimmune diseases are not well known.: Aim: To describe the causes for consultation in an emergency room of patients with systemic autoimmune diseases.: Material and ... ...

Title translation	Causes for consultation in the emergency room among patients with systemic autoimmune diseases.
Abstract	Background: The causes of acute decompensations of patients with systemic autoimmune diseases are not well known. Aim: To describe the causes for consultation in an emergency room of patients with systemic autoimmune diseases. Material and methods: Review of medical records of patients with systemic autoimmune diseases, aged over 14 years, consulting in an emergency room of a general hospital during three months. Results: In the study period, 166 patients with systemic autoimmune diseases consulted in the emergency room, of a total of 18,153 consultations (0.9%). Patients with rheumatoid arthritis were those that consulted with higher frequency (37%) followed by patients with systemic lupus erythematosus (21%). The most common causes for consultation were cardiovascular diseases in 25%, followed by digestive disorders in 15%. The most common diagnosis was chest pain with suspected ischemic heart disease in 36%. No differences in cardiovascular risk factors were observed between those patients consulting for cardiovascular diseases and those consulting for other causes. Conclusions: The most common cause of consultation in the emergency room of patients with systemic autoimmune diseases is cardiovascular.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Autoimmune Diseases/classification ; Autoimmune Diseases/therapy ; Chile ; Emergency Service, Hospital/statistics & numerical data ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Tertiary Care Centers ; Young Adult
Language	Spanish
Publishing date	2015-12
Publishing country	Chile
Document type	Journal Article ; Observational Study
ZDB-ID	732136-3
ISSN	0717-6163 ; 0034-9887
ISSN (online)	0717-6163
ISSN	0034-9887
DOI	10.4067/S0034-98872015001200007
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Article ; Online: Updating our understanding of pulmonary disease associated with HIV infection.

Estébanez-Muñoz, Miriam / Soto-Abánades, Clara I / Ríos-Blanco, Juan J / Arribas, Jose R

Archivos de bronconeumologia

2012 Volume 48, Issue 4, Page(s) 126–132

Abstract: The introduction of highly active antiretroviral therapy (HAART) has resulted in a reduction of opportunistic infections associated with cellular and humoral immunosuppression. However, what is still unclear is the impact of HAART on the development of ... ...

Abstract	The introduction of highly active antiretroviral therapy (HAART) has resulted in a reduction of opportunistic infections associated with cellular and humoral immunosuppression. However, what is still unclear is the impact of HAART on the development of other diseases not associated with AIDS, such as lung cancer and COPD. The aim of this paper is to review the most innovative and relevant aspects of lung pathology in patients infected with HIV.
MeSH term(s)	AIDS-Related Opportunistic Infections/epidemiology ; AIDS-Related Opportunistic Infections/prevention & control ; Antiretroviral Therapy, Highly Active ; Comorbidity ; Female ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/epidemiology ; Influenza, Human/epidemiology ; Lung Diseases/epidemiology ; Lung Neoplasms/epidemiology ; Male ; Pneumococcal Vaccines ; Pneumocystis carinii ; Pneumonia, Pneumocystis/diagnosis ; Pneumonia, Pneumocystis/drug therapy ; Pneumonia, Pneumocystis/epidemiology ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/etiology ; Smoking/epidemiology ; Spain ; Substance Abuse, Intravenous/epidemiology ; Tuberculosis, Pulmonary/diagnosis ; Tuberculosis, Pulmonary/epidemiology
Chemical Substances	Pneumococcal Vaccines
Language	Spanish
Publishing date	2012-04
Publishing country	Spain
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	733126-5
ISSN	1579-2129 ; 0300-2896
ISSN (online)	1579-2129
ISSN	0300-2896
DOI	10.1016/j.arbres.2011.12.001
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Article ; Online: Absceso del músculo iliopsoas: tratamiento y evolución en una serie de 35 pacientes.

Fernández-Ruiz, Mario / Estébanez-Muñoz, Miriam / López-Medrano, Francisco / Aguado, José María

Enfermedades infecciosas y microbiologia clinica

2012 Volume 30, Issue 6, Page(s) 307–311

Abstract: Introduction: The present study was aimed at reviewing the iliopsoas abscess (IPA) from a contemporary perspective, on the basis of experience from two tertiary referral centres.: Material and methods: We performed a retrospective analysis of 35 ... ...

Title translation	Iliopsoas abscess: therapeutic approach and outcome in a series of 35 patients.
Abstract	Introduction: The present study was aimed at reviewing the iliopsoas abscess (IPA) from a contemporary perspective, on the basis of experience from two tertiary referral centres. Material and methods: We performed a retrospective analysis of 35 cases of IPA diagnosed between 1998 and 2009. Their clinical and microbiological features were recorded, as well as their long-term outcome according to the type of treatment: antibiotics alone (10 patients), or antibiotics plus percutaneous drainage or surgery (25 patients). Results: Primary abscess occurred in 8 patients. The most frequent source of secondary abscesses was spondylodiscitis. The classic clinical triad (fever, pain and functional impairment) was present in 10 patients, with a median duration of symptoms before diagnosis of 12 days. Staphylococcus aureus was the most frequently isolated microorganism. At the end of a median follow-up of 454 days, the risk of poor outcome (related death and/or relapse) was higher among patients with diabetes mellitus (44.4% vs. 7.7%; P=.027), with no significant differences according to the therapeutic approach (20.0% in the group of antibiotics alone vs. 28.0% in the group with drainage or surgery). Conclusions: In our series, most cases of IPA were due to S. aureus and secondary to a skeletal source. Antibiotic therapy seems effective in the long-term, although diabetic patients had a higher risk of relapse.
MeSH term(s)	Adult ; Aged ; Anti-Bacterial Agents/therapeutic use ; Combined Modality Therapy ; Comorbidity ; Diabetes Complications/drug therapy ; Diabetes Complications/epidemiology ; Diabetes Complications/microbiology ; Diabetes Complications/surgery ; Discitis/complications ; Discitis/microbiology ; Drainage ; Enterobacteriaceae Infections/drug therapy ; Enterobacteriaceae Infections/epidemiology ; Enterobacteriaceae Infections/surgery ; Female ; Hospitals, University/statistics & numerical data ; Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/epidemiology ; Male ; Middle Aged ; Prognosis ; Psoas Abscess/drug therapy ; Psoas Abscess/epidemiology ; Psoas Abscess/microbiology ; Psoas Abscess/surgery ; Psoas Abscess/therapy ; Recurrence ; Retrospective Studies ; Spain/epidemiology ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/epidemiology ; Staphylococcal Infections/surgery ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents
Language	Spanish
Publishing date	2012-06
Publishing country	Spain
Document type	English Abstract ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1070941-1
ISSN	1578-1852 ; 0213-005X
ISSN (online)	1578-1852
ISSN	0213-005X
DOI	10.1016/j.eimc.2011.09.016
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Article ; Online: Enfermedad desmielinizante en pacientes infectados por el virus de la inmunodeficiencia humana sin inmunodepresión severa.

Estébanez-Muñoz, Miriam / Montes, Maria Luisa / Ruiz-Seco, Pilar / Royo-Orejas, Aranzazu / González-García, Juan / Arribas, José Ramón

Enfermedades infecciosas y microbiologia clinica

2010 Volume 28, Issue 9, Page(s) 608–611

Abstract: Objective: Human immunodeficiency virus (HIV) infected patients who did not have severe immunodepression were analysed for multiple demyelinating lesions.: Methods: Patients with a CD4 greater than 200/μL were selected after a search was made in a ... ...

Title translation	Demyelinating disease in human immunodeficiency virus-infected patients without severe immunodepression.
Abstract	Objective: Human immunodeficiency virus (HIV) infected patients who did not have severe immunodepression were analysed for multiple demyelinating lesions. Methods: Patients with a CD4 greater than 200/μL were selected after a search was made in a computerised data base. Results: Four patients were found, three were co-infected with hepatitis C virus (HCV), with one of them on treatment with peg-interferón α-2b and ribavirin. Conclusion: HIV infected patients can develop demyelinating disease without having severe immunodepression, probably favoured by other factors, such as co-infection wIth HCV.
MeSH term(s)	Adult ; Cross-Sectional Studies ; Demyelinating Diseases/virology ; Female ; HIV Infections/complications ; Humans ; Male ; Retrospective Studies
Language	Spanish
Publishing date	2010-11
Publishing country	Spain
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	1070941-1
ISSN	1578-1852 ; 0213-005X
ISSN (online)	1578-1852
ISSN	0213-005X
DOI	10.1016/j.eimc.2009.12.007
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