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  1. Book ; Online ; E-Book: Feedback control for personalized medicine

    Hernandez-Vargas, Esteban A.

    2022  

    Author's details edited by Esteban A. Hernandez-Vargas
    Keywords Precision medicine
    Subject code 610.28
    Language English
    Size 1 online resource (309 pages)
    Publisher Academic Press
    Publishing place London, England
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-323-90665-6 ; 9780323901710 ; 978-0-323-90665-4 ; 0323901719
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Mathematical modeling, simulations, and AI for emergent pandemic diseases

    Hernandez-Vargas, Esteban A. / Velasco-Hernández, Jorge X.

    lessons learned from COVID-19

    2023  

    Author's details edited by Esteban A. Hernandez-Vargas, Jorge X. Velasco-Hernández
    Keywords Artificial intelligence/Medical applications ; COVID-19 (Disease)/Computer simulation ; COVID-19 (Disease)/Epidemiology/Mathematical models
    Subject code 610.285
    Language English
    Dates of publication 2023-2023
    Size 1 online resource (xvii, 331 pages) :, illustrations
    Publisher Academic Press
    Publishing place London, England
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-323-95065-5 ; 0-323-95064-7 ; 978-0-323-95065-7 ; 978-0-323-95064-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online ; E-Book: Modeling and control of infectious diseases in the host

    Hernandez-Vargas, Esteban A.

    with MATLAB and R

    2019  

    Author's details Esteban A. Hernandez-Vargas
    Keywords Communicable diseases/Mathematical models ; Numerical analysis/Computer programs ; R (Computer program language)
    Subject code 616.9015118
    Language English
    Size 1 Online-Ressource (xiii, 243 Seiten), Illustrationen
    Publisher Elsevier AP Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020030551
    ISBN 978-0-12-813111-4 ; 9780128130520 ; 0-12-813111-X ; 0128130520
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Carotid bodies in naked mole rats: Are the sensing mechanisms still there?

    Moya, Esteban A

    Acta physiologica (Oxford, England)

    2022  Volume 236, Issue 2, Page(s) e13880

    MeSH term(s) Animals ; Carotid Body ; Mole Rats
    Language English
    Publishing date 2022-09-09
    Publishing country England
    Document type Editorial
    ZDB-ID 2218636-0
    ISSN 1748-1716 ; 1748-1708
    ISSN (online) 1748-1716
    ISSN 1748-1708
    DOI 10.1111/apha.13880
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs 229: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: EPAS1/HIF-2α: a key regulator for chronic hypoxia across species.

    Moya, Esteban A

    The Journal of physiology

    2022  Volume 600, Issue 18, Page(s) 4053–4054

    MeSH term(s) Basic Helix-Loop-Helix Transcription Factors/genetics ; Humans ; Hypoxia
    Chemical Substances Basic Helix-Loop-Helix Transcription Factors
    Language English
    Publishing date 2022-08-21
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP283554
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.65: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Persistent transgene expression in peripheral tissues one year post intravenous and intramuscular administration of AAV vectors containing the alphaherpesvirus latency-associated promoter 2.

    Maturana, Carola J / Engel, Esteban A

    Frontiers in virology (Lausanne, Switzerland)

    2024  Volume 4

    Abstract: Significant progress has been made in enhancing recombinant adeno-associated virus (rAAV) for clinical investigation. Despite its versatility as a gene delivery platform, the inherent packaging constraint of 4.7 kb imposes restrictions on the range of ... ...

    Abstract Significant progress has been made in enhancing recombinant adeno-associated virus (rAAV) for clinical investigation. Despite its versatility as a gene delivery platform, the inherent packaging constraint of 4.7 kb imposes restrictions on the range of diseases it can address. In this context, we present findings of an exceptionally compact and long-term promoter that facilitates the expression of larger genes compared to conventional promoters. This compact promoter originated from the genome of the alphaherpesvirus pseudorabies virus, latency-associated promoter 2 (LAP2, 404 bp). Promoter driving an mCherry reporter was packaged into single strand (ss) AAV8 and AAV9 vectors and injected into adult C57BL/6 mice at a dose of 5 × 1011 vg/mouse by single intravenous or intramuscular administration. An ssAAV8 and ssAAV9 vector with elongation factor-1α promoter (EF1α, 1264 bp) was injected side-by-side for comparison. After 400 days, we sacrificed the mice and examined mCherry expression in liver, kidney, heart, lung, spleen, pancreas, skeletal muscle, and brain. We found that LAP2 exhibited robust transgene expression across a wide range of cells and tissues comparable to the larger EF1α, which is currently recognized as a rather potent and ubiquitous promoter. The AAV8-LAP2 and AAV9-LAP2 constructs displayed strong transduction and transcription in liver, kidney, and skeletal muscle on both route of administration. However, no expression was detected in the heart, lung, spleen, pancreas, and brain. The outcomes of our investigation propose the viability of LAP2 for gene therapy applications demanding the expression of large or multiple therapeutic genes following a single viralvector administration.
    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-818X
    ISSN (online) 2673-818X
    DOI 10.3389/fviro.2024.1379991
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Reply to

    Jesmond Dalli / Esteban A. Gomez

    Nature Communications, Vol 14, Iss 1, Pp 1-

    Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples

    2023  Volume 4

    Keywords Science ; Q
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Three dimensional analysis of the exhalation flow in the proximity of the mouth.

    Berlanga, F A / Gomez, P / Esteban, A / Liu, L / Nielsen, P V

    Heliyon

    2024  Volume 10, Issue 4, Page(s) e26283

    Abstract: The human exhalation flow is characterized in this work from the three-dimensional velocimetry results obtained by using the stereo particle image velocimetry (SPIV) measurement technique on the flow emitted from a realistic airway model. For this ... ...

    Abstract The human exhalation flow is characterized in this work from the three-dimensional velocimetry results obtained by using the stereo particle image velocimetry (SPIV) measurement technique on the flow emitted from a realistic airway model. For this purpose, the transient exhalation flow through the mouth of a person performing two different breaths corresponding to two metabolic rates, standing relaxed (SR) and walking active (WA), is emulated and studied. To reproduce the flow realistically, a detailed three-dimensional model obtained from computed tomography measurements on real subjects is used. To cope with the variability of the experimental data, a subsequent analysis of the results is performed using the TR-PIV (time resolved particle image velocimetry) technique. Exhalation produces a transient jet that becomes a puff when flow emission ends. Three-dimensional vector fields of the jet velocity are obtained in five equally spaced transverse planes up to a distance of Image 1 from the mouth at equally spaced time instants Image 2 which will be referred to as phases (
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e26283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online: Integrative Computational Systems Biology Approaches in Immunology and Medicine

    Kaderali, Lars / Theis, Fabian / Hernandez-Vargas, Esteban A. / Ganusov, Vitaly V. / Ciupe, Stanca M. / Mehr, Ramit / Ribeiro, Ruy

    2019  

    Keywords Science: general issues ; Medical microbiology & virology ; Microbiology (non-medical) ; mathematical modeling ; multiscale modeling ; systems biolgoy ; immunology ; infections
    Size 1 electronic resource (290 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021229854
    ISBN 9782889458011 ; 2889458016
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  10. Article: Membrane-protected molecularly imprinted polymers: Towards selectivity improvement of liquid-phase microextraction

    Martín-Esteban, A.

    Trends in analytical chemistry. 2021 May, v. 138

    2021  

    Abstract: Sample preparation is still considered the bottle-neck of the whole analytical process. Nowadays, several sample preparation techniques are available, however all of them suffer from lack of the selectivity. At this regard, molecularly imprinted polymers ...

    Abstract Sample preparation is still considered the bottle-neck of the whole analytical process. Nowadays, several sample preparation techniques are available, however all of them suffer from lack of the selectivity. At this regard, molecularly imprinted polymers (MIPs) are considered excellent materials able to perform selective extractions. Recently, new objectives in sample preparation have been set, including to use smaller initial sample sizes; to facilitate automation; and, to minimize the amount of glassware and organic solvents needed. MIP incorporation to other microextraction techniques offers a new strategy in order to fulfil current sample preparation requirements. However, even using MIPs, the complexity of the sample can affect recoveries of target analytes, negatively affecting the analytical method precision and accuracy. The use of a porous membrane, as a protective sleeve, is one of the simplest approaches to circumvent the difficulties mentioned above in the analysis of complex and “dirty” samples. Accordingly, the present paper pretends to provide an overview of micro-extraction approaches developed during last years based on the use of membrane-protected MIPs and how such approaches have open new pathways in the development of liquid phase micro-extraction methods with improved analytical characteristics. Advantages, drawbacks and future expected trends are also critically assessed.
    Keywords automation ; chemical species ; liquid-phase microextraction ; molecular imprinting
    Language English
    Dates of publication 2021-05
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2014041-1
    ISSN 0165-9936
    ISSN 0165-9936
    DOI 10.1016/j.trac.2021.116236
    Database NAL-Catalogue (AGRICOLA)

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