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  1. Article ; Online: Improving Quality of Life and Reducing Behavioral Problems of People With Intellectual and Developmental Disabilities Through Deinstitutionalization.

    Navas, Patricia / Esteban, Laura / Arias, Victor / Verdugo, Miguel Ángel

    Psicothema

    2024  Volume 36, Issue 2, Page(s) 113–122

    Abstract: Antecedents: People with intellectual and developmental disability (IDD) with extensive support needs are more likely to live in segregated and highly institutionalized environments. The aim of this study was to analyze changes in functioning and ... ...

    Abstract Antecedents: People with intellectual and developmental disability (IDD) with extensive support needs are more likely to live in segregated and highly institutionalized environments. The aim of this study was to analyze changes in functioning and quality of life for people with IDD and extensive support needs after transitioning to ordinary homes in the community.
    Method: The sample included 54 adults with IDD and extensive support needs, who were assessed at three time points: before transition, six months later, and one year after transition. The Resident Choice Scale, San Martin Quality of Life Scale, Active Support Participation Measure, and the Behavior Problem section of the Inventory for Client and Agency Planning were administered. Partial least squares-structural equation modeling (PLS-SEM) and t-tests for repeated measures were carried out.
    Results: There were significant improvements in decision-making, participation and independence in daily activities and quality of life, as well as a reduction in the presence and intensity of behavioral problems.
    Conclusions: The benefits found in this study support transformation processes towards more inclusive services and professional practices that foster people's rights and feeling of belonging to the community.
    MeSH term(s) Humans ; Quality of Life ; Male ; Intellectual Disability/psychology ; Female ; Adult ; Developmental Disabilities/psychology ; Middle Aged ; Deinstitutionalization ; Problem Behavior/psychology ; Activities of Daily Living ; Young Adult ; Aged
    Language English
    Publishing date 2024-04-15
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2421645-8
    ISSN 1886-144X ; 1886-144X
    ISSN (online) 1886-144X
    ISSN 1886-144X
    DOI 10.7334/psicothema2023.303
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  2. Book ; Online: Synthesis of pulses from particle detectors with a Generative Adversarial Network (GAN)

    Regadío, Alberto / Esteban, Luis / Sánchez-Prieto, Sebastián

    2024  

    Abstract: To address the possible lack or total absence of pulses from particle detectors during the development of its associate electronics, we propose a model that can generate them without losing the features of the real ones. This model is based on artificial ...

    Abstract To address the possible lack or total absence of pulses from particle detectors during the development of its associate electronics, we propose a model that can generate them without losing the features of the real ones. This model is based on artificial neural networks, namely Generative Adversarial Networks (GAN). We describe the proposed network architecture, its training methodology and the approach to train the GAN with real pulses from a scintillator receiving radiation from sources of ${}^{137}$Cs and ${}^{22}$Na. The Generator was installed in a Xilinx's System-On-Chip (SoC). We show how the network is capable of generating pulses with the same shape as the real ones that even match the data distributions in the original pulse-height histogram data.
    Keywords Physics - Instrumentation and Detectors ; Computer Science - Machine Learning
    Publishing date 2024-01-10
    Publishing country us
    Document type Book ; Online
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  3. Article ; Online: Descemet membrane endothelial keratoplasty and corneal biomechanics.

    Hernández Esteban, L / Orduña Domingo, E

    Archivos de la Sociedad Espanola de Oftalmologia

    2020  Volume 95, Issue 9, Page(s) 429–438

    Abstract: Objective: To study the behaviour of the biomechanical properties of the cornea in DMEK (Descemet membrane endothelial keratoplasty).: Method: Prospective longitudinal observational study. 21 pre and post-DMEK eyes. 3-month follow-up with the dynamic ...

    Title translation Queratoplastia endotelial de la membrana de Descemet y biomecánica corneal.
    Abstract Objective: To study the behaviour of the biomechanical properties of the cornea in DMEK (Descemet membrane endothelial keratoplasty).
    Method: Prospective longitudinal observational study. 21 pre and post-DMEK eyes. 3-month follow-up with the dynamic Scheimpflug Analyzer (Corvis ST, Oculus; Wetzlar, Germany). The following parameters were measured: IOPnc: non-corrected intraocular pressure (IOP), IOPb: IOP corrected by biomechanics, maximum deflection amplitude (DefA), CCT: central corneal pachymetry, flattening speed 1 and 2, peak distance, HC deformation amplitude: deformation amplitude in maximum concavity, integrated inverse concave radius, DAR 1 and 2: deformation amplitude at 1mm and 2mm from the corneal apex, respectively. ARTh: Ambrosial pachymetric ratio, SP1: stiffness parameter, CBI: Corvis Biomechanical index and the maximum inverse radius. Pre-operative and post-operative measurements were performed with a 3-month follow-up and compared with a paired sample t-test.
    Results: There was a significant decrease in the IOPnc of 1.54±3mmHg (p<0.05), a significant increase in the post-surgical IOPb of 3.79±3.18mmHg (p<0.001), a significant pachymetric decrease of 164.4±91.35μm (p<0.001) after the intervention. All dynamic parameters of the Scheimpflug analyzer changed significantly after surgery (p<0.05), except the ARTh and IWC variables.
    Conclusions: Variables indicate a decrease in corneal strength post-DMEK, with an increase in IOPb, at least the first 3 months after surgery. This finding is especially relevant in the follow-up of patients with coexisting glaucoma.
    Language Spanish
    Publishing date 2020-06-20
    Publishing country Spain
    Document type Journal Article
    ISSN 2173-5794
    ISSN (online) 2173-5794
    DOI 10.1016/j.oftal.2020.03.024
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  4. Article ; Online: The association of lipid transfer protein VPS13A with endosomes is mediated by sorting nexin SNX5.

    Tornero-Écija, Alba / Zapata-Del-Baño, Antonia / Antón-Esteban, Laura / Vincent, Olivier / Escalante, Ricardo

    Life science alliance

    2023  Volume 6, Issue 6

    Abstract: Human VPS13 proteins are implicated in severe neurological diseases. These proteins play an important role in lipid transport at membrane contact sites between different organelles. Identification of adaptors that regulate the subcellular localization of ...

    Abstract Human VPS13 proteins are implicated in severe neurological diseases. These proteins play an important role in lipid transport at membrane contact sites between different organelles. Identification of adaptors that regulate the subcellular localization of these proteins at specific membrane contact sites is essential to understand their function and role in disease. We have identified the sorting nexin SNX5 as an interactor of VPS13A that mediates its association with endosomal subdomains. As for the yeast sorting nexin and Vps13 endosomal adaptor Ypt35, this association involves the VPS13 adaptor-binding (VAB) domain in VPS13A and a PxP motif in SNX5. Notably, this interaction is impaired by mutation of a conserved asparagine residue in the VAB domain, which is also required for Vps13-adaptor binding in yeast and is pathogenic in VPS13D. VPS13A fragments containing the VAB domain co-localize with SNX5, whereas the more C-terminal part of VPS13A directs its localization to the mitochondria. Overall, our results suggest that a fraction of VPS13A localizes to junctions between the endoplasmic reticulum, mitochondria, and SNX5-containing endosomes.
    MeSH term(s) Humans ; Sorting Nexins/genetics ; Sorting Nexins/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Vesicular Transport Proteins/genetics ; Vesicular Transport Proteins/metabolism ; Endosomes/metabolism ; Proteins/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism
    Chemical Substances lipid transfer protein ; Sorting Nexins ; Vesicular Transport Proteins ; SNX5 protein, human ; VPS13A protein, human ; VPS13D protein, human ; Proteins ; VPS13 protein, S cerevisiae ; Saccharomyces cerevisiae Proteins
    Language English
    Publishing date 2023-03-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2575-1077
    ISSN (online) 2575-1077
    DOI 10.26508/lsa.202201852
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  5. Article ; Online: Conocimientos sobre COVID-19 en población general adulta tras dos años de pandemia.

    Ceñera Fernández, Jennifer / González Esteban, Laura / Moure García, Camino / Cernuda Martínez, José Antonio

    Global health promotion

    2023  Volume 31, Issue 1, Page(s) 111–119

    Abstract: Objetivo: identificar el nivel de conocimientos sobre la COVID-19 que tiene la población adulta residente en Gijón (España) después de dos años de pandemia.: Métodos: se realizó un estudio descriptivo transversal entre marzo del 2021 y marzo del 2022. ...

    Abstract Objetivo: identificar el nivel de conocimientos sobre la COVID-19 que tiene la población adulta residente en Gijón (España) después de dos años de pandemia.
    Métodos: se realizó un estudio descriptivo transversal entre marzo del 2021 y marzo del 2022. Los datos se obtuvieron mediante un cuestionario telefónico sobre una muestra estratificada de tres zonas básicas de salud de Gijón, España (Calzada, Zarracina y Parque-Somió). El tamaño muestral se compuso de 305 personas. Se empleó el análisis ji-cuadrado para estudiar la relación entre variables categóricas y ANOVA para comparar las medias de la puntuación total por zona básica. Se realizaron regresiones logísticas para calcular las
    Resultados: se encontraron diferencias en la puntuación media del nivel de conocimientos entre Parque-Somió y Calzada (
    Conclusiones: el nivel de conocimientos avanzado se presenta sobre todo en las zonas básicas de salud con mayor nivel socioeconómico, población con nivel educativo alto, de 25 a 45 años, que se ha informado por su entorno y con historia previa de seguimiento por ser contacto estrecho.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Retrospective Studies ; Alkalies ; Lactose/analogs & derivatives
    Chemical Substances basica ; Alkalies ; Lactose (J2B2A4N98G)
    Language English
    Publishing date 2023-11-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2502036-5
    ISSN 1757-9767 ; 1757-9759
    ISSN (online) 1757-9767
    ISSN 1757-9759
    DOI 10.1177/17579759231204352
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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: A community living experience: Views of people with intellectual disability with extensive support needs, families, and professionals.

    Esteban, Laura / Navas, Patricia / Verdugo, Miguel Ángel / Iriarte, Edurne García / Arias, Víctor B

    Research in developmental disabilities

    2023  Volume 137, Page(s) 104503

    Abstract: Background: Despite the benefits of community living for people with intellectual disabilities (ID) and extensive support needs, they remain highly institutionalized.: Aims: To qualitatively analyze the perceptions of people with ID, including those ... ...

    Abstract Background: Despite the benefits of community living for people with intellectual disabilities (ID) and extensive support needs, they remain highly institutionalized.
    Aims: To qualitatively analyze the perceptions of people with ID, including those with extensive support needs, professionals, and family members six months after the implementation of 11 community homes for 47 people in different regions of Spain METHODS: Thematic analysis of 77 individual interviews conducted with 13 people with ID, 30 professionals and 34 family members was performed using Nvivo12.
    Results: Seven themes were found: (1) "the room as I like it", (2) "sometimes I don't obey", (3) "here I do a bit of everything", (4) "lots of people love me here", (5) "all thanks to them, who have helped me" (6) "I miss my mom", and (7) "I'm happy here".
    Implications: Transitioning into the community has shown a clear positive change in emotional well-being, opportunities to participate in activities or exercise control over one's life. Nevertheless, certain restrictions were still present in people's lives, which significantly limit their right to independent living. While many of these restrictions may disappear, professional practices typical of a medical model can be recreated in services located in the community.
    MeSH term(s) Humans ; Intellectual Disability ; Family/psychology ; Spain
    Language English
    Publishing date 2023-04-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639175-8
    ISSN 1873-3379 ; 0891-4222
    ISSN (online) 1873-3379
    ISSN 0891-4222
    DOI 10.1016/j.ridd.2023.104503
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    Zs.B 2592: Show issues Location:
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  7. Article ; Online: A Clinical Role of PET-MRI in Prostate Cancer?

    Gammel, Michael C M / Solari, Esteban L / Eiber, Matthias / Rauscher, Isabel / Nekolla, Stephan G

    Seminars in nuclear medicine

    2023  Volume 54, Issue 1, Page(s) 132–140

    Abstract: PET/MRI is a relevant application field for prostate cancer management, offering advantages in early diagnosis, staging, and therapy planning. Despite drawbacks such as higher costs, longer acquisition time, and the need for skilled personnel, the ... ...

    Abstract PET/MRI is a relevant application field for prostate cancer management, offering advantages in early diagnosis, staging, and therapy planning. Despite drawbacks such as higher costs, longer acquisition time, and the need for skilled personnel, the technical integration of PET and MRI provides valuable information for detecting primary tumors, identifying metastases, and characterizing the disease, leading to more accurate staging and personalized treatment strategies. However, PET/MRI adoption has been slow, but ongoing technological advancements and AI integration might overcome challenges and improve clinical utility. As precision medicine gains importance in oncology, PET/MRI's multiparametric data can tailor treatment plans to individual patients, providing a comprehensive assessment of tumor biology and aggressiveness for more effective therapeutic strategies.
    MeSH term(s) Male ; Humans ; Neoplasm Staging ; Prostatic Neoplasms/pathology ; Positron-Emission Tomography ; Magnetic Resonance Imaging
    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 120248-0
    ISSN 1558-4623 ; 0001-2998
    ISSN (online) 1558-4623
    ISSN 0001-2998
    DOI 10.1053/j.semnuclmed.2023.08.001
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 763: Show issues Location:
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  8. Article ; Online: Three topologies of deep neural networks for pulse height extraction.

    Regadío, Alberto / García Tejedor, J Ignacio / Esteban, Luis / Sánchez-Prieto, Sebastián

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

    2023  Volume 204, Page(s) 111137

    Abstract: Pulse shaping is a common technique for optimizing signal-to-noise ratio (SNR) in particle detectors. Although analog or digital linear shapers are typically used for this purpose, there are nonlinear approaches, such as neural networks (NN), which have ... ...

    Abstract Pulse shaping is a common technique for optimizing signal-to-noise ratio (SNR) in particle detectors. Although analog or digital linear shapers are typically used for this purpose, there are nonlinear approaches, such as neural networks (NN), which have demonstrated their potential to outperform linear ones. Their nonlinear nature makes it possible to optimize the SNR of incoming pulses and extract diverse information, such as particle type and energy, with extremely short shaping time to avoid crowding. This paper shows three different NNs for shaping pulses: (a) convolutional NN (CNN); (b) recurrent NN (RNN); (c) self-attenuating NN. These NNs shape the pulses and return them unfolded avoiding stacking, and even estimate the height of the pulses when there has been saturation in the preamplifier. In this work we show the architectures of the NNs and their results using CR-RC pulses with Brownian and white noise, but they could be extrapolated to any shape and type of noise. The results obtained show that when the noise level is low and the frequency is low, all the topologies presented are a valid solution, but with white noise and high pulse arrival frequency, CNN is a better solution than the others. In the case of Brownian noise, the three topologies presented give similar results.
    Language English
    Publishing date 2023-11-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1142596-9
    ISSN 1872-9800 ; 0883-2889 ; 0969-8043
    ISSN (online) 1872-9800
    ISSN 0883-2889 ; 0969-8043
    DOI 10.1016/j.apradiso.2023.111137
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    Ue I Zs.279: Show issues Location:
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  9. Article ; Online: Fortalezas y debilidades del proceso de evaluación de tecnología sanitaria en distintos países de Europa y Latinoamérica

    Esteban, Lifschitz / Hugo Norberto, Catalano

    Revista Argentina de Salud Pública, Vol 12, Pp 1-

    2020  Volume 5

    Abstract: La Evaluación de Tecnologías Sanitarias (ETESA) es una herramienta técnica que intenta reducir la incertidumbre a la hora de tomar decisiones de cobertura en salud. Métodos: el presente trabajo es una revisión narrativa sobre el proceso de ETESA en un ... ...

    Abstract La Evaluación de Tecnologías Sanitarias (ETESA) es una herramienta técnica que intenta reducir la incertidumbre a la hora de tomar decisiones de cobertura en salud. Métodos: el presente trabajo es una revisión narrativa sobre el proceso de ETESA en un grupo de países de Europa y Latinoamérica a fin de realizar un análisis comparativo de una serie de variables que resultan relevantes para brindar solidez al proceso. Resultados: se encontraron similitudes y diferencias entre los países, tanto en el número de entidades participantes como en el foco de la decisión y hasta la dependencia del poder político. Discusión: los hallazgos han permitido identificar una serie de lecciones aprendidas que merecerían ser consideradas a la hora de avanzar en la creación de una Agencia Nacional de ETESA en Argentina.
    Keywords Medicine (General) ; R5-920 ; Public aspects of medicine ; RA1-1270
    Language Spanish
    Publishing date 2020-07-01T00:00:00Z
    Publisher Ministerio de Salud
    Document type Article ; Online
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  10. Article: Practical tools for quantitative analysis of coastal vulnerability and sea level rise impacts—application in a Caribbean island and assessment of the 1.5 °C threshold

    Biondi, Esteban L / Guannel, Greg

    Regional environmental change. 2018 Dec., v. 18, no. 8

    2018  

    Abstract: The quantitative analysis of hurricane impacts on coastal development in the Caribbean is surprisingly infrequent and many tools to assess physical vulnerability to sea level rise (SLR) are insufficient to evaluate risk in coastal areas exposed to wave ... ...

    Abstract The quantitative analysis of hurricane impacts on coastal development in the Caribbean is surprisingly infrequent and many tools to assess physical vulnerability to sea level rise (SLR) are insufficient to evaluate risk in coastal areas exposed to wave attack during extreme events. This paper proposes a practical methodology to quantify coastal hazards and evaluate SLR impact scenarios in coastal areas, providing quantitative input for coastal vulnerability analysis. We illustrate the implementation of the proposed methodology with results from a site-specific analysis. We quantify how storm wave impacts penetrate farther inland and reach higher elevations for increasing SLR conditions. We also show that the increase in elevation of storm wave impacts is more than the nominal increase in mean sea level, and that elevation increase may be on the order of up to twice the nominal SLR. By developing design parameters for multiple scenarios, as opposed to the determination of a single SLR value for design established by consensus, this approach generates information that we argue encourages resilient design and embedding future adaptation in coastal design. We discuss how government planners and regulators, as well as real estate developers, lenders, and investors, can improve coastal planning and resilient design of coastal projects by using this approach.
    Keywords altitude ; coasts ; hurricanes ; planning ; quantitative analysis ; risk ; sea level ; Caribbean
    Language English
    Dates of publication 2018-12
    Size p. 2227-2236.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    ZDB-ID 1464515-4
    ISSN 1436-3798
    ISSN 1436-3798
    DOI 10.1007/s10113-018-1397-4
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