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  1. Article ; Online: Reticulated Platelets: A Promising Prognosis Marker in Cardiovascular Diseases.

    Esteve-Pastor, María Asunción / Soler-Espejo, Eva / Marín, Francisco

    Thrombosis and haemostasis

    2023  Volume 124, Issue 4, Page(s) 320–323

    MeSH term(s) Humans ; Cardiovascular Diseases ; Blood Platelets ; Platelet Count ; Prognosis ; Flow Cytometry
    Language English
    Publishing date 2023-09-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/a-2170-1892
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    Uh III Zs.192: Show issues Location:
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  2. Article ; Online: Reducing bleeding risk in patients on oral anticoagulation therapy.

    Soler-Espejo, Eva / Esteve-Pastor, María Asunción / Rivera-Caravaca, José Miguel / Roldan, Vanessa / Marín, Francisco

    Expert review of cardiovascular therapy

    2023  Volume 21, Issue 12, Page(s) 923–936

    Abstract: Introduction: Oral anticoagulation (OAC) significantly mitigates thromboembolism risks in atrial fibrillation (AF) and venous thromboembolism (VTE) patients yet concern about major bleeding events persist. In fact, clinically relevant hemorrhages can be ...

    Abstract Introduction: Oral anticoagulation (OAC) significantly mitigates thromboembolism risks in atrial fibrillation (AF) and venous thromboembolism (VTE) patients yet concern about major bleeding events persist. In fact, clinically relevant hemorrhages can be life-threatening. Bleeding risk is dynamic and influenced by factors such as age, new comorbidities, and drug therapies, and should not be assessed solely based on static baseline factors.
    Areas covered: We comprehensively review the bleeding risk associated with OAC therapy. Emphasizing the importance of assessing both thromboembolic and bleeding risks, we present clinical tools for estimating stroke and systemic embolism (SSE) and bleeding risk in AF and VTE patients. We also address overlapping risk factors and the dynamic nature of bleeding risk.
    Expert opinion: The OAC management is undergoing constant transformation, motivated by the primary objective of mitigating thromboembolism and bleeding hazards, thereby amplifying patient safety throughout the course of treatment. The future of OAC embraces personalized approaches and innovative therapies, driven by advanced pathophysiological insights and technological progress. This holds promise for improving patient outcomes and revolutionizing anticoagulation practices.
    MeSH term(s) Humans ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/prevention & control ; Anticoagulants/adverse effects ; Stroke/etiology ; Stroke/prevention & control ; Hemorrhage/chemically induced ; Hemorrhage/epidemiology ; Comorbidity ; Risk Factors ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Administration, Oral
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2023-12-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2192343-7
    ISSN 1744-8344 ; 1477-9072
    ISSN (online) 1744-8344
    ISSN 1477-9072
    DOI 10.1080/14779072.2023.2275662
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Periprocedural use of antithrombotic therapy in interventional cardiology in Spain: are we doing better than other specialties?

    Anguita-Gámez, María / Vivas, David / Ferrandis, Raquel / Esteve-Pastor, María Asunción / Marín, Francisco / Anguita Sánchez, Manuel

    Revista espanola de cardiologia (English ed.)

    2024  

    Language Spanish
    Publishing date 2024-04-03
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 2592481-3
    ISSN 1885-5857 ; 1885-5857
    ISSN (online) 1885-5857
    ISSN 1885-5857
    DOI 10.1016/j.rec.2024.02.017
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  4. Article: Reticulated Platelets: A Promising Prognosis Marker in Cardiovascular Diseases

    Esteve-Pastor, María Asunción / Soler-Espejo, Eva / Marín, Francisco

    Thrombosis and Haemostasis

    2023  Volume 124, Issue 04, Page(s) 320–323

    Language English
    Publishing date 2023-09-07
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/a-2170-1892
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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.192: Show issues Location:
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  5. Article ; Online: Heart Failure and Cardiac Events: Is a Consecutive Measurement of Biomarkers a Simple and Practical Approach?

    Rivera-Caravaca, José Miguel / Esteve-Pastor, María Asunción

    Thrombosis and haemostasis

    2019  Volume 119, Issue 12, Page(s) 1891–1893

    MeSH term(s) Biomarkers/blood ; Fibrinolysis ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Humans ; Myocardium/metabolism ; Myocardium/pathology ; Plasminogen Activator Inhibitor 1/blood ; Prognosis ; Receptors, Urokinase Plasminogen Activator/blood ; Urokinase-Type Plasminogen Activator/blood
    Chemical Substances Biomarkers ; Plasminogen Activator Inhibitor 1 ; Receptors, Urokinase Plasminogen Activator ; Urokinase-Type Plasminogen Activator (EC 3.4.21.73)
    Language English
    Publishing date 2019-12-05
    Publishing country Germany
    Document type Editorial
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/s-0039-3400274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.192: Show issues Location:
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    Zs.MO 433: Show issues

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  6. Article ; Online: Stroke and Thromboembolism in Warfarin-Treated Patients with Atrial Fibrillation: Comparing the CHA2DS2-VASc and GARFIELD-AF Risk Scores.

    Proietti, Marco / Rivera-Caravaca, José Miguel / Esteve-Pastor, María Asunción / Marín, Francísco / Lip, Gregory Y H

    Thrombosis and haemostasis

    2021  Volume 121, Issue 8, Page(s) 1107–1114

    Abstract: Background: Evaluation of thromboembolic risk is essential in anticoagulated atrial fibrillation (AF) patients. The CHA: Methods: We analyzed warfarin-treated patients from SPORTIF III and V studies. Any thromboembolic event (TE) was an : Results: ...

    Abstract Background: Evaluation of thromboembolic risk is essential in anticoagulated atrial fibrillation (AF) patients. The CHA
    Methods: We analyzed warfarin-treated patients from SPORTIF III and V studies. Any thromboembolic event (TE) was an
    Results: A total of 3,665 patients (median [interquartile range] age: 72 [66-77] years; 30.5% female) were included in this analysis. After a mean (standard deviation) follow-up of 566.3 (142.5) days, 148 (4.03%) TEs were recorded. Both continuous CHA
    Conclusion: In a warfarin-treated trial cohort of AF patients, both CHA
    MeSH term(s) Aged ; Anticoagulants/adverse effects ; Anticoagulants/therapeutic use ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Clinical Trials as Topic ; Decision Support Techniques ; Female ; Humans ; Male ; Predictive Value of Tests ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Stroke/diagnosis ; Stroke/etiology ; Stroke/prevention & control ; Thromboembolism/diagnosis ; Thromboembolism/etiology ; Thromboembolism/prevention & control ; Time Factors ; Treatment Outcome ; Warfarin/adverse effects ; Warfarin/therapeutic use
    Chemical Substances Anticoagulants ; Warfarin (5Q7ZVV76EI)
    Language English
    Publishing date 2021-01-26
    Publishing country Germany
    Document type Comparative Study ; Journal Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/a-1333-4448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.192: Show issues Location:
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    Zs.MO 433: Show issues

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  7. Article: Heart Failure and Cardiac Events: Is a Consecutive Measurement of Biomarkers a Simple and Practical Approach?

    Rivera-Caravaca, José Miguel / Esteve-Pastor, María Asunción

    Thrombosis and Haemostasis

    2019  Volume 119, Issue 12, Page(s) 1891–1893

    Language English
    Publishing date 2019-12-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/s-0039-3400274
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.192: Show issues Location:
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    Zs.MO 433: Show issues

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  8. Article ; Online: Hypertension and Atrial Fibrillation: Balancing Stroke and Bleeding Risks.

    Esteve-Pastor, María Asunción / Rivera-Caravaca, José Miguel / Lip, Gregory Y H

    American journal of hypertension

    2017  Volume 30, Issue 11, Page(s) 1063–1065

    MeSH term(s) Atrial Fibrillation ; Blood Pressure ; Humans ; Hypertension ; Registries ; Stroke
    Language English
    Publishing date 2017-10-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 639383-4
    ISSN 1941-7225 ; 1879-1905 ; 0895-7061
    ISSN (online) 1941-7225 ; 1879-1905
    ISSN 0895-7061
    DOI 10.1093/ajh/hpx135
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    Zs.A 2329: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article: High medium-term incidence of major cardiovascular events in discharged patients with unstable angina.

    Herrero-Brocal, Marta / Marín, Francisco / Valverde, Laura / García-Barrios, Ana M / Fuertes, Laura / Cambra, Cristina / Torres-Mezcua, Fernando / Hortelano, Ignacio / Villamia, Beatriz / Esteve-Pastor, María Asunción / Orenes-Piñero, Esteban / Martínez, Juan Gabriel Martínez / Rivera-Caravaca, José Miguel / Ruiz-Nodar, Juan M

    International journal of cardiology. Heart & vasculature

    2023  Volume 46, Page(s) 101209

    Abstract: The introduction of high-sensitivity troponin (hsTn) assays has reduced the diagnosis of unstable angina (UA) in favor of non-ST elevation myocardial infarction (NSTEMI) in the context of non-ST elevation acute coronary syndrome (NSTEACS). It is unclear ... ...

    Abstract The introduction of high-sensitivity troponin (hsTn) assays has reduced the diagnosis of unstable angina (UA) in favor of non-ST elevation myocardial infarction (NSTEMI) in the context of non-ST elevation acute coronary syndrome (NSTEACS). It is unclear whether the detection of these hsTn levels affects the prognosis and therefore whether a different therapeutic approach is warranted. This study aims to determine whether using hsTn results in medium-term prognostic differences in patients with UA and NSTEMI.
    Methods: This multicenter, prospective registry study included consecutive patients who underwent hsTn assays and were discharged with a diagnosis of NSTEACS. Patients were followed for two years. Outcomes were the occurrence of major adverse cardiovascular events (MACE: cardiovascular death, non-fatal myocardial infarction, and non-fatal ischemic stroke), major bleeding, and all-cause mortality.
    Results: Patients with UA and NSTEMI did not show differences in terms of the invasive interventions received, the coronary artery disease diagnosed, the type of revascularization performed, or the proportion presenting MACE (UA 18.1% vs. NSTEMI 18.9%; p = 0.79). However, patients with NSTEMI had higher cardiovascular mortality at two years (UA 4% vs. NSTEMI 9.2%; p = 0.012), as well as, all-cause mortality (UA vs. 7.9% vs. NSTEMI 16.4%; p = 0.002).
    Conclusions: Medium-term incidence of MACE was similar in patients with UA and NSTEMI, but cardiovascular and all-cause mortality in NSTEMI patients was over twice that of patients with UA.
    Language English
    Publishing date 2023-04-26
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 2818464-6
    ISSN 2352-9067
    ISSN 2352-9067
    DOI 10.1016/j.ijcha.2023.101209
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  10. Article: Impact of Integrated Care Management on Clinical Outcomes in Atrial Fibrillation Patients: A Report From the FANTASIIA Registry.

    Esteve-Pastor, María Asunción / Ruiz-Ortiz, Martín / Muñiz, Javier / Roldán-Rabadán, Inmaculada / Otero, Déborah / Cequier, Ángel / Bertomeu-Martínez, Vicente / Badimón, Lina / Anguita, Manuel / Lip, Gregory Y H / Marín, Francisco

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 856222

    Abstract: Background: An integrated and holistic approach is increasingly advocated in patients with atrial fibrillation (AF), based on the "Atrial fibrillation Better Care (ABC) pathway: A, Avoid stroke with anticoagulation; B, better symptom management; C, ... ...

    Abstract Background: An integrated and holistic approach is increasingly advocated in patients with atrial fibrillation (AF), based on the "Atrial fibrillation Better Care (ABC) pathway: A, Avoid stroke with anticoagulation; B, better symptom management; C, cardiovascular and comorbidity risk management." The aim of this study was to examine the prevalence of adherence to each component of the ABC pathway and to analyze its impact on long-term prognosis in the "real-world" cohort of AF patients from the FANTASIIA registry.
    Methods: This prospective study included consecutive AF outpatients anticoagulated with direct oral anticoagulants (DOAC) or vitamin K antagonists (VKA) from June 2013 to October 2014. From the ABC pathway, adherence to the "A criterion" was defined by a time in the therapeutic range (TTR) ≥ 70% or correct dose with DOAC; "B criterion" adherence was defined by a European Heart Rhythm Association (EHRA) Symptom Scale I-II; and "C criterion" adherence was defined as optimized risk factors and comorbidity management. Baseline features and embolic events, severe bleeding, and all-cause and cardiovascular mortality rates up to 3 years of follow-up were analyzed, and a Cox multivariate analysis was performed to investigate the role of each component of the ABC pathway in predicting major events.
    Results: A total of 1,955 AF patients (age: 74.4 ± 9.4 years; 43.2% female patients) were included in this study: adherence to A criterion was observed in 920 (47.1%) patients; adherence to B criterion was observed in 1,791 (91.6%) patients; and adherence to C criterion was observed in 682 (34.8%) patients. Only 394 (20.2%) of the whole population had good control of AF according to the ABC pathway. After a median follow-up of 1,078 days (IQR: 766-1,113), adherence to A criterion was independently associated with reduced cardiovascular mortality [HR: 0.67, 95%CI (0.45-0.99);
    Conclusion: In real-world anticoagulated AF patients from FANTASIIA registry, we observed a lack of adherence to integrated care management of AF following the ABC pathway. AF managed according to the ABC pathway was associated with a significant reduction in adverse outcomes during long follow-up, suggesting the benefit of a holistic and integrated approach to AF management.
    Language English
    Publishing date 2022-05-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.856222
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