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Article ; Online: Clinical features and magnesium levels: Novel insights in 15q11.2 BP1-BP2 copy number variants.

Meossi, C / Carrer, A / Ciaccio, C / Estienne, M / Silipigni, R / Sciacca, F L / Pantaleoni, C / D'Arrigo, S / Milani, D

Journal of intellectual disability research : JIDR

2023 Volume 67, Issue 7, Page(s) 679–689

Abstract: Background: Investigating copy number variations (CNVs) such as microdeletions or microduplications can significantly contribute to discover the aetiology of neurodevelopmental disorders. 15q11.2 genomic region, including NIPA1 and NIPA2 genes, contains ...

Abstract	Background: Investigating copy number variations (CNVs) such as microdeletions or microduplications can significantly contribute to discover the aetiology of neurodevelopmental disorders. 15q11.2 genomic region, including NIPA1 and NIPA2 genes, contains a recurrent but rare CNV, flanked by the break points BP1 and BP2. Both BP1-BP2 microdeletion and microduplication have been associated with intellectual disability (ID), neuropsychiatric/behavioural disturbances and mild clinical features, even if with incomplete penetrance and variable expressivity. The pathogenic role of this CNV is quite unclear though. Unknown variants in other DNA regions and parent-of-origin effect (POE) are some of the mechanisms that have been proposed as an explanation of the wide phenotypic variability. As NIPA1 and NIPA2 encode for proteins that mediate magnesium (Mg Methods: Thirty one children with ID and/or other neurodevelopmental disorders carrying either a duplication or a deletion in 15q11.2 BP1-BP2 region have been recruited. When available, blood samples from parents have been analysed to identify the CNV origin. All participants underwent family and medical data collection, physical examination and neuropsychiatric assessment. Electroencephalogram (EEG) and brain magnetic resonance imaging (MRI) scan were performed in 15 children. In addition, 11 families agreed to participate to the assessment of blood and urinary Mg Results: We observed a highly variable phenotypic spectrum of developmental issues encompassing ID in most subjects as well as a variety of behavioural disorders such as autism and attention-deficit disorder/attention-deficit hyperactivity disorder. Dysmorphic traits and malformations were detected only in a minority of the participants, and no clear association with growth anomalies was found. Abnormal brain MRI and/or EEG were reported respectively in 64% and 92% of the subjects. Inheritance assessment highlighted an excess of duplication of maternal origin, while cardiac alterations were detected only in children with 15q11.2 CNV inherited from the father. We found great variability in Mg Conclusions: This study provides further evidence that 15q11.2 BP1-BP2 CNV is associated with a broad spectrum of neurodevelopmental disorders and POE might be an explanation for clinical variability. However, some issues may question the real impact of 15q11.2 CNV on the phenotype in the carriers: DNA sequencing could be useful to exclude other pathogenic gene mutations. Our results do not support the possibility that urinary Mg
MeSH term(s)	Humans ; Chromosome Aberrations ; Magnesium ; DNA Copy Number Variations/genetics ; Neurodevelopmental Disorders/genetics ; Intellectual Disability/genetics ; Biomarkers
Chemical Substances	Magnesium (I38ZP9992A) ; Biomarkers
Language	English
Publishing date	2023-05-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1103832-9
ISSN	1365-2788 ; 0964-2633
ISSN (online)	1365-2788
ISSN	0964-2633
DOI	10.1111/jir.13038
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Article ; Online: Repetitive Sleep Starts in Allan-Herndon-Dudley Syndrome.

Solazzi, Roberta / Nanni, Giuliana / Esposito, Silvia / Estienne, Margherita / Freri, Elena / Zibordi, Federica / Canafoglia, Laura / Castellotti, Barbara / Granata, Tiziana

Pediatric neurology

2023 Volume 147, Page(s) 24–27

Abstract: Allan-Herndon-Dudley syndrome (AHDS) is caused by mutations in the SLC16A2 gene, encoding for the monocarboxylate transporter 8 (MCT8). Central hypothyroidism and chronic peripheral thyrotoxicosis result in a severe phenotype, mainly characterized by ... ...

Abstract	Allan-Herndon-Dudley syndrome (AHDS) is caused by mutations in the SLC16A2 gene, encoding for the monocarboxylate transporter 8 (MCT8). Central hypothyroidism and chronic peripheral thyrotoxicosis result in a severe phenotype, mainly characterized by poor growth, intellectual disability, spastic tetraparesis, and movement disorders, including paroxysmal ones (startle reaction and paroxysmal dyskinesias). Seizures are rarely reported. We conducted a retrospective analysis on video electroencephalography (EEG) recordings in four subjects with AHDS, focused on paroxysmal events. Among other manifestations recorded on EEG, we diagnosed repetitive sleep starts (RSS) in all subjects. RSS are a paroxysmal nonepileptic phenomenon occurring during sleep, similar to epileptic spasms in their clinical and electromyography characteristics, but not related to any EEG change. This is the first report on RSS in AHDS. We present video-EEG polygraphic documentation, suggesting that RSS could be underestimated or misdiagnosed. The importance of a correct diagnosis is crucial in a therapeutic perspective.
MeSH term(s)	Humans ; Retrospective Studies ; Sleep-Wake Transition Disorders/complications ; Mental Retardation, X-Linked/genetics ; Mutation ; Muscle Hypotonia/genetics ; Muscular Atrophy/complications ; Monocarboxylic Acid Transporters/genetics ; Symporters/genetics
Chemical Substances	Monocarboxylic Acid Transporters ; SLC16A2 protein, human ; Symporters
Language	English
Publishing date	2023-06-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	639164-3
ISSN	1873-5150 ; 0887-8994
ISSN (online)	1873-5150
ISSN	0887-8994
DOI	10.1016/j.pediatrneurol.2023.06.012
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Article ; Online: Effects of dietary menhaden oil on growth and reproduction in gilts farrowed by sows that consumed diets containing menhaden oil during gestation and lactation.

Petrone, R C / Williams, K A / Estienne, M J

Animal : an international journal of animal bioscience

2019 Volume 13, Issue 9, Page(s) 1944–1951

Abstract: In sows, n-3 fatty acids increase litter sizes, however, effects on gilt reproductive development have not been adequately studied. Moreover, not determined are effects of feeding n-3 fatty acids to sows on reproduction in offspring. The objective here ... ...

Abstract	In sows, n-3 fatty acids increase litter sizes, however, effects on gilt reproductive development have not been adequately studied. Moreover, not determined are effects of feeding n-3 fatty acids to sows on reproduction in offspring. The objective here was to determine effects of 4% dietary menhaden oil on growth and puberty in gilts farrowed by sows fed menhaden oil. Sows (n = 44) were assigned to: (1) control gestation and lactation diets, or (2) diets including menhaden oil. For primiparous sows only, total litter size and born alive were greater (P < 0.05) in females fed menhaden oil. Conversely, pigs from primiparous controls were heavier (P < 0.05) than pigs from primiparous sows fed menhaden oil (parity by diet interactions, P < 0.01). Diet did not affect (P > 0.20) other sow and litter characteristics. At weaning, 84 gilts from control- or menhaden oil sows were placed three gilts per pen and provided control diets or diets containing menhaden oil. Nursery and grow-finish feed intake and feed efficiency were similar (P > 0.21) for gilts from the different sows and weight gain was similar (P > 0.24) for gilts fed control or menhaden diets. Gilts fed menhaden oil tended to eat less in the nursery (1.18±0.08 kg v. 0.98±0.08 kg; P = 0.09) and overall (1.83±0.04 kg v. 1.72±0.04 kg; P = 0.06). Thus, overall feed to gain was greater (2.52±0.03 v. 2.33±0.03; P < 0.01) and nursery (2.12±0.04 v. 1.80±0.04; P = 0.10) and grow-finish (3.07±0.19 v. 2.58±0.19; P = 0.08) feed to gain tended to be greater, for control gilts. Age at puberty was greater (P = 0.02) for gilts from menhaden oil-fed sows (205.1±3.2 days) compared to gilts from controls (193.9±3.2 days) and tended to be greater (P = 0.09), for controls (203.5±3.2 days) compared to gilts fed menhaden oil (195.5±3.2 days). A tendency existed (P = 0.09) for greater follicular fluid in gilts fed menhaden oil, however, ovulation rate and ovarian, luteal and uterine weights were not affected by sow diet, gilt diet or the interaction (P > 0.23). Feeding gilts menhaden oil enhanced feed efficiency and hastened puberty onset. Gilts from sows consuming menhaden oil exhibited delayed puberty and retaining females from sows fed this feedstuff may be ill advised.
MeSH term(s)	Animal Feed/analysis ; Animals ; Diet/veterinary ; Dietary Fats, Unsaturated/pharmacology ; Dietary Supplements ; Fatty Acids/pharmacology ; Fatty Acids, Omega-3/pharmacology ; Female ; Fish Oils/pharmacology ; Lactation ; Litter Size/drug effects ; Male ; Parity/drug effects ; Pregnancy ; Reproduction/drug effects ; Swine/growth & development ; Swine/physiology ; Weaning ; Weight Gain/drug effects
Chemical Substances	Dietary Fats, Unsaturated ; Fatty Acids ; Fatty Acids, Omega-3 ; Fish Oils ; Menhaden oil (1D8HWC57D0)
Language	English
Publishing date	2019-02-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2257920-5
ISSN	1751-732X ; 1751-7311
ISSN (online)	1751-732X
ISSN	1751-7311
DOI	10.1017/S1751731119000193
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Article: Effects of dietary menhaden oil on growth and reproduction in gilts farrowed by sows that consumed diets containing menhaden oil during gestation and lactation

Petrone, R. C / Estienne, M. J / Williams, K. A

Animal. 2019 Sept., v. 13, no. 9

2019

Abstract	In sows, n-3 fatty acids increase litter sizes, however, effects on gilt reproductive development have not been adequately studied. Moreover, not determined are effects of feeding n-3 fatty acids to sows on reproduction in offspring. The objective here was to determine effects of 4% dietary menhaden oil on growth and puberty in gilts farrowed by sows fed menhaden oil. Sows (n = 44) were assigned to: (1) control gestation and lactation diets, or (2) diets including menhaden oil. For primiparous sows only, total litter size and born alive were greater (P < 0.05) in females fed menhaden oil. Conversely, pigs from primiparous controls were heavier (P < 0.05) than pigs from primiparous sows fed menhaden oil (parity by diet interactions, P < 0.01). Diet did not affect (P > 0.20) other sow and litter characteristics. At weaning, 84 gilts from control- or menhaden oil sows were placed three gilts per pen and provided control diets or diets containing menhaden oil. Nursery and grow-finish feed intake and feed efficiency were similar (P > 0.21) for gilts from the different sows and weight gain was similar (P > 0.24) for gilts fed control or menhaden diets. Gilts fed menhaden oil tended to eat less in the nursery (1.18±0.08 kg v. 0.98±0.08 kg; P = 0.09) and overall (1.83±0.04 kg v. 1.72±0.04 kg; P = 0.06). Thus, overall feed to gain was greater (2.52±0.03 v. 2.33±0.03; P < 0.01) and nursery (2.12±0.04 v. 1.80±0.04; P = 0.10) and grow-finish (3.07±0.19 v. 2.58±0.19; P = 0.08) feed to gain tended to be greater, for control gilts. Age at puberty was greater (P = 0.02) for gilts from menhaden oil-fed sows (205.1±3.2 days) compared to gilts from controls (193.9±3.2 days) and tended to be greater (P = 0.09), for controls (203.5±3.2 days) compared to gilts fed menhaden oil (195.5±3.2 days). A tendency existed (P = 0.09) for greater follicular fluid in gilts fed menhaden oil, however, ovulation rate and ovarian, luteal and uterine weights were not affected by sow diet, gilt diet or the interaction (P > 0.23). Feeding gilts menhaden oil enhanced feed efficiency and hastened puberty onset. Gilts from sows consuming menhaden oil exhibited delayed puberty and retaining females from sows fed this feedstuff may be ill advised.
Keywords	diet ; feed conversion ; feed intake ; feeds ; follicular fluid ; gilts ; lactation ; litter size ; menhaden ; menhaden oil ; omega-3 fatty acids ; ovulation ; pregnancy ; progeny ; puberty ; sows ; weaning ; weight gain
Language	English
Dates of publication	2019-09
Size	p. 1944-1951.
Publishing place	Cambridge University Press
Document type	Article
ZDB-ID	2257920-5
ISSN	1751-732X ; 1751-7311
ISSN (online)	1751-732X
ISSN	1751-7311
DOI	10.1017/S1751731119000193
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Article ; Online: Type of accommodation during gestation affects growth performance and reproductive characteristics of gilt offspring.

Estienne, M J / Harper, A F

Journal of animal science

2010 Volume 88, Issue 1, Page(s) 400–407

Abstract: The objective was to determine effects of the type of gestation accommodation to which dams were exposed on growth performance and age at puberty in gilt offspring. Yorkshire x Landrace gilts (n = 81; 26.9 +/- 0.8 kg of BW) were placed in pens of 3 gilts ...

Abstract	The objective was to determine effects of the type of gestation accommodation to which dams were exposed on growth performance and age at puberty in gilt offspring. Yorkshire x Landrace gilts (n = 81; 26.9 +/- 0.8 kg of BW) were placed in pens of 3 gilts each. Each pen contained gilts farrowed exclusively by gilts exposed to 1 of 3 gestation accommodations: 1) individual crates throughout gestation; 2) group pens throughout gestation; or 3) crates for 30 d postmating and then group pens for the remainder of gestation (n = 9 pens/group). Performance during the 5-wk nursery period was similar among groups. The grow-finish period ended at a BW of 108.9 +/- 0.8 kg, and ADG (0.98 +/- 0.02 kg) was not affected (P = 0.14) by treatment. However, pig BW was affected by accommodation type x time (P = 0.04), with gilts farrowed by females housed in crates throughout gestation being heaviest during the last 4 wk. There was no effect of treatment on ADFI (2.61 +/- 0.07 kg; P = 0.54); however, G:F was enhanced (P < 0.05) in gilts farrowed by females housed in crates throughout (0.385 +/- 0.005) or for the first 30 d of gestation and then groups (0.382 +/- 0.005) compared with gilts from females kept in groups throughout gestation (0.367 +/- 0.005). Gilts from females gestated in crates throughout gestation tended (P < 0.09) to have less backfat (10.9 +/- 0.5 mm) than gilts from females gestated in groups (12.5 +/- 0.5 mm). After grow-finish, gilts were checked for estrus once daily. Mean age at puberty (171.9 +/- 4.4 d) did not differ among groups (P = 0.61); however, fewer gilts farrowed by females gestated in crates throughout gestation (P = 0.03) reached puberty by 165 d of age (13%) compared with the other 2 groups (44%). Although specific mechanisms need to be determined, we suggest that the type of gestation accommodation in which gilts are kept may affect production performance of gilt offspring, possibly by fetal programming.
MeSH term(s)	Animal Welfare ; Animals ; Female ; Fetal Development ; Housing, Animal ; Pregnancy ; Swine/growth & development ; Swine/physiology ; Weight Gain
Language	English
Publishing date	2010-01
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	390959-1
ISSN	1525-3163 ; 0021-8812
ISSN (online)	1525-3163
ISSN	0021-8812
DOI	10.2527/jas.2009-2081
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Article: Effects of inclusion of spray-dried porcine plasma in lactation diets on sow and litter performance

Carter, S.D / Chiba, L.I / Estienne, M.J / Lima, G.J.M.M / Lindemann, M.D

Livestock science. 2018 Oct., v. 216

2018

Abstract: A cooperative study, utilizing 404 primi- and multi-parous crossbred sows from five experiment stations (AL, KY, OK, VA, and Brazil), was conducted to determine the effects of dietary inclusion of 0.50% spray-dried porcine plasma (SDPP; Appetein, APC, ... ...

Abstract	A cooperative study, utilizing 404 primi- and multi-parous crossbred sows from five experiment stations (AL, KY, OK, VA, and Brazil), was conducted to determine the effects of dietary inclusion of 0.50% spray-dried porcine plasma (SDPP; Appetein, APC, Inc., Ankeny, IA) on sow and litter performance. Crossbred sows were fed corn and soybean meal-based diets containing a minimum of 0.50% SID lysine during gestation. Sows were allotted at farrowing, based on body wt, to two dietary treatments. The control (C) diet was a fortified corn, soybean meal based diet. Spray-dried porcine plasma was added to the control diet at 0.50% at the expense of soybean meal to formulate the test diet. Both diets were formulated to 0.90% SID lysine and 3414 kcal/kg ME. A common trace mineral and vitamin premix was used at all stations with the exception of Brazil. Sows were allowed ad libitum access to feed. Sows were weighed within 24 h after farrowing, and all litters were adjusted to ≥10 pigs/litter by d 2 following farrowing. Average sow parity, number of pigs on d 2, and lactation length for the C and SDPP treatments were, respectively: 2.5 and 2.3; 11.0 and 10.7; and 23 and 23 d The ADFI during lactation for C and SDPP diets was similar (5.65 kg/d; P > 0.10). The number of pigs weaned (9.9 vs. 9.7), litter weaning weights (68.4 vs. 69.1 kg), litter weight gains (51.6 vs. 52.2), sow weight change during lactation (−6.0 vs. −8.3 kg), and wean-to-estrus interval (7.5 vs. 7.2 d) were not affected (P > 0.10) by dietary treatment. There were no station x treatment interactions (P > 0.10). After evaluating the entire data set, the data were sorted by parity (≤3 vs. ≥4) to evaluate the effects of SDPP in young vs. older sows. In older, mature sows, SDPP tended to increase (P ≤ 0.10) the no. of pigs weaned (9.6 vs. 10.3), percentage survival (86 vs. 91), litter wt at weaning (64.5 vs. 70.3 kg), and daily litter wt change (2.20 vs. 2.47 kg). Overall, these data suggest no benefit of inclusion of spray-dried porcine plasma in lactation diets of younger sows; however, SDPP increased litter performance in older, mature sows.
Keywords	corn ; crossbreds ; data collection ; experimental diets ; farrowing ; lactation ; litter weight ; lysine ; nutritional intervention ; pregnancy ; sows ; soybean meal ; soybeans ; spray drying ; trace elements ; weaning ; weight gain ; Brazil
Language	English
Dates of publication	2018-10
Size	p. 32-35.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2226176-X
ISSN	1878-0490 ; 1871-1413
ISSN (online)	1878-0490
ISSN	1871-1413
DOI	10.1016/j.livsci.2018.05.007
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Article ; Online: Correction to: Myoclonic status epilepticus and cerebellar hypoplasia associated with a novel variant in the GRIA3 gene.

Rinaldi, Berardo / Ge, Yu-Han / Freri, Elena / Tucci, Arianna / Granata, Tiziana / Estienne, Margherita / Sun, Jia-Hui / Gérard, Bénédicte / Bayat, Allan / Efthymiou, Stephanie / Gervasini, Cristina / Shi, Yun Stone / Houlden, Henry / Marchisio, Paola / Milani, Donatella

Neurogenetics

2021 Volume 23, Issue 1, Page(s) 81

Language	English
Publishing date	2021-11-26
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1339887-8
ISSN	1364-6753 ; 1364-6745
ISSN (online)	1364-6753
ISSN	1364-6745
DOI	10.1007/s10048-021-00678-x
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Article ; Online: Myoclonic status epilepticus and cerebellar hypoplasia associated with a novel variant in the GRIA3 gene.

Neurogenetics

2021 Volume 23, Issue 1, Page(s) 27–35

Abstract: AMPA-type glutamate receptors (AMPARs) are postsynaptic ionotropic receptors which mediate fast excitatory currents. AMPARs have a heterotetrameric structure, variably composed by the four subunits GluA1-4 which are encoded by genes GRIA1-4. Increasing ... ...

Abstract	AMPA-type glutamate receptors (AMPARs) are postsynaptic ionotropic receptors which mediate fast excitatory currents. AMPARs have a heterotetrameric structure, variably composed by the four subunits GluA1-4 which are encoded by genes GRIA1-4. Increasing evidence support the role of pathogenic variants in GRIA1-4 genes as causative for syndromic intellectual disability (ID). We report an Italian pedigree where some male individuals share ID, seizures and facial dysmorphisms. The index subject was referred for severe ID, myoclonic seizures, cerebellar signs and short stature. Whole exome sequencing identified a novel variant in GRIA3, c.2360A > G, p.(Glu787Gly). The GRIA3 gene maps to chromosome Xq25 and the c.2360A > G variant was transmitted by his healthy mother. Subsequent analysis in the family showed a segregation pattern compatible with the causative role of this variant, further supported by preliminary functional insights. We provide a detailed description of the clinical evolution of the index subjects and stress the relevance of myoclonic seizures and cerebellar syndrome as cardinal features of his presentation.
MeSH term(s)	Cerebellum/abnormalities ; Child ; Developmental Disabilities ; Humans ; Intellectual Disability/genetics ; Male ; Nervous System Malformations ; Pedigree ; Status Epilepticus
Language	English
Publishing date	2021-11-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1339887-8
ISSN	1364-6753 ; 1364-6745
ISSN (online)	1364-6753
ISSN	1364-6745
DOI	10.1007/s10048-021-00666-1
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Article ; Online: 16p13 microduplication without CREBBP involvement: Moving toward a phenotype delineation.

Ciaccio, Claudia / Tucci, Arianna / Scuvera, Giulietta / Estienne, Margherita / Esposito, Susanna / Milani, Donatella

European journal of medical genetics

2017 Volume 60, Issue 3, Page(s) 159–162

Abstract: The short arm of chromosome 16 is one of the less stable regions of our genome, as over 10% of the euchromatic region of 16p is composed of highly complex low copy repeats that are known to be predisposed to rearrangements mediated by non-allelic ... ...

Abstract	The short arm of chromosome 16 is one of the less stable regions of our genome, as over 10% of the euchromatic region of 16p is composed of highly complex low copy repeats that are known to be predisposed to rearrangements mediated by non-allelic homologous recombination. The 16p13.3p13.13 molecular region has been defined as the 16p duplication hotspot, and duplications of chromosome 16p13 have recently been confirmed to cause a recognizable syndrome, with CREBBP being the main phenotype-causing gene. To date, only one case report is present in the literature with a 16p13 duplication without CREBBP involvement; we describe here a second analogous case with a not previously reported 16p13.2p13.13 microduplication. This paper allows us to better delineate the clinical features of 16p13 microduplications that do not encompass CREBBP and, concurrently, to narrow the molecular region responsible for congenital heart defects in 16p duplications as well as to propose GRIN2A as a candidate gene for epilepsy.
MeSH term(s)	Abnormalities, Multiple/genetics ; CREB-Binding Protein/genetics ; Child ; Chromosomes, Human, Pair 16/genetics ; Epilepsy/genetics ; Female ; Gene Duplication/genetics ; Genetic Predisposition to Disease ; Heart Defects, Congenital/genetics ; Humans ; Receptors, N-Methyl-D-Aspartate/genetics
Chemical Substances	N-methyl D-aspartate receptor subtype 2A ; Receptors, N-Methyl-D-Aspartate ; CREB-Binding Protein (EC 2.3.1.48) ; CREBBP protein, human (EC 2.3.1.48)
Language	English
Publishing date	2017-03
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	2184135-4
ISSN	1878-0849 ; 1769-7212
ISSN (online)	1878-0849
ISSN	1769-7212
DOI	10.1016/j.ejmg.2016.12.006
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Article ; Online: Effects of group-size-floor space allowance during the nursery phase of production on growth, physiology, and hematology in replacement gilts.

Callahan, S R / Cross, A J / DeDecker, A E / Lindemann, M D / Estienne, M J

Journal of animal science

2017 Volume 95, Issue 1, Page(s) 201–211

Abstract: The objective was to determine effects of nursery group-size-floor space allowance on growth, physiology, and hematology of replacement gilts. A 3 × 3 factorial arrangement of treatments was used wherein gilts classified as large, medium, or small ( = ... ...

Abstract	The objective was to determine effects of nursery group-size-floor space allowance on growth, physiology, and hematology of replacement gilts. A 3 × 3 factorial arrangement of treatments was used wherein gilts classified as large, medium, or small ( = 2537; BW = 5.6 ± 0.6 kg) from 13 groups of weaned pigs were placed in pens of 14, 11, or 8 pigs resulting in floor space allowances of 0.15, 0.19, or 0.27 m/pig, respectively. Pigs were weighed on d 0 (weaning) and d 46 (exit from nursery). The ADG was affected by group-size-floor space allowance × pig size ( = 0.04). Large- and medium-size gilts allowed the most floor space had greater ( < 0.05) ADG than similar size gilts allowed the least floor space but for small size gilts there was no effect ( > 0.05) of group size-floor space allowance. Mortality in the nursery was not affected ( > 0.05) by treatment, size, or treatment × size and overall was approximately 2.1%. Complete blood counts and blood chemistry analyses were performed on samples collected at d 6 and 43 from a subsample of gilts ( = 18/group-size-floor space allowance) within a single group. The concentration ( < 0.01) and percentage ( = 0.03) of reticulocytes was the least and red blood cell distribution width the greatest ( < 0.01) in gilts allowed 0.15 m floor space (effects of treatment). Blood calcium was affected by treatment ( = 0.02) and concentrations for gilts allowed the greatest and intermediate amounts of floor space were greater ( < 0.05) than for gilts allowed the least floor space. Serum concentrations of cortisol were not affected by treatment × day ( = 0.27). Cortisol concentrations increased from d 6 to d 43 in all groups and were affected by day ( < 0.01) but not treatment ( = 0.53). Greater space allowance achieved by placing fewer pigs per pen in the nursery affected blood parameters and resulted in large- and medium-size replacement gilts displaying increased ADG. Further study will determine if these effects influence lifetime reproductive capacity and sow longevity.
MeSH term(s)	Animals ; Female ; Floors and Floorcoverings ; Hematology ; Housing, Animal ; Reproduction ; Sus scrofa ; Swine/growth & development ; Swine/physiology ; Weaning
Language	English
Publishing date	2017-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	390959-1
ISSN	1525-3163 ; 0021-8812
ISSN (online)	1525-3163
ISSN	0021-8812
DOI	10.2527/jas.2016.0842
Database	MEDical Literature Analysis and Retrieval System OnLINE

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