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Article ; Online: Safety of ventricular arrhythmia radiofrequency ablation with half-normal saline irrigation.

Hasegawa, Kanae / Yoneda, Zachary T / Powers, Edward M / Tokutake, Kenichi / Kurata, Masaaki / Richardson, Travis D / Montgomery, Jay A / Shen, Sharon / Estrada, Juan C / Saavedra, Pablo J / Emerson, Amy / Walker, Marilyn L / Tandri, Harikrishna / Michaud, Gregory F / Kanagasundram, Arvindh N / Stevenson, William G

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

2024 Volume 26, Issue 2

Abstract: Aims: Failure of radiofrequency (RF) ablation of ventricular arrhythmias is often due to inadequate lesion size. Irrigated RF ablation with half-normal saline (HNS) has the potential to increase lesion size and reduce sodium delivery to the patient if ... ...

Abstract	Aims: Failure of radiofrequency (RF) ablation of ventricular arrhythmias is often due to inadequate lesion size. Irrigated RF ablation with half-normal saline (HNS) has the potential to increase lesion size and reduce sodium delivery to the patient if the same volume of RF irrigant were used for normal saline (NS) and HNS but could increase risks related to steam pops and lesion size. This study aims to assess periprocedural complications and acute ablation outcome of ventricular arrhythmias ablation with HNS. Methods and results: Prospective assessment of outcomes was performed in 1024 endocardial and/or epicardial RF ablation procedures in 935 consecutive patients (median age 64 years, 71.2% men, 73.4% cardiomyopathy, 47.2% sustained ventricular tachycardia). Half-normal saline was selected at the discretion of the treating physician. Radiofrequency ablation power was generally titrated to a ≤15 Ω impedance fall with intracardiac echocardiography monitoring. Half-normal saline was used in 900 (87.9%) and NS in 124 (12.1%) procedures. Any adverse event within 30 days occurred in 13.0% of patients treated with HNS RF ablation including 4 (0.4%) strokes/transient ischaemic attacks and 34 (3.8%) pericardial effusions requiring treatment (mostly related to epicardial access). Two steam pops with perforation required surgical repair (0.2%). Patients who received NS irrigation had less severe disease and arrhythmias. In multivariable models, adverse events and acute success of the procedure were not related to the type of irrigation. Conclusion: Half-normal saline irrigation RF ablation with power guided by impedance fall and intracardiac echocardiography has an acceptable rate of complications and acute ablation success while administering half of the saline load expected for NS irrigation.
MeSH term(s)	Male ; Humans ; Middle Aged ; Female ; Saline Solution/adverse effects ; Steam ; Prospective Studies ; Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/surgery ; Radiofrequency Ablation ; Catheter Ablation/adverse effects ; Catheter Ablation/methods ; Tachycardia, Ventricular/surgery ; Therapeutic Irrigation/adverse effects
Chemical Substances	Saline Solution ; Steam
Language	English
Publishing date	2024-02-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1449879-0
ISSN	1532-2092 ; 1099-5129
ISSN (online)	1532-2092
ISSN	1099-5129
DOI	10.1093/europace/euae018
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Article ; Online: Stroke and Bleeding Risks of Endocardial Ablation for Ventricular Arrhythmias.

JACC. Clinical electrophysiology

2023 Volume 10, Issue 2, Page(s) 193–202

Abstract: Background: Risks of radiofrequency catheter ablation for ventricular arrhythmias include emboli and bleeding complications but data on antithrombotic regimens are limited and guidelines do not specify a systematic approach.: Objectives: This study ... ...

Abstract	Background: Risks of radiofrequency catheter ablation for ventricular arrhythmias include emboli and bleeding complications but data on antithrombotic regimens are limited and guidelines do not specify a systematic approach. Objectives: This study sought to assess embolic and bleeding complications in relation to pre-periprocedure and post-periprocedure antithrombotic regimens. Methods: Prospective assessment for complications was performed for 663 endocardial radiofrequency catheter ablation procedures in 616 consecutive patients (median age 64 years [Q1-Q3: 54-73 years], 70.3% men, 71.6% with cardiomyopathy, 44.5% with sustained ventricular tachycardia). Results: There were 2 strokes (0.3%; 95% CI: 0.0%-0.8%), 1 transient ischemic attack (0.15%), and 2 pulmonary emboli (0.3%). There were 39 bleeding complications (5.9%) including 11 pericardial effusions (1.7%), and 28 related to vascular access (4.2%). Consistent with the prevalence of coronary artery disease (47.5%), atrial fibrillation (30.0%), and prior stroke (10.6%), preprocedure, 464 patients (70.0%) were taking antithrombotic agents including 220 (33.2%) taking aspirin alone (ASA), and 163 (24.6%) taking warfarin or a direct acting oral anticoagulant (DOAC). Preprocedure non-ASA antiplatelet use (OR: 2.846; P = 0.011) and DOAC use (OR: 2.585; P = 0.032) were associated with risk of bleeding complications. Following ablation, 49.8% of patients were treated with ASA 325 mg/d and 30.3% received DOACs or warfarin. New DOAC or warfarin administration was initiated in only 6.6% of patients. Overall, 39.7% of patients continued the same preprocedure antithrombotic regimen. Conclusions: Stroke is a rare complication of radiofrequency catheter ablation for ventricular arrhythmia using ASA 325 mg/d as a minimal postprocedure regimen with more potent regimens for selected patients.
MeSH term(s)	Male ; Humans ; Middle Aged ; Female ; Warfarin/adverse effects ; Anticoagulants/adverse effects ; Hemorrhage/etiology ; Hemorrhage/chemically induced ; Fibrinolytic Agents ; Prospective Studies ; Stroke/etiology ; Stroke/epidemiology ; Atrial Fibrillation/surgery ; Aspirin/adverse effects
Chemical Substances	Warfarin (5Q7ZVV76EI) ; Anticoagulants ; Fibrinolytic Agents ; Aspirin (R16CO5Y76E)
Language	English
Publishing date	2023-12-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2846739-5
ISSN	2405-5018 ; 2405-500X ; 2405-500X
ISSN (online)	2405-5018 ; 2405-500X
ISSN	2405-500X
DOI	10.1016/j.jacep.2023.10.011
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Article ; Online: Pulmonary Vein Myocardial Sleeve Length and its Association With Sex and 4q25/PITX2 Genotype.

JACC. Clinical electrophysiology

2023 Volume 9, Issue 7 Pt 2, Page(s) 1147–1157

Abstract: Background: Experimental evidence suggests genetic variation in 4q25/PITX2 modulates pulmonary vein (PV) myocardial sleeve length. Although PV sleeves are the main target of atrial fibrillation (AF) ablation, little is known about the association ... ...

Abstract	Background: Experimental evidence suggests genetic variation in 4q25/PITX2 modulates pulmonary vein (PV) myocardial sleeve length. Although PV sleeves are the main target of atrial fibrillation (AF) ablation, little is known about the association between different PV sleeve characteristics with ablation outcomes. Objectives: This study sought to evaluate the association between clinical and genetic (4q25) risk factors with PV sleeve length in humans, and to evaluate the association between PV sleeve length and recurrence after AF ablation. Methods: In a prospective, observational study of patients undergoing de novo AF ablation, PV sleeve length was measured using electroanatomic voltage mapping before ablation. The sentinel 4q25 AF susceptibility single nucleotide polymorphism, rs2200733, was genotyped. The primary analysis tested the association between clinical and genetic (4q25) risk factors with PV sleeve length using a multivariable linear regression model. Covariates included age, sex, body mass index, height, and persistent AF. The association between PV sleeve length and atrial arrhythmia recurrence (>30 seconds) was tested using a multivariable Cox proportional hazards model. Results: Between 2014 and 2019, 197 participants were enrolled (median age 63 years [IQR: 55 to 70 years], 133 male [67.5%]). In multivariable modeling, men were found to have PV sleeves 2.94 mm longer than women (95% CI: 0.99-4.90 mm; P < 0.001). Sixty participants (30.5%) had one 4q25 risk allele and 6 (3.1%) had 2 alleles. There was no association between 4q25 genotype and PV sleeve length. Forty-six participants (23.4%) experienced arrhythmia recurrence within 3 to 12 months, but there was no association between recurrence and PV sleeve length. Conclusions: Common genetic variation at 4q25 was not associated with PV sleeve length and PV sleeve length was not associated with ablation outcomes. Men did have longer PV sleeves than women, but more research is needed to define the potential clinical significance of this observation.
MeSH term(s)	Female ; Humans ; Male ; Middle Aged ; Atrial Fibrillation/genetics ; Atrial Fibrillation/surgery ; Genotype ; Prospective Studies ; Pulmonary Veins/surgery ; Risk Factors ; Aged ; Homeobox Protein PITX2
Language	English
Publishing date	2023-03-22
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, N.I.H., Extramural
ZDB-ID	2846739-5
ISSN	2405-5018 ; 2405-500X ; 2405-500X
ISSN (online)	2405-5018 ; 2405-500X
ISSN	2405-500X
DOI	10.1016/j.jacep.2022.12.028
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Article ; Online: A Mechanistic Clinical Trial Using (

Shoemaker, M Benjamin / Yoneda, Zachary T / Crawford, Diane M / Akers, Wendell S / Richardson, Travis / Montgomery, Jay A / Phillips, Sharon / Shyr, Yu / Saavedra, Pablo / Estrada, Juan C / Kanagasundram, Arvindh / Shen, Sharon T / Michaud, Gregory F / Crossley, George / Ellis, Christopher R / Knollmann, Bjorn C

Circulation. Arrhythmia and electrophysiology

2022 Volume 15, Issue 10, Page(s) e010713

Abstract: Background: Experimental data suggest ryanodine receptor-mediated intracellular calcium leak is a mechanism for atrial fibrillation (AF), but evidence in humans is still needed. Propafenone is composed of two enantiomers that are equally potent sodium- ... ...

Abstract	Background: Experimental data suggest ryanodine receptor-mediated intracellular calcium leak is a mechanism for atrial fibrillation (AF), but evidence in humans is still needed. Propafenone is composed of two enantiomers that are equally potent sodium-channel blockers; however, Methods: Participants were randomized 4:4:1 to a one-time intravenous dose of Results: A total of 193 participants were enrolled and 165 (85%) completed the study protocol (median age: 63 years, 58% male, 95% paroxysmal AF). Sustained AF and/or atrial flutter was induced in 60 participants (84.5%) receiving Conclusions: There is no difference in AF inducibility between Registration: https://clinicaltrials.gov; Unique Identifier: NCT02710669.
MeSH term(s)	Humans ; Male ; Middle Aged ; Female ; Propafenone/adverse effects ; Ryanodine Receptor Calcium Release Channel ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/prevention & control ; Atrial Fibrillation/drug therapy ; Atrial Flutter/diagnosis ; Atrial Flutter/prevention & control ; Calcium/metabolism ; Sodium ; Anti-Arrhythmia Agents/therapeutic use
Chemical Substances	Propafenone (68IQX3T69U) ; Ryanodine Receptor Calcium Release Channel ; Calcium (SY7Q814VUP) ; Sodium (9NEZ333N27) ; Anti-Arrhythmia Agents
Language	English
Publishing date	2022-09-27
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2426129-4
ISSN	1941-3084 ; 1941-3149
ISSN (online)	1941-3084
ISSN	1941-3149
DOI	10.1161/CIRCEP.121.010713
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Article ; Online: Twinkling artifact associated with guidewire placement.

Bennett, Jeremy M / Estrada, Juan C / Shoemaker, Moore Benjamin / Pretorius, Mias

Anesthesia and analgesia

2015 Volume 121, Issue 1, Page(s) 69–71

MeSH term(s)	Aged ; Artifacts ; Atrial Fibrillation/diagnostic imaging ; Atrial Fibrillation/physiopathology ; Atrial Fibrillation/surgery ; Cardiac Catheters ; Cryosurgery/instrumentation ; Echocardiography, Doppler, Color ; Echocardiography, Transesophageal ; Equipment Design ; Humans ; Male ; Predictive Value of Tests ; Pulmonary Veins/diagnostic imaging ; Pulmonary Veins/physiopathology ; Pulmonary Veins/surgery ; Punctures ; Treatment Outcome
Language	English
Publishing date	2015-03-19
Publishing country	United States
Document type	Case Reports ; Journal Article ; Video-Audio Media
ZDB-ID	80032-6
ISSN	1526-7598 ; 0003-2999
ISSN (online)	1526-7598
ISSN	0003-2999
DOI	10.1213/ANE.0000000000000683
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Article: Consistency of fuzzy rules in an ecological context

Gutiérrez-Estrada, Juan C / David T. Bilton / Inmaculada Pulido-Calvo

Ecological modelling. 2013 Feb. 24, v. 251

2013

Abstract: In this paper, we assess the performance of fuzzy inference systems (FISs) and the consistency of fuzzy rules generated from a meta-analysis exploring diversity–environment relationships, in a system of temporary and fluctuating ponds located in two ... ...

Abstract	In this paper, we assess the performance of fuzzy inference systems (FISs) and the consistency of fuzzy rules generated from a meta-analysis exploring diversity–environment relationships, in a system of temporary and fluctuating ponds located in two regions of southern England. The analyses focus on aquatic coleopteran assemblages, which act as excellent surrogates of wider freshwater macroinvertebrate diversity. Evaluated FISs were calibrated using evolutionary algorithms and the consistency of the rules examined using a consistency index specifically developed in this work. The best fit accounted for 76% of observed variability in the Shannon diversity index across ponds in the validation phase, which was 56 points better than the benchmark value established by a generalized additive model (GAM). The analysis of fuzzy rules indicated that the basic dynamics of this system are controlled by 8 rules. Another 10 complementary rules were detected, suggesting that more than a single dimension controlled the dynamics of the system. Therefore, water beetle diversity appears to be driven by a relatively short set of rules which relate diversity and environmental factors in a non-linear manner. These rules can be grouped according to their consistency levels, which reflect differences in coleopteran community composition.
Keywords	algorithms ; Coleoptera ; community structure ; environmental factors ; freshwater ; macroinvertebrates ; meta-analysis ; models ; ponds ; England
Language	English
Dates of publication	2013-0224
Size	p. 187-198.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	191971-4
ISSN	0304-3800
ISSN	0304-3800
DOI	10.1016/j.ecolmodel.2012.12.013
Database	NAL-Catalogue (AGRICOLA)

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Article: Effects of environmental conditions and fishing operations on the performance of a bottom trawl

Queirolo, Dante / Hurtado, Carlos F / Gaete, Erick / Soriguer, Milagrosa C / Erzini, Karim / Gutiérrez-Estrada, Juan C

ICES journal of marine science. 2012 Mar., v. 69, no. 2

2012

Abstract: Queirolo, D., Hurtado, C. F., Gaete, E., Soriguer, M. C., Erzini, K., and Gutiérrez-Estrada, J. C. 2012. Effects of environmental conditions and fishing operations on the performance of a bottom trawl. – ICES Journal of Marine Science, 69: 293–302. Trawl ...

Abstract	Queirolo, D., Hurtado, C. F., Gaete, E., Soriguer, M. C., Erzini, K., and Gutiérrez-Estrada, J. C. 2012. Effects of environmental conditions and fishing operations on the performance of a bottom trawl. – ICES Journal of Marine Science, 69: 293–302. Trawl performance was studied based on net spread and variability in the contact of the footrope with the seabed and their relationship with vessel operations, catch weight, and environmental conditions. Artificial neural networks (ANNs) and generalized additive models (GAMs) were used to model the response of each variable. For the variables net spread and variability in footrope contact (VFC), the ANN models were more accurate than the GAMs, with greater generalization capacity in the validation phase. In the best ANN model for net spread, all variables were significant. The relationship between tow direction and wind direction (tactic) was most important in the sensitivity analysis. Net spread increased with increasing towing speed and windspeed, and decreased with increasing wave height. In the ANN model for VFC, there were differences among vessels, and both scope ratio and catch size were not significant. VFC increased with increasing depth and decreased with increasing towing speed and windspeed. The results demonstrate that both operational variables and environmental conditions affect trawl performance, and suggest that survey protocols designed based on this information might help to improve the precision of biomass estimates.
Keywords	biomass ; environmental factors ; equipment performance ; fish industry ; fish nets ; fishing boats ; marine science ; neural networks ; surveys ; wind direction ; wind speed ; yields
Language	English
Dates of publication	2012-03
Size	p. 293-302.
Publishing place	Oxford University Press
Document type	Article
ZDB-ID	1468003-8
ISSN	1095-9289 ; 1054-3139
ISSN (online)	1095-9289
ISSN	1054-3139
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Article ; Online: Efficacy of a Bio-Absorbable Antibacterial Envelope to Prevent Cardiac Implantable Electronic Device Infections in High-Risk Subjects.

Kolek, Matthew J / Patel, Neel J / Clair, Walter K / Whalen, S Patrick / Rottman, Jeffrey N / Kanagasundram, Arvindh / Shen, Sharon T / Saavedra, Pablo J / Estrada, Juan C / Abraham, Robert L / Ellis, Christopher R

Journal of cardiovascular electrophysiology

2015 Volume 26, Issue 10, Page(s) 1111–1116

Abstract: Introduction: Cardiac implantable electronic device (CIED) infections are potentially preventable complications associated with high morbidity, mortality, and cost. A recently developed bio-absorbable antibacterial envelope (TYRX™-A) might prevent CIED ... ...

Abstract	Introduction: Cardiac implantable electronic device (CIED) infections are potentially preventable complications associated with high morbidity, mortality, and cost. A recently developed bio-absorbable antibacterial envelope (TYRX™-A) might prevent CIED infections in high-risk subjects. However, data regarding safety and efficacy have not been published. Methods and results: In a single-center retrospective cohort study, we compared the prevalence of CIED infections among subjects with ≥2 risk factors treated with the TYRX™-A envelope (N = 135), the nonabsorbable TYRX™ envelope (N = 353), and controls who did not receive an envelope (N = 636). Infection was ascertained by individual chart review. The mean (95% confidence interval) number of risk factors was 3.08 (2.84-3.32) for TYRX™-A, 3.20 (3.07-3.34) for TYRX™, and 3.09 (2.99-3.20) for controls, P = 0.3. After a minimum 300 days follow-up, the prevalence of CIED infection was 0 (0%) for TYRX™-A, 1 (0.3%) for TYRX™, and 20 (3.1%) for controls (P = 1 for TYRX™-A vs. TYRX™, P = 0.03 for TYRX™-A vs. controls, and P = 0.002 for TYRX™ vs. controls). In a propensity score-matched cohort of 316 recipients of either envelope and 316 controls, the prevalence of infection was 0 (0%) and 9 (2.8%), respectively, P = 0.004. When limited to 122 TYRX™-A recipients and 122 propensity-matched controls, the prevalence of CIED infections was 0 (0%) and 5 (4.1%), respectively, P = 0.024. Conclusions: Among high-risk subjects, the TYRX™-A bio-absorbable envelope was associated with a very low prevalence of CIED related infections that was comparable to that seen with the nonabsorbable envelope.
MeSH term(s)	Absorbable Implants/statistics & numerical data ; Aged ; Anti-Bacterial Agents/administration & dosage ; Causality ; Cohort Studies ; Defibrillators, Implantable/statistics & numerical data ; Delayed-Action Preparations/administration & dosage ; Drug Implants/administration & dosage ; Female ; Humans ; Male ; Middle Aged ; Pacemaker, Artificial/statistics & numerical data ; Prevalence ; Prosthesis-Related Infections/diagnosis ; Prosthesis-Related Infections/epidemiology ; Prosthesis-Related Infections/prevention & control ; Retrospective Studies ; Risk Factors ; Sex Distribution ; Survival Rate ; Tennessee/epidemiology ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents ; Delayed-Action Preparations ; Drug Implants
Language	English
Publishing date	2015-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1025989-2
ISSN	1540-8167 ; 1045-3873
ISSN (online)	1540-8167
ISSN	1045-3873
DOI	10.1111/jce.12768
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Article ; Online: Enhanced external counterpulsation treatment improves arterial wall properties and wave reflection characteristics in patients with refractory angina.

Nichols, Wilmer W / Estrada, Juan C / Braith, Randy W / Owens, Karen / Conti, C Richard

Journal of the American College of Cardiology

2006 Volume 48, Issue 6, Page(s) 1208–1214

Abstract: Objectives: To determine if arterial properties and wave reflection characteristics are favorably altered after enhanced external counterpulsation (EECP) treatment in patients with refractory angina.: Background: Early return of reflected waves from ... ...

Abstract	Objectives: To determine if arterial properties and wave reflection characteristics are favorably altered after enhanced external counterpulsation (EECP) treatment in patients with refractory angina. Background: Early return of reflected waves from the lower body, resulting from increased arterial stiffness, augments central aortic pressure and increases left ventricular (LV) afterload and myocardial oxygen demand. EECP acutely enhances coronary perfusion (supply) and reduces LV afterload (demand). However, the mechanisms responsible for the sustained beneficial effects of EECP treatment are unclear. Methods: Radial artery pressure waveforms were recorded by applanation tonometry and central aortic pressure waveforms generated using a mathematical transfer function in 20 patients with stable refractory angina. Data were collected before and after 34 1-h EECP sessions. Augmentation index (AI(a)) and timing of the reflected pressure wave were calculated from the aortic waveform. Results: EECP treatment caused a decline in AI(a) and an increase in reflected wave travel time. These modifications in wave reflection characteristics caused a decrease in aortic systolic pressure and wasted LV pressure energy. The average number of angina episodes and Canadian Cardiovascular Society (CCS) class, both decreased in concordance with the physiologic changes due to EECP treatment. Conclusions: EECP treatment reduces arterial stiffness and improves wave reflection characteristics in patients with refractory angina. These changes decrease LV afterload and myocardial oxygen demand and reduce the number of angina episodes, therefore enabling patients to participate in continuous exercise programs which in turn may provide long-term benefits and sustained improved quality of life.
MeSH term(s)	Aged ; Angina Pectoris/physiopathology ; Angina Pectoris/therapy ; Aorta/physiopathology ; Blood Pressure ; Counterpulsation/methods ; Elasticity ; Female ; Humans ; Male ; Middle Aged ; Myocardium/metabolism ; Oxygen/metabolism ; Pulse ; Radial Artery/physiopathology ; Severity of Illness Index ; Systole ; Ventricular Function, Left
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2006-09-19
Publishing country	United States
Document type	Clinical Trial ; Journal Article
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2006.04.094
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Article ; Online: Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas.

Samper, Enrique / Morgado, Lucia / Estrada, Juan C / Bernad, Antonio / Hubbard, Alan / Cadenas, Susana / Melov, Simon

Free radical biology & medicine

2008 Volume 46, Issue 3, Page(s) 387–396

Abstract: Lymphomas adapt to their environment by undergoing a complex series of biochemical changes that are currently not well understood. To better define these changes, we examined the gene expression and gene ontology profiles of thymic lymphomas from a ... ...

Abstract	Lymphomas adapt to their environment by undergoing a complex series of biochemical changes that are currently not well understood. To better define these changes, we examined the gene expression and gene ontology profiles of thymic lymphomas from a commonly used model of carcinogenesis, the p53(-/-) mouse. These tumors show a highly significant upregulation of mitochondrial biogenesis, mitochondrial protein translation, mtDNA copy number, reactive oxygen species, antioxidant defenses, proton transport, ATP synthesis, hypoxia response, and glycolysis, indicating a fundamental change in the bioenergetic profile of the transformed T cell. Our results suggest that T cell tumorigenesis involves a simultaneous upregulation of mitochondrial biogenesis, mitochondrial respiration, and glycolytic activity. These processes would allow cells to adapt to the stressful tumor environment by facilitating energy production and thereby promote tumor growth. Understanding these adaptations is likely to result in improved therapeutic strategies for this tumor type.
MeSH term(s)	Animals ; DNA, Mitochondrial/analysis ; Electron Transport Chain Complex Proteins/genetics ; Electron Transport Chain Complex Proteins/metabolism ; Gene Expression Profiling ; Glycolysis/genetics ; Lymphoma, T-Cell/genetics ; Lymphoma, T-Cell/metabolism ; Lymphoma, T-Cell/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mitochondria/genetics ; Mitochondria/metabolism ; Oxidative Stress/genetics ; Oxygen Consumption ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; Thymus Gland/metabolism ; Thymus Gland/pathology ; Tumor Suppressor Protein p53/genetics
Chemical Substances	DNA, Mitochondrial ; Electron Transport Chain Complex Proteins ; Myc protein, mouse ; Proto-Oncogene Proteins c-myc ; Tumor Suppressor Protein p53
Language	English
Publishing date	2008-10-30
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2008.10.036
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