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Article ; Online: Cyclic intravenous pamidronate in a very low-birthweight infant with osteogenesis imperfecta.

Eto, Shohei / Hada, Satoshi / Fukuhara, Rie / Nishimura, Gen / Takagi, Masaki

Pediatrics international : official journal of the Japan Pediatric Society

2018 Volume 60, Issue 5, Page(s) 485–486

MeSH term(s)	Bone Density Conservation Agents/administration & dosage ; Bone Density Conservation Agents/therapeutic use ; Diphosphonates/administration & dosage ; Diphosphonates/therapeutic use ; Drug Administration Schedule ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases/diagnosis ; Infant, Premature, Diseases/drug therapy ; Infant, Very Low Birth Weight ; Infusions, Intravenous ; Male ; Osteogenesis Imperfecta/diagnosis ; Osteogenesis Imperfecta/drug therapy
Chemical Substances	Bone Density Conservation Agents ; Diphosphonates ; pamidronate (OYY3447OMC)
Language	English
Publishing date	2018-04-26
Publishing country	Australia
Document type	Case Reports ; Journal Article
ZDB-ID	1470376-2
ISSN	1442-200X ; 1328-8067
ISSN (online)	1442-200X
ISSN	1328-8067
DOI	10.1111/ped.13535
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Article ; Online: Impact of CKLF-like MARVEL transmembrane domain containing 6 (CMTM6) expression in gastric cancer.

Nishi, Masaaki / Shimada, Mitsuo / Yoshikawa, Kozo / Higashijima, Jun / Tokunaga, Takuya / Kashihara, Hideya / Takasu, Chie / Eto, Shohei / Yoshimoto, Toshiaki

The journal of medical investigation : JMI

2021 Volume 68, Issue 3.4, Page(s) 362–367

Abstract: Background : CKLF-like MARVEL transmembrane domain containing 6 (CMTM6) is the master regulator of programmed cell death-ligand 1 (PD-L1). We aimed to clarify the significance of CMTM6 expression in gastric cancer (GC). Methods : A total of 105 patients ... ...

Abstract	Background : CKLF-like MARVEL transmembrane domain containing 6 (CMTM6) is the master regulator of programmed cell death-ligand 1 (PD-L1). We aimed to clarify the significance of CMTM6 expression in gastric cancer (GC). Methods : A total of 105 patients who had undergone curative surgical resection for stage II / III GC at Tokushima University Hospital were included in this study. The expression of CMTM6 was examined by immunohistochemistry. Additionally, the relationship of each expression level to several prognostic factors was examined using univariate and multivariate analyses. Results : CMTM6 was not positively correlated with any of the factors examined. The overall survival (OS) rates were significantly poorer in the CMTM6 high-expression group than in the CMTM low-expression group (5-year OS : 57.2% vs. 79.2%, respectively ; p < 0.05). Disease-free survival (DFS) was significantly poorer in the CMTM high-expression group than in the CMTM6 low-expression group (5-year DFS : 52.8% vs. 72.4%, respectively ; p < 0.05). Multivariate analysis confirmed CMTM6 expression as an independent prognostic factor in DFS (p < 0.05). CMTM6 expression tended to be correlated with PD-L1 expression (p = 0.07). Conclusions : CMTM6 is associated with a poor prognosis and immunotolerance through PD-L1 in GC. J. Med. Invest. 68 : 362-367, August, 2021.
MeSH term(s)	B7-H1 Antigen ; Chemokines ; Humans ; MARVEL Domain-Containing Proteins ; Myelin Proteins ; Prognosis ; Stomach Neoplasms/surgery ; Survival Rate
Chemical Substances	B7-H1 Antigen ; CKLF protein, human ; Chemokines ; MARVEL Domain-Containing Proteins ; Myelin Proteins
Language	English
Publishing date	2021-11-10
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1435233-3
ISSN	1349-6867 ; 1343-1420
ISSN (online)	1349-6867
ISSN	1343-1420
DOI	10.2152/jmi.68.362
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Article ; Online: SDF-1 expression after preoperative chemoradiotherapy is associated with prognosis in patients with advanced lower rectal cancer.

Okikawa, Shohei / Higashijima, Jun / Nishi, Masaaki / Yoshimoto, Toshiaki / Eto, Shohei / Takasu, Chie / Kashihara, Hideya / Tokunaga, Takuya / Yoshikawa, Kozo / Shimada, Mitsuo

The journal of medical investigation : JMI

2021 Volume 68, Issue 3.4, Page(s) 309–314

Abstract: Stromal cell-derived factor-1 (SDF-1) expression is associated with cancer progression, as a biomarker of prognosis. We clarified the significance of SDF-1 expression on chemoradiotherapy (CRT) resistance and prognosis in advanced lower rectal cancer ... ...

Abstract	Stromal cell-derived factor-1 (SDF-1) expression is associated with cancer progression, as a biomarker of prognosis. We clarified the significance of SDF-1 expression on chemoradiotherapy (CRT) resistance and prognosis in advanced lower rectal cancer patients. We evaluated 98 patients with advanced lower rectal cancer who underwent preoperative CRT. All patients received 40 Gy of radiation therapy, with concurrent chemotherapy containing fluorinated pyrimidines, followed by surgical resection. SDF-1 expression in surgical specimens was examined by immunohistochemistry. We divided the patients into SDF-1-positive- (n = 52) and SDF-1-negative groups (n = 46) and compared the clinicopathological factors and survival rates. The SDF-1-positive group was more resistant to CRT than the SDF-1-negative group (non-responder rate, 63.5% vs. 47.8%, respectively ; p = 0.12). Overall survival (OS) in the SDF-1 positive group was significantly poorer vs. the SDF-1-negative group (5-year OS, 73.4% vs. 88.0%, respectively ; p = 0.02), and disease-free survival (DFS) was worse (5-year DFS, 61.0% vs. 74.1%, respectively ; p = 0.07). Multivariate analysis confirmed that SDF-1 expression was a significant independent prognostic predictor of OS (p = 0.04). SDF-1 expression after preoperative CRT is significantly associated with a poor prognosis in advanced lower rectal cancer patients and is a promising biomarker. J. Med. Invest. 68 : 309-314, August, 2021.
MeSH term(s)	Chemoradiotherapy ; Disease-Free Survival ; Humans ; Neoplasm Staging ; Prognosis ; Rectal Neoplasms/drug therapy ; Rectum
Language	English
Publishing date	2021-11-10
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1435233-3
ISSN	1349-6867 ; 1343-1420
ISSN (online)	1349-6867
ISSN	1343-1420
DOI	10.2152/jmi.68.309
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Article ; Online: Usefulness of Diagnostic Staging Laparoscopy for Advanced Gastric Cancer.

Yoshikawa, Kozo / Shimada, Mitsuo / Higashijima, Jun / Tokunaga, Takuya / Nishi, Masaaki / Takasu, Chie / Kashihara, Hideya / Eto, Shohei / Yoshimoto, Toshiaki

The American surgeon

2021 Volume 89, Issue 4, Page(s) 685–690

Abstract: Background: For advanced gastric cancer (AGC), peritoneal metastasis is the most common determinant of unresectability, but accurate preoperative diagnosis for peritoneal metastasis is challenging. Staging laparoscopy (SL) can detect unsuspected ... ...

Abstract	Background: For advanced gastric cancer (AGC), peritoneal metastasis is the most common determinant of unresectability, but accurate preoperative diagnosis for peritoneal metastasis is challenging. Staging laparoscopy (SL) can detect unsuspected peritoneal metastasis. This study retrospectively evaluated the utility of SL and its indication in patients with AGC. Methods: In this study, we enrolled 114 patients with pathologically diagnosed gastric adenocarcinoma who underwent SL. Results: Of the 114 patients, 43 (37.7%) had peritoneal metastasis (P1 or CY1). Higher age, larger tumor size, type 4 GC, deeper tumor depth, elevated CA125, and ascites findings in preoperative CT were found to be significant predictors of peritoneal metastasis. In multivariate analysis, peritoneal metastasis was associated with type 4 GC (odds ratio [OR]: 6.11; 95% confidence interval [CI]: 1.87-19.8; P < .01) and ascites in CT (OR: 4.25; 95% CI: 1.48-12.1; P < .01). Conclusions: Staging laparoscopy is an effective tool to detect peritoneal metastasis from AGC. It can increase the curative resection rate and decrease unnecessary laparotomies.
MeSH term(s)	Humans ; Peritoneal Neoplasms/diagnosis ; Peritoneal Neoplasms/surgery ; Peritoneal Neoplasms/pathology ; Ascites/surgery ; Stomach Neoplasms/surgery ; Stomach Neoplasms/pathology ; Retrospective Studies ; Neoplasm Staging ; Laparoscopy
Language	English
Publishing date	2021-08-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/00031348211038554
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Article ; Online: A Transabdominal Robotic Purse-String Suture Technique for Transanal Total Mesorectal Excision.

Tokunaga, Takuya / Kashihara, Hideya / Higashijima, Jun / Yoshikawa, Kozo / Nishi, Masaaki / Takasu, Chie / Eto, Shohei / Yoshimoto, Toshiaki / Shimada, Mitsuo

Journal of laparoendoscopic & advanced surgical techniques. Part A

2021 Volume 31, Issue 8, Page(s) 937–941

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Humans ; Laparoscopy ; Rectal Neoplasms/surgery ; Rectum/surgery ; Robotic Surgical Procedures ; Robotics ; Suture Techniques ; Transanal Endoscopic Surgery
Language	English
Publishing date	2021-07-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1381909-4
ISSN	1557-9034 ; 1092-6429
ISSN (online)	1557-9034
ISSN	1092-6429
DOI	10.1089/lap.2021.0286
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Article: Secondary aorto-duodenal fistula successfully treated with a novel surgical method: A case report.

Tsuneki, Takao / Yuasa, Yasuhiro / Fukuta, Mizuki / Maki, Hidenori / Matsuo, Yuta / Mori, Osamu / Eto, Shohei / Fujiwara, Satoshi / Tomibayashi, Atsusi / Otani, Takashi

International journal of surgery case reports

2020 Volume 72, Page(s) 17–21

Abstract: Introduction: Secondary aorto-duodenal fistula (sADF) is a complication of abdominal aorta artificial blood vessel replacement that often leads to death. However, an optimal operative method has not yet been established. We describe a patient who ... ...

Abstract	Introduction: Secondary aorto-duodenal fistula (sADF) is a complication of abdominal aorta artificial blood vessel replacement that often leads to death. However, an optimal operative method has not yet been established. We describe a patient who underwent artificial blood vessel reimplantation and duodenectomy after endovascular aneurysmal repair (EVAR) with positive outcomes. Presentation of case: An 84-year-old man underwent artificial blood vessel replacement in 2015. In September 2016, he visited our emergency department and was diagnosed with sADF based on computed tomography. Urgent EVAR was performed, followed by duodenal segmental resection on the next day without opening the syringeal part to minimize the pollution of the operative field. Artificial blood vessel reimplantation and omental flap transposition were performed. As of 2020, about 3 years after surgery, there has been no relapse of the infection. Discussion: Using our novel operative method, we can minimize exposure of the artificial blood vessel and surrounding tissue to intestinal juice and pus. We believe that this reduces the risk of postoperative artificial blood vessel reinfection. Conclusion: Controlling bleeding by EVAR and resection of the duodenum and artificial blood vessels as a group without opening the syringeal part can contribute to positive long-term results as this method minimizes the pollution of the duodenectomy surgical field.
Language	English
Publishing date	2020-05-29
Publishing country	Netherlands
Document type	Case Reports
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2020.05.041
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Article ; Online: Transoral Anvil Delivery System With Tension-Free Method for Esophagojejunostomy After Laparoscopic Total Gastrectomy Prevents The Postoperative Stenosis.

Yoshikawa, Kozo / Shimada, Mitsuo / Higashijima, Jun / Tokunaga, Takuya / Nishi, Masaaki / Takasu, Chie / Kashihara, Hideya / Eto, Shohei / Yoshimoto, Toshiaki

The American surgeon

2020 Volume 89, Issue 4, Page(s) 1066–1068

MeSH term(s)	Humans ; Constriction, Pathologic/surgery ; Anastomosis, Surgical/methods ; Postoperative Complications/prevention & control ; Postoperative Complications/surgery ; Laparoscopy/methods ; Gastrectomy/adverse effects ; Gastrectomy/methods ; Stomach Neoplasms/surgery ; Surgical Stapling/methods ; Retrospective Studies ; Jejunum/surgery
Language	English
Publishing date	2020-12-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/0003134820973393
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Article: A long-term survival case of advanced biliary cancer with repeated resection due to recurrence in the pancreaticogastrostomy site after pancreaticoduodenectomy.

Eto, Shohei / Ishikawa, Masashi / Asanoma, Michihito / Tashiro, Yoshihiko / Matsuyama, Kazuo / Oshio, Takehito

Annals of hepato-biliary-pancreatic surgery

2018 Volume 22, Issue 2, Page(s) 173–177

Abstract: A 62-year-old man underwent endoscopic mucosal resection for early gastric cancer. The follow-up computed tomography revealed biliary dilatation. The tumor was located in the lower bile duct with biliary dilatation, and no evidence of metastasis in other ...

Abstract	A 62-year-old man underwent endoscopic mucosal resection for early gastric cancer. The follow-up computed tomography revealed biliary dilatation. The tumor was located in the lower bile duct with biliary dilatation, and no evidence of metastasis in other organs was noted. The patient underwent subtotal stomach-preserving pancreatoduodenectomy with pancreaticogastrostomy and Billroth I anastomosis. At 13 months after the operation, gastrointestinal endoscopy revealed a tumor lesion in the pancreaticogastrostomy site. Computed tomography revealed that the lesion was low enhanced in the pancreaticogastrostomy site and there was no evidence of other distant metastasis. Partial pancreatectomy was performed. Pathological findings of the tumor in the stump of the pancreas revealed findings similar to that of primary biliary carcinoma. Apparently, the patient was diagnosed with recurrence of bile duct cancer via the pancreatic duct. The patient underwent adjuvant chemotherapy for one year subsequent to partial pancreatectomy as the second operation. For 40 months after the second operation, there has been no evidence of recurrence of cancer.
Language	English
Publishing date	2018-05-30
Publishing country	Korea (South)
Document type	Case Reports
ZDB-ID	3012179-6
ISSN	2508-5859 ; 2508-5778
ISSN (online)	2508-5859
ISSN	2508-5778
DOI	10.14701/ahbps.2018.22.2.173
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Article ; Online: Usefulness of a multidisciplinary surgical site infection team in colorectal surgery.

Eto, Shohei / Yoshikawa, Kozo / Takehara, Yukako / Yoshimoto, Toshiaki / Takasu, Chie / Kashihara, Hideya / Nishi, Masaaki / Tokunaga, Takuya / Nakao, Toshihiro / Higashijima, Jun / Iwata, Takashi / Shimada, Mitsuo

The journal of medical investigation : JMI

2021 Volume 68, Issue 3.4, Page(s) 256–259

Abstract: Background : Surgical site infection (SSI) is an adverse event that places a major burden on patients and staff. In this study, we examined the occurrence of SSI and the characteristics of patients referred to the SSI team after colorectal surgery. ... ...

Abstract	Background : Surgical site infection (SSI) is an adverse event that places a major burden on patients and staff. In this study, we examined the occurrence of SSI and the characteristics of patients referred to the SSI team after colorectal surgery. Methods : In total, 955 patients underwent colorectal surgery at our hospital from 2014 to 2019. Of these 955 patients, 516 received therapeutic support by the SSI team from 2017 to 2019. All patients were evaluated using an SSI surveillance sheet, and we checked for reports of SSI once a month. Each attending physician performed SSI prophylaxis (use of new instruments before wound irrigation and closure). Results : SSI occurred in 80 (8.4%) patients. The incidence of SSI and the incidence of surface SSI were higher in the patients who did not receive intervention by the SSI team than in the patients who did. Organ / space SSI occurred in 18 patients. Among patients with surface SSI, Enterococcus was the most commonly detected bacteria. Among the 18 patients with organ / space SSI, 5 developed anastomotic leakage and 4 developed intra-abdominal abscesses. Conclusions : An SSI team for prevention and treatment of infection may contribute to reduction of SSI. J. Med. Invest. 68 : 256-259, August, 2021.
MeSH term(s)	Colorectal Surgery/adverse effects ; Humans ; Incidence ; Risk Factors ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/etiology ; Surgical Wound Infection/prevention & control ; Therapeutic Irrigation
Language	English
Publishing date	2021-11-10
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1435233-3
ISSN	1349-6867 ; 1343-1420
ISSN (online)	1349-6867
ISSN	1343-1420
DOI	10.2152/jmi.68.256
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Article ; Online: Lymphocyte to C-reactive protein ratio predicts long-term outcomes for patients with lower rectal cancer.

Nishi, Masaaki / Shimada, Mistuo / Tokunaga, Takuya / Higashijima, Jun / Yoshikawa, Kozo / Kashihara, Hideya / Takasu, Chie / Ishikawa, Daichi / Wada, Yuma / Eto, Shohei / Yoshimoto, Toshiaki

World journal of surgical oncology

2021 Volume 19, Issue 1, Page(s) 201

Abstract: Backgrounds: The lymphocyte to C-reactive protein (CRP) ratio (LCR) is an indicator of systemic inflammation and host-tumor cell interactions. The aim of this study was to investigate the prognostic significance of LCR in lower rectal cancer patients ... ...

Abstract	Backgrounds: The lymphocyte to C-reactive protein (CRP) ratio (LCR) is an indicator of systemic inflammation and host-tumor cell interactions. The aim of this study was to investigate the prognostic significance of LCR in lower rectal cancer patients who received preoperative chemo-radiotherapy (CRT). Methods: Forty-eight patients with lower rectal cancer who underwent CRT followed by curative surgery were enrolled in this study. Routine blood examinations were performed before and after CRT were used to calculate pre-CRT LCR and post-CRT LCR. The median LCR was used to stratify patients into low and high LCR groups for analysis. The correlation between pre- and post-CRT LCR and clinical outcomes was retrospectively investigated. Results: The pre-CRT LCR was significantly higher than the post-CRT LCR (11,765 and 6780, respectively, P < 0.05). The 5-year overall survival rate was significantly higher for patients with high post-CRT LCR compared with low post-CRT LCR (90.6% and 65.5%, respectively, P < 0.05). In univariate analysis, post-CRT LCR, post-CRT neutrophil to lymphocyte ratio, and fStage were significant prognostic factors for overall survival. In multivariate analysis, post-CRT LCR, but not other clinicopathological factors or prognostic indexes, was a significant prognostic factor for overall survival (P < 0.05). Conclusions: Post-CRT LCR could be a prognostic biomarker for patients with lower rectal cancer.
MeSH term(s)	C-Reactive Protein ; Chemoradiotherapy ; Humans ; Lymphocytes/pathology ; Neoplasm Staging ; Prognosis ; Rectal Neoplasms/pathology ; Rectal Neoplasms/therapy ; Retrospective Studies
Chemical Substances	C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2021-07-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2118383-1
ISSN	1477-7819 ; 1477-7819
ISSN (online)	1477-7819
ISSN	1477-7819
DOI	10.1186/s12957-021-02319-x
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