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  1. Article ; Online: Policy direction for the development of pediatric emergency care in Korea

    Eun Young Kim

    Pediatric Emergency Medicine Journal, Vol 10, Iss 1, Pp 1-

    2023  Volume 2

    Keywords Medicine ; R
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Korean Society of Pediatric Emergency Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: 10th Anniversary of Clinical Endoscopy

    Eun Young Kim

    Clinical Endoscopy, Vol 54, Iss 5, Pp 631-

    2021  Volume 632

    Keywords Internal medicine ; RC31-1245 ; Diseases of the digestive system. Gastroenterology ; RC799-869
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Hoon Jai Chun
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Biobanks as a Treasury for Precision Medicine

    Eun-Young Kim

    Healthcare Informatics Research, Vol 27, Iss 2, Pp 93-

    2021  Volume 94

    Keywords Computer applications to medicine. Medical informatics ; R858-859.7
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher The Korean Society of Medical Informatics
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Effects of Medical Education Program Using Virtual Reality

    Hyeon-Young Kim / Eun-Young Kim

    International Journal of Environmental Research and Public Health, Vol 20, Iss 3895, p

    A Systematic Review and Meta-Analysis

    2023  Volume 3895

    Abstract: Several studies have examined the effect of virtual reality (VR) education. However, they are mostly systematic reviews or meta-analyses focusing on doctors and residents; they fail to consider VR medical education for a broader range of learners. We ... ...

    Abstract Several studies have examined the effect of virtual reality (VR) education. However, they are mostly systematic reviews or meta-analyses focusing on doctors and residents; they fail to consider VR medical education for a broader range of learners. We evaluated the effectiveness of VR education for health professionals and identified the essential features of education. Randomized controlled trials published from January 2000 to April 2020 were identified from PubMed, Embase, CINAHL, and the Cochrane Library (n = 299). The randomized studies’ bias risk was evaluated using Cochrane’s Risk of Bias tool. Meta- and subgroup-analyses were conducted using Review Manager 5.4.1. The overall effect was measured using Hedges’ g and determined using Z-statistics ( p < 0.05). Heterogeneity was assessed using X 2 and I 2 statistics. Among the identified records, 25 studies were selected through systematic review, and 18 studies were included in the meta-analysis. We identified a significant improvement in the VR group’s skill and satisfaction levels, and that less immersive VR was more efficacious for knowledge outcomes than fully immersive VR. Maximizing the advantages of VR will increase learning opportunities and complement the limited clinical experience, thus improving medical services. A systematic and efficient VR medical education program will greatly enhance learners’ core competencies.
    Keywords virtual reality ; health personnel ; unlicensed ; randomized controlled trial ; systematic review ; Medicine ; R
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Case report

    Eun Young Kim / Tae Young Kil / Min Kyu Kim

    Veterinary and Animal Science, Vol 22, Iss , Pp 100318- (2023)

    Amniotic fluid-derived mesenchymal stem cell treatment in a dog with a spinal cord injury

    2023  

    Abstract: Spinal Cord Injury (SCI) refers to complete or incomplete damage to the spinal cord, which comprises the central nervous system. SCI in dogs, like humans, is mostly caused by external trauma, and the degree of impact is dependent on the location of the ... ...

    Abstract Spinal Cord Injury (SCI) refers to complete or incomplete damage to the spinal cord, which comprises the central nervous system. SCI in dogs, like humans, is mostly caused by external trauma, and the degree of impact is dependent on the location of the injury in the spine. Stem cell therapy is a promising avenue for SCI research. In this report, we investigate the therapeutic potential of amniotic fluid-derived mesenchymal stem cells (AF-MSCs) in dogs with spinal cord injuries. A 2-year-old male beagle dog presented with sensory and motor incomplete symptoms resulting in an inability to control the legs, hips, and genitourinary system due to an injury in the lumbar region of the spinal cord. In addition to the administration of surgical decompression, AF-MSCs were directly injected into the damaged spinal tissue. Approximately 15–16 weeks after stem cell transplantation, the dog's hind limb movement improved, and spinal cord regeneration was confirmed through magnetic resonance imaging (MRI). Eventually, the dog was able to walk independently, although not perfectly. In conclusion, AF-MSC-based stem cell transplantation may be beneficial for SCIs.
    Keywords Canine (dog) ; Spinal cord injury ; Amniotic fluid ; Mesenchymal stem cells ; Stem cell therapy ; Veterinary medicine ; SF600-1100
    Subject code 571
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Transcriptional Control of Trpm6 by the Nuclear Receptor FXR

    Eun Young Kim / Jae Man Lee

    International Journal of Molecular Sciences, Vol 23, Iss 1980, p

    2022  Volume 1980

    Abstract: Farnesoid x receptor (FXR) is a nuclear bile acid receptor that belongs to the nuclear receptor superfamily. It plays an essential role in bile acid biosynthesis, lipid and glucose metabolism, liver regeneration, and vertical sleeve gastrectomy. A loss ... ...

    Abstract Farnesoid x receptor (FXR) is a nuclear bile acid receptor that belongs to the nuclear receptor superfamily. It plays an essential role in bile acid biosynthesis, lipid and glucose metabolism, liver regeneration, and vertical sleeve gastrectomy. A loss of the FXR gene or dysregulations of FXR-mediated gene expression are associated with the development of progressive familial intrahepatic cholestasis, tumorigenesis, inflammation, and diabetes mellitus. Magnesium ion (Mg 2+ ) is essential for mammalian physiology. Over 600 enzymes are dependent on Mg 2+ for their activity. Here, we show that the Trpm6 gene encoding a Mg 2+ channel is a direct FXR target gene in the intestinal epithelial cells of mice. FXR expressed in the intestinal epithelial cells is absolutely required for sustaining a basal expression of intestinal Trpm6 that can be robustly induced by the treatment of GW4064, a synthetic FXR agonist. Analysis of FXR ChIP-seq data revealed that intron regions of Trpm6 contain two prominent FXR binding peaks. Among them, the proximal peak from the transcription start site contains a functional inverted repeat 1 (IR1) response element that directly binds to the FXR-RXRα heterodimer. Based on these results, we proposed that an intestinal FXR-TRPM6 axis may link a bile acid signaling to Mg 2+ homeostasis.
    Keywords nuclear receptor ; FXR ; bile acid ; Trpm6 ; small intestine ; colon ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 570
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Coexisting with the Life of Patients with Hemodialysis

    Eun-Young Kim / Ye-Na Lee

    International Journal of Environmental Research and Public Health, Vol 19, Iss 2163, p

    Qualitative Meta-Synthesis Study of Life of Caregivers of Patients with Hemodialysis

    2022  Volume 2163

    Abstract: As the number of patients with hemodialysis (HD) continues to increase, so too does the number of people depending on caregivers. There is need to pay attention to the lives of caregivers of patients with HD, where sacrifices are forced. This study ... ...

    Abstract As the number of patients with hemodialysis (HD) continues to increase, so too does the number of people depending on caregivers. There is need to pay attention to the lives of caregivers of patients with HD, where sacrifices are forced. This study systematically reviewed and synthesized qualitative studies that explored the experiences of caregivers caring for patients with HD using the meta-synthesis method. We searched literature using four databases (i.e., PubMed, Excerpta Medica dataBASE, Cumulated Index to Nursing and Allied Health Literature, and Web of Science), and finally ten publications were selected. Four themes and nine subtopics were derived from analyzing and synthesizing the research results. The synthesized themes were: “bearing the burden of life as a caregiver,” “reconstructing life to maintain hemodialysis”, “the fading of caregiver’s own life,” and “effort to relieve the burden.” The results of this study can contribute to the development of interventional studies to improve the quality of life of HD patients. These studies provide an integrated and in-depth perspective on the experiences of caregivers who care for HD patients.
    Keywords renal dialysis ; caregivers ; systematic review ; qualitative research ; Medicine ; R
    Subject code 360
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Transcriptional Regulation of Hepatic Autophagy by Nuclear Receptors

    Eun Young Kim / Jae Man Lee

    Cells, Vol 11, Iss 620, p

    2022  Volume 620

    Abstract: Autophagy is an adaptive self-eating process involved in degradation of various cellular components such as carbohydrates, lipids, proteins, and organelles. Its activity plays an essential role in tissue homeostasis and systemic metabolism in response to ...

    Abstract Autophagy is an adaptive self-eating process involved in degradation of various cellular components such as carbohydrates, lipids, proteins, and organelles. Its activity plays an essential role in tissue homeostasis and systemic metabolism in response to diverse challenges, including nutrient depletion, pathogen invasion, and accumulations of toxic materials. Therefore, autophagy dysfunctions are intimately associated with many human diseases such as cancer, neurodegeneration, obesity, diabetes, infection, and aging. Although its acute post-translational regulation is well described, recent studies have also shown that autophagy can be controlled at the transcriptional and post-transcriptional levels. Nuclear receptors (NRs) are in general ligand-dependent transcription factors consisting of 48 members in humans. These receptors extensively control transcription of a variety of genes involved in development, metabolism, and inflammation. In this review, we discuss the roles and mechanisms of NRs in an aspect of transcriptional regulation of hepatic autophagy, and how the NR-driven autophagy pathway can be harnessed to treat various liver diseases.
    Keywords autophagy ; macroautophagy ; nuclear receptor ; liver ; Biology (General) ; QH301-705.5
    Subject code 571 ; 570
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Basal Autophagy Is Necessary for A Pharmacologic PPARα Transactivation

    Eun Young Kim / Jae Man Lee

    Cells, Vol 11, Iss 754, p

    2022  Volume 754

    Abstract: Autophagy is a conserved cellular process of catabolism leading to nutrient recycling upon starvation and maintaining tissue and energy homeostasis. Tissue-specific loss of core-autophagy-related genes often triggers diverse diseases, including cancer, ... ...

    Abstract Autophagy is a conserved cellular process of catabolism leading to nutrient recycling upon starvation and maintaining tissue and energy homeostasis. Tissue-specific loss of core-autophagy-related genes often triggers diverse diseases, including cancer, neurodegeneration, inflammatory disease, metabolic disorder, and muscle disease. The nutrient-sensing nuclear receptors peroxisome proliferator-activated receptor α (PPARα) plays a key role in fasting-associated metabolisms such as autophagy, fatty acid oxidation, and ketogenesis. Here we show that autophagy defects impede the transactivation of PPARα. Liver-specific ablation of the Atg7 gene in mice showed reduced expression levels of PPARα target genes in response to its synthetic agonist ligands. Since NRF2, an antioxidant transcription factor, is activated in autophagy-deficient mice due to p62/SQSTM1 accumulation and its subsequent interaction with KEAP1, an E3 ubiquitin ligase. We hypothesize that the nuclear accumulation of NRF2 by autophagy defects blunts the transactivation of PPARα. Consistent with this idea, we find that NRF2 activation is sufficient to inhibit the pharmacologic transactivation of PPARα, which is dependent on the Nrf2 gene. These results reveal an unrecognized requirement of basal autophagy for the transactivation of PPARα by preventing NRF2 from a nuclear translocation and suggest a clinical significance of basal autophagy to expect a pharmacologic efficacy of synthetic PPARα ligands.
    Keywords basal autophagy ; PPARα ; ATG7 ; NRF2 ; KEAP1 ; transactivation ; Biology (General) ; QH301-705.5
    Subject code 571
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Sharing Our Experience of Operating an Endoscopy Unit in the Midst of a COVID-19 Outbreak

    Jimin Han / Eun Young Kim

    Clinical Endoscopy, Vol 53, Iss 2, Pp 243-

    2020  Volume 245

    Keywords Internal medicine ; RC31-1245 ; Diseases of the digestive system. Gastroenterology ; RC799-869 ; covid19
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher Korean Society of Gastrointestinal Endoscopy
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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