Article ; Online: Population-specific causal disease effect sizes in functionally important regions impacted by selection
Nature Communications, Vol 12, Iss 1, Pp 1-
2021 Volume 15
Abstract: Trans-ethnic genetic correlation is significantly less than 1 for many diseases. Here, the authors stratify this correlation by genomic annotations, finding that loci whose causal disease effect sizes differ between ethnicities are likely impacted by ... ...
| Abstract | Trans-ethnic genetic correlation is significantly less than 1 for many diseases. Here, the authors stratify this correlation by genomic annotations, finding that loci whose causal disease effect sizes differ between ethnicities are likely impacted by selection, particularly positive selection. |
|---|---|
| Keywords | Science ; Q |
| Language | English |
| Publishing date | 2021-02-01T00:00:00Z |
| Publisher | Nature Portfolio |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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