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  1. Article ; Online: Microdose Lithium Treatment Reduced Inflammatory Factors and Neurodegeneration in Organotypic Hippocampal Culture of Old SAMP-8 Mice.

    Toricelli, Mariana / Evangelista, Sebastiana Ribeiro / Buck, Hudson Sousa / Viel, Tania Araujo

    Cellular and molecular neurobiology

    2020  Volume 41, Issue 7, Page(s) 1509–1520

    Abstract: It was already shown that microdoses of lithium carbonate ( ... ...

    Abstract It was already shown that microdoses of lithium carbonate (Li
    MeSH term(s) Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Animals ; Cell Death/drug effects ; Disease Models, Animal ; Hippocampus/drug effects ; Hippocampus/metabolism ; Lithium/pharmacology ; Mice, Transgenic ; Neurons/drug effects ; Neurons/metabolism ; Neuroprotective Agents/pharmacology ; Phenylmercury Compounds/pharmacology
    Chemical Substances Neuroprotective Agents ; Phenylmercury Compounds ; 4-(4-sulfophenylazo)-2-mercuriphenol (69630-03-1) ; Lithium (9FN79X2M3F)
    Language English
    Publishing date 2020-07-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 283404-2
    ISSN 1573-6830 ; 0272-4340
    ISSN (online) 1573-6830
    ISSN 0272-4340
    DOI 10.1007/s10571-020-00916-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1727: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Neuroprotective Effects of Kinin B2 Receptor in Organotypic Hippocampal Cultures of Middle-Aged Mice.

    Toricelli, Mariana / Evangelista, Sebastiana Ribeiro / Oliveira, Larissa Rolim / Viel, Tania Araujo / Buck, Hudson Sousa

    Frontiers in aging neuroscience

    2019  Volume 11, Page(s) 168

    Abstract: Aging is a multifactorial phenomenon that results in several changes at cellular and molecular levels and is considered the main risk factor for some neurodegenerative diseases. Several evidence show the participation of the kallikrein-kinin system (KKS) ...

    Abstract Aging is a multifactorial phenomenon that results in several changes at cellular and molecular levels and is considered the main risk factor for some neurodegenerative diseases. Several evidence show the participation of the kallikrein-kinin system (KKS) in neurodegeneration and this system has been associated with inflammation and immunogenic responses in the central and peripheral systems by the activation of the B1 and B2 receptors. Previous work by our group showed that bradykinin (BK) and the B2 receptor played a possible role in neuroprotection. Therefore, the objective of this study was to evaluate the participation of B2 receptors in cell viability, neuroinflammatory response and neuroplasticity in organotypic hippocampal cultures (OHCs) of 6- and 12-month-old mice. It was observed that activation of the B2 receptor by bradykinin decreased the inflammatory response and increased plasticity in 12-month-old slices. Conversely, there was an increase in the inflammatory response and a decrease in neural plasticity in the 6-month-old slices. In both ages, an increase in cell viability was observed. This data suggests that the function of the kinin B2 receptor in the hippocampus is modulated by age, providing neuroprotective action in old age.
    Language English
    Publishing date 2019-07-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2019.00168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Genotoxic and mutagenic evaluation of water samples from a river under the influence of different anthropogenic activities.

    Batista, Nelson Jorge Carvalho / de Carvalho Melo Cavalcante, Ana Amélia / de Oliveira, Maria Geci / Medeiros, Eugênia Cristina Nascimento / Machado, Joseane Lustosa / Evangelista, Sebastiana Ribeiro / Dias, Johnny F / Dos Santos, Carla E I / Duarte, Anaí / da Silva, Fernanda R / da Silva, Juliana

    Chemosphere

    2016  Volume 164, Page(s) 134–141

    Abstract: Pollution of aquatic ecosystems is associated with the discharge of mostly industrial and urban effluents, which may cause loss of biodiversity and damage to public health. This study aims to evaluate the toxicity and mutagenicity of water samples ... ...

    Abstract Pollution of aquatic ecosystems is associated with the discharge of mostly industrial and urban effluents, which may cause loss of biodiversity and damage to public health. This study aims to evaluate the toxicity and mutagenicity of water samples collected in the Corrente River, a major waterway in the river basin district of Pedro II, Piauí (Brazil). This river is exposed to intense anthropogenic influence from urban, automotive mechanical and family farm waste, and it is used as the main source of water supply by the population. Water samples were collected during the rainy and dry seasons, at four sites in the Corrente River, and evaluated by physicochemical, microbiological and inorganic elements analyses. The samples were evaluated for mutagenicity using the Allium cepa test (toxicity, chromosomal aberration and micronucleus tests) and fish (Tilapia rendalli and Hoplias malabaricus). The physicochemical, microbiological and inorganic results show a large contribution to the pollution loads at collection points in the town of Pedro II, demonstrating the influence of urban pollution. The Al, Si, Ti, Cr, Ni and Cu contents were determined by PIXE. These same Corrente River water samples demonstrated mutagenic effect for A. cepa and fish, as well as toxicity in the A. cepa test. The observations of mutagenic effect may suggest that the complex mixture of agents is comprised of both clastogenic and aneugenic agents. This study also showed the need for constant monitoring in places with environmental degradation caused by urban sewage discharges.
    MeSH term(s) Animals ; Brazil ; Characiformes/metabolism ; Cichlids/metabolism ; Fresh Water/analysis ; Micronucleus Tests/veterinary ; Mutagenicity Tests ; Onions/drug effects ; Rivers/chemistry ; Seasons ; Toxicity Tests ; Water Pollutants, Chemical/toxicity
    Chemical Substances Water Pollutants, Chemical
    Language English
    Publishing date 2016-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2016.08.091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2540: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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