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Article ; Online: Injury-induced inflammatory signaling and hematopoiesis in

Evans, Cory J / Liu, Ting / Girard, Juliet R / Banerjee, Utpal

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 12, Page(s) e2119109119

Abstract: Inflammatory response in Drosophila to sterile (axenic) injury in embryos and adults has received some attention in recent years, and most concentrate on the events at the injury site. Here we focus on the effect sterile injury has on the hematopoietic ... ...

Abstract	Inflammatory response in Drosophila to sterile (axenic) injury in embryos and adults has received some attention in recent years, and most concentrate on the events at the injury site. Here we focus on the effect sterile injury has on the hematopoietic organ, the lymph gland, and the circulating blood cells in the larva, the developmental stage at which major events of hematopoiesis are evident. In mammals, injury activates Toll-like receptor/NF-κB signaling in macrophages, which then express and secrete secondary, proinflammatory cytokines. In Drosophila larvae, distal puncture injury of the body wall epidermis causes a rapid activation of Toll and Jun kinase (JNK) signaling throughout the hematopoietic system and the differentiation of a unique blood cell type, the lamellocyte. Furthermore, we find that Toll and JNK signaling are coupled in their activation. Secondary to this Toll/JNK response, a cytokine, Upd3, is induced as a Toll pathway transcriptional target, which then promotes JAK/STAT signaling within the blood cells. Toll and JAK/STAT signaling are required for the emergence of the injury-induced lamellocytes. This is akin to the derivation of specialized macrophages in mammalian systems. Upstream, at the injury site, a Duox- and peroxide-dependent signal causes the activation of the proteases Grass and SPE, needed for the activation of the Toll-ligand Spz, but microbial sensors or the proteases most closely associated with them during septic injury are not involved in the axenic inflammatory response.
MeSH term(s)	Animals ; Drosophila/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Hematopoiesis ; Inflammation ; Phenotype ; Signal Transduction ; Wasps/metabolism ; Wounds and Injuries
Chemical Substances	Drosophila Proteins
Language	English
Publishing date	2022-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2119109119
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Article ; Online: Drosophila hematopoiesis: Markers and methods for molecular genetic analysis.

Evans, Cory J / Liu, Ting / Banerjee, Utpal

Methods (San Diego, Calif.)

2014 Volume 68, Issue 1, Page(s) 242–251

Abstract: Analyses of the Drosophila hematopoietic system are becoming more and more prevalent as developmental and functional parallels with vertebrate blood cells become more evident. Investigative work on the fly blood system has, out of necessity, led to the ... ...

Abstract	Analyses of the Drosophila hematopoietic system are becoming more and more prevalent as developmental and functional parallels with vertebrate blood cells become more evident. Investigative work on the fly blood system has, out of necessity, led to the identification of new molecular markers for blood cell types and lineages and to the refinement of useful molecular genetic tools and analytical methods. This review briefly describes the Drosophila hematopoietic system at different developmental stages, summarizes the major useful cell markers and tools for each stage, and provides basic protocols for practical analysis of circulating blood cells and of the lymph gland, the larval hematopoietic organ.
MeSH term(s)	Animals ; Cell Lineage ; Developmental Biology/methods ; Drosophila ; Hematopoiesis/genetics ; Larva ; Lymph/cytology ; Lymph/metabolism
Language	English
Publishing date	2014-03-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1066584-5
ISSN	1095-9130 ; 1046-2023
ISSN (online)	1095-9130
ISSN	1046-2023
DOI	10.1016/j.ymeth.2014.02.038
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Article: Drosophila hematopoiesis: Markers and methods for molecular genetic analysis

Evans, Cory J / Ting Liu / Utpal Banerjee

Methods. 2014 June 15, v. 68

2014

Abstract	Analyses of the Drosophila hematopoietic system are becoming more and more prevalent as developmental and functional parallels with vertebrate blood cells become more evident. Investigative work on the fly blood system has, out of necessity, led to the identification of new molecular markers for blood cell types and lineages and to the refinement of useful molecular genetic tools and analytical methods. This review briefly describes the Drosophila hematopoietic system at different developmental stages, summarizes the major useful cell markers and tools for each stage, and provides basic protocols for practical analysis of circulating blood cells and of the lymph gland, the larval hematopoietic organ.
Keywords	analytical methods ; blood cells ; Drosophila ; genetic markers ; hematopoiesis ; larvae ; lymph ; vertebrates
Language	English
Dates of publication	2014-0615
Size	p. 242-251.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	1066584-5
ISSN	1095-9130 ; 1046-2023
ISSN (online)	1095-9130
ISSN	1046-2023
DOI	10.1016/j.ymeth.2014.02.038
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Article: Fly-CURE, a multi-institutional CURE using

Merkle, Julie A / Devergne, Olivier / Kelly, Seth M / Croonquist, Paula A / Evans, Cory J / Hwalek, Melanie A / Straub, Victoria L / Hamill, Danielle R / Peister, Alexandra / Puthoff, David P / Saville, Ken J / Siders, Jamie L / Villanueva Gonzalez, Zully J / Wittke-Thompson, Jacqueline K / Bieser, Kayla L / Stamm, Joyce / Vrailas-Mortimer, Alysia D / Kagey, Jacob D

Journal of microbiology & biology education

2023 Volume 24, Issue 3

Abstract: The Fly-CURE is a genetics-focused multi-institutional Course-Based Undergraduate Research Experience (CURE) that provides undergraduate students with hands-on research experiences within a course. Through the Fly-CURE, undergraduate students at diverse ... ...

Abstract	The Fly-CURE is a genetics-focused multi-institutional Course-Based Undergraduate Research Experience (CURE) that provides undergraduate students with hands-on research experiences within a course. Through the Fly-CURE, undergraduate students at diverse types of higher education institutions across the United States map and characterize novel mutants isolated from a genetic screen in
Language	English
Publishing date	2023-09-21
Publishing country	United States
Document type	Journal Article
ISSN	1935-7877
ISSN	1935-7877
DOI	10.1128/jmbe.00245-22
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Article: Fly-CURE, a Multi-institutional CURE using

Merkle, Julie A / Devergne, Olivier / Kelly, Seth M / Croonquist, Paula A / Evans, Cory J / Hwalek, Melanie A / Straub, Victoria L / Hamill, Danielle R / Puthoff, David P / Saville, Kenneth J / Siders, Jamie L / Gonzalez, Zully J Villanueva / Wittke-Thompson, Jackie K / Bieser, Kayla L / Stamm, Joyce / Vrailas-Mortimer, Alysia D / Kagey, Jacob D

bioRxiv : the preprint server for biology

2023

Abstract	The Fly-CURE is a genetics-focused multi-institutional Course-Based Undergraduate Research Experience (CURE) that provides undergraduate students with hands-on research experiences within a course. Through the Fly-CURE, undergraduate students at diverse types of higher education institutions across the United States map and characterize novel mutants isolated from a genetic screen in
Language	English
Publishing date	2023-01-19
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.01.16.524319
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Article ; Online: Pvr expression regulators in equilibrium signal control and maintenance of Drosophila blood progenitors.

Mondal, Bama Charan / Shim, Jiwon / Evans, Cory J / Banerjee, Utpal

eLife

2014 Volume 3, Page(s) e03626

Abstract: Blood progenitors within the lymph gland, a larval organ that supports hematopoiesis in Drosophila melanogaster, are maintained by integrating signals emanating from niche-like cells and those from differentiating blood cells. We term the signal from ... ...

Abstract	Blood progenitors within the lymph gland, a larval organ that supports hematopoiesis in Drosophila melanogaster, are maintained by integrating signals emanating from niche-like cells and those from differentiating blood cells. We term the signal from differentiating cells the 'equilibrium signal' in order to distinguish it from the 'niche signal'. Earlier we showed that equilibrium signaling utilizes Pvr (the Drosophila PDGF/VEGF receptor), STAT92E, and adenosine deaminase-related growth factor A (ADGF-A) (Mondal et al., 2011). Little is known about how this signal initiates during hematopoietic development. To identify new genes involved in lymph gland blood progenitor maintenance, particularly those involved in equilibrium signaling, we performed a genetic screen that identified bip1 (bric à brac interacting protein 1) and Nucleoporin 98 (Nup98) as additional regulators of the equilibrium signal. We show that the products of these genes along with the Bip1-interacting protein RpS8 (Ribosomal protein S8) are required for the proper expression of Pvr.
MeSH term(s)	Animals ; Cell Differentiation/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster/cytology ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Genes, Insect ; Genetic Association Studies ; Genetic Testing ; Hematopoiesis ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Lymph Nodes/cytology ; Models, Biological ; Phenotype ; RNA Interference ; Receptor Protein-Tyrosine Kinases/metabolism ; Reproducibility of Results ; Signal Transduction/genetics
Chemical Substances	Drosophila Proteins ; Pvr protein, Drosophila (EC 2.7.10.1) ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1)
Language	English
Publishing date	2014-09-08
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.03626
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Article: Transcriptional regulation of hematopoiesis in Drosophila.

Evans, Cory J / Banerjee, Utpal

Blood cells, molecules & diseases

2003 Volume 30, Issue 2, Page(s) 223–228

Abstract: As in mammals, blood cells in Drosophila are derived from a common multipotent hematopoietic precursor population. In the embryo, these precursors are derived from the head mesoderm, whereas larval hematopoietic precursors are found in a specialized ... ...

Abstract	As in mammals, blood cells in Drosophila are derived from a common multipotent hematopoietic precursor population. In the embryo, these precursors are derived from the head mesoderm, whereas larval hematopoietic precursors are found in a specialized organ called the lymph gland. This shift in location of hematopoietic differentiation is reminiscent of similar events that occur during mammalian development. Recent analysis has identified several transcriptional regulators in Drosophila that influence hematopoietic lineage commitment. Interestingly, many of these factors are similar to factors directing mammalian hematopoietic differentiation. Although Drosophila blood cells are much less varied in terms of specific lineages, it would appear that many mechanistic aspects by which hematopoietic cell fate is determined have been conserved between Drosophila and mammals. Herein, we describe the Drosophila blood cell types, their physical origin, and the transcriptional regulators that govern this process.
MeSH term(s)	Animals ; Drosophila/genetics ; Gene Expression Regulation/physiology ; Hematopoiesis/genetics ; Hemocytes/physiology ; Transcription, Genetic
Language	English
Publishing date	2003-05-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1237083-6
ISSN	1096-0961 ; 1079-9796
ISSN (online)	1096-0961
ISSN	1079-9796
DOI	10.1016/s1079-9796(03)00028-7
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Article: DNase II: genes, enzymes and function.

Evans, Cory J / Aguilera, Renato J

Gene

2003 Volume 322, Page(s) 1–15

Abstract: Deoxyribonuclease (DNase) II, which was discovered more than 50 years ago, is a mammalian endonuclease that functions optimally at acid pH in the absence of divalent cations. Its lysosomal localization and ubiquitous tissue distribution suggested that ... ...

Abstract	Deoxyribonuclease (DNase) II, which was discovered more than 50 years ago, is a mammalian endonuclease that functions optimally at acid pH in the absence of divalent cations. Its lysosomal localization and ubiquitous tissue distribution suggested that this enzyme played a role in the degradation of exogenous DNA encountered by phagocytosis, although the relative importance of such a role was unknown. Subsequent investigations also suggested that DNase II was important for DNA fragmentation and degradation during cell death. Within the last few years, our work and that of others has lead to the cloning of various mammalian DNase II genes as well as the identification and characterization of highly homologous genes in the invertebrates Caenorhabditis elegans and Drosophila melanogaster. Interestingly, studies of the C. elegans DNase II homolog NUC-1 were the first to suggest that DNase II enzymes were fundamentally important in engulfment-mediated DNA degradation, particularly that associated with programmed cell death, due to the presence of persistent apoptotic-cell nuclei within phagocytic cells in nuc-1 mutants. Similarly, mutation of the Drosophila DNase II-like gene was found to result in the accumulation of low-molecular-weight DNA throughout the animals. Homozygous mutation (knockout) of the DNase II gene in mice revealed a much more complex and extensive phenotype including perinatal lethality. The lethality of DNase II-knockout mice is likely the result of multiple developmental defects, the most obvious being a loss of definitive erythropoiesis. Closer examination revealed that a defect in engulfment-mediated DNA degradation is the primary defect in DNase II-null mice. In this review, we have compiled information from studies on DNase II from various organisms to provide a consensus model for the role of DNase II enzymes in DNA degradation.
MeSH term(s)	Amino Acid Sequence ; Animals ; Apoptosis/genetics ; DNA Fragmentation ; Endodeoxyribonucleases/genetics ; Endodeoxyribonucleases/metabolism ; Humans ; Models, Biological ; Molecular Sequence Data ; Sequence Homology, Amino Acid
Chemical Substances	Endodeoxyribonucleases (EC 3.1.-) ; deoxyribonuclease II (EC 3.1.22.1)
Language	English
Publishing date	2003-12-11
Publishing country	Netherlands
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2003.08.022
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Zs.A 1357: Show issues

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Article ; Online: The

Evans, Cory J / Bieser, Kayla L / Acevedo-Vasquez, Katherine S / Augustine, Emyli J / Bowen, Skyler / Casarez, Veronica A / Feliciano, Vanessa I / Glazier, Ashley / Guinan, Haley R / Hallman, Randy / Haugan, Elizabeth / Hehr, Lauren A / Hunnicutt, Shawna N / Leifer, Isabella / Mauger, Meaghan / Mauger, Morgan / Melendez, Norma Y / Milshteyn, Larry / Moore, Eric /

Nguyen, Sarah A / Phanphouvong, Sierra C / Pinal, David M / Pope, Hailee M / Salinas, Mark-Brandon M / Shellin, Matthew / Small, Ivana / Yeoh, Neelufar C / Yokomizo, Alexandra M K / Kagey, Jacob D

microPublication biology

2022 Volume 2022

Abstract: ... The ... ...

Abstract	The mutation
Language	English
Publishing date	2022-10-25
Publishing country	United States
Document type	Journal Article
ISSN	2578-9430
ISSN (online)	2578-9430
DOI	10.17912/micropub.biology.000653
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Article: Variation of NimC1 expression in Drosophila stocks and transgenic strains

Honti, Viktor / Cinege, Gyöngyi / Csordás, Gábor / Kurucz, Éva / Zsámboki, János / Evans, Cory J / Banerjee, Utpal / Andó, István

Fly. 2013 Oct. 30, v. 7, no. 4

2013

Abstract: The NimC1 molecule has been described as a phagocytosis receptor, and is being used as a marker for professional phagocytes, the plasmatocytes, in Drosophila melanogaster. In studies including tumor-biology, developmental biology, and cell mediated ... ...

Abstract	The NimC1 molecule has been described as a phagocytosis receptor, and is being used as a marker for professional phagocytes, the plasmatocytes, in Drosophila melanogaster. In studies including tumor-biology, developmental biology, and cell mediated immunity, monoclonal antibodies (P1a and P1b) to the NimC1 antigen are used. As we observed that these antibodies did not react with plasmatocytes of several strains and genetic combinations, a molecular analysis was performed on the structure of the nimC1 gene. In these strains we found 2 deletions and an insertion within the nimC1 gene, which may result in the production of a truncated NimC1 protein. The NimC1 positivity was regained by recombining the mutation with a wild-type allele or by using nimC1 mutant lines under heterozygous conditions. By means of these procedures or using the recombined stock, NimC1 can be used as a marker for phagocytic cells in the majority of the possible genetic backgrounds.
Keywords	Drosophila melanogaster ; alleles ; antigens ; cell-mediated immunity ; genetic background ; genetically modified organisms ; heterozygosity ; monoclonal antibodies ; mutants ; mutation ; phagocytes ; phagocytosis ; strains
Language	English
Dates of publication	2013-1030
Size	p. 263-268.
Publishing place	Taylor & Francis
Document type	Article
Note	NAL-light
ISSN	1933-6942
DOI	10.4161/fly.25654
Database	NAL-Catalogue (AGRICOLA)

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