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  1. Article ; Online: Improving HPV-Related Oropharyngeal Cancer Knowledge and HPV Vaccination Rates via Virtual Workshops.

    Evans, Lauran K / Azar, Shaghauyegh S / Chen, Haidee / Saad, Miryam / Subhash, Sneha / Su-Velez, Brooke M / St John, Maie A

    The Laryngoscope

    2024  

    Abstract: Objective: To validate the efficacy of a virtual, interdisciplinary workshop in improving HPV knowledge, and vaccination practices among primary care and dental trainees.: Methods: A virtual platform was utilized to hold HPV educational workshops ... ...

    Abstract Objective: To validate the efficacy of a virtual, interdisciplinary workshop in improving HPV knowledge, and vaccination practices among primary care and dental trainees.
    Methods: A virtual platform was utilized to hold HPV educational workshops with primary care and dental trainees. Online surveys were distributed before and after the 1-h interactive workshop, led by otolaryngology residents. Surveys included the workshop's impact on (a) improving knowledge of HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) and (b) affecting change in HPV vaccination practices. The vaccination rates of trainees were recorded prior to and after workshop attendance.
    Results: After the workshop, participants demonstrated significantly improved scores related to knowledge of HPV in the head and neck (p = 0.003) and showed an increased comfort level with counseling on HPV vaccination (p = 0.002). Respondents were also more aware that the HPV vaccine is approved to prevent OPSCC (61% vs. 95%, p < 0.05). Ninety-seven percent of respondents stated that the workshop changed their HPV vaccination practices, and 95% of those not fully vaccinated stated they would now be more likely to receive the vaccine themselves. There was a significant increase in the average number of HPV vaccines administered at the studied trainee clinic, from 16.83 vaccines/month to 37.6 vaccines/month (percent increase = 123%) in 5 months following the workshop (p = 0.002).
    Conclusion: The present interactive virtual workshop demonstrates efficacy in improving HPV-related knowledge and vaccination practices among trainees. The virtual nature of the course facilitates knowledge transfer and can be used to foster multi-institutional partnerships regarding medical education and vaccination efforts.
    Level of evidence: 4 Laryngoscope, 2024.
    Language English
    Publishing date 2024-02-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.31351
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  2. Article ; Online: A Trigeminal Schwannoma Masked by Solely Vestibulocochlear Symptoms.

    Evans, Lauran K / Peraza, Lazaro / Zamboni, Anthony

    Journal of the American Academy of Audiology

    2020  Volume 31, Issue 6, Page(s) 449–454

    Abstract: Background: Intracranial schwannomas are most commonly associated with the vestibulocochlear nerve, often leading to hearing loss, tinnitus, and vestibular dysfunction. Much less often, a schwannoma can arise from the trigeminal nerve which can lead to ... ...

    Abstract Background: Intracranial schwannomas are most commonly associated with the vestibulocochlear nerve, often leading to hearing loss, tinnitus, and vestibular dysfunction. Much less often, a schwannoma can arise from the trigeminal nerve which can lead to facial pain, numbness, and weakness.
    Purpose: We explored a case of a patient with an magnetic resonance imaging (MRI)-confirmed trigeminal schwannoma that was mistaken for a vestibulocochlear schwannoma because of a myriad of ipsilateral vestibulocochlear symptoms.
    Research design: This is a retrospective chart review and case study, with no statistics applied.
    Results: This diagnostic error led to clinical confusion and inaccurate medical record-keeping. Radiologists and radiation oncologists deemed the patient's symptoms to be unrelated to the asymptomatic trigeminal schwannoma, and she was referred to an otolaryngologist following complaints of ear fullness, ear pain, and hearing loss. The patient's audiogram showed ipsilateral, asymmetric sensorineural hearing loss, and she was diagnosed with concurrent Meniere's disease. Alternative explanations, such as an additional schwannoma or external compression of the vestibulocochlear nerve, were considered, but not apparent on MRI.
    Conclusions: From this case, we see that symptoms do not always concur with imaging results and that multiple etiologies, especially when one is rare, can confuse a clinical picture.
    MeSH term(s) Audiometry ; Cochlea/diagnostic imaging ; Cranial Nerve Neoplasms/diagnosis ; Cranial Nerve Neoplasms/diagnostic imaging ; Diagnostic Errors ; Ear Neoplasms/diagnosis ; Female ; Humans ; Labyrinth Diseases/diagnosis ; Magnetic Resonance Imaging ; Middle Aged ; Neurilemmoma/diagnosis ; Neurilemmoma/diagnostic imaging ; Trigeminal Nerve Diseases/diagnosis ; Trigeminal Nerve Diseases/diagnostic imaging ; Vestibule, Labyrinth/diagnostic imaging
    Language English
    Publishing date 2020-08-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1132599-9
    ISSN 2157-3107 ; 1050-0545
    ISSN (online) 2157-3107
    ISSN 1050-0545
    DOI 10.3766/jaaa.19033
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  3. Article: Cutaneous head and neck angiosarcoma: The 30-year UCLA experience.

    Evans, Lauran K / Sutton, Sarah / Echanique, Kristen / Armaneous, Michael / Palacios, Victoria / Sajed, Dipti / St John, Maie

    Laryngoscope investigative otolaryngology

    2023  Volume 8, Issue 6, Page(s) 1557–1563

    Abstract: Background: Cutaneous angiosarcoma is an aggressive tumor commonly found in the head and neck region. There is no consensus regarding the definitive treatment for angiosarcoma.: Methods: This was a retrospective chart review that evaluated 64 ... ...

    Abstract Background: Cutaneous angiosarcoma is an aggressive tumor commonly found in the head and neck region. There is no consensus regarding the definitive treatment for angiosarcoma.
    Methods: This was a retrospective chart review that evaluated 64 patients from 1983 to 2019. Demographic and clinical variables were examined for impact on recurrence using the time to recurrence and the overall survival in Kaplan-Meier curves.
    Results: Average age at diagnosis was 71 (32-95) years, with a 2.8 male: female ratio. Surgery was utilized in 62% of patients, with mean defect size of 11.4 ± 8.1 cm. Recurrence was found in 70% of patients, and mean time to recurrence was 15.3 ± 12.3 months. Decreased recurrence was associated with use of intraoperative frozen section analysis (
    Conclusions: Negative margins are associated with decreased recurrence, and intraoperative frozen section analysis may be considered to obtain preliminary surgical margins.Level of Evidence: 4.
    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type Journal Article
    ISSN 2378-8038
    ISSN 2378-8038
    DOI 10.1002/lio2.1173
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  4. Article ; Online: COVID-19 Drive-Through Point of Screening and Testing (POST) System: A Safe, Efficient, and Adaptable Model for Nasopharyngeal Swab Collection.

    Evans, Lauran K / Shinagawa, Austin / Sutton, Sarah / Calvo, Lisa

    Disaster medicine and public health preparedness

    2020  Volume 16, Issue 1, Page(s) 194–200

    Abstract: Objective: The authors aim to demonstrate that the current drive-through testing model at a health district was improved in certain parameters compared with a previous testing protocol, and to provide the methodology of the current model for other ... ...

    Abstract Objective: The authors aim to demonstrate that the current drive-through testing model at a health district was improved in certain parameters compared with a previous testing protocol, and to provide the methodology of the current model for other coronavirus disease (COVID-19) testing sites to potentially emulate.
    Methods: Initially, a small drive-through site was constructed at a converted tuberculosis clinic, but due to an increase in testing needs, an expanded point of screening and testing (POST) system was developed in an event center parking lot to administer tests to a higher volume of patients.
    Results: An average of 51.1 patients was tested each day (2.0 tests per personnel in personal protective equipment [PPE] per hour) at the initial tuberculosis clinic drive-through site, which increased to 217.8 patients tested each day (5.9 tests per personnel in PPE per hour) with the new drive-through POST system (P < 0.001). Mean testing time was 3.4 minutes and the total time on-site averaged 14.4 minutes.
    Conclusions: This POST drive-through system serves as an efficient, safe, and adaptable model for high volume COVID-19 nasopharyngeal swabbing that the authors recommend other COVID-19 testing sites nationwide consider adopting for their own use.
    MeSH term(s) COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19 Testing ; Humans ; Nasopharynx ; Personal Protective Equipment ; SARS-CoV-2 ; Tuberculosis
    Keywords covid19
    Language English
    Publishing date 2020-09-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2375268-3
    ISSN 1938-744X ; 1935-7893
    ISSN (online) 1938-744X
    ISSN 1935-7893
    DOI 10.1017/dmp.2020.313
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  5. Article ; Online: Perceptual Evaluation of Vocal Fold Vibratory Asymmetry.

    Azar, Shaghauyegh S / Pillutla, Pranati / Evans, Lauran K / Zhang, Zhaoyan / Kreiman, Jody / Chhetri, Dinesh K

    The Laryngoscope

    2021  Volume 131, Issue 12, Page(s) 2740–2746

    Abstract: Objectives: Laryngeal vibratory asymmetry occurring with paresis may result in a perceptually normal or abnormal voice. The present study aims to determine the relationships between the degree of vibratory asymmetry, acoustic measures, and perception of ...

    Abstract Objectives: Laryngeal vibratory asymmetry occurring with paresis may result in a perceptually normal or abnormal voice. The present study aims to determine the relationships between the degree of vibratory asymmetry, acoustic measures, and perception of sound stimuli.
    Study design: Animal Model of Voice Production, Perceptual Analysis of Voice.
    Methods: In an in vivo canine model of phonation, symmetric and asymmetric laryngeal vibration were obtained via graded unilateral recurrent laryngeal nerve (RLN) stimulation simulating near paralysis to full activation. Phonation was performed at various contralateral RLN and bilateral superior laryngeal nerve stimulation levels. Naïve listeners rated the perceptual quality of 182 unique phonatory samples using a visual sort-and-rate task. Cepstral peak prominence (CPP) was calculated for each phonatory condition. The relationships among vibratory symmetry, CPP, and perceptual ratings were evaluated.
    Results: A significant relationship emerged between RLN stimulation and perceptual rating, such that sound samples from low RLN levels were preferred to those from high RLN levels. When symmetric vibration was achieved at mid-RLN stimulation, listeners preferred samples from symmetric vibration over those from asymmetric vibration. However, when symmetry was achieved at high RLN levels, a strained voice quality resulted that listeners dispreferred over asymmetric conditions at lower RLN levels. CPP did not have a linear relationship with perceptual ratings.
    Conclusions: Laryngeal vibratory asymmetry produces variable perceptual differences in phonatory sound quality. Though CPP has been correlated with dysphonia in previous research, its complex relationship with quality limits its usefulness as clinical marker of voice quality perception.
    Level of evidence: NA, basic science Laryngoscope, 131:2740-2746, 2021.
    MeSH term(s) Acoustics ; Animals ; Disease Models, Animal ; Dogs ; Dysphonia/diagnosis ; Dysphonia/physiopathology ; Electric Stimulation ; Female ; Humans ; Laryngeal Nerves/physiopathology ; Male ; Phonation/physiology ; Vibration ; Vocal Cord Paralysis/complications ; Vocal Cord Paralysis/physiopathology ; Vocal Cords/innervation ; Vocal Cords/physiopathology ; Voice Quality/physiology
    Language English
    Publishing date 2021-06-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.29679
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  6. Article ; Online: Cancer of the Larynx and Hypopharynx.

    Echanique, Kristen A / Evans, Lauran K / Han, Albert Y / Chhetri, Dinesh K / St John, Maie A

    Hematology/oncology clinics of North America

    2021  Volume 35, Issue 5, Page(s) 933–947

    Abstract: The Radiation Therapy Oncology Group 91-11 trial and US Veterans Affairs trial revolutionized the way locally advanced laryngeal cancers are treated. Adjuvant therapies exist aimed toward laryngeal preservation using docetaxel, cisplatin, and ... ...

    Abstract The Radiation Therapy Oncology Group 91-11 trial and US Veterans Affairs trial revolutionized the way locally advanced laryngeal cancers are treated. Adjuvant therapies exist aimed toward laryngeal preservation using docetaxel, cisplatin, and fluorouracil. Cetuximab is a cornerstone of treatment due to the large role of epidermal growth factor receptor in laryngeal and hypopharyngeal carcinomas. In addition, the immune system is vital in the prevention of recurrence, and various immunomodulators against programmed cell death receptor 1 are being investigated. Multidisciplinary management of the patient with laryngeal and hypopharyngeal is key, as many vital functions are affected by this devastating disease.
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Squamous Cell/drug therapy ; Cisplatin/therapeutic use ; Fluorouracil/therapeutic use ; Humans ; Hypopharyngeal Neoplasms/drug therapy ; Hypopharynx ; Laryngeal Neoplasms/drug therapy
    Chemical Substances Cisplatin (Q20Q21Q62J) ; Fluorouracil (U3P01618RT)
    Language English
    Publishing date 2021-07-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 93115-9
    ISSN 1558-1977 ; 0889-8588
    ISSN (online) 1558-1977
    ISSN 0889-8588
    DOI 10.1016/j.hoc.2021.05.005
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  7. Article: A Trigeminal Schwannoma Masked by Solely Vestibulocochlear Symptoms

    Evans, Lauran K. / Peraza, Lazaro / Zamboni, Anthony

    Journal of the American Academy of Audiology

    2020  Volume 31, Issue 06, Page(s) 449–454

    Abstract: Background: Intracranial schwannomas are most commonly associated with the vestibulocochlear nerve, often leading to hearing loss, tinnitus, and vestibular dysfunction. Much less often, a schwannoma can arise from the trigeminal nerve which can lead to ... ...

    Abstract Background: Intracranial schwannomas are most commonly associated with the vestibulocochlear nerve, often leading to hearing loss, tinnitus, and vestibular dysfunction. Much less often, a schwannoma can arise from the trigeminal nerve which can lead to facial pain, numbness, and weakness.
    Purpose: We explored a case of a patient with an magnetic resonance imaging (MRI)-confirmed trigeminal schwannoma that was mistaken for a vestibulocochlear schwannoma because of a myriad of ipsilateral vestibulocochlear symptoms.
    Research Design: This is a retrospective chart review and case study, with no statistics applied.
    Results: This diagnostic error led to clinical confusion and inaccurate medical record-keeping. Radiologists and radiation oncologists deemed the patient's symptoms to be unrelated to the asymptomatic trigeminal schwannoma, and she was referred to an otolaryngologist following complaints of ear fullness, ear pain, and hearing loss. The patient's audiogram showed ipsilateral, asymmetric sensorineural hearing loss, and she was diagnosed with concurrent Meniere's disease. Alternative explanations, such as an additional schwannoma or external compression of the vestibulocochlear nerve, were considered, but not apparent on MRI.
    Conclusions: From this case, we see that symptoms do not always concur with imaging results and that multiple etiologies, especially when one is rare, can confuse a clinical picture.
    Keywords acoustic neuroma ; medical error ; neurilemmoma ; trigeminal ; vestibulocochlear
    Language English
    Publishing date 2020-06-01
    Publisher Thieme Medical Publishers
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 1132599-9
    ISSN 2157-3107 ; 1050-0545
    ISSN (online) 2157-3107
    ISSN 1050-0545
    DOI 10.3766/jaaa.19033
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  8. Article ; Online: Biofeedback Training Improves Swallowing in a Unique Case of Upper Esophageal Sphincter Hypotonicity.

    Romain, Dustin / Evans, Lauran K / Diaz, Yvette / Allen, Kathryn / Galek, Kristine

    The Laryngoscope

    2020  Volume 131, Issue 5, Page(s) E1567–E1569

    Abstract: Hypotonicity of the upper esophageal sphincter (UES) has been reported only two times previously in the literature, with no reports of treatment options for this rarity. We present a third case of hypotonic UES found during high-resolution pharyngeal ... ...

    Abstract Hypotonicity of the upper esophageal sphincter (UES) has been reported only two times previously in the literature, with no reports of treatment options for this rarity. We present a third case of hypotonic UES found during high-resolution pharyngeal manometry. Although the patient had nearly absent resting pressures of the UES, pressures during and post-swallow were normal. It was hypothesized that the patient might be able to increase pre-swallow UES pressure using biofeedback. Using a chin up/out maneuver during manometry, the patient was able to achieve a more normal swallow pressure pattern. This case also highlights the need to complete manometry alongside other swallow imaging techniques for effective treatment planning and patient outcomes. Laryngoscope, 131:E1567-E1569, 2021.
    MeSH term(s) Biofeedback, Psychology/instrumentation ; Biofeedback, Psychology/methods ; Deglutition/physiology ; Deglutition Disorders/diagnosis ; Deglutition Disorders/physiopathology ; Deglutition Disorders/therapy ; Esophageal Sphincter, Upper/physiopathology ; Humans ; Male ; Manometry/instrumentation ; Manometry/methods ; Middle Aged ; Treatment Outcome
    Language English
    Publishing date 2020-10-30
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.29226
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  9. Article: COVID-19 Drive-Through Point of Screening and Testing (POST) System: A Safe, Efficient, and Adaptable Model for Nasopharyngeal Swab Collection

    Evans, Lauran K / Shinagawa, Austin / Sutton, Sarah / Calvo, Lisa

    Disaster Med Public Health Prep

    Abstract: OBJECTIVE: The authors aim to demonstrate that the current drive-through testing model at a health district was improved in certain parameters compared with a previous testing protocol, and to provide the methodology of the current model for other ... ...

    Abstract OBJECTIVE: The authors aim to demonstrate that the current drive-through testing model at a health district was improved in certain parameters compared with a previous testing protocol, and to provide the methodology of the current model for other coronavirus disease (COVID-19) testing sites to potentially emulate. METHODS: Initially, a small drive-through site was constructed at a converted tuberculosis clinic, but due to an increase in testing needs, an expanded point of screening and testing (POST) system was developed in an event center parking lot to administer tests to a higher volume of patients. RESULTS: An average of 51.1 patients was tested each day (2.0 tests per personnel in personal protective equipment [PPE] per hour) at the initial tuberculosis clinic drive-through site, which increased to 217.8 patients tested each day (5.9 tests per personnel in PPE per hour) with the new drive-through POST system (P < 0.001). Mean testing time was 3.4 minutes and the total time on-site averaged 14.4 minutes. CONCLUSIONS: This POST drive-through system serves as an efficient, safe, and adaptable model for high volume COVID-19 nasopharyngeal swabbing that the authors recommend other COVID-19 testing sites nationwide consider adopting for their own use.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #740018
    Database COVID19

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  10. Article ; Online: COVID-19 Drive-Through Point of Screening and Testing (POST) System

    Evans, Lauran K. / Shinagawa, Austin / Sutton, Sarah / Calvo, Lisa

    Disaster Medicine and Public Health Preparedness

    A Safe, Efficient, and Adaptable Model for Nasopharyngeal Swab Collection

    2020  , Page(s) 1–7

    Abstract: ABSTRACT Objective: The authors aim to demonstrate that the current drive-through testing model at a health district was improved in certain parameters compared with a previous testing protocol, and to provide the methodology of the current model for ... ...

    Abstract ABSTRACT Objective: The authors aim to demonstrate that the current drive-through testing model at a health district was improved in certain parameters compared with a previous testing protocol, and to provide the methodology of the current model for other coronavirus disease (COVID-19) testing sites to potentially emulate. Methods: Initially, a small drive-through site was constructed at a converted tuberculosis clinic, but due to an increase in testing needs, an expanded point of screening and testing (POST) system was developed in an event center parking lot to administer tests to a higher volume of patients. Results: An average of 51.1 patients was tested each day (2.0 tests per personnel in personal protective equipment [PPE] per hour) at the initial tuberculosis clinic drive-through site, which increased to 217.8 patients tested each day (5.9 tests per personnel in PPE per hour) with the new drive-through POST system ( P < 0.001). Mean testing time was 3.4 minutes and the total time on-site averaged 14.4 minutes. Conclusions: This POST drive-through system serves as an efficient, safe, and adaptable model for high volume COVID-19 nasopharyngeal swabbing that the authors recommend other COVID-19 testing sites nationwide consider adopting for their own use.
    Keywords Public Health, Environmental and Occupational Health ; covid19
    Language English
    Publisher Cambridge University Press (CUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2375268-3
    ISSN 1938-744X ; 1935-7893
    ISSN (online) 1938-744X
    ISSN 1935-7893
    DOI 10.1017/dmp.2020.313
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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