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  1. Article ; Online: Correction

    Deus Thindwa / Megan Landes / Monique van Lettow / Annie Kanyemba / Ernest Nkhoma / Happy Phiri / Thokozani Kalua / Joep J van Oosterhout / Evelyn J Kim / Beth A Tippett Barr / NEMAPP Consortium

    PLoS ONE, Vol 14, Iss 5, p e

    Pregnancy intention and contraceptive use among HIV-positive Malawian women at 4-26 weeks post-partum: A nested cross-sectional study.

    2019  Volume 0217330

    Abstract: This corrects the article DOI:10.1371/journal.pone.0215947.]. ...

    Abstract [This corrects the article DOI:10.1371/journal.pone.0215947.].
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Protocol for a Case-Control Study to Investigate the Association of Pellagra With Isoniazid Exposure During Tuberculosis Preventive Treatment Scale-Up in Malawi

    Scott A. Nabity / Kelvin Mponda / Steve Gutreuter / Diya Surie / Anne Williams / Andrea J. Sharma / Elizabeth R. Schnaubelt / Rebekah E. Marshall / Hannah L. Kirking / Suzgo B. Zimba / Joram L. Sunguti / Laphiod Chisuwo / Mabvuto J. Chiwaula / Jesse F. Gregory / Robin da Silva / Michael Odo / Andreas Jahn / Thokozani Kalua / Rose Nyirenda /
    Belaineh Girma / James Mpunga / Nicole Buono / Alice Maida / Evelyn J. Kim / Laurence J. Gunde / Tigest F. Mekonnen / Andrew F. Auld / Adamson S. Muula / John E. Oeltmann

    Frontiers in Public Health, Vol

    2020  Volume 8

    Abstract: Background: Pellagra is caused by niacin (vitamin B3) deficiency and manifested by a distinctive dermatitis. Isoniazid is critical for treating tuberculosis globally and is a component of most regimens to prevent tuberculosis. Isoniazid may contribute to ...

    Abstract Background: Pellagra is caused by niacin (vitamin B3) deficiency and manifested by a distinctive dermatitis. Isoniazid is critical for treating tuberculosis globally and is a component of most regimens to prevent tuberculosis. Isoniazid may contribute to pellagra by disrupting intracellular niacin synthesis. In 2017, Malawian clinicians recognized a high incidence of pellagra-like rashes after scale-up of isoniazid preventive treatment (IPT) to people living with HIV (PLHIV). This increase in pellagra incidence among PLHIV coincided with a seasonal period of sustained food insecurity in the region, which obscured epidemiological interpretations. Although isoniazid has been implicated as a secondary cause of pellagra for decades, no hypothesis-driven epidemiological study has assessed this relationship in a population exposed to isoniazid. We developed this case-control protocol to assess the association between large-scale isoniazid distribution and pellagra in Malawi.Methods: We measure the relative odds of having pellagra among isoniazid-exposed people compared to those without exposure while controlling for other pellagra risk factors. Secondary aims include measuring time from isoniazid initiation to onset of dermatitis, comparing niacin metabolites 1-methylnicotinamide (1-MN), and l-methyl-2-pyridone-5-carboxamide (2-PYR) in urine as a proxy for total body niacin status among subpopulations, and describing clinical outcomes after 30-days multi-B vitamin (containing 300 mg nicotinamide daily) therapy and isoniazid cessation (if exposed). We aim to enroll 197 participants with pellagra and 788 age- and sex-matched controls (1:4 ratio) presenting at three dermatology clinics. Four randomly selected community clinics within 3–25 km of designated dermatology clinics will refer persons with pellagra-like symptoms to one of the study enrollment sites for diagnosis. Trained study dermatologists will conduct a detailed exposure questionnaire and perform anthropometric measurements. A subset of enrollees will provide ...
    Keywords isoniazid ; tuberculosis preventive treatment ; tuberulosis ; human immuno defficiency virus (HIV) ; pellagra ; niacin (nicotinic acid) ; Public aspects of medicine ; RA1-1270
    Subject code 150
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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