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  1. Book: Tiergestützte Interventionen mit Kindern und Jugendlichen

    Liese-Evers, Melanie / Heier, Meike

    Ein Praxisbuch

    2021  

    Author's details Melanie Liese-Evers arbeitet als Literaturwissenschaftlerin und pädagogische Fachkraft mit Grundschülern und hochbegabten Kindern und Jugendlichen. Sie ist zertifizierte Fachkraft für tiergestützte Interventionen. Meike Heier arbeitet seit mehr als 20 Jahren in der Kinder- und Jugendhilfe. Sie ist Diplom-Psychologin und zertifizierte Fachkraft für tiergestützte Interventionen
    Keywords Lernen ; Entwicklung ; Bedürfnisse ; Kommunikation ; Sicherheitsregeln ; Verhaltensbiologie ; Vertrauen aufbauen ; Gefühle äüßern lernen ; tiergestützte Intervention
    Language German
    Size 192 p.
    Edition 1
    Publisher Junfermann Verlag
    Document type Book
    Note PDA Manuell_15
    Format 167 x 237 x 14
    ISBN 9783749501878 ; 3749501874
    Database PDA

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  2. Article: Nachteilsausgleich : ein paar grundsätzliche Gedanken zu einem Konzept für mehr Chancengleichheit in der Schule

    Evers, Michael

    Unterstützte Kommunikation

    2020  Volume 25, Issue 3, Page(s) 44–46

    Language German
    Document type Article
    ZDB-ID 1384940-2
    ISSN 1863-4877
    Database bibnet.org

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  3. Article ; Online: A Large Pedunculated Mass.

    Oluyadi, Fareedat / Minish, Bailey / Evers, Michael

    American family physician

    2023  Volume 107, Issue 1, Page(s) 87–88

    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412694-4
    ISSN 1532-0650 ; 0002-838X ; 0572-3612
    ISSN (online) 1532-0650
    ISSN 0002-838X ; 0572-3612
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Extracellular ATP and Macropinocytosis: Their Interactive and Mutually Supportive Roles in Cell Growth, Drug Resistance, and EMT in Cancer.

    Evers, Maria / Song, Jingwen / Chen, Xiaozhuo

    Sub-cellular biochemistry

    2022  Volume 98, Page(s) 61–83

    Abstract: Macropinocytosis is one of the major mechanisms by which cancer cells uptake extracellular nutrients from tumor microenvironment (TME) and plays very important roles in various steps of tumorigenesis. We previously reported the unexpected finding that ... ...

    Abstract Macropinocytosis is one of the major mechanisms by which cancer cells uptake extracellular nutrients from tumor microenvironment (TME) and plays very important roles in various steps of tumorigenesis. We previously reported the unexpected finding that intratumoral and extracellular ATP (eATP), as one of the major drastically upregulated extracellular nutrients and messengers in tumors, is taken up by cancer cells through macropinocytosis in large quantities and significantly contributing to cancer cell growth, survival, and increased resistance to chemo and target drugs. Inhibition of macropinocytosis substantially reduced eATP uptake by cancer cells and slowed down tumor growth in vivo. More recently, we have found the eATP also plays a very important role in inducing epithelial-to-mesenchymal transition (EMT), and that macropinocytosis is an essential facilitator in the induction. Thus, macropinocytosis and eATP, working in coordination, appear to play some previously unrecognized but very important roles in EMT and metastasis. As a result, they are likely to be interactive and communicative with each other, regulating each other's activity for various needs of host tumor cells. They are also likely to be an integral part of the future new anticancer therapeutic strategies. Moreover, it is undoubted that we have not identified all the important activities coordinated by ATP and macropinocytosis. This review describes our findings in how eATP and macropinocytosis work together to promote cancer cell growth, resistance, and EMT. We also list scientific challenges facing eATP research and propose to target macropinocytosis and eATP to reduce drug resistance and slow down metastasis.
    MeSH term(s) Adenosine Triphosphate ; Cell Cycle ; Drug Resistance ; Humans ; Neoplasms/drug therapy ; Tumor Microenvironment
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2022-04-04
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 0306-0225 ; 0096-8757
    ISSN 0306-0225 ; 0096-8757
    DOI 10.1007/978-3-030-94004-1_4
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  5. Book ; Online: Multi-dimensional parameter-space partitioning of spatio-temporal simulation ensembles

    Evers, Marina / Linsen, Lars

    2022  

    Abstract: Numerical simulations are commonly used to understand the parameter dependence of given spatio-temporal phenomena. Sampling a multi-dimensional parameter space and running the respective simulations leads to an ensemble of a large number of spatio- ... ...

    Abstract Numerical simulations are commonly used to understand the parameter dependence of given spatio-temporal phenomena. Sampling a multi-dimensional parameter space and running the respective simulations leads to an ensemble of a large number of spatio-temporal simulation runs. A main objective for analyzing the ensemble is to partition (or segment) the multi-dimensional parameter space into connected regions of simulation runs with similar behavior. To facilitate such an analysis, we propose a novel visualization method for multi-dimensional parameter-space partitions. Our visualization is based on the concept of a hyper-slicer, which allows for undistorted views of the parameter-space segments' extent and transitions. For navigation within the parameter space, interactions with a 2D embedding of the parameter-space samples, including their segment memberships, are supported. Parameter-space partitions are generated in a semi-automatic fashion by analyzing the similarity space of the ensemble's simulation runs. Clusters of similar simulation runs induce the segments of the parameter-space partition. We link the parameter-space partitioning visualizations to similarity-space visualizations of the ensemble's simulation runs and embed them into an interactive visual analysis tool that supports the analysis of all facets of the spatio-temporal simulation ensemble targeted at the overarching goal of analyzing the parameter-space partitioning. The partitioning can then be visually analyzed and interactively refined. We evaluated our approach with experts within case studies from three different domains.

    Comment: 14 pages, 9 figures
    Keywords Computer Science - Human-Computer Interaction
    Subject code 000
    Publishing date 2022-05-02
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Particle movement in the spheronizer – Experimental investigations with respect to the toroidal and poloidal direction

    Evers, Maria / Weis, Dominik / Antonyuk, Sergiy / Thommes, Markus

    Powder technology. 2022 May, v. 404

    2022  

    Abstract: Oberservation of particle movement during wet granulation is crucial for identifying granulation mechanisms, process optimizations and troubleshooting. An example of such a process is spheronization, which is commonly used as a wet granulation technique ... ...

    Abstract Oberservation of particle movement during wet granulation is crucial for identifying granulation mechanisms, process optimizations and troubleshooting. An example of such a process is spheronization, which is commonly used as a wet granulation technique to produce spherical, pharmaceutical pellets. Due to the dense particle bed, measurements of poloidal pellet velocities remain a challenge and have not been yet been reported in literature. In this work, a modelling approach was used in combination with particle image velocimetry (PIV) and mixing progress as a surrogate parameter to obtain information about the movement inside the pellet bed, including those parts not visible from outside the pellet bed. A good agreement between the experiment and the simulation was found. Regions of low poloidal velocities were found in both experiments and simulations. The initial pellet shape was not identified as a significant influence on the mixing progress.
    Keywords measurement ; mixing ; models ; particle image velocimetry ; particles ; pelleting ; pellets ; powders ; spheronization
    Language English
    Dates of publication 2022-05
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 0032-5910
    DOI 10.1016/j.powtec.2022.117452
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Wachsende Herausforderung - zunehmendes Übernahmeinteresse

    Evers, Marc

    Finanzierung, Leasing, Factoring : FLF Vol. 64, No. 5 , p. 215-217

    DIHK-Report Unternehmensnachfolge 2016

    2017  Volume 64, Issue 5, Page(s) 215–217

    Author's details Dr. Marc Evers
    Language German
    Publisher Verl. für Absatzwirtschaft
    Publishing place Frankfurt, M
    Document type Article
    ZDB-ID 718728-2
    ISSN 0174-3163
    Database ECONomics Information System

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  8. Article ; Online: Associations between socio-spatially different urban areas and knowledge, attitudes, practices and antibiotic use: A cross-sectional study in the Ruhr Metropolis, Germany.

    Schmiege, Dennis / Falkenberg, Timo / Moebus, Susanne / Kistemann, Thomas / Evers, Mariele

    PloS one

    2022  Volume 17, Issue 3, Page(s) e0265204

    Abstract: Inappropriate and excessive antibiotic use fuels the development of antibiotic resistance. Determinants of antibiotic use, including knowledge and attitudes, are manifold and vary on different spatial scales. The objective of this study was to examine ... ...

    Abstract Inappropriate and excessive antibiotic use fuels the development of antibiotic resistance. Determinants of antibiotic use, including knowledge and attitudes, are manifold and vary on different spatial scales. The objective of this study was to examine the associations between socio-spatially diverse urban areas and knowledge, attitudes, practices and antibiotic use within a metropolitan city. A cross-sectional survey was conducted in the general population in socio-spatially different areas in Dortmund, Germany, in February and March 2020. Three urban areas were chosen to represent diverse socio-spatial contexts (socio-spatially disadvantaged: A, intermediate: B, socio-spatially disadvantaged: C). Participants were selected via simple random sampling. The questionnaire comprised knowledge and attitude statements and questions around antibiotic use and handling practices. Differences between the areas were examined by estimating odds ratios (OR) and corresponding 95% confidence intervals by multiple logistic regression. Overall, 158 participants were included. Participants of Area C showed the lowest proportions of correct knowledge statements, indicated more often attitudes contrary to common recommendations, lower risk awareness and reported more often antibiotic use (C: 40.8%; A: 32.7%; B: 26.5%) and potential mishandling practices (C: 30.4%; A: 9.6%; B: 17.3%). The multiple logistic regression confirmed these differences. Around 42.3% (C), 33.3% (A) and 20.0% (B) of the diseases mentioned for which an antibiotic was used are mainly caused by viral pathogens. A common misconception across all areas was the perception of antibiotic resistance as an individual rather than a universal issue. This study reveals distinct differences between socio-spatially diverse urban areas within a metropolitan city, regarding knowledge, attitudes and practices around antibiotics and ABR. Our findings confirm that enhanced efforts are required to better inform the population about the adequate use and handling of antibiotics. This study emphasizes the need for future interventions to be tailored to the specific local socio-economic context.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Cross-Sectional Studies ; Drug Resistance, Microbial ; Germany ; Health Knowledge, Attitudes, Practice ; Humans ; Surveys and Questionnaires
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-03-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0265204
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  9. Article ; Online: Coping with uncertainty in water management: Qualitative system analysis as a vehicle to visualize the plurality of practitioners' uncertainty handling routines.

    Höllermann, Britta / Evers, Mariele

    Journal of environmental management

    2019  Volume 235, Page(s) 213–223

    Abstract: Accelerated environmental and societal change and its dynamic present a challenge for water management, making it increasingly relevant to integrate uncertainties into the decision-making process. The challenge to science informing practice is how to ... ...

    Abstract Accelerated environmental and societal change and its dynamic present a challenge for water management, making it increasingly relevant to integrate uncertainties into the decision-making process. The challenge to science informing practice is how to provide scientific uncertainty information in a way that this information becomes usable for practitioners. We know that practitioners have developed routines in order to cope with uncertainties, but in order to facilitate the transfer of uncertainty information, this study analyses by whom, when and where in the decision-making process uncertainty routines are used. This research contributes to the plurality of practitioners' perspectives on decision-making under uncertainty in water management. Based on expert elicitation we show that, depending on the business unit and on the time horizon of the management object, practitioners are using different uncertainty routines and hence are in need of more tailor-made uncertainty information to inform their decision-making. Our qualitative systems modeling approach highlighting a reservoir management example serves as a boundary object visualizing the intersection of uncertainty routines and fostering cross-communication and acknowledgement of different perspectives among practitioners. It thus provides a platform for learning. Moreover, it provides a clear understanding of the uncertainty information needs which scientists may cover and increases the usability of their research findings, closing the science-practice gap in adaptive management and transformation processes.
    MeSH term(s) Adaptation, Psychological ; Communication ; Decision Making ; Uncertainty ; Water Quality
    Language English
    Publishing date 2019-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2019.01.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7556: Show issues

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  10. Book: Tiergestützte Interventionen mit Kindern und Jugendlichen. Ein Praxisbuch

    Liese-Evers, Melanie / Heier, Meike

    2021  

    Abstract: Möglichkeiten und Grenzen tiergestützter Interventionen mit Kindern und Jugendlichen in sozialen und pädagogischen Einrichtungen wie Schulen, Kindertagesstätten und Institutionen der Jugendhilfe werden betrachtet. Dabei werden auch rechtliche Aspekte und ...

    Title translation Animal-assisted interventions with children and adolescents. A practice book (DeepL)
    Abstract Möglichkeiten und Grenzen tiergestützter Interventionen mit Kindern und Jugendlichen in sozialen und pädagogischen Einrichtungen wie Schulen, Kindertagesstätten und Institutionen der Jugendhilfe werden betrachtet. Dabei werden auch rechtliche Aspekte und "Stolperfallen" betrachtet, die Fähigkeiten der jeweiligen "tierischen Mitarbeiter" dargestellt, Konzepte für eine qualitativ hochwertige Arbeit geboten und Kenntnisse für den respektvollen Umgang mit den Tieren vermittelt. Praktische Ideen und Tipps geben zudem Impulse, um die eigene Arbeit kreativ zu erweitern und zu gestalten. - Inhalt: (A) Grundlagen und Vorbereitung tiergestützter Interventionen. (1) Theoretische Grundlagen der tiergestützten Arbeit. (2) Von der Idee zur Praxis. (3) Das Tier im sozialen Einsatz - das passende Setting finden: Auswahl geeigneter Tiere, Bedürfnisse, Zielsetzung, Anforderungen, Eignung. - (B) Praxis der tiergestützten Arbeit. (4) In der Praxis. - (C) Anhang.
    Keywords Animal Assisted Therapy ; Animals ; Bildung und Erziehung ; Education ; Interspecies Interaction ; Interspeziesinteraktion ; Intervention ; Social Casework ; Sozialarbeit ; Tiere ; Tierunterstützte Therapie
    Language German
    Size 140 S., 49 S. Anhang
    Publisher Junfermann
    Publishing place Paderborn
    Document type Book
    ISBN 978-3-7495-0228-8 ; 3-7495-0228-5
    Database PSYNDEX

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