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  1. Book: Pharmacotherapy of pulmonary hypertension

    Humbert, Marc / Evgenov, Oleg V. / Stasch, Johannes-Peter

    (Handbook of experimental pharmacology ; 218)

    2013  

    Author's details Marc Humbert ; Oleg V. Evgenov ; Johannes-Peter Stasch ed
    Series title Handbook of experimental pharmacology ; 218
    Collection
    Keywords Pulmonale Hypertonie ; Pharmakotherapie
    Subject Arzneimitteltherapie ; Arzneitherapie ; Medikamentöse Therapie ; Lungenhochdruck ; Pulmonale hypertension ; Pulmonal-arterielle Hypertonie ; PAH
    Language English
    Size IX, 576 S. : Ill., graph. Darst., 235 mm x 155 mm
    Publisher Springer
    Publishing place Heidelberg u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT017833470
    ISBN 978-3-642-38663-3 ; 3-642-38663-6 ; 9783642386640 ; 3642386644
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 A 2960 available for loan (reading room) Lesesaal EG

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  2. Article: Soluble guanylate cyclase stimulators in pulmonary hypertension.

    Stasch, Johannes-Peter / Evgenov, Oleg V

    Handbook of experimental pharmacology

    2013  Volume 218, Page(s) 279–313

    Abstract: Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signalling pathway. On binding of NO to its prosthetic haem group, sGC catalyses the synthesis of the second messenger cyclic guanosine monophosphate (cGMP), which promotes ... ...

    Abstract Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signalling pathway. On binding of NO to its prosthetic haem group, sGC catalyses the synthesis of the second messenger cyclic guanosine monophosphate (cGMP), which promotes vasodilation and inhibits smooth muscle proliferation, leukocyte recruitment, platelet aggregation and vascular remodelling through a number of downstream mechanisms. The central role of the NO-sGC-cGMP pathway in regulating pulmonary vascular tone is demonstrated by the dysregulation of NO production, sGC activity and cGMP degradation in pulmonary hypertension (PH). The sGC stimulators are novel pharmacological agents that directly stimulate sGC, both independently of NO and in synergy with NO. Optimisation of the first sGC stimulator, YC-1, led to the development of the more potent and more specific sGC stimulators, BAY 41-2272, BAY 41-8543 and riociguat (BAY 63-2521). Other sGC stimulators include CFM-1571, BAY 60-4552, vericiguat (BAY 1021189), the acrylamide analogue A-350619 and the aminopyrimidine analogues. BAY 41-2272, BAY 41-8543 and riociguat induced marked dose-dependent reductions in mean pulmonary arterial pressure and vascular resistance with a concomitant increase in cardiac output, and they also reversed vascular remodelling and right heart hypertrophy in several experimental models of PH. Riociguat is the first sGC stimulator that has entered clinical development. Clinical trials have shown that it significantly improves pulmonary vascular haemodynamics and increases exercise ability in patients with pulmonary arterial hypertension (PAH), chronic thromboembolic PH and PH associated with interstitial lung disease. Furthermore, riociguat reduces mean pulmonary arterial pressure in patients with PH associated with chronic obstructive pulmonary disease and improves cardiac index and pulmonary vascular resistance in patients with PH associated with left ventricular systolic dysfunction. These promising results suggest that sGC stimulators may constitute a valuable new therapy for PH. Other trials of riociguat are in progress, including a study of the haemodynamic effects and safety of riociguat in patients with PH associated with left ventricular diastolic dysfunction, and long-term extensions of the phase 3 trials investigating the efficacy and safety of riociguat in patients with PAH and chronic thromboembolic PH. Finally, sGC stimulators may also have potential therapeutic applications in other diseases, including heart failure, lung fibrosis, scleroderma and sickle cell disease.
    MeSH term(s) Animals ; Clinical Trials as Topic ; Cyclic GMP/physiology ; Guanylate Cyclase/physiology ; Heterocyclic Compounds, 2-Ring/therapeutic use ; Humans ; Hypertension, Pulmonary/drug therapy ; Morpholines/therapeutic use ; Nitric Oxide/physiology ; Pyrazoles/therapeutic use ; Pyridines/therapeutic use ; Pyrimidines/therapeutic use ; Receptors, Cytoplasmic and Nuclear/physiology ; Soluble Guanylyl Cyclase
    Chemical Substances 3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine ; BAY 41-8543 ; Heterocyclic Compounds, 2-Ring ; Morpholines ; Pyrazoles ; Pyridines ; Pyrimidines ; Receptors, Cytoplasmic and Nuclear ; Nitric Oxide (31C4KY9ESH) ; Guanylate Cyclase (EC 4.6.1.2) ; Soluble Guanylyl Cyclase (EC 4.6.1.2) ; Cyclic GMP (H2D2X058MU) ; vericiguat (LV66ADM269) ; riociguat (RU3FE2Y4XI)
    Language English
    Publishing date 2013-10-03
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/978-3-642-38664-0_12
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

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  3. Article: Dynamic assessment of pulmonary edema.

    Evgenov, Oleg V

    Critical care medicine

    2004  Volume 32, Issue 12, Page(s) 2561–2; author reply 2562–3

    MeSH term(s) Critical Care/methods ; Critical Illness ; Extracellular Fluid/metabolism ; Extracellular Space ; Female ; Humans ; Intensive Care Units ; Male ; Pulmonary Circulation ; Pulmonary Edema/diagnosis ; Pulmonary Edema/metabolism ; Sensitivity and Specificity ; Thermodilution/methods
    Language English
    Publishing date 2004-12
    Publishing country United States
    Document type Comment ; Comparative Study ; Letter
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/01.ccm.0000153897.65173.cd
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Book: Pharmacotherapy of pulmonary hypertension

    Humbert, Marc / Evgenov, Oleg V / Stasch, Johannes-Peter

    (Handbook of experimental pharmacology, ; volume 218)

    2013  

    Author's details Marc Humbert, Oleg V. Evgenov, Johannes-Peter Stasch, editors
    Series title Handbook of experimental pharmacology, ; volume 218
    MeSH term(s) Hypertension, Pulmonary/drug therapy ; Antihypertensive Agents/therapeutic use
    Language English
    Size ix, 576 pages :, illustrations (chiefly color) ;, 24 cm.
    Document type Book
    ISBN 9783642386633 ; 3642386636 ; 9783642386640 ; 3642386644
    Database Catalogue of the US National Library of Medicine (NLM)

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  5. Book ; Online: Pharmacotherapy of Pulmonary Hypertension

    Humbert, Marc / Evgenov, Oleg V / Stasch, Johannes-Peter

    (Handbook of Experimental Pharmacology ; 218)

    2013  

    Abstract: Over the past decade, major advancements in the understanding of the molecular mechanisms and pathophysiology of pulmonary hypertension occurred in parallel with the discovery and development of new therapies. Pharmacological agents that modulate the ... ...

    Author's details edited by Marc Humbert, Oleg V. Evgenov, Johannes-Peter Stasch
    Series title Handbook of Experimental Pharmacology ; 218
    Abstract Over the past decade, major advancements in the understanding of the molecular mechanisms and pathophysiology of pulmonary hypertension occurred in parallel with the discovery and development of new therapies. Pharmacological agents that modulate the main pathophysiological pathways of pulmonary arterial hypertension have changed the course of this devastating disease by relieving symptoms and improving and prolonging patients' lives. The first part of the book covers definition, classification, pathophysiology, pathology, biomarkers and animal models of pulmonary hypertension, thus laying the
    MeSH term(s) Hypertension, Pulmonary/drug therapy
    Keywords Internal medicine ; Medical laboratories ; Medicine ; Pharmaceutical technology ; Pneumology ; Toxicology ; Medizin / Gesundheit # Biochemie / Labormedizin ; Medizin / Gesundheit # Innere Medizin ; Medizin / Gesundheit # Pneumologie / HNO ; Medizin / Gesundheit # Sonstiges ; Technik / Wissen # Biologie
    Language English
    Size Online-Ressource (IX, 576 p. 66 illus., 56 illus. in color), online resource
    Publisher Springer Berlin Heidelberg
    Publishing place Berlin, Heidelberg ;s.l
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9783642386633 ; 9783642386640 ; 3642386636 ; 3642386644
    DOI 10.1007/978-3-642-38664-0
    Database Former special subject collection: coastal and deep sea fishing

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  6. Article ; Online: Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary disease.

    Stasch, Johannes-Peter / Pacher, Pál / Evgenov, Oleg V

    Circulation

    2011  Volume 123, Issue 20, Page(s) 2263–2273

    MeSH term(s) Animals ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/metabolism ; Enzyme Inhibitors/therapeutic use ; Guanylate Cyclase/antagonists & inhibitors ; Guanylate Cyclase/metabolism ; Humans ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/metabolism ; Receptors, Cytoplasmic and Nuclear/antagonists & inhibitors ; Receptors, Cytoplasmic and Nuclear/metabolism ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Soluble Guanylyl Cyclase
    Chemical Substances Enzyme Inhibitors ; Receptors, Cytoplasmic and Nuclear ; Guanylate Cyclase (EC 4.6.1.2) ; Soluble Guanylyl Cyclase (EC 4.6.1.2)
    Language English
    Publishing date 2011-05-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.110.981738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.60: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Definition and classification of pulmonary hypertension.

    Humbert, Marc / Montani, David / Evgenov, Oleg V / Simonneau, Gérald

    Handbook of experimental pharmacology

    2013  Volume 218, Page(s) 3–29

    Abstract: Pulmonary hypertension is defined as an increase of mean pulmonary arterial pressure ≥25 mmHg at rest as assessed by right heart catheterization. According to different combinations of values of pulmonary wedge pressure, pulmonary vascular resistance and ...

    Abstract Pulmonary hypertension is defined as an increase of mean pulmonary arterial pressure ≥25 mmHg at rest as assessed by right heart catheterization. According to different combinations of values of pulmonary wedge pressure, pulmonary vascular resistance and cardiac output, a hemodynamic classification of pulmonary hypertension has been proposed. Of major importance is the pulmonary wedge pressure which allows to distinguish pre-capillary (pulmonary wedge pressure ≤15 mmHg) and post-capillary (pulmonary wedge pressure >15 mmHg) pulmonary hypertension. Pre-capillary pulmonary hypertension includes the clinical groups 1 (pulmonary arterial hypertension), 3 (pulmonary hypertension due to lung diseases and/or hypoxia), 4 (chronic thrombo-embolic pulmonary hypertension) and 5 (pulmonary hypertension with unclear and/or multifactorial mechanisms). Post-capillary pulmonary hypertension corresponds to the clinical group 2 (pulmonary hypertension due to left heart diseases).
    MeSH term(s) Animals ; Familial Primary Pulmonary Hypertension ; Humans ; Hypertension, Pulmonary/classification ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/physiopathology
    Language English
    Publishing date 2013
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/978-3-642-38664-0_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

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  8. Article: Role of nitrosative stress and activation of poly(ADP-ribose) polymerase-1 in cardiovascular failure associated with septic and hemorrhagic shock.

    Evgenov, Oleg V / Liaudet, Lucas

    Current vascular pharmacology

    2005  Volume 3, Issue 3, Page(s) 293–299

    Abstract: Reactive oxygen and nitrogen species, particularly peroxynitrite, are potent inducers of tissue damage during systemic inflammatory response and circulatory shock. Recent evidence indicates that the toxicity of these species largely depends on their ... ...

    Abstract Reactive oxygen and nitrogen species, particularly peroxynitrite, are potent inducers of tissue damage during systemic inflammatory response and circulatory shock. Recent evidence indicates that the toxicity of these species largely depends on their ability to trigger activation of the nuclear enzyme poly(adenosine 5'-diphosphate ribose) polymerase-1 (PARP-1). Following excessive activation, PARP-1 depletes the intracellular stores of its substrate, nicotinamide adenine dinucleotide, thus slowing glycolysis, generation of high energy phosphates, and mitochondrial electron transport. Consequently, the severe metabolic crisis induced by PARP-1 activation results in acute cell dysfunction and necrotic cell death. In addition, activation of PARP-1 plays an important role in the upregulation of inflammatory cascades via a functional association with mitogen-activated protein kinases and several transcription factors, such as nuclear factor kappa B, resulting in augmented expression of pro-inflammatory cytokines, chemokines, adhesion molecules, and enzymes. In severe sepsis and hemorrhage, PARP-1 activation has emerged as one of the central mechanisms of systemic inflammation, endothelial dysfunction, peripheral vascular failure, and reduction of cardiac contractility. Innovative therapeutic strategies based on the pharmacological inhibition of PARP-1 catalytic activity might provide benefits by preventing tissue injury, organ dysfunction, and lethality associated with these conditions.
    MeSH term(s) Animals ; Cardiovascular Diseases/metabolism ; Enzyme Activation ; Enzyme Inhibitors/pharmacology ; Humans ; Hypoxia/metabolism ; Inflammation Mediators/metabolism ; Poly(ADP-ribose) Polymerase Inhibitors ; Poly(ADP-ribose) Polymerases/metabolism ; Reactive Nitrogen Species/metabolism ; Reactive Oxygen Species/metabolism ; Sepsis/metabolism ; Shock, Hemorrhagic/metabolism ; Signal Transduction
    Chemical Substances Enzyme Inhibitors ; Inflammation Mediators ; Poly(ADP-ribose) Polymerase Inhibitors ; Reactive Nitrogen Species ; Reactive Oxygen Species ; Poly(ADP-ribose) Polymerases (EC 2.4.2.30)
    Language English
    Publishing date 2005-06-13
    Publishing country United Arab Emirates
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2192362-0
    ISSN 1570-1611
    ISSN 1570-1611
    DOI 10.2174/1570161054368580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6282: Show issues Location:
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  9. Article: Administration of methylene blue in human septic shock: renaissance of an old drug?

    Evgenov, Oleg V / Bjertnaes, Lars J

    Critical care medicine

    2003  Volume 31, Issue 5, Page(s) 1601–2; author reply 1602

    MeSH term(s) Blood Volume/drug effects ; Capillary Permeability/drug effects ; Guanylate Cyclase/antagonists & inhibitors ; Humans ; Methylene Blue/adverse effects ; Methylene Blue/therapeutic use ; Research Design/standards ; Risk Factors ; Shock, Septic/drug therapy ; Shock, Septic/physiopathology ; Vasoconstrictor Agents/adverse effects ; Vasoconstrictor Agents/therapeutic use
    Chemical Substances Vasoconstrictor Agents ; Guanylate Cyclase (EC 4.6.1.2) ; Methylene Blue (T42P99266K)
    Language English
    Publishing date 2003-05
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/01.CCM.0000065671.24509.4B
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1261: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Therapeutic potential of soluble guanylate cyclase agonists in pulmonary hypertension

    Kohane Daniel S / Evgenov Oleg V / Zapol Warren M

    BMC Pharmacology, Vol 7, Iss Suppl 1, p S

    2007  Volume 2

    Keywords Therapeutics. Pharmacology ; RM1-950 ; Medicine ; R ; DOAJ:Therapeutics ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2007-07-01T00:00:00Z
    Publisher BioMed Central
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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