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Article ; Online: Atherosclerosis and Hippocampal Volumes in Older Adults: The Role of Age and Blood Pressure.

Kapasi, Alifiya / Capuano, Ana W / Lamar, Melissa / Leurgans, Sue E / Evia, Arnold M / Bennett, David A / Arfanakis, Konstantinos / Schneider, Julie A

Journal of the American Heart Association

2024 Volume 13, Issue 3, Page(s) e031551

Abstract: Background: Lower hippocampal volume is associated with late-life cognitive decline and is an important, but nonspecific marker for clinical Alzheimer's dementia. Cerebrovascular disease may also be associated with hippocampal volume. Here we study the ... ...

Abstract	Background: Lower hippocampal volume is associated with late-life cognitive decline and is an important, but nonspecific marker for clinical Alzheimer's dementia. Cerebrovascular disease may also be associated with hippocampal volume. Here we study the role of intracranial large vessel disease (atherosclerosis) in association with hippocampal volume and the potential role of age, average late-life blood pressure across all visits, and other factors (sex, apolipoprotein ε4 [ Methods and results: Data came from 765 community-based older people (91 years old on average at death; 72% women), from 2 ongoing clinical-pathologic cohort studies. Participants completed baseline assessment, annual standardized blood pressure measurements, vascular risk assessment for diabetes, and blood draws to determine Conclusions: Atherosclerosis severity is associated with lower hippocampal volume, independent of neurodegenerative and other cerebrovascular pathologies. Higher systolic blood pressures and advanced age attenuate associations.
MeSH term(s)	Humans ; Female ; Aged ; Aged, 80 and over ; Male ; Blood Pressure/physiology ; Apolipoprotein E4/genetics ; Alzheimer Disease/pathology ; Hippocampus/diagnostic imaging ; Diabetes Mellitus/pathology ; Atherosclerosis/diagnostic imaging ; Atherosclerosis/epidemiology ; Atherosclerosis/pathology
Chemical Substances	Apolipoprotein E4
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.123.031551
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Article ; Online: Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is associated with abnormalities in white matter structural integrity and connectivity: An ex-vivo diffusion MRI and pathology investigation.

Tazwar, Mahir / Evia, Arnold M / Ridwan, Abdur Raquib / Leurgans, Sue E / Bennett, David A / Schneider, Julie A / Arfanakis, Konstantinos

Neurobiology of aging

2024 Volume 140, Page(s) 81–92

Abstract: Limbic predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is common in older adults and is associated with neurodegeneration, cognitive decline and dementia. In this MRI and pathology investigation we tested the hypothesis ... ...

Abstract	Limbic predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is common in older adults and is associated with neurodegeneration, cognitive decline and dementia. In this MRI and pathology investigation we tested the hypothesis that LATE-NC is associated with abnormalities in white matter structural integrity and connectivity of a network of brain regions typically harboring TDP-43 inclusions in LATE, referred to here as the "LATE-NC network". Ex-vivo diffusion MRI and detailed neuropathological data were collected on 184 community-based older adults. Linear regression revealed an independent association of higher LATE-NC stage with lower diffusion anisotropy in a set of white matter connections forming a pattern of connectivity that is consistent with the stereotypical spread of this pathology in the brain. Graph theory analysis revealed an association of higher LATE-NC stage with weaker integration and segregation in the LATE-NC network. Abnormalities were significant in stage 3, suggesting that they are detectable in later stages of the disease. Finally, LATE-NC network abnormalities were associated with faster cognitive decline, specifically in episodic and semantic memory.
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	604505-4
ISSN	1558-1497 ; 0197-4580
ISSN (online)	1558-1497
ISSN	0197-4580
DOI	10.1016/j.neurobiolaging.2024.04.002
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Article ; Online: Association of Age-Related Neuropathologic Findings at Autopsy With a Claims-Based Epilepsy Diagnosis in Older Adults.

Oveisgharan, Shahram / Grodstein, Francine / Evia, Arnold M / James, Bryan D / Capuano, Ana W / Chen, Yi / Arfanakis, Konstantinos / Schneider, Julie A / Bennett, David A

Neurology

2024 Volume 102, Issue 7, Page(s) e209172

Abstract: Background and objectives: Epilepsy is 1 of the 3 most common neurologic diseases of older adults, but few studies have examined its underlying pathologies in older age. We examined the associations of age-related brain pathologies with epilepsy in ... ...

Abstract	Background and objectives: Epilepsy is 1 of the 3 most common neurologic diseases of older adults, but few studies have examined its underlying pathologies in older age. We examined the associations of age-related brain pathologies with epilepsy in older persons. Methods: Clinical and pathologic data came from 2 ongoing clinical pathologic cohort studies of community-dwelling older adults. Epilepsy was ascertained using Medicare fee-for-service Parts A and B claims data that were linked to data from the cohort studies. The postmortem pathologic assessment collected indices of 9 pathologies including Alzheimer disease, hippocampal sclerosis, macroinfarcts, and cerebral amyloid angiopathy. The fixed brain hemisphere was imaged using 3T MRI scanners before the pathologic assessments in a subgroup of participants. Results: The participants (n = 1,369) were on average 89.3 (6.6) years at death, and 67.0% were women. Epilepsy was identified in 58 (4.2%) participants. Cerebral amyloid angiopathy (odds ratio [OR] = 2.21, 95% CI 1.24-3.95, Discussion: Cerebrovascular pathologies and cortical atrophy were associated with epilepsy in older persons.
MeSH term(s)	United States/epidemiology ; Humans ; Female ; Aged ; Aged, 80 and over ; Male ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/pathology ; Hippocampal Sclerosis ; Medicare ; Cerebral Amyloid Angiopathy/pathology ; Autopsy ; Epilepsy/diagnostic imaging ; Epilepsy/epidemiology ; Epilepsy/pathology ; Atrophy/pathology ; Brain/diagnostic imaging ; Brain/pathology
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000209172
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Article ; Online: Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is associated with lower R

Tazwar, Mahir / Evia, Arnold M / Tamhane, Ashish A / Ridwan, Abdur Raquib / Leurgans, Sue E / Bennett, David A / Schneider, Julie A / Arfanakis, Konstantinos

Neurobiology of aging

2022 Volume 117, Page(s) 128–138

Abstract: Limbic predominant age-related transactive response DNA binding protein 43 (TDP-43) encephalopathy neuropathological change (LATE-NC) is common in persons older than 80 years of age and is associated with cognitive decline and increased likelihood of ... ...

Abstract	Limbic predominant age-related transactive response DNA binding protein 43 (TDP-43) encephalopathy neuropathological change (LATE-NC) is common in persons older than 80 years of age and is associated with cognitive decline and increased likelihood of dementia. The MRI signature of LATE-NC has not been fully determined. In this study, the association of LATE-NC with the transverse relaxation rate, R
MeSH term(s)	Aged ; Aged, 80 and over ; Alzheimer Disease/pathology ; Brain/metabolism ; Cognitive Dysfunction/complications ; Cognitive Dysfunction/etiology ; DNA-Binding Proteins/metabolism ; Humans ; Magnetic Resonance Imaging ; Nervous System Diseases/pathology ; TDP-43 Proteinopathies/diagnostic imaging ; TDP-43 Proteinopathies/metabolism ; White Matter/pathology
Chemical Substances	DNA-Binding Proteins
Language	English
Publishing date	2022-05-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	604505-4
ISSN	1558-1497 ; 0197-4580
ISSN (online)	1558-1497
ISSN	0197-4580
DOI	10.1016/j.neurobiolaging.2022.05.009
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Article ; Online: Neuropathologic correlates of cerebral microbleeds in community-based older adults.

Nikseresht, Grant / Evia, Arnold M / Nag, Sukriti / Leurgans, Sue E / Capuano, Ana W / Agam, Gady / Barnes, Lisa L / Bennett, David A / Schneider, Julie A / Arfanakis, Konstantinos

Neurobiology of aging

2023 Volume 129, Page(s) 89–98

Abstract: Cerebral microbleeds (CMBs) appearing as hypointense foci on ... ...

Abstract	Cerebral microbleeds (CMBs) appearing as hypointense foci on T
MeSH term(s)	Humans ; Aged ; Cerebral Hemorrhage/diagnostic imaging ; Cerebral Hemorrhage/complications ; Cerebral Amyloid Angiopathy/diagnostic imaging ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/complications ; Alzheimer Disease/diagnosis ; Aging ; Magnetic Resonance Imaging/methods
Language	English
Publishing date	2023-05-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	604505-4
ISSN	1558-1497 ; 0197-4580
ISSN (online)	1558-1497
ISSN	0197-4580
DOI	10.1016/j.neurobiolaging.2023.05.005
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Article ; Online: Brain autopsies of critically ill COVID-19 patients demonstrate heterogeneous profile of acute vascular injury, inflammation and age-linked chronic brain diseases.

Agrawal, Sonal / Farfel, Jose M / Arfanakis, Konstantinos / Al-Harthi, Lena / Shull, Tanner / Teppen, Tara L / Evia, Arnold M / Patel, Mayur B / Ely, E Wesley / Leurgans, Sue E / Bennett, David A / Mehta, Rupal / Schneider, Julie A

Acta neuropathologica communications

2022 Volume 10, Issue 1, Page(s) 186

Abstract: Background: This study examined neuropathological findings of patients who died following hospitalization in an intensive care unit with SARS-CoV-2.: Methods: Data originate from 20 decedents who underwent brain autopsy followed by ex-vivo imaging ... ...

Abstract	Background: This study examined neuropathological findings of patients who died following hospitalization in an intensive care unit with SARS-CoV-2. Methods: Data originate from 20 decedents who underwent brain autopsy followed by ex-vivo imaging and dissection. Systematic neuropathologic examinations were performed to assess histopathologic changes including cerebrovascular disease and tissue injury, neurodegenerative diseases, and inflammatory response. Cerebrospinal fluid (CSF) and fixed tissues were evaluated for the presence of viral RNA and protein. Results: The mean age-at-death was 66.2 years (range: 26-97 years) and 14 were male. The patient's medical history included cardiovascular risk factors or diseases (n = 11, 55%) and dementia (n = 5, 25%). Brain examination revealed a range of acute and chronic pathologies. Acute vascular pathologic changes were common in 16 (80%) subjects and included infarctions (n = 11, 55%) followed by acute hypoxic/ischemic injury (n = 9, 45%) and hemorrhages (n = 7, 35%). These acute pathologic changes were identified in both younger and older groups and those with and without vascular risk factors or diseases. Moderate-to-severe microglial activation were noted in 16 (80%) brains, while moderate-to-severe T lymphocyte accumulation was present in 5 (25%) brains. Encephalitis-like changes included lymphocytic cuffing (n = 6, 30%) and neuronophagia or microglial nodule (most prominent in the brainstem, n = 6, 30%) were also observed. A single brain showed vasculitis-like changes and one other exhibited foci of necrosis with ball-ring hemorrhages reminiscent of acute hemorrhagic leukoencephalopathy changes. Chronic pathologies were identified in only older decedents: 7 brains exhibited neurodegenerative diseases and 8 brains showed vascular disease pathologies. CSF and brain samples did not show evidence of viral RNA or protein. Conclusions: Acute tissue injuries and microglial activation were the most common abnormalities in COVID-19 brains. Focal evidence of encephalitis-like changes was noted despite the lack of detectable virus. The majority of older subjects showed age-related brain pathologies even in the absence of known neurologic disease. Findings of this study suggest that acute brain injury superimposed on common pre-existing brain disease may put older subjects at higher risk of post-COVID neurologic sequelae.
MeSH term(s)	Humans ; Male ; Female ; COVID-19/pathology ; SARS-CoV-2 ; Autopsy ; Critical Illness ; Vascular System Injuries/pathology ; Brain/pathology ; Encephalitis/pathology ; Inflammation/pathology ; RNA, Viral
Chemical Substances	RNA, Viral
Language	English
Publishing date	2022-12-17
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2715589-4
ISSN	2051-5960 ; 2051-5960
ISSN (online)	2051-5960
ISSN	2051-5960
DOI	10.1186/s40478-022-01493-7
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Article ; Online: ARTS: A novel In-vivo classifier of arteriolosclerosis for the older adult brain.

Makkinejad, Nazanin / Evia, Arnold M / Tamhane, Ashish A / Javierre-Petit, Carles / Leurgans, Sue E / Lamar, Melissa / Barnes, Lisa L / Bennett, David A / Schneider, Julie A / Arfanakis, Konstantinos

NeuroImage. Clinical

2021 Volume 31, Page(s) 102768

Abstract: Brain arteriolosclerosis, one of the main pathologies of cerebral small vessel disease, is common in older adults and has been linked to lower cognitive and motor function and higher odds of dementia. In spite of its frequency and associated morbidity, ... ...

Abstract	Brain arteriolosclerosis, one of the main pathologies of cerebral small vessel disease, is common in older adults and has been linked to lower cognitive and motor function and higher odds of dementia. In spite of its frequency and associated morbidity, arteriolosclerosis can only be diagnosed at autopsy. Therefore, the purpose of this work was to develop an in-vivo classifier of arteriolosclerosis based on brain MRI. First, an ex-vivo classifier of arteriolosclerosis was developed based on features related to white matter hyperintensities, diffusion anisotropy and demographics by applying machine learning to ex-vivo MRI and pathology data from 119 participants of the Rush Memory and Aging Project (MAP) and Religious Orders Study (ROS), two longitudinal cohort studies of aging that recruit non-demented older adults. The ex-vivo classifier showed good performance in predicting the presence of arteriolosclerosis, with an average area under the receiver operating characteristic curve AUC = 0.78. The ex-vivo classifier was then translated to in-vivo based on available in-vivo and ex-vivo MRI data on the same participants. The in-vivo classifier was named ARTS (short for ARTerioloSclerosis), is fully automated, and provides a score linked to the likelihood a person suffers from arteriolosclerosis. The performance of ARTS in predicting the presence of arteriolosclerosis in-vivo was tested in a separate, 91% dementia-free group of 79 MAP/ROS participants and exhibited an AUC = 0.79 in persons with antemortem intervals shorter than 2.4 years. This level of performance in mostly non-demented older adults is notable considering that arteriolosclerosis can only be diagnosed at autopsy. The scan-rescan reproducibility of the ARTS score was excellent, with an intraclass correlation of 0.99, suggesting that application of ARTS in longitudinal studies may show high sensitivity in detecting small changes. Finally, higher ARTS scores in non-demented older adults were associated with greater decline in cognition two years after baseline MRI, especially in perceptual speed which has been linked to arteriolosclerosis and small vessel disease. This finding was shown in a separate group of 369 non-demented MAP/ROS participants and was validated in 72 non-demented Black participants of the Minority Aging Research Study (MARS) and also in 244 non-demented participants of the Alzheimer's Disease Neuroimaging Initiative 2 and 3. The results of this work suggest that ARTS may have broad implications in the advancement of diagnosis, prevention and treatment of arteriolosclerosis. ARTS is publicly available at https://www.nitrc.org/projects/arts/.
MeSH term(s)	Aged ; Alzheimer Disease ; Arteriolosclerosis/diagnostic imaging ; Brain/diagnostic imaging ; Humans ; Longitudinal Studies ; Magnetic Resonance Imaging ; Reproducibility of Results
Language	English
Publishing date	2021-07-24
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2701571-3
ISSN	2213-1582 ; 2213-1582
ISSN (online)	2213-1582
ISSN	2213-1582
DOI	10.1016/j.nicl.2021.102768
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Article ; Online: Association of White Matter Hyperintensities With Pathology and Progression of Parkinsonism in Aging.

Oveisgharan, Shahram / Yu, Lei / Poole, Victoria N / Evia, Arnold M / Barnes, Lisa L / Schneider, Julie A / Arfanakis, Konstantinos / Bennett, David A / Buchman, Aron S

JAMA neurology

2021 Volume 78, Issue 12, Page(s) 1494–1502

Abstract: Importance: Progressive parkinsonism is common in older adults without a diagnosis of Parkinson disease and is associated with adverse health outcomes, but its pathologic basis is controversial.: Objective: To examine if the burden of cerebral white ... ...

Abstract	Importance: Progressive parkinsonism is common in older adults without a diagnosis of Parkinson disease and is associated with adverse health outcomes, but its pathologic basis is controversial. Objective: To examine if the burden of cerebral white matter hyperintensity (WMH), a common manifestation of cerebrovascular disease pathologies, is associated with the rate of progressive parkinsonism. Design, setting, and participants: This community-based cohort study included participants recruited in 3 ongoing cohorts that began enrollment in 1994, 1997, and 2004. Prior to death, participants were observed for a mean of 7.5 years, with annual clinical assessments. From 4427 participants enrolled in the 3 cohorts, 2134 died. Postmortem autopsy was performed in 1725 decedents, and 598 also had ex vivo brain magnetic resonance imaging. Participants were excluded if they were missing any of the 9 postmortem pathology indices (n = 22) or repeated parkinsonism assessment (n = 41) or had received a clinical diagnosis of Parkinson disease at any point before or during the study (n = 19). Data were analyzed from April 2020 to August 2021. Exposures: WMH burden was assessed using a modified Fazekas rating scale. Main outcomes and measures: Parkinsonism was assessed annually using 26 items of a modified motor portion of the Unified Parkinson's Disease Rating Scale. A summary score was developed from the item scores, with higher scores indicating more severe parkinsonism. Results: Of 516 included decedents, 364 (70.5%) were female, and the mean (SD) age at death was 90.2 (6.4) years. Higher WMH was associated with faster progressive parkinsonism (estimate, 0.024; SE, 0.008; P = .002). The attenuation of this association was greater when controlling for indices of cerebrovascular disease pathologies than when controlling for neurodegenerative pathologies (cerebrovascular disease: estimate, 0.019; SE, 0.008; P = .02; neurodegenerative: estimate, 0.022; SE, 0.008; P = .003), but both remained significant. Conclusions and relevance: In this cohort study, higher levels of both WMH and indices of cerebrovascular disease pathologies in aging brains were associated with more rapid progressive parkinsonism. Further studies are needed to determine if in vivo brain imaging of older adults for evidence of WMH and aggressive medical treatment of vascular risk factors and diseases can reduce the occurrence or severity of late-life parkinsonism.
MeSH term(s)	Aged ; Aged, 80 and over ; Aging/pathology ; Brain/pathology ; Cohort Studies ; Disease Progression ; Female ; Humans ; Male ; Parkinsonian Disorders/pathology ; White Matter/pathology
Language	English
Publishing date	2021-11-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2702023-X
ISSN	2168-6157 ; 2168-6149
ISSN (online)	2168-6157
ISSN	2168-6149
DOI	10.1001/jamaneurol.2021.3996
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Article ; Online: Associations of amygdala volume and shape with transactive response DNA-binding protein 43 (TDP-43) pathology in a community cohort of older adults.

Makkinejad, Nazanin / Schneider, Julie A / Yu, Junxiao / Leurgans, Sue E / Kotrotsou, Aikaterini / Evia, Arnold M / Bennett, David A / Arfanakis, Konstantinos

Neurobiology of aging

2019 Volume 77, Page(s) 104–111

Abstract: Transactive response DNA-binding protein 43 (TDP-43) pathology is common in old age and is strongly associated with cognitive decline and dementia above and beyond contributions from other neuropathologies. TDP-43 pathology in aging typically originates ... ...

Abstract	Transactive response DNA-binding protein 43 (TDP-43) pathology is common in old age and is strongly associated with cognitive decline and dementia above and beyond contributions from other neuropathologies. TDP-43 pathology in aging typically originates in the amygdala, a brain region also affected by other age-related neuropathologies such as Alzheimer's pathology. The purpose of this study was two-fold: to determine the independent effects of TDP-43 pathology on the volume, as well as shape, of the amygdala in a community cohort of older adults, and to determine the contribution of amygdala volume to the variance of the rate of cognitive decline after accounting for the contributions of neuropathologies and demographics. Cerebral hemispheres from 198 participants of the Rush Memory and Aging Project and the Religious Orders Study were imaged with MRI ex vivo and underwent neuropathologic examination. Measures of amygdala volume and shape were extracted for all participants. Regression models controlling for neuropathologies and demographics showed an independent negative association of TDP-43 with the volume of the amygdala. Shape analysis revealed a unique pattern of amygdala deformation associated with TDP-43 pathology. Finally, mixed-effects models showed that amygdala volume explained an additional portion of the variance of the rate of decline in global cognition, episodic memory, semantic memory, and perceptual speed, above and beyond what was explained by demographics and neuropathologies.
MeSH term(s)	Aged ; Aged, 80 and over ; Aging/metabolism ; Aging/pathology ; Aging/psychology ; Alzheimer Disease ; Amygdala/diagnostic imaging ; Amygdala/metabolism ; Amygdala/pathology ; Cognition ; Cohort Studies ; DNA-Binding Proteins/metabolism ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Memory, Episodic ; Neuroimaging ; Organ Size
Chemical Substances	DNA-Binding Proteins ; TARDBP protein, human
Language	English
Publishing date	2019-01-31
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	604505-4
ISSN	1558-1497 ; 0197-4580
ISSN (online)	1558-1497
ISSN	0197-4580
DOI	10.1016/j.neurobiolaging.2019.01.022
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Article ; Online: White Matter Integrity Reductions in Intermittent Explosive Disorder.

Lee, Royce / Arfanakis, Konstantinos / Evia, Arnold M / Fanning, Jennifer / Keedy, Sarah / Coccaro, Emil F

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

2016 Volume 41, Issue 11, Page(s) 2697–2703

Abstract: Intermittent explosive disorder (IED), as described in DSM-5, is the categorical expression of pathological impulsive aggression. Previous work has identified neurobiological correlates of the disorder in patterns of frontal-limbic brain activity and ... ...

Abstract	Intermittent explosive disorder (IED), as described in DSM-5, is the categorical expression of pathological impulsive aggression. Previous work has identified neurobiological correlates of the disorder in patterns of frontal-limbic brain activity and dysregulation of serotonergic neurotransmission. Given the importance of short- and-long range white matter connections of the brain in social and emotional behavior, studies of white matter connectivity in impulsive aggression are warranted. Diffusion tensor imaging (DTI) studies in the related conditions of antisocial and borderline personality disorder have produced preliminary evidence of disturbed white matter connectivity in these disorders, but to date there have been no DTI studies in IED. A total of 132 male and female adults between the ages of 18 and 55 years underwent Turboprop-DTI on a 3-Tesla MRI scanner. Of these, 42 subjects had IED, 40 were normal controls, and 50 were clinical psychiatric controls with psychiatric disorders without IED. All subjects were free of alcohol, psychotropic medications, or drugs of abuse. The diffusion tensor was calculated in each voxel and maps of fractional anisotropy (FA) were generated. Tract-based spatial statistics (TBSS) were used to compare FA along the white matter skeleton among the three subject groups. IED was associated with lower FA in two clusters located in the superior longitudinal fasciculus (SLF) when compared with the psychiatric and healthy controls. Impulsive aggression and borderline personality disorder, but not psychopathy or antisocial personality disorder, was associated with lower FA in the two clusters within the SLF. In conclusion, IED was associated with lower white matter integrity in long-range connections between the frontal and temporoparietal regions.
MeSH term(s)	Adolescent ; Adult ; Anisotropy ; Borderline Personality Disorder/diagnostic imaging ; Brain/diagnostic imaging ; Brain/pathology ; Diffusion Tensor Imaging ; Disruptive, Impulse Control, and Conduct Disorders/diagnostic imaging ; Female ; Humans ; Imaging, Three-Dimensional ; Linear Models ; Male ; Middle Aged ; Neuropsychological Tests ; Perforant Pathway/diagnostic imaging ; Personality ; Psychiatric Status Rating Scales ; White Matter/diagnostic imaging ; Young Adult
Language	English
Publishing date	2016-10
Publishing country	England
Document type	Journal Article
ZDB-ID	639471-1
ISSN	1740-634X ; 0893-133X
ISSN (online)	1740-634X
ISSN	0893-133X
DOI	10.1038/npp.2016.74
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