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  1. Article ; Online: Predictors of anastomotic leak and conduit necrosis after oesophagectomy: Results from the oesophago-gastric anastomosis audit (OGAA).

    Griffiths, Ewen A

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

    2024  Volume 50, Issue 6, Page(s) 107983

    Abstract: Background: Both anastomotic leak (AL) and conduit necrosis (CN) after oesophagectomy are associated with high morbidity and mortality. Therefore, the identification of preoperative, modifiable risk factors is desirable. The aim of this study was to ... ...

    Abstract Background: Both anastomotic leak (AL) and conduit necrosis (CN) after oesophagectomy are associated with high morbidity and mortality. Therefore, the identification of preoperative, modifiable risk factors is desirable. The aim of this study was to generate a risk scoring model for AL and CN after oesophagectomy.
    Methods: Patients undergoing curative resection for oesophageal cancer were identified from the international Oesophagogastric Anastomosis Audit (OGAA) from April 2018-December 2018. Definitions for AL and CN were those set out by the Oesophageal Complications Consensus Group. Univariate and multivariate analyses were performed to identify risk factors for both AL and CN. A risk score was then produced for both AL and CN using the derivation set, then internally validated using the validation set.
    Results: This study included 2247 oesophagectomies across 137 hospitals in 41 countries. The AL rate was 14.2% and CN rate was 2.7%. Preoperative factors that were independent predictors of AL were cardiovascular comorbidity and chronic obstructive pulmonary disease. The risk scoring model showed insufficient predictive ability in internal validation (area under the receiver-operating-characteristic curve [AUROC] = 0.618). Preoperative factors that were independent predictors of CN were: body mass index, Eastern Cooperative Oncology Group performance status, previous myocardial infarction and smoking history. These were converted into a risk-scoring model and internally validated using the validation set with an AUROC of 0.775.
    Conclusion: Despite a large dataset, AL proves difficult to predict using preoperative factors. The risk-scoring model for CN provides an internally validated tool to estimate a patient's risk preoperatively.
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 632519-1
    ISSN 1532-2157 ; 0748-7983
    ISSN (online) 1532-2157
    ISSN 0748-7983
    DOI 10.1016/j.ejso.2024.107983
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    Zs.A 1149: Show issues Location:
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  2. Conference proceedings ; Online: How to understand volcanic processes on Jupiter’s moon Io

    McEwen, A.

    XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

    2023  

    Abstract: Jupiter’s large moon Io is intensely tidally heated and is covered by >100 very active volcanic centers (greater than Kilauea’s average heat flow). These are high-temperature eruptions that can be monitored remotely, even from Earth-based telescopes. ... ...

    Abstract Jupiter’s large moon Io is intensely tidally heated and is covered by >100 very active volcanic centers (greater than Kilauea’s average heat flow). These are high-temperature eruptions that can be monitored remotely, even from Earth-based telescopes. However, there are multiple key questions that can only be answered by a spacecraft mission dedicated to Io: Is the magma dominantly mafic or ultramafic in composition? Are the eruptions sourced directly from the mantle or from shallow magma chambers? What is the role of sulfur and sulfur compounds in the volcanism? What is Io’s total heat flow and how does it vary with latitude and longitude? How does the volcanism relate to the tectonics producing >10 km high mountains? What is the distribution of melt in Io’s interior? Is there a magma ocean? Is the orbital resonance creating the tidal heat in equilibrium or does it vary periodically? How has Io evolved over time? A spacecraft mission with at least 10 close flybys of Io can address these questions, provided it carries the right science payload including visible cameras designed to measure liquid lava temperatures as well as map the surface topography and monitor activity, thermal-IR cameras sensitive from 1-50 microns, magnetometer and gravity science experiments to understand interior melt and lithospheric thickness, and a mass spectrometer to measure the composition of erupted gases. This is the basic concept of the Io Volcano Observer mission concept, which will be expanded for NASA’s New Frontiers mission opportunity, with substantial European collaborations.
    Language English
    Publishing country de
    Document type Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Embedding simulation in genetic counselor education from the first week of training: Learning outcomes, standardized clients, and students' satisfaction.

    Jacobs, Chris / McEwen, Alison

    Journal of genetic counseling

    2024  

    Abstract: Health professional educators routinely utilize simulation to prepare students for practice. However, there is little evidence to show whether simulation enhances learning for genetic counseling students. This study aimed to (i) develop simulation ... ...

    Abstract Health professional educators routinely utilize simulation to prepare students for practice. However, there is little evidence to show whether simulation enhances learning for genetic counseling students. This study aimed to (i) develop simulation learning outcomes and standardized clients for genetic counselor student education and (ii) evaluate students' experiences of learning from face-to-face and virtual simulation in the first week of training in an Australasian master of genetic counseling program. Using the principles of co-design, eight experienced genetic counselors from across Australasia attended an online discussion and one-to-one meetings to develop simulation learning outcomes and build detailed authentic standardized clients. Six learning outcomes were identified: establishing an effective counseling relationship, eliciting information, assessing need, delivering difficult news and helping clients cope with complex emotions, effective communication and facilitating adaptation. Standardized clients were mapped to the learning outcomes and other requirements of the program. Between 2019 and 2022, 106 first year students participated in face-to-face or virtual simulation workshops with two standardized clients on Day 5 of their training. Following the experience, 103 students completed an anonymous survey using a modified version of a validated satisfaction with simulation scale (n = 49 face-to-face in 2019 and 2020 and n = 54 virtual in 2021 and 2022). Responses were analyzed using descriptive statistics and content analysis. Mean satisfaction overall was 95.9% (SD 3.5), 96.2 (SD 4.0) face-to-face, and 95.8 (SD 3.7) virtual. Overall, responses indicated that simulation-based learning and working with standardized clients was a valuable learning experience (100%), developed communication skills and created a sense of reality (99%). For a minority of participants (n = 4), the simulation was too challenging. Key learning related to consolidation of counseling skills, reflective practice, and preparation for clinical placement. In conclusion, exposing novice student genetic counselors to authentic clinical scenarios using standardized clients in face-to-face or virtual classrooms enhanced clinical learning.
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1117799-8
    ISSN 1573-3599 ; 1059-7700
    ISSN (online) 1573-3599
    ISSN 1059-7700
    DOI 10.1002/jgc4.1857
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    Zs.A 4263: Show issues Location:
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  4. Article ; Online: Social Capital from Online Social Media is Associated with Visiting a Healthcare Practitioner at Least Once a Year Among College Students.

    Fogel, Joshua / Ewen, Ashaney

    Delaware journal of public health

    2023  Volume 9, Issue 2, Page(s) 122–128

    Abstract: ...

    Abstract :
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Journal Article
    ISSN 2639-6378
    ISSN (online) 2639-6378
    DOI 10.32481/djph.2023.06.023
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  5. Article ; Online: Diagnosis and treatment of junctional cancer from a global perspective.

    Wijnhoven, Bas P L / Griffiths, Ewen A

    Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    2024  

    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639470-x
    ISSN 1442-2050 ; 1120-8694
    ISSN (online) 1442-2050
    ISSN 1120-8694
    DOI 10.1093/dote/doae017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2378: Show issues Location:
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  6. Article ; Online: Race, ethnicity, and ancestry reporting in genetic counseling research: A focused mapping review and synthesis.

    Arpone, Marta / Turbitt, Erin / McEwen, Alison

    Journal of genetic counseling

    2024  

    Abstract: Studies on the use of Race, Ethnicity, and Ancestry (REA) concepts and terms in genetic research are limited. We aimed to describe the collection, reporting, and use of REA data in genetic counseling research. We undertook a focused mapping review and ... ...

    Abstract Studies on the use of Race, Ethnicity, and Ancestry (REA) concepts and terms in genetic research are limited. We aimed to describe the collection, reporting, and use of REA data in genetic counseling research. We undertook a focused mapping review and synthesis of the Journal of Genetic Counseling 2021 publications. We used a mapping proforma based on the Race, Ethnicity, And Culture in Health checklist to extract data. Of the 177 screened articles, 132 met our inclusion criteria of reporting primary data about participants. The sample REA characteristics were described in 80 (61%) articles, with 6% providing a definition or conceptualization of the REA term/s used and 23% including a rationale for their study in terms of REA factors. Group labels were most often reported using population descriptors, such as "race," "ethnicity," "race/ethnicity," and "ancestry." Several group labels were used under different population descriptors. For instance, the group labels "White" and "Asian" were used under all population descriptors. Most studies (79%) ascertained REA characteristics by participants' self-report. Three (15%) of the 20 qualitative studies mentioned the relevance of the interviewers' REA characteristics in relation to the participants' REA characteristics. Of the 55 quantitative studies, 19 (35%) used REA factors in the data analysis. Of the 80 articles describing the sample REA characteristics, 20% referred moderately or a great deal to any REA factors in the results interpretation, 46% acknowledged the REA factors in the study limitations, and 15% discussed the implications of REA reporting for genetic counseling practice. Our review documents extensive variation in how sample REA characteristics are described and used in genetic counseling research. Our findings provide a baseline against which to evaluate the effects of guidelines and recommendations for the collection, responsible use, and report of participants' REA characteristics in genetic counseling research.
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1117799-8
    ISSN 1573-3599 ; 1059-7700
    ISSN (online) 1573-3599
    ISSN 1059-7700
    DOI 10.1002/jgc4.1884
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4263: Show issues Location:
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  7. Article ; Online: Genetic counselling and testing for neurodegenerative disorders using a proposed standard of practice for ALS/MND: diagnostic testing comes first.

    Crook, Ashley / McEwen, Alison

    European journal of human genetics : EJHG

    2022  Volume 30, Issue 4, Page(s) 394–395

    MeSH term(s) Amyotrophic Lateral Sclerosis/diagnosis ; Amyotrophic Lateral Sclerosis/genetics ; Diagnostic Techniques and Procedures ; Genetic Counseling ; Humans ; Motor Neuron Disease ; Neurodegenerative Diseases
    Language English
    Publishing date 2022-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1141470-4
    ISSN 1476-5438 ; 1018-4813
    ISSN (online) 1476-5438
    ISSN 1018-4813
    DOI 10.1038/s41431-021-01036-z
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    Zs.A 3589: Show issues Location:
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  8. Article ; Online: Predictors of textbook outcome following oesophagogastric cancer surgery.

    Velayudham, Ganesh K / Dermanis, Alexander / Kamarajah, Sivesh K / Griffiths, Ewen A

    Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    2024  

    Abstract: Textbook outcome (TO) is a composite measure representing an ideal perioperative course, which has been utilized to assess the quality of care in oesophagogastric cancer (OGC) surgery. We aim to determine TO rates among OGC patients in a UK tertiary ... ...

    Abstract Textbook outcome (TO) is a composite measure representing an ideal perioperative course, which has been utilized to assess the quality of care in oesophagogastric cancer (OGC) surgery. We aim to determine TO rates among OGC patients in a UK tertiary center, investigate predictors of TO attainment, and evaluate the relationship between TO and survival. A retrospective analysis of a prospectively collected departmental database between 2006 and 2021 was conducted. Patients that underwent radical OGC surgery with curative intent were included. TO attainment required margin-negative resection, adequate lymphadenectomy, uncomplicated postoperative course, and no hospital readmission. Predictors of TO were investigated using multivariable logistic regression. The association between TO and survival was evaluated using Kaplan-Meier analysis and Cox regression modeling. In sum, 667 esophageal cancer and 312 gastric cancer patients were included. TO was achieved in 35.1% of esophagectomy patients and 51.3% of gastrectomy patients. Several factors were independently associated with a low likelihood of TO attainment: T3 stage (odds ratio (OR): 0.41, 95% confidence interval (CI) [0.22-0.79], p = 0.008) and T4 stage (OR:0.26, 95% CI [0.08-0.72], p = 0.013) in the esophagectomy cohort and high BMI (OR:0.93, 95% CI [0.88-0.98], p = 0.011) in the gastrectomy cohort. TO attainment was associated with greater overall survival and recurrence-free survival in esophagectomy and gastrectomy cohorts. TO is a relevant quality metric that can be utilized to compare surgical performance between centers and investigate patients at risk of TO failure. Enhancement of preoperative care measures can improve TO rates and, subsequently, long-term survival.
    Language English
    Publishing date 2024-03-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639470-x
    ISSN 1442-2050 ; 1120-8694
    ISSN (online) 1442-2050
    ISSN 1120-8694
    DOI 10.1093/dote/doae023
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    Zs.A 2378: Show issues Location:
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  9. Article: Special Issue: "Genetic Counseling and Genetic Testing in Precision Medicine".

    Turbitt, Erin / Jacobs, Chris / McEwen, Alison

    Journal of personalized medicine

    2023  Volume 13, Issue 8

    Abstract: Progress in genomic technologies has spurred innovation in healthcare and medicine, contributing to improved health and well-being [ ... ]. ...

    Abstract Progress in genomic technologies has spurred innovation in healthcare and medicine, contributing to improved health and well-being [...].
    Language English
    Publishing date 2023-07-27
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13081192
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  10. Article ; Online: (In)visibility of LGBTQIA+ people and relationships in healthcare: A scoping review.

    Mitchell, Lucas A / Jacobs, Chris / McEwen, Alison

    Patient education and counseling

    2023  Volume 114, Page(s) 107828

    Abstract: Objective: To identify and map research into the visibility of LGBTQIA+ people and their relationships in healthcare, with the view to inform future research and practice.: Method: Five databases were systematically searched for published and grey ... ...

    Abstract Objective: To identify and map research into the visibility of LGBTQIA+ people and their relationships in healthcare, with the view to inform future research and practice.
    Method: Five databases were systematically searched for published and grey literature. Primary research reporting on visibility of LGBTQIA+ people in healthcare was included. Two reviewers independently screened the studies until an acceptable level of agreement was reached. A narrative synthesis was conducted and findings mapped to a taxonomy of microaggressions involving three sub-categories: microinsults, microassaults and microinvalidations.
    Results: The microaggressions identified included Microinsults: 'Perception of health professionals' knowledge and comfort' and 'Disclosure'; Microassaults: 'Discrimination and stigma'; Microvalidations: 'Accessing and navigating through services', 'Encounters of assumptions and stereotypes', 'Validating identities and including relationships', and 'Reading the environment'.
    Conclusion: Despite growing societal acceptance, microaggressions still exist within healthcare. Groups within LGBTQIA+ communities have varying levels of visibility in research and healthcare based on the studies included.
    Practice implications: The limited visibility of LGBT and lack of visibility of QIA+ people and their relationships in healthcare highlight the need to include the views of all LGBTQIA+ communities in research, and to ensure health professionals and clinical services are equipped to address this (in)visibility gap.
    MeSH term(s) Humans ; Delivery of Health Care ; Health Personnel ; Sexual and Gender Minorities ; Social Stigma
    Language English
    Publishing date 2023-05-29
    Publishing country Ireland
    Document type Journal Article ; Systematic Review
    ZDB-ID 605590-4
    ISSN 1873-5134 ; 0738-3991
    ISSN (online) 1873-5134
    ISSN 0738-3991
    DOI 10.1016/j.pec.2023.107828
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    Zs.A 1465: Show issues Location:
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