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  1. Article ; Online: How good is good enough? Lessons learned from review of outcomes of 50 patients following extraoral open reduction and internal fixation of condylar neck and base fractures at a regional major trauma centre.

    Leow, Julian / Exley, Rebecca / Holmes, Simon / Bhatti, Nabeel

    The British journal of oral & maxillofacial surgery

    2023  Volume 62, Issue 1, Page(s) 83–88

    Abstract: The management of mandibular fractures is routine owing to their frequency, particularly those of the mandibular condyle, which are invariably common. Notwithstanding disparities in the literature, the international consensus towards which fractures of ... ...

    Abstract The management of mandibular fractures is routine owing to their frequency, particularly those of the mandibular condyle, which are invariably common. Notwithstanding disparities in the literature, the international consensus towards which fractures of the mandibular condyle benefit from open surgical intervention is almost universally accepted. Closed reduction or non-operative management may be utilised in certain circumstances. Whilst outcome research has addressed complications with respect to operative side effects, outcomes related to the quality of bone repair and the setting in which this is delivered have not been universally addressed. The aim of this study was to determine the predictability of translating an indicated operative treatment plan into an acceptable functional result. We evaluated the outcomes of 59 extracapsular condylar fractures in 50 patients who were treated by extraoral open reduction and internal fixation (ORIF) between March 2021 and August 2022. We reviewed demographic data, surgical approach, and plating strategy, and critically evaluated the clinical and radiological outcomes. Whilst we found that the quality of reduction was not universally perfect, the majority were within tolerance, which we set according to the Strasbourg Osteosynthesis Research Group (SORG) definition for minimal displacement (<2 mm overlap and 10° angulation). The cohort had good functional occlusion and minimal long-term postoperative complications. Two patients required re-operation for non-union, and we discuss causality in these cases. In conclusion, we found that ORIF of condylar neck and base fractures is predictable in real-time surgical practice with respect to functional outcome. However, if imperfectly reduced, there is a small risk of non-union.
    MeSH term(s) Humans ; Treatment Outcome ; Trauma Centers ; Mandibular Condyle/diagnostic imaging ; Mandibular Condyle/surgery ; Mandibular Condyle/injuries ; Fracture Fixation, Internal/methods ; Mandibular Fractures/diagnostic imaging ; Mandibular Fractures/surgery
    Language English
    Publishing date 2023-11-27
    Publishing country Scotland
    Document type Review ; Journal Article
    ZDB-ID 605685-4
    ISSN 1532-1940 ; 0266-4356
    ISSN (online) 1532-1940
    ISSN 0266-4356
    DOI 10.1016/j.bjoms.2023.11.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Development of a patient-reported outcomes and experience measure for Orthognathic surgery: validation of the Northwick Park Orthognathic Questionnaire (NOQ).

    Chegini, S / Campbell, S-J / Klontzas, M E / Chopra, R / Wright, H / Exley, R / Thusu, S / McKenny, E / Heliotis, M

    International journal of oral and maxillofacial surgery

    2021  Volume 51, Issue 5, Page(s) 659–664

    Abstract: Orthognathic surgery aims to correct dentoskeletal and facial discrepancies. The expected benefits are functional, cosmetic, and psychological. In a previous publication, this group assessed the determinants of patient satisfaction to formulate the ... ...

    Abstract Orthognathic surgery aims to correct dentoskeletal and facial discrepancies. The expected benefits are functional, cosmetic, and psychological. In a previous publication, this group assessed the determinants of patient satisfaction to formulate the Northwick Park Orthognathic Questionnaire (NOQ). The aim of the present study was to validate this questionnaire. A total of 118 postoperative patients prospectively completed the NOQ, 30 of whom completed the questionnaire a second time. The mean completion rate was 87.6 ± 10%. Response reproducibility was high: 92% of patients gave identical responses (range 81-100%). The intra-class correlation coefficient (ICC) was 0.96 (0.96 ± 0.072). Average test-retest scores for each domain were as follows (range in parenthesis): reasons for treatment 93% (60-100%), preoperative experience 96% (81-100%), preparation for surgery 95% (81-100%), inpatient experience 89% (55-100%), post-discharge experience 83% (55-100%), benefits of treatment 92% (71-100%), overall patient education 91% (62-100%). Internal validity using Cronbach's alpha was 0.72 (standard deviation 0.23, range 0.5-1). The results confirm the consistency of responses and the reliability of the information collected with the NOQ. The NOQ is a novel questionnaire and a valid metric to quantify a patient's perception of their experience. Its adoption may aid in making targeted improvements to patient care.
    MeSH term(s) Aftercare ; Humans ; Orthognathic Surgery ; Patient Discharge ; Patient Reported Outcome Measures ; Psychometrics ; Quality of Life ; Reproducibility of Results ; Surveys and Questionnaires
    Language English
    Publishing date 2021-10-29
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 353721-3
    ISSN 1399-0020 ; 0901-5027
    ISSN (online) 1399-0020
    ISSN 0901-5027
    DOI 10.1016/j.ijom.2021.10.007
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  3. Article: Presynaptic nicotinic receptors: a dynamic and diverse cholinergic filter of striatal dopamine neurotransmission.

    Exley, R / Cragg, S J

    British journal of pharmacology

    2007  Volume 153 Suppl 1, Page(s) S283–97

    Abstract: The effects of nicotine on dopamine transmission from mesostriatal dopamine neurons are central to its reinforcing properties. Only recently however, has the influence of presynaptic nicotinic receptors (nAChRs) on dopaminergic axon terminals within ... ...

    Abstract The effects of nicotine on dopamine transmission from mesostriatal dopamine neurons are central to its reinforcing properties. Only recently however, has the influence of presynaptic nicotinic receptors (nAChRs) on dopaminergic axon terminals within striatum begun to be understood. Here, rather than simply enhancing (or inhibiting) dopamine release, nAChRs perform the role of a presynaptic filter, whose influence on dopamine release probability depends on presynaptic activity in dopaminergic as well as cholinergic neurons. Both mesostriatal dopaminergic neurons and striatal cholinergic interneurons play key roles in motivational and sensorimotor processing by the basal ganglia. Moreover, it appears that the striatal influence of dopamine and ACh cannot be fully appreciated without an understanding of their reciprocal interactions. We will review the powerful filtering by nAChRs of striatal dopamine release and discuss its dependence on activity in dopaminergic and cholinergic neurons. We will also review how nicotine, acting via nAChR desensitization, promotes the sensitivity of dopamine synapses to activity. This filtering action might provide a mechanism through which nicotine promotes how burst activity in dopamine neurons facilitates goal-directed behaviour and reinforcement processing. More generally, it indicates that we should not restrict our view of presynaptic nAChRs to simply enhancing neurotransmitter release. We will also summarize current understanding of the forms and functions of the diverse nAChRs purported to exist on dopaminergic axons. A greater understanding of nAChR form and function is imperative to guide the design of ligands with subtype-selective efficacy for improved therapeutic interventions in nicotine addiction as well as Parkinson's disease.
    MeSH term(s) Animals ; Dopamine/physiology ; Humans ; Neostriatum/physiology ; Parasympathetic Nervous System/physiology ; Presynaptic Terminals/physiology ; Receptor Cross-Talk/physiology ; Receptors, Nicotinic/physiology ; Receptors, Presynaptic/physiology ; Synaptic Transmission/physiology
    Chemical Substances Receptors, Nicotinic ; Receptors, Presynaptic ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2007-11-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1038/sj.bjp.0707510
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  4. Article ; Online: Rhabdomyosarcoma of the trachea: first reported case treated with proton beam therapy.

    Exley, R / Bernstein, J M / Brennan, B / Rothera, M P

    The Journal of laryngology and otology

    2012  Volume 126, Issue 9, Page(s) 966–969

    Abstract: Objective: We report a case of rhabdomyosarcoma of the trachea in a 14-month-old child, and we present the first reported use of proton beam therapy for this tumour.: Case report: A 14-month-old girl presented acutely with a seven-day history of ... ...

    Abstract Objective: We report a case of rhabdomyosarcoma of the trachea in a 14-month-old child, and we present the first reported use of proton beam therapy for this tumour.
    Case report: A 14-month-old girl presented acutely with a seven-day history of biphasic stridor. Emergency endoscopic debulking of a posterior tracheal mass was undertaken. Histological examination revealed an embryonal rhabdomyosarcoma with anaplasia. Multimodality therapy with surgery and chemotherapy was administered in the UK, and proton beam therapy in the USA.
    Conclusion: Only three cases of rhabdomyosarcoma of the trachea have previously been reported in the world literature. This is the first reported case of treatment of this tumour with proton beam therapy. Compared with conventional radiotherapy, proton beam therapy may confer improved long-term outcome in children, with benefits including reduced irradiation of the spinal cord.
    MeSH term(s) Adolescent ; Airway Obstruction/diagnosis ; Airway Obstruction/etiology ; Anaplasia ; Child ; Combined Modality Therapy ; Diagnosis, Differential ; Endoscopy/methods ; Female ; Humans ; Infant ; Magnetic Resonance Imaging ; Male ; Proton Therapy ; Respiratory Sounds/etiology ; Rhabdomyosarcoma, Embryonal/diagnosis ; Rhabdomyosarcoma, Embryonal/pathology ; Rhabdomyosarcoma, Embryonal/radiotherapy ; Tracheal Neoplasms/diagnosis ; Tracheal Neoplasms/pathology ; Tracheal Neoplasms/radiotherapy ; Treatment Outcome
    Language English
    Publishing date 2012-09
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 218299-3
    ISSN 1748-5460 ; 0022-2151
    ISSN (online) 1748-5460
    ISSN 0022-2151
    DOI 10.1017/S002221511200151X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Structure-based design of chimeric antigens for multivalent protein vaccines.

    Hollingshead, S / Jongerius, I / Exley, R M / Johnson, S / Lea, S M / Tang, C M

    Nature communications

    2018  Volume 9, Issue 1, Page(s) 1051

    Abstract: There is an urgent need to develop vaccines against pathogenic bacteria. However, this is often hindered by antigenic diversity and difficulties encountered manufacturing membrane proteins. Here we show how to use structure-based design to develop ... ...

    Abstract There is an urgent need to develop vaccines against pathogenic bacteria. However, this is often hindered by antigenic diversity and difficulties encountered manufacturing membrane proteins. Here we show how to use structure-based design to develop chimeric antigens (ChAs) for subunit vaccines. ChAs are generated against serogroup B Neisseria meningitidis (MenB), the predominant cause of meningococcal disease in wealthy countries. MenB ChAs exploit factor H binding protein (fHbp) as a molecular scaffold to display the immunogenic VR2 epitope from the integral membrane protein PorA. Structural analyses demonstrate fHbp is correctly folded and the PorA VR2 epitope adopts an immunogenic conformation. In mice, immunisation with ChAs generates fHbp and PorA antibodies that recognise the antigens expressed by clinical MenB isolates; these antibody responses correlate with protection against meningococcal disease. Application of ChAs is therefore a potentially powerful approach to develop multivalent subunit vaccines, which can be tailored to circumvent pathogen diversity.
    MeSH term(s) Animals ; Antibodies, Bacterial/immunology ; Antigens, Bacterial/immunology ; Bacterial Proteins/immunology ; Humans ; Meningococcal Vaccines/immunology ; Neisseria meningitidis, Serogroup B/immunology
    Chemical Substances Antibodies, Bacterial ; Antigens, Bacterial ; Bacterial Proteins ; Meningococcal Vaccines
    Language English
    Publishing date 2018-03-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-018-03146-7
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  6. Article ; Online: Rare giant frontal sinus osteoma mimicking fibrous dysplasia.

    Exley, R P / Markey, A / Rutherford, S / Bhalla, R K

    The Journal of laryngology and otology

    2015  Volume 129, Issue 3, Page(s) 283–287

    Abstract: Objective: To present the first report of a giant frontal sinus osteoma treated by excision and single-stage reconstruction with custom-made titanium cranioplasty and left orbital roof prostheses.: Case report: A 31-year-old man with a history of ... ...

    Abstract Objective: To present the first report of a giant frontal sinus osteoma treated by excision and single-stage reconstruction with custom-made titanium cranioplasty and left orbital roof prostheses.
    Case report: A 31-year-old man with a history of chronic frontal sinusitis presented with a deforming, painless, midline forehead swelling of 11 years' duration, which had been treated unsuccessfully in Nigeria. Differential diagnosis included both benign and malignant bony tumours. Computerised tomography revealed a giant bony frontal sinus tumour extending beyond the sinus roof and breaching the left orbit, consistent with fibrous dysplasia. Given the extent of the tumour, open craniectomy was performed for surgical extirpation. Histological analysis identified multiple osteomas. This surgical approach achieved excellent cosmesis, with no evidence of recurrence at 12-month follow up.
    Conclusion: Forehead swelling may pose diagnostic and management dilemmas for the ENT surgeon; however, effective management is facilitated by a multidisciplinary approach.
    MeSH term(s) Adult ; Bone Neoplasms/diagnosis ; Bone Neoplasms/pathology ; Bone Neoplasms/surgery ; Diagnosis, Differential ; Fibrous Dysplasia of Bone/diagnosis ; Fibrous Dysplasia of Bone/pathology ; Fibrous Dysplasia of Bone/surgery ; Frontal Sinus/pathology ; Frontal Sinus/surgery ; Frontal Sinusitis/pathology ; Frontal Sinusitis/surgery ; Humans ; Male ; Orbit/pathology ; Osteoma/diagnosis ; Osteoma/pathology ; Osteoma/surgery ; Paranasal Sinus Neoplasms/diagnosis ; Paranasal Sinus Neoplasms/pathology ; Paranasal Sinus Neoplasms/surgery ; Prostheses and Implants ; Reconstructive Surgical Procedures/methods ; Titanium ; Tomography, X-Ray Computed
    Chemical Substances Titanium (D1JT611TNE)
    Language English
    Publishing date 2015-03
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 218299-3
    ISSN 1748-5460 ; 0022-2151
    ISSN (online) 1748-5460
    ISSN 0022-2151
    DOI 10.1017/S0022215114003211
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  7. Article ; Online: Gender differences in patients with severe dental infections presenting to hospital.

    Kent, Samuel / Regan, Alisdair / McDonald, Christopher / Henry, Alastair / Dawoud, Basim / Hennedige, Anusha / Kulkarni, Raghav / Logan, Greg / Exley, Rebecca / Gilbert, Kayleigh / Kyzas, Panos / Morrison, Roderick / McCaul, James

    British dental journal

    2021  

    Abstract: Introduction Gender differences have been documented in prevalence and morbidity of caries, gingivitis and oral health, but not previously in cervicofacial infection. Identification and minimisation of gender inequalities is a World Health Organisation ... ...

    Abstract Introduction Gender differences have been documented in prevalence and morbidity of caries, gingivitis and oral health, but not previously in cervicofacial infection. Identification and minimisation of gender inequalities is a World Health Organisation priority, and there are physiological, behavioural and cultural reasons to suspect that sex and gender differences may be present.Methods Analysis was carried out of the MTReC National Snapshot audit of cervicofacial infections. This database was created by oral and maxillofacial surgery trainees in 2017 and records over 400 variables in 1,002 individual patients admitted to hospital with severe odontogenic infection.Results Records were available for 1,002 patients with cervicofacial infection (456 females and 546 males). There were significant differences between recorded gender in those presenting with airway compromise (male 7% vs female 2%, p = 0.001), severe inflammatory response syndrome (male 60% vs female 39%, p = 0.007) and requirement for awake fibre-optic intubation on admission (male 4% vs female 1%, p = 0.014).Discussion These results suggest that male patients access healthcare later in their disease than female patients, and with more severe systemic compromise. This may be due to prevalent cultural and behavioural norms. As equality of access is the responsibility of the administrator, we discuss methods which might improve timely presentation in males with cervicofacial infections.
    Language English
    Publishing date 2021-02-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-020-2351-7
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  8. Article ; Online: Serotonin spillover onto the axon initial segment of motoneurons induces central fatigue by inhibiting action potential initiation.

    Cotel, Florence / Exley, Richard / Cragg, Stephanie J / Perrier, Jean-François

    Proceedings of the National Academy of Sciences of the United States of America

    2013  Volume 110, Issue 12, Page(s) 4774–4779

    Abstract: Motor fatigue induced by physical activity is an everyday experience characterized by a decreased capacity to generate motor force. Factors in both muscles and the central nervous system are involved. The central component of fatigue modulates the ... ...

    Abstract Motor fatigue induced by physical activity is an everyday experience characterized by a decreased capacity to generate motor force. Factors in both muscles and the central nervous system are involved. The central component of fatigue modulates the ability of motoneurons to activate muscle adequately independently of the muscle physiology. Indirect evidence indicates that central fatigue is caused by serotonin (5-HT), but the cellular mechanisms are unknown. In a slice preparation from the spinal cord of the adult turtle, we found that prolonged stimulation of the raphe-spinal pathway--as during motor exercise--activated 5-HT1A receptors that decreased motoneuronal excitability. Electrophysiological tests combined with pharmacology showed that focal activation of 5-HT1A receptors at the axon initial segment (AIS), but not on other motoneuronal compartments, inhibited the action potential initiation by modulating a Na(+) current. Immunohistochemical staining against 5-HT revealed a high-density innervation of 5-HT terminals on the somatodendritic membrane and a complete absence on the AIS. This observation raised the hypothesis that a 5-HT spillover activates receptors at this latter compartment. We tested it by measuring the level of extracellular 5-HT with cyclic voltammetry and found that prolonged stimulations of the raphe-spinal pathway increased the level of 5-HT to a concentration sufficient to activate 5-HT1A receptors. Together our results demonstrate that prolonged release of 5-HT during motor activity spills over from its release sites to the AIS of motoneurons. Here, activated 5-HT1A receptors inhibit firing and, thereby, muscle contraction. Hence, this is a cellular mechanism for central fatigue.
    MeSH term(s) Action Potentials/physiology ; Animals ; Axons/metabolism ; Cell Membrane/metabolism ; Fatigue/metabolism ; Membrane Potentials/physiology ; Motor Neurons/cytology ; Motor Neurons/metabolism ; Muscle Contraction/physiology ; Receptor, Serotonin, 5-HT1A/metabolism ; Serotonin/metabolism ; Sodium/metabolism ; Turtles/physiology
    Chemical Substances Receptor, Serotonin, 5-HT1A (112692-38-3) ; Serotonin (333DO1RDJY) ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2013-03-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1216150110
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  9. Article ; Online: Unusual presentation of an asymptomatic pseudomeningocele within the sphenoid sinus.

    McNamara, K J / Exley, R P / Khwaja, S / Bhalla, R K

    The Journal of laryngology and otology

    2013  Volume 127, Issue 12, Page(s) 1238–1241

    Abstract: Objective: We report the rare case of a 55-year-old woman with an asymptomatic left sphenoid sinus pseudomeningocele mimicking a mucocele.: Case report: A 55-year-old woman was found to have an incidental mass in the left sphenoid sinus on computed ... ...

    Abstract Objective: We report the rare case of a 55-year-old woman with an asymptomatic left sphenoid sinus pseudomeningocele mimicking a mucocele.
    Case report: A 55-year-old woman was found to have an incidental mass in the left sphenoid sinus on computed tomography. Magnetic resonance imaging confirmed the presence of a mucocele. A left endoscopic sphenoidotomy was performed to drain the mucocele. Despite an anatomical puncture through a stenosed sphenoid ostium, alarmingly, the opening leaked cerebrospinal fluid. A dehiscent lateral wall was identified with a dural opening communicating with the sphenoid sinus. This was immediately repaired with a free nasal septal mucosal graft. Six months post-operatively, the patient remained free from cerebrospinal fluid leakage.
    Conclusion: Pseudomeningoceles are extremely rare in the absence of trauma or iatrogenic injury. Surgeons should be alert to their presence as they can mimic a unilateral mucocele or nasal polyp. Endoscopic management lends itself to a single-stage repair.
    MeSH term(s) Contrast Media ; Diagnosis, Differential ; Drainage/adverse effects ; Drainage/methods ; Female ; Humans ; Incidental Findings ; Magnetic Resonance Imaging ; Middle Aged ; Mucocele/diagnosis ; Mucocele/diagnostic imaging ; Mucocele/surgery ; Natural Orifice Endoscopic Surgery/methods ; Sphenoid Sinus/abnormalities ; Sphenoid Sinus/diagnostic imaging ; Sphenoid Sinus/surgery ; Tomography, X-Ray Computed ; Treatment Outcome
    Chemical Substances Contrast Media
    Language English
    Publishing date 2013-12
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 218299-3
    ISSN 1748-5460 ; 0022-2151
    ISSN (online) 1748-5460
    ISSN 0022-2151
    DOI 10.1017/S0022215113002247
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  10. Article ; Online: Striatal α5 nicotinic receptor subunit regulates dopamine transmission in dorsal striatum.

    Exley, Richard / McIntosh, J Michael / Marks, Michael J / Maskos, Uwe / Cragg, Stephanie J

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2012  Volume 32, Issue 7, Page(s) 2352–2356

    Abstract: Polymorphisms in the gene for the α5 nicotinic acetylcholine receptor (nAChR) subunit are associated with vulnerability to nicotine addiction. However, the underlying normal functions of α5-containing nAChRs in the brain are poorly understood. Striatal ... ...

    Abstract Polymorphisms in the gene for the α5 nicotinic acetylcholine receptor (nAChR) subunit are associated with vulnerability to nicotine addiction. However, the underlying normal functions of α5-containing nAChRs in the brain are poorly understood. Striatal dopamine (DA) transmission is critical to the acquisition and maintenance of drug addiction and is modulated strongly by nicotine acting at heteromeric β2-containing (β2*) nAChRs. We explored whether α5 subunits, as well as α4, α6, and β3 subunits, participate in the powerful regulation of DA release probability by β2* nAChRs in nucleus accumbens (NAc) core and in dorsal striatum [caudatoputamen (CPu)]. We detected evoked dopamine release using fast-scan cyclic voltammetry at carbon-fiber microelectrodes in striatal slices from mice with deletions of α4, α5, α6, or β3 subunits. We show that the nAChR subtypes that dominantly regulate dopamine transmission depend critically upon α5 subunits in the dorsal CPu in α4α5(non-α6)β2-nAChRs but not in NAc core, where α4α6β2β3-nAChRs are required. These data reveal the distinct populations of nAChRs that govern DA transmission in NAc core versus dorsal CPu. Furthermore, they indicate that α5 subunits are critical to the regulation of DA transmission by α4β2* nAChRs in regions of striatum associated with habitual and instrumental responses (dorsal CPu) rather than pavlovian associations (NAc).
    MeSH term(s) Animals ; Caudate Nucleus/metabolism ; Corpus Striatum/metabolism ; Dopamine/metabolism ; Dopaminergic Neurons/metabolism ; Habituation, Psychophysiologic ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nucleus Accumbens/metabolism ; Putamen/metabolism ; Receptors, Nicotinic/physiology ; Synaptic Transmission/physiology
    Chemical Substances Receptors, Nicotinic ; nicotinic receptor alpha5 subunit, mouse ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2012-03-06
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.4985-11.2012
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