Article ; Online: Marine Inspired 2-(5-Halo-1H-indol-3-yl)-N,N-dimethylethanamines as Modulators of Serotonin Receptors: An Example Illustrating the Power of Bromine as Part of the Uniquely Marine Chemical Space.
2017 Volume 15, Issue 8
Abstract: In previous studies, we have isolated several marine indole alkaloids and evaluated them in the forced swim test (FST) and locomotor activity test, revealing their potential as antidepressant and sedative drug leads. Amongst the reported metabolites to ... ...
Abstract | In previous studies, we have isolated several marine indole alkaloids and evaluated them in the forced swim test (FST) and locomotor activity test, revealing their potential as antidepressant and sedative drug leads. Amongst the reported metabolites to display such activities was 5-bromo- |
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MeSH term(s) | Acetamides/chemical synthesis ; Acetamides/chemistry ; Acetamides/pharmacology ; Animals ; Antidepressive Agents/chemistry ; Hydrocarbons, Brominated/chemistry ; Indole Alkaloids/pharmacology ; Indoles/chemical synthesis ; Indoles/chemistry ; Indoles/pharmacology ; Marine Biology ; Mice ; N,N-Dimethyltryptamine/analogs & derivatives ; N,N-Dimethyltryptamine/chemistry ; N,N-Dimethyltryptamine/pharmacology ; Receptors, Serotonin/drug effects |
Chemical Substances | 2-(1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide ; Acetamides ; Antidepressive Agents ; Hydrocarbons, Brominated ; Indole Alkaloids ; Indoles ; Receptors, Serotonin ; serotonin 5 receptor ; 5-bromo-N,N-dimethyltryptamine (2F81I6UW8C) ; N,N-Dimethyltryptamine (WUB601BHAA) |
Language | English |
Publishing date | 2017-08-09 |
Publishing country | Switzerland |
Document type | Journal Article |
ZDB-ID | 2175190-0 |
ISSN | 1660-3397 ; 1660-3397 |
ISSN (online) | 1660-3397 |
ISSN | 1660-3397 |
DOI | 10.3390/md15080248 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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