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  1. Article ; Online: Sensitive Positron Emission Tomography Imaging of PD-L1 Expression in Human Breast and Lung Carcinoma Xenografts Using the Radiometalated Peptide Ga-68-TRAP-WL12.

    Quigley, Neil Gerard / Steiger, Katja / Färber, Stefanie Felicitas / Richter, Frauke / Weichert, Wilko / Notni, Johannes

    Molecular pharmaceutics

    2024  Volume 21, Issue 4, Page(s) 1827–1837

    Abstract: Noninvasive imaging of the immune checkpoint protein programmed death ligand 1 (PD-L1; synonyms: CD274, B7-H1) holds great promise to improve patient selection and, thus, response rates for immune checkpoint therapy (ICT) with monoclonal antibodies ... ...

    Abstract Noninvasive imaging of the immune checkpoint protein programmed death ligand 1 (PD-L1; synonyms: CD274, B7-H1) holds great promise to improve patient selection and, thus, response rates for immune checkpoint therapy (ICT) with monoclonal antibodies targeting the PD1/PD-L1 axis. The PD-L1 specific peptide WL12 (cyclo(AcY-(
    MeSH term(s) Humans ; Animals ; Mice ; Gallium Radioisotopes/chemistry ; B7-H1 Antigen/metabolism ; Heterografts ; Tissue Distribution ; Peptides/chemistry ; Lung Neoplasms/diagnostic imaging ; Cell Line, Tumor ; Adenocarcinoma of Lung ; Positron-Emission Tomography/methods ; Lung/metabolism
    Chemical Substances Gallium-68 (98B30EPP5S) ; Gallium Radioisotopes ; B7-H1 Antigen ; Peptides
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.3c01128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6250: Show issues Location:
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  2. Article: Effect of Carbohydration on the Theranostic Tracer PSMA I&T.

    Schmidt, Alexander / Wirtz, Martina / Färber, Stefanie Felicitas / Osl, Theresa / Beck, Roswitha / Schottelius, Margret / Schwaiger, Markus / Wester, Hans-Jürgen

    ACS omega

    2018  Volume 3, Issue 7, Page(s) 8278–8287

    Abstract: To investigate the effect of carbohydrate moieties on the pharmacokinetic profile of prostate-specific membrane antigen (PSMA) inhibitors, carbohydrated derivatives of the established PSMA-targeted radiopharmaceutical PSMA I&T were developed and ... ...

    Abstract To investigate the effect of carbohydrate moieties on the pharmacokinetic profile of prostate-specific membrane antigen (PSMA) inhibitors, carbohydrated derivatives of the established PSMA-targeted radiopharmaceutical PSMA I&T were developed and evaluated. As observed for the reference PSMA I&T, the
    Language English
    Publishing date 2018-07-25
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN 2470-1343
    DOI 10.1021/acsomega.8b00790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Therapeutic Radiopharmaceuticals Targeting Integrin αvβ6.

    Färber, Stefanie Felicitas / Wurzer, Alexander / Reichart, Florian / Beck, Roswitha / Kessler, Horst / Wester, Hans-Jürgen / Notni, Johannes

    ACS omega

    2018  Volume 3, Issue 2, Page(s) 2428–2436

    Abstract: The epithelial integrin αvβ6 is expressed by many malignant carcinoma cell types, including pancreatic cancer, and thus represents a promising target for radionuclide therapy. The peptide cyclo(FRGDLAFp( ...

    Abstract The epithelial integrin αvβ6 is expressed by many malignant carcinoma cell types, including pancreatic cancer, and thus represents a promising target for radionuclide therapy. The peptide cyclo(FRGDLAFp(
    Language English
    Publishing date 2018-02-27
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN 2470-1343
    DOI 10.1021/acsomega.8b00035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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