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  1. Article: Editorial: Extracellular matrix in development and disorders of the nervous system.

    Jakovcevski, Igor / Andjus, Pavle R / Förster, Eckart

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1153484

    Language English
    Publishing date 2023-02-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1153484
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  2. Book ; Online ; Thesis: Einfluss eines Hitzeschocks auf Mikrogliazellen und die Morphologie des Gyrus dentatus in hippocampalen Schnittkulturen der Ratte

    Weninger, Jasmin [Verfasser] / Förster, Eckart [Gutachter] / Wellmer, Jörg [Gutachter]

    2024  

    Author's details Jasmin Zannette Weninger ; Gutachter: Eckart Förster, Jörg Wellmer ; Medizinische Fakultät
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Ruhr-Universität Bochum
    Publishing place Bochum
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  3. Article: Tetrodotoxin prevents heat-shock induced granule cell dispersion in hippocampal slice cultures.

    Ahrari, Ala / Meseke, Maurice / Förster, Eckart

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 906262

    Abstract: Granule cell dispersion (GCD) has been associated as a pathological feature of temporal lobe epilepsy (TLE). Early-life epileptiform activity such as febrile seizures has been proposed to have a causal link to developing chronic TLE. During postnatal ... ...

    Abstract Granule cell dispersion (GCD) has been associated as a pathological feature of temporal lobe epilepsy (TLE). Early-life epileptiform activity such as febrile seizures has been proposed to have a causal link to developing chronic TLE. During postnatal development, the hippocampus may be particularly vulnerable to hyperexcitability-induced insults since neuronal migration and differentiation are still ongoing in the hippocampus. Further, the extracellular matrix (ECM), here in particular the protein reelin, has been implicated in the pathophysiology of GCD. Thus, loss of reelin-expressing cells, Cajal-Retzius cells and subsets of interneurons, may be related to GCD. To study the possible role of febrile seizures, we previously induced GCD
    Language English
    Publishing date 2022-08-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.906262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online ; Thesis: Der Effekt von Reelin auf die frühe neuronale Aktivität und das glutamaterge System im Neocortex

    Rabaia, Obada [Verfasser] / Förster, Eckart [Gutachter] / Schmidt, Matthias [Gutachter]

    2023  

    Author's details Obada Rabaia ; Gutachter: Eckart Förster, Matthias Schmidt ; Medizinische Fakultät
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Ruhr-Universität Bochum
    Publishing place Bochum
    Document type Book ; Online ; Thesis
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  5. Book ; Online ; Thesis: Der Einfluss von Reelin auf die Funktion von GABA\(_B}\)-Rezeptoren während der postnatalen Entwicklung des Neocortex der Maus

    Jbara, Abdalrahim [Verfasser] / Förster, Eckart [Gutachter] / Schmidt, Matthias [Gutachter]

    2023  

    Author's details Abdalrahim Jbara ; Gutachter: Eckart Förster, Matthias Schmidt ; Medizinische Fakultät
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Ruhr-Universität Bochum
    Publishing place Bochum
    Document type Book ; Online ; Thesis
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  6. Article: Considering the Role of Extracellular Matrix Molecules, in Particular Reelin, in Granule Cell Dispersion Related to Temporal Lobe Epilepsy.

    Leifeld, Jennifer / Förster, Eckart / Reiss, Gebhard / Hamad, Mohammad I K

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 917575

    Abstract: The extracellular matrix (ECM) of the nervous system can be considered as a dynamically adaptable compartment between neuronal cells, in particular neurons and glial cells, that participates in physiological functions of the nervous system. It is mainly ... ...

    Abstract The extracellular matrix (ECM) of the nervous system can be considered as a dynamically adaptable compartment between neuronal cells, in particular neurons and glial cells, that participates in physiological functions of the nervous system. It is mainly composed of carbohydrates and proteins that are secreted by the different kinds of cell types found in the nervous system, in particular neurons and glial cells, but also other cell types, such as pericytes of capillaries, ependymocytes and meningeal cells. ECM molecules participate in developmental processes, synaptic plasticity, neurodegeneration and regenerative processes. As an example, the ECM of the hippocampal formation is involved in degenerative and adaptive processes related to epilepsy. The role of various components of the ECM has been explored extensively. In particular, the ECM protein reelin, well known for orchestrating the formation of neuronal layer formation in the cerebral cortex, is also considered as a player involved in the occurrence of postnatal granule cell dispersion (GCD), a morphologically peculiar feature frequently observed in hippocampal tissue from epileptic patients. Possible causes and consequences of GCD have been studied in various
    Language English
    Publishing date 2022-06-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.917575
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  7. Article: Heat-Shock Induces Granule Cell Dispersion and Microgliosis in Hippocampal Slice Cultures.

    Weninger, Jasmin / Meseke, Maurice / Rana, Shaleen / Förster, Eckart

    Frontiers in cell and developmental biology

    2021  Volume 9, Page(s) 626704

    Abstract: Granule cell dispersion (GCD) has been found in the dentate gyrus (dg) of patients with temporal lobe epilepsy (TLE) and a history of febrile seizures but was also recently observed in pediatric patients that did not suffer from epilepsy. This indicates ... ...

    Abstract Granule cell dispersion (GCD) has been found in the dentate gyrus (dg) of patients with temporal lobe epilepsy (TLE) and a history of febrile seizures but was also recently observed in pediatric patients that did not suffer from epilepsy. This indicates that GCD might not always be disease related, but instead could reflect normal morphological variation. Thus, distribution of newborn granule cells within the hilar region is part of normal dg development at early stages but could be misinterpreted as pathological GCD. In turn, pathological GCD may be caused, for example, by genetic mutations, such as the reeler mutation. GCD in the reeler mutant goes along with an increased susceptibility to epileptiform activity. Pathological GCD in combination with epilepsy is caused by experimental administration of the glutamate receptor agonist kainic acid in rodents. In consequence, the interpretation of GCD and the role of febrile seizures remain controversial. Here, we asked whether febrile temperatures alone might be sufficient to trigger GCD and used hippocampal slice cultures as
    Language English
    Publishing date 2021-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.626704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Impact of Depletion of Microglia/Macrophages on Regeneration after Spinal Cord Injury.

    Jakovčevski, Igor / Förster, Eckart / Reiss, Gebhard / Schachner, Melitta

    Neuroscience

    2021  Volume 459, Page(s) 129–141

    Abstract: Microglia/macrophages play important functional roles in regeneration after central nervous system injury. Infiltration of circulating macrophages and proliferation of resident microglia occur within minutes following spinal cord injury. Activated ... ...

    Abstract Microglia/macrophages play important functional roles in regeneration after central nervous system injury. Infiltration of circulating macrophages and proliferation of resident microglia occur within minutes following spinal cord injury. Activated microglia/macrophages clear tissue debris, but activation over time may hamper repair. To study the role of these cells in regeneration after spinal cord injury we used CD11b-herpes simplex virus thymidine kinase (HSVTK) (TK) transgenic mice, in which viral thymidine kinase activates ganciclovir toxicity in CD11b-expressing myeloid cells, including macrophages and microglia. A severe reduction in number of these cells was seen in TK versus wild-type littermate mice at 1 week and 5 weeks after injury, and numbers of Mac-2 expressing activated microglia/macrophages were almost completely reduced at these time points. One week after injury TK mice showed better locomotor recovery, but recovery was similar to wild-type mice as measured weekly up to 5 weeks thereafter. At 5 weeks after injury, numbers of axons at the lesion site and neurons in the lumbar spinal cord did not differ between groups. Also, catecholaminergic innervation of spinal motoneurons was similar. However, cholinergic innervation was lower and glial scarring was increased in TK mice compared to wild-type mice. We conclude that reducing numbers of CD11b-expressing cells improves locomotor recovery in the early phase after spinal cord injury, but does not affect recovery in the following 4 weeks. These observations point to differences in outcomes of astrocytic response and cholinergic innervation under CD11b cell ablation, which are, however, not reflected in the locomotor parameters analyzed at 5 weeks after injury.
    MeSH term(s) Animals ; Macrophages ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microglia ; Recovery of Function ; Spinal Cord ; Spinal Cord Injuries
    Language English
    Publishing date 2021-02-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2021.02.010
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1215: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Tiagabine and zonisamide differentially regulate the glial properties in an astrocyte-microglia co-culture model of inflammation.

    Ismail, Fatme Seval / Faustmann, Pedro M / Förster, Eckart / Corvace, Franco / Faustmann, Timo Jendrik

    Naunyn-Schmiedeberg's archives of pharmacology

    2023  Volume 396, Issue 11, Page(s) 3253–3267

    Abstract: Due to the role of astrocytes and microglia in the pathophysiology of epilepsy and limited studies of antiseizure medication (ASM) effects on glial cells, we studied tiagabine (TGB) and zonisamide (ZNS) in an astrocyte-microglia co-culture model of ... ...

    Abstract Due to the role of astrocytes and microglia in the pathophysiology of epilepsy and limited studies of antiseizure medication (ASM) effects on glial cells, we studied tiagabine (TGB) and zonisamide (ZNS) in an astrocyte-microglia co-culture model of inflammation. Different concentrations of ZNS (10, 20, 40, 100 µg/ml) or TGB (1, 10, 20, 50 µg/ml) were added to primary rat astrocytes co-cultures with 5-10% (M5, physiological conditions) or 30-40% (M30, pathological inflammatory conditions) microglia for 24 h, aiming to study glial viability, microglial activation, connexin 43 (Cx43) expression and gap-junctional coupling. ZNS led to the reduction of glial viability by only 100 µg/ml under physiological conditions. By contrast, TGB revealed toxic effects with a significant, concentration-dependent reduction of glial viability under physiological and pathological conditions. After the incubation of M30 co-cultures with 20 µg/ml TGB, the microglial activation was significantly decreased and resting microglia slightly increased, suggesting possible anti-inflammatory features of TGB under inflammatory conditions. Otherwise, ZNS caused no significant changes of microglial phenotypes. The gap-junctional coupling was significantly decreased after the incubation of M5 co-cultures with 20 and 50 µg/ml TGB, which can be related to its anti-epileptic activity under noninflammatory conditions. A significant decrease of Cx43 expression and cell-cell coupling was found after the incubation of M30 co-cultures with 10 µg/ml ZNS, suggesting additional anti-seizure effects of ZNS with the disruption of glial gap-junctional communication under inflammatory conditions. TGB and ZNS differentially regulated the glial properties. Developing novel ASMs targeting glial cells may have future potential as an "add-on" therapy to classical ASMs targeting neurons.
    MeSH term(s) Rats ; Animals ; Astrocytes ; Microglia ; Coculture Techniques ; Tiagabine/metabolism ; Tiagabine/pharmacology ; Connexin 43/metabolism ; Zonisamide/pharmacology ; Zonisamide/metabolism ; Cell Communication ; Neuroglia/metabolism ; Inflammation/pathology
    Chemical Substances Tiagabine (Z80I64HMNP) ; Connexin 43 ; Zonisamide (459384H98V)
    Language English
    Publishing date 2023-05-25
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-023-02538-x
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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.5: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Book: Kooperation bei der Versorgung psychisch kranker Kinder und Jugendlicher

    Förster, Eckart

    (Beiheft zur "Praxis der Kinderpsychologie und Kinderpsychiatrie" ; 23)

    1981  

    Author's details hrsg. von Eckart Förster
    Series title Beiheft zur "Praxis der Kinderpsychologie und Kinderpsychiatrie" ; 23
    Praxis der Kinderpsychologie und Kinderpsychiatrie
    Collection Praxis der Kinderpsychologie und Kinderpsychiatrie
    Keywords MENTAL DISORDERS / IN ADOLESCENCE ; MENTAL DISORDERS / IN INFANCY AND CHILDHOOD ; MENTAL DISORDERS / THERAPY ; Kinderpsychiatrie ; Kooperation ; Jugendpsychiatrie
    Subject Zusammenarbeit ; Cooperation ; Partnerschaft ; Jugend ; Kind
    Language German
    Size 95 S.
    Publisher Verl. für Med. Psychologie im Verl. Vandenhoeck & Ruprecht
    Publishing place Göttingen
    Publishing country Germany
    Document type Book
    HBZ-ID HT001053110
    ISBN 3-525-45226-8 ; 978-3-525-45226-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    ZS B 1131 -BEIH.23- verfügbar in Königswinter Königswinter

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