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  1. Article: Im Corona-Gespräch: Reinhold Förster über Schleimhautimmunität und inhalative Impfstoffe

    Förster, Reinhold

    Laborjournal

    2022  Volume 29, Issue 9, Page(s) 14

    Language German
    Document type Article
    ZDB-ID 1237282-1
    ISSN 1612-8354
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4842: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Imaging cytomegalovirus infection and ensuing immune responses.

    Bošnjak, Berislav / Lueder, Yvonne / Messerle, Martin / Förster, Reinhold

    Current opinion in immunology

    2023  Volume 82, Page(s) 102307

    Abstract: Cytomegaloviruses (CMVs) possess exquisite mechanisms enabling colonization, replication, and release allowing spread to new hosts. Moreover, they developed ways to escape the control of the host immune responses and hide latently within the host cells. ... ...

    Abstract Cytomegaloviruses (CMVs) possess exquisite mechanisms enabling colonization, replication, and release allowing spread to new hosts. Moreover, they developed ways to escape the control of the host immune responses and hide latently within the host cells. Here, we outline studies that visualized individual CMV-infected cells using reporter viruses. These investigations provided crucial insights into all steps of CMV infection and mechanisms the host's immune response struggles to control it. Uncovering complex viral and cellular interactions and underlying molecular as well as immunological mechanisms are a prerequisite for the development of novel therapeutic interventions for successful treatment of CMV-related pathologies in neonates and transplant patients.
    MeSH term(s) Infant, Newborn ; Humans ; Cytomegalovirus Infections ; Cytomegalovirus ; Immunity
    Language English
    Publishing date 2023-03-28
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2023.102307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2773: Show issues Location:
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  3. Article ; Online: NK cell dysfunction in severe COVID-19: TGF-β-induced downregulation of integrin beta-2 restricts NK cell cytotoxicity.

    Barros-Martins, Joana / Förster, Reinhold / Bošnjak, Berislav

    Signal transduction and targeted therapy

    2022  Volume 7, Issue 1, Page(s) 32

    MeSH term(s) COVID-19 ; Down-Regulation ; Humans ; Integrins ; Killer Cells, Natural ; SARS-CoV-2 ; Transforming Growth Factor beta
    Chemical Substances Integrins ; Transforming Growth Factor beta
    Language English
    Publishing date 2022-01-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-022-00892-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Challenges of CRISPR-Based Gene Editing in Primary T Cells.

    Rezalotfi, Alaleh / Fritz, Lea / Förster, Reinhold / Bošnjak, Berislav

    International journal of molecular sciences

    2022  Volume 23, Issue 3

    Abstract: Adaptive T-cell immunotherapy holds great promise for the successful treatment of leukemia, as well as other types of cancers. More recently, it was also shown to be an effective treatment option for chronic virus infections in immunosuppressed patients. ...

    Abstract Adaptive T-cell immunotherapy holds great promise for the successful treatment of leukemia, as well as other types of cancers. More recently, it was also shown to be an effective treatment option for chronic virus infections in immunosuppressed patients. Autologous or allogeneic T cells used for immunotherapy are usually genetically modified to express novel T-cell or chimeric antigen receptors. The production of such cells was significantly simplified with the CRISPR/Cas system, allowing for the deletion or insertion of novel genes at specific locations within the genome. In this review, we describe recent methodological breakthroughs that were important for the conduction of these genetic modifications, summarize crucial points to be considered when conducting such experiments, and highlight the potential pitfalls of these approaches.
    MeSH term(s) CRISPR-Cas Systems ; Gene Editing/methods ; Humans ; Immunotherapy ; T-Lymphocytes
    Language English
    Publishing date 2022-02-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23031689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hide and seek with SARS-CoV-2: spike receptor-binding domain-specific memory B cells still recognize Omicron variant.

    Odak, Ivan / Förster, Reinhold / Bošnjak, Berislav

    Signal transduction and targeted therapy

    2022  Volume 7, Issue 1, Page(s) 343

    MeSH term(s) COVID-19 ; Humans ; Memory B Cells ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/genetics
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-10-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-022-01192-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Lymph-Derived Neutrophils Primarily Locate to the Subcapsular and Medullary Sinuses in Resting and Inflamed Lymph Nodes.

    de Castro Pinho, Jenny / Förster, Reinhold

    Cells

    2021  Volume 10, Issue 6

    Abstract: Neutrophils are the first immune cells to be recruited from the blood to the tissue site of an infection or inflammation. It has been suggested that neutrophils are capable of migrating from the infected tissue via lymphatic vessels to the draining lymph ...

    Abstract Neutrophils are the first immune cells to be recruited from the blood to the tissue site of an infection or inflammation. It has been suggested that neutrophils are capable of migrating from the infected tissue via lymphatic vessels to the draining lymph nodes. However, it remains elusive as to which areas within the lymph nodes can be reached by such reversely migrating cells. To address this question, we applied a model for adoptive neutrophil transfer into the afferent lymphatic vessel that drains towards the popliteal lymph node in mice. We showed that resting and in vitro-activated neutrophils did not enter the lymph node parenchyma but localized primarily in the subcapsular and medullary sinuses. Within the medulla, neutrophils show random migration and are able to sense laser-induced sterile tissue injury by massively swarming to the damaged tissue site. Co-injected dendritic cells supported the entry of resting neutrophils into the lymph node parenchyma via the subcapsular sinus. In contrast, in vivo-activated adoptively transferred neutrophils were capable of migrating into the interfollicular areas of the lymph node. Collectively, the data presented here give further insights into the functional behavior of neutrophils within the lymph nodes.
    MeSH term(s) Animals ; Cell Movement/immunology ; Lymph/cytology ; Lymph/immunology ; Lymph Nodes/immunology ; Mice ; Mice, Inbred C57BL ; Neutrophils/immunology
    Language English
    Publishing date 2021-06-12
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10061486
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online ; Thesis: Identifizierung molekularer Mechanismen zur Induktion von immunologischer Toleranz unter Verwendung des CRISPR/Cas9- und HoxB8-Systems

    Frenk, David Nikolas [Verfasser] / Förster, Reinhold [Akademischer Betreuer]

    2022  

    Author's details David Nikolas Frenk ; Akademischer Betreuer: Reinhold Förster ; Institut für Immunologie
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Bibliothek der Medizinischen Hochschule Hannover
    Publishing place Hannover
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  8. Article ; Online: Combating COVID-19: MVA Vector Vaccines Applied to the Respiratory Tract as Promising Approach Toward Protective Immunity in the Lung.

    Förster, Reinhold / Fleige, Henrike / Sutter, Gerd

    Frontiers in immunology

    2020  Volume 11, Page(s) 1959

    Abstract: The lung is the vital target organ of coronavirus disease 2019 (COVID-19) caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In the majority of patients the most active virus replication seems to be found in the upper ... ...

    Abstract The lung is the vital target organ of coronavirus disease 2019 (COVID-19) caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In the majority of patients the most active virus replication seems to be found in the upper respiratory tract, severe cases however suffer from SARS-like disease associated with virus replication in lung tissues. Due to the current lack of suitable anti-viral drugs the induction of protective immunity such as neutralizing antibodies in the lung is the key aim of the only alternative approach-the development and application of SARS-CoV-2 vaccines. However, past experience from experimental animals, livestock, and humans showed that induction of immunity in the lung is limited following application of vaccines at peripheral sides such as skin or muscles. Based on several considerations we therefore propose here to consider the application of a Modified Vaccinia virus Ankara (MVA)-based vaccine to mucosal surfaces of the respiratory tract as a favorable approach to combat COVID-19.
    MeSH term(s) Administration, Mucosal ; Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Betacoronavirus/chemistry ; Bronchi/immunology ; COVID-19 ; Coronavirus Infections/prevention & control ; Coronavirus Infections/virology ; Humans ; Immunoglobulin A/metabolism ; Lymphoid Tissue/immunology ; Pandemics/prevention & control ; Plasma Cells/immunology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/virology ; Respiratory Mucosa/drug effects ; Respiratory Mucosa/immunology ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/immunology ; T-Lymphocytes/immunology ; Vaccination ; Vaccines, Attenuated/immunology ; Vaccinia virus/immunology ; Viral Vaccines/administration & dosage ; Viral Vaccines/immunology
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; Immunoglobulin A ; Spike Glycoprotein, Coronavirus ; Vaccines, Attenuated ; Viral Vaccines ; spike protein, SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.01959
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Differential retention of lymph-borne CD8 memory T cell subsets in the subcapsular sinus of resting and inflamed lymph nodes.

    Nikolova, Ginka / Weiss, Siegfried / Bosnjak, Berislav / Förster, Reinhold

    Cellular & molecular immunology

    2020  Volume 18, Issue 5, Page(s) 1317–1319

    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes/immunology ; Immunologic Memory ; Inflammation/immunology ; Inflammation/pathology ; Lymph/immunology ; Lymph Nodes/immunology ; Lymph Nodes/pathology ; Mice
    Language English
    Publishing date 2020-05-12
    Publishing country China
    Document type Letter
    ZDB-ID 2435097-7
    ISSN 2042-0226 ; 1672-7681
    ISSN (online) 2042-0226
    ISSN 1672-7681
    DOI 10.1038/s41423-020-0451-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6681: Show issues Location:
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  10. Article ; Online: Imaging dendritic cell functions.

    Bošnjak, Berislav / Do, Kim Thi Hoang / Förster, Reinhold / Hammerschmidt, Swantje I

    Immunological reviews

    2021  Volume 306, Issue 1, Page(s) 137–163

    Abstract: Dendritic cells (DCs) are crucial for the appropriate initiation of adaptive immune responses. During inflammation, DCs capture antigens, mature, and migrate to lymphoid tissues to present foreign material to naïve T cells. These cells get activated and ... ...

    Abstract Dendritic cells (DCs) are crucial for the appropriate initiation of adaptive immune responses. During inflammation, DCs capture antigens, mature, and migrate to lymphoid tissues to present foreign material to naïve T cells. These cells get activated and differentiate either into pathogen-specific cytotoxic CD8
    MeSH term(s) Antigen Presentation ; CD8-Positive T-Lymphocytes ; Dendritic Cells ; Humans ; Immune Tolerance ; T-Lymphocytes, Cytotoxic
    Language English
    Publishing date 2021-12-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13050
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