Article ; Online: Stellenwert von ASS-Provokationen beim Analgetika-Intoleranz-Syndrom.
2024
Abstract: Background: Nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD) is often characterized by a severe course of chronic rhinosinusitis with nasal polyps (CRSwNP), comorbid asthma, and NSAID hypersensitivity. The gold standard for N- ... ...
| Title translation | Importance of aspirin challenges in patients with NSAID-exacerbated respiratory disease. |
|---|---|
| Abstract | Background: Nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD) is often characterized by a severe course of chronic rhinosinusitis with nasal polyps (CRSwNP), comorbid asthma, and NSAID hypersensitivity. The gold standard for N-ERD diagnosis is challenge with acetylsalicylic acid (ASA). In expert recommendations, the diagnosis of N-ERD is established based on a plausible positive history of NSAID hypersensitivity and CRSwNP with asthma. Objective: The following review describes the performance of ASA challenges and their sensitivity and specificity. It also examines the extent to which a positive history of NSAID hypersensitivity correlates with ASA challenge results in clinical trials and when ASA challenges should be performed. Results and conclusion: ASA challenges have high sensitivity and specificity. In clinical ASA challenge studies, there is a high concordance between a positive history of NSAID hypersensitivity obtained by rhinologists and the measured data of ASA challenge in patients with CRSwNP and comorbid asthma. Therefore, ASA challenge is primarily indicated in patients with an unclear history of NSAID hypersensitivity. |
| Language | German |
| Publishing date | 2024-04-10 |
| Publishing country | Germany |
| Document type | English Abstract ; Journal Article ; Review |
| ZDB-ID | 200040-4 |
| ISSN | 1433-0458 ; 0017-6192 |
| ISSN (online) | 1433-0458 |
| ISSN | 0017-6192 |
| DOI | 10.1007/s00106-024-01460-9 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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