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Article ; Online: Drought reconstruction since 1796 CE based on tree-ring widths in the upper Heilongjiang (Amur) River basin in Northeast Asia and its linkage to Pacific Ocean climate variability

Y. Xu / H. Zhang / F. Chen / S. Wang / M. Hu / M. Hadad / F. Roig

Climate of the Past, Vol 19, Pp 2079-

2023 Volume 2092

Abstract: The economic and environmental impacts of persistent droughts in East Asia are of growing concern, and therefore it is important to study the cyclicity and causes of these regional droughts. The self-calibrating Palmer drought severity index (scPDSI) has ...

Abstract	The economic and environmental impacts of persistent droughts in East Asia are of growing concern, and therefore it is important to study the cyclicity and causes of these regional droughts. The self-calibrating Palmer drought severity index (scPDSI) has been extensively employed to describe the severity of regional drought, and several scPDSI reconstructions based on tree rings have been produced. We compiled a tree-ring chronology for Hailar pine ( Pinus sylvestris var. mongolica ) from two sites in the Hailar region in the upper Heilongjiang (Amur) River basin. Analysis of the climate response revealed that scPDSI was the primary factor limiting tree ring growth from May to July. The mean May to July scPDSI in the Hailar region since 1796 was reconstructed from the tree-ring width chronology. The results of spatial correlation analysis revealed that the reconstructed scPDSI in this region responded significantly to climate change. Analysis of the synoptic climatology indicated that the drought in the upper Heilongjiang (Amur) River basin is closely related to El Niño–Southern Oscillation (ENSO) and the Silk Road teleconnection. The results of atmospheric water cycle analysis show that water vapor transport processes are the dominant factor in the development of drought in this region.
Keywords	Environmental pollution ; TD172-193.5 ; Environmental protection ; TD169-171.8 ; Environmental sciences ; GE1-350
Subject code	550
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Inter-Alpha Inhibitor Proteins Modify the Microvasculature after Exposure to Hypoxia–Ischemia and Hypoxia in Neonatal Rats

Francesco Girolamo / Yow-Pin Lim / Daniela Virgintino / Barbara S. Stonestreet / Xiaodi F. Chen

International Journal of Molecular Sciences, Vol 24, Iss 6743, p

2023 Volume 6743

Abstract: Microvasculature develops during early brain development. Hypoxia–ischemia (HI) and hypoxia (H) predispose to brain injury in neonates. Inter-alpha inhibitor proteins (IAIPs) attenuate injury to the neonatal brain after exposure to HI. However, the ... ...

Abstract	Microvasculature develops during early brain development. Hypoxia–ischemia (HI) and hypoxia (H) predispose to brain injury in neonates. Inter-alpha inhibitor proteins (IAIPs) attenuate injury to the neonatal brain after exposure to HI. However, the effects of IAIPs on the brain microvasculature after exposure to HI have not been examined in neonates. Postnatal day-7 rats were exposed to sham treatment or right carotid artery ligation and 8% oxygen for 90 min. HI comprises hypoxia (H) and ischemia to the right hemisphere (HI-right) and hypoxia to the whole body, including the left hemisphere (H-left). Human IAIPs (hIAIPs, 30 mg/kg) or placebo were injected immediately, 24 and 48 h after HI/H. The brains were analyzed 72 h after HI/H to determine the effects of hIAIPs on the microvasculature by laminin immunohistochemistry and calculation of (1) the percentage area stained by laminin, (2) cumulative microvessel length, and (3) density of tunneling nanotubes (TNTs), which are sensitive indicators of the earliest phases of neo-vascularization/collateralization. hIAIPs mainly affected the percent of the laminin-stained area after HI/H, cumulative vessel length after H but not HI, and TNT density in females but not males. hIAIPs modify the effects of HI/H on the microvasculature after brain injury in neonatal rats and exhibit sex-related differential effects. Our findings suggest that treatment with hIAIPs after exposure to H and HI in neonatal rats affects the laminin content of the vessel basal lamina and angiogenic responses in a sex-related fashion.
Keywords	blood–brain barrier ; hypoxia–ischemia ; inter-alpha inhibitor proteins ; laminin ; tunneling nanotubes ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Radiologic evaluation of compensatory lung growth using computed tomography by comparison with histological data from a large animal model

Keiji Ohata / Toyofumi F. Chen-Yoshikawa / Masatsugu Hamaji / Takeshi Kubo / Tatsuo Nakamura / Hiroshi Date

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 9

Abstract: Abstract Non-invasive analysis using computed tomography (CT) data may be a promising candidate to evaluate neo-alveolarization in adult lungs following lung resection. This study evaluates and compares the validity of CT analysis with histologic ... ...

Abstract	Abstract Non-invasive analysis using computed tomography (CT) data may be a promising candidate to evaluate neo-alveolarization in adult lungs following lung resection. This study evaluates and compares the validity of CT analysis with histologic morphometry for compensatory lung growth in a large animal model. We calculated the radiologic tissue volume and the radiologic lung weight from CT data taken at 1, 3, and 6 months post-surgery on 15 male beagle dogs that had a right thoractotomy, bilobectomy, or pneumonectomy (n = 5 in each group). Results were analyzed using one-way ANOVA and were subsequently compared to histologic findings of tissue samples at 6 months post-surgery using Pearson’s correlation. An increase in radiologic tissue volume and radiologic lung weight was identified, which was positively correlated with histologic lung parenchymal amounts (correlation coefficient = 0.955 and 0.934, respectively, p < 0.001). Histology of lung specimens at 6 months post-surgery revealed an increase in the tissue amount in both Bilobectomy and Peumonectomy groups, which was consistent with compensatory lung growth. Radiologic tissue volume and radiologic lung weight reflected compensatory lung growth following lung resection. Radiologic assessment using CT data can be a promising clinical modality to evaluate postoperative lung growth.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Overall lifestyle changes in adulthood are associated with cancer incidence in the Norwegian Women and Cancer Study (NOWAC) – a prospective cohort study

Sairah L. F. Chen / Therese H. Nøst / Edoardo Botteri / Pietro Ferrari / Tonje Braaten / Torkjel M. Sandanger / Kristin B. Borch

BMC Public Health, Vol 23, Iss 1, Pp 1-

2023 Volume 12

Abstract: Abstract Background Cancer is a leading cause of premature death worldwide and incidence is expected to rise in the coming decades. Many cohort studies, measuring lifestyle factors at one time-point, have observed that overall healthy lifestyles were ... ...

Abstract	Abstract Background Cancer is a leading cause of premature death worldwide and incidence is expected to rise in the coming decades. Many cohort studies, measuring lifestyle factors at one time-point, have observed that overall healthy lifestyles were inversely related to cancer incidence. However, there is little knowledge on the impact of lifestyle modification within adulthood. Methods Using the Norwegian Women and Cancer study, two repeated self-reported assessments of lifestyle behaviours were used to calculate healthy lifestyle index scores at each time-point (N = 66 233). The associations between change in healthy lifestyle index score and lifestyle-related cancer incidence, including alcohol-, tobacco-, obesity-, and reproductive-related, and site-specific breast and colorectal cancer incidence were estimated using Cox proportional hazard regression models. To assess nonlinearity in the dose–response relationships, restricted cubic spline models were used. Results Independent of baseline lifestyle, positive lifestyle changes were inversely related to the incidence of overall lifestyle-related cancers, as well as alcohol-related, tobacco-related, obesity-related, and reproductive-related cancers, but not breast and colorectal site-specific cancers. An association between lifestyle worsening and cancer incidence compared to stable lifestyle was observed. Conclusions This study provides evidence that overall lifestyle changes among cancer-free women between the ages of 41 and 76 impact the incidence of many cancer types. Regardless of baseline lifestyle, there was a negative dose–response relationship between magnitude of positive lifestyle change and the incidence of overall lifestyle-related cancers. We observed that underlying this trend was an especially clear association between lifestyle worsening and increased risk compared to stable lifestyle. For adult women, maintaining a stable healthy lifestyle and lifestyle improvement are important for preventing the occurrence of many cancer types.
Keywords	Lifestyle ; Cancer ; Women ; Change ; Prevention ; Composite index ; Public aspects of medicine ; RA1-1270
Subject code	616 ; 610
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Nigrostriatal dopamine modulates the striatal-amygdala pathway in auditory fear conditioning

Allen P. F. Chen / Lu Chen / Kaiyo W. Shi / Eileen Cheng / Shaoyu Ge / Qiaojie Xiong

Nature Communications, Vol 14, Iss 1, Pp 1-

2023 Volume 14

Abstract: Abstract The auditory striatum, a sensory portion of the dorsal striatum, plays an essential role in learning and memory. In contrast to its roles and underlying mechanisms in operant conditioning, however, little is known about its contribution to ... ...

Abstract	Abstract The auditory striatum, a sensory portion of the dorsal striatum, plays an essential role in learning and memory. In contrast to its roles and underlying mechanisms in operant conditioning, however, little is known about its contribution to classical auditory fear conditioning. Here, we reveal the function of the auditory striatum in auditory-conditioned fear memory. We find that optogenetically inhibiting auditory striatal neurons impairs fear memory formation, which is mediated through the striatal-amygdala pathway. Using calcium imaging in behaving mice, we find that auditory striatal neuronal responses to conditioned tones potentiate across memory acquisition and expression. Furthermore, nigrostriatal dopaminergic projections plays an important role in modulating conditioning-induced striatal potentiation. Together, these findings demonstrate the existence of a nigro-striatal-amygdala circuit for conditioned fear memory formation and expression.
Keywords	Science ; Q
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A new hybrid Artificial Intelligence (AI) approach for hydro energy sites selection and integration

Jong, F. Chen / Ahmed, Musse Mohamud / Lau, W. Kin / Denis Lee, H. Aik

Heliyon. 2022 Sept., v. 8, no. 9 p.e10638-

2022

Abstract: The increase of energy demand in this era leads exploration of new renewable energy sites. Renewable energy offers multiple benefits; hence it is suitable to be harnessed to meet power needs. In Sarawak, exploitation of hydro energy is a very feasible ... ...

Abstract	The increase of energy demand in this era leads exploration of new renewable energy sites. Renewable energy offers multiple benefits; hence it is suitable to be harnessed to meet power needs. In Sarawak, exploitation of hydro energy is a very feasible potential due to the abundant river flows and high rainfall volume. Thus, in this paper, 155 potential Hydro Energy Sites (HES) are identified and divided into six districts using a raw and unprocessed data provided by Sarawak Energy Berhad (SEB). Since there are no similar researches previously done for identification and integration of hydro energy sources, in this paper, two stage complex data management was built using 155 HES locations in Sarawak. New spatial mapping technique were used for the first stage. From the new spatial mapping technique, the mapped data were categorized into groups, analysed and created new accurate mapping locations on the Sarawak map in terms of the districts using GIS Spatial tools. Their exact geographical locations were identified, and their coordinate systems have been retrieved as complete final data with geo-referencing technique in QGIS with ID numbers. Moreover, the power capacity of each location of all the 155 HES was quantified. By employing this data, the identified locations have been integrated into the already created 155 HES sites. For the second stage, a new two-part AI hybrid approach has been proposed and applied to improve optimal transmission line routing for each district to locate transmission line paths. The first part of hybrid AI implemented in this paper was TSP-GA and second part implemented in this paper was based on improved fuzzy logic with TSP-GA together. To ensure the optimal results are reliably achieved, both first part of TSP-GA and second part of improved fuzzy TSP-GA are utilized to generate the transmission line routing. These two approaches are required to obtain the minimal values of total distance and total elevation difference of each HES. Based on the benchmarking results, fuzzy TSP-GA successfully improved 12.99% for Song district, 7.52% for Kapit district, 3.71% for Belaga district, 1.54% for Marudi district, 18.01% for Limbang district, 11.00% for Lawas district when comparing against the ordinary TSP-GA approach.
Keywords	Borneo ; energy ; fuzzy logic ; information management ; rain ; renewable energy sources ; rivers ; Fuzzy logic operation ; Genetic algorithm ; Hydro energy sites ; Mixed integer-linear-programming ; Travelling salesman problem
Language	English
Dates of publication	2022-09
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e10638
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Quantification and evaluation of atmospheric ammonia emissions with different methods

Y. Zhao / M. Yuan / X. Huang / F. Chen / J. Zhang

Atmospheric Chemistry and Physics, Vol 20, Pp 4275-

a case study for the Yangtze River Delta region, China

2020 Volume 4294

Abstract: To explore the effects of data and method on emission estimation, two inventories of NH 3 emissions of the Yangtze River Delta (YRD) region in eastern China were developed for 2014 based on constant emission factors (E1) and those characterizing ... ...

Abstract	To explore the effects of data and method on emission estimation, two inventories of NH 3 emissions of the Yangtze River Delta (YRD) region in eastern China were developed for 2014 based on constant emission factors (E1) and those characterizing agricultural processes (E2). The latter derived the monthly emission factors and activity data integrating the local information of soil, meteorology, and agricultural processes. The total emissions were calculated to be 1765 and 1067 Gg with E1 and E2, respectively, and clear differences existed in seasonal and spatial distributions. Elevated emissions were found in March and September in E2, attributed largely to the increased top dressing fertilization and to the enhanced NH 3 volatilization under high temperature, respectively. A relatively large discrepancy between the inventories existed in the northern YRD with abundant croplands. With the estimated emissions 38 % smaller in E2, the average of simulated NH 3 concentrations with an air quality model using E2 was 27 % smaller than that using E1 at two ground sites in the YRD. At the suburban site in Pudong, Shanghai (SHPD), the simulated NH 3 concentrations with E1 were generally larger than observations, and the modeling performance was improved, indicated by the smaller normalized mean errors (NMEs) when E2 was applied. In contrast, very limited improvement was found at the urban site JSPAES, as E2 failed to improve the emission estimation of transportation and residential activities. Compared to NH 3 , the modeling performance for inorganic aerosols was better for most cases, and the differences between the simulated concentrations with E1 and E2 were clearly smaller, at 7 %, 3 %, and 12 % (relative to E1) for <math xmlns="http://www.w3.org/1998/Math/MathML" id="M6" display="inline" overflow="scroll" dspmath="mathml"><mrow class="chem"><msubsup><mi mathvariant="normal">NH</mi><mn mathvariant="normal">4</mn><mo>+</mo></msubsup></mrow></math> ...
Keywords	Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	511
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A new hybrid Artificial Intelligence (AI) approach for hydro energy sites selection and integration.

Jong, F Chen / Ahmed, Musse Mohamud / Lau, W Kin / Denis Lee, H Aik

Heliyon

2022 Volume 8, Issue 9, Page(s) e10638

Abstract	The increase of energy demand in this era leads exploration of new renewable energy sites. Renewable energy offers multiple benefits; hence it is suitable to be harnessed to meet power needs. In Sarawak, exploitation of hydro energy is a very feasible potential due to the abundant river flows and high rainfall volume. Thus, in this paper, 155 potential Hydro Energy Sites (HES) are identified and divided into six districts using a raw and unprocessed data provided by Sarawak Energy Berhad (SEB). Since there are no similar researches previously done for identification and integration of hydro energy sources, in this paper, two stage complex data management was built using 155 HES locations in Sarawak. New spatial mapping technique were used for the first stage. From the new spatial mapping technique, the mapped data were categorized into groups, analysed and created new accurate mapping locations on the Sarawak map in terms of the districts using GIS Spatial tools. Their exact geographical locations were identified, and their coordinate systems have been retrieved as complete final data with geo-referencing technique in QGIS with ID numbers. Moreover, the power capacity of each location of all the 155 HES was quantified. By employing this data, the identified locations have been integrated into the already created 155 HES sites. For the second stage, a new two-part AI hybrid approach has been proposed and applied to improve optimal transmission line routing for each district to locate transmission line paths. The first part of hybrid AI implemented in this paper was TSP-GA and second part implemented in this paper was based on improved fuzzy logic with TSP-GA together. To ensure the optimal results are reliably achieved, both first part of TSP-GA and second part of improved fuzzy TSP-GA are utilized to generate the transmission line routing. These two approaches are required to obtain the minimal values of total distance and total elevation difference of each HES. Based on the benchmarking results, fuzzy TSP-GA successfully improved 12.99% for Song district, 7.52% for Kapit district, 3.71% for Belaga district, 1.54% for Marudi district, 18.01% for Limbang district, 11.00% for Lawas district when comparing against the ordinary TSP-GA approach.
Language	English
Publishing date	2022-09-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e10638
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Development of a novel electroporation method for the oyster parasite Perkinsus marinus

Hirokazu Sakamoto / Xiaoxia X. Lin / Yun D. Bai / Xue F. Chen / Ziyue Z. Zhang / Yui Honjo / Kenji Hikosaka

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 9

Abstract: Abstract Gene manipulation techniques are fundamental to molecular biology and are continuously being improved. However, gene transfection methods are not established for many unicellular eukaryotes (protists), thereby hindering molecular biological ... ...

Abstract	Abstract Gene manipulation techniques are fundamental to molecular biology and are continuously being improved. However, gene transfection methods are not established for many unicellular eukaryotes (protists), thereby hindering molecular biological investigations. The oyster parasite Perkinisus marinus is one of the few protists with established gene transfection and drug selection. Nevertheless, the present protocols are tedious, requiring a specific electroporator and pulse conditions which limits the accessibility of this technique across different research groups. Here, we present alternative buffer and electroporation conditions that make the protocol less restrictive. We revealed the pulse condition that enables the introduction of plasmids into P. marinus cell using Ingenio electroporation buffer and NEPA21 electroporator. We found that number of cells and plasmid concentration were critical parameters for the electroporation system. We also constructed a simpler expression plasmid that is removed needless regions for gene expression in the parasite. Our findings resolved the equipment restriction in electroporation of P. marinus and would be a good reference for electroporation in other protists, in particular other Perkinsozoa parasites and core dinoflagellates.
Keywords	Medicine ; R ; Science ; Q
Subject code	612
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Optimal iron content in ready-to-use therapeutic foods for the treatment of severe acute malnutrition in the community settings

Jai K Das / Zulfiqar Ahmed Bhutta / Abigail Smith / Aamer Imdad / Olivia Tsistinas / Emily Tanner-Smith / Melissa François / Fanny F Chen

BMJ Open, Vol 12, Iss

a protocol for the systematic review and meta-analysis

2022 Volume 3

Keywords	Medicine ; R
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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