Article ; Online: New therapeutic perspectives for IgA nephropathy in children.
Pediatric nephrology (Berlin, Germany)
2020 Volume 36, Issue 3, Page(s) 497–506
Abstract: Childhood IgA nephropathy (cIgAN) differs from the adult by having an abrupt clinical onset, often presenting as an acute attack that can progress to a chronic phase. No treatment guidelines have been established for the treatment of cIgAN. Given the ... ...
Abstract | Childhood IgA nephropathy (cIgAN) differs from the adult by having an abrupt clinical onset, often presenting as an acute attack that can progress to a chronic phase. No treatment guidelines have been established for the treatment of cIgAN. Given the severity of acute attack in children, and the number of life-years at stake, pediatricians prescribe immunosuppression in addition to renin-angiotensin system blockade. Non-specific immunosuppressors, such as corticosteroids, have systemic toxic effects, and given recent therapeutic advances in adult glomerulonephritis, new tailored strategies should be expected for children. The mucosal immune system has been highlighted as a key player in IgAN pathogenesis, and several biomarkers have been identified with a direct role in pathogenesis. In this review, we discuss current studies of conventional and novel therapeutic approaches for cIgAN. |
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MeSH term(s) | Child ; Glomerulonephritis, IGA/diagnosis ; Glomerulonephritis, IGA/drug therapy ; Humans ; Immunoglobulin A ; Immunosuppression Therapy ; Renin-Angiotensin System |
Chemical Substances | Immunoglobulin A |
Language | English |
Publishing date | 2020-02-10 |
Publishing country | Germany |
Document type | Journal Article ; Review |
ZDB-ID | 631932-4 |
ISSN | 1432-198X ; 0931-041X |
ISSN (online) | 1432-198X |
ISSN | 0931-041X |
DOI | 10.1007/s00467-020-04475-w |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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