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  1. Article ; Online: Work status among middle-aged and older individuals in China: the effects on physical and mental health.

    Fu, Yi / Li, Xiaohan

    Frontiers in public health

    2024  Volume 12, Page(s) 1322398

    Abstract: Objective: China's middle-aged and older population is a rich source of human capital. Therefore, considering the health of this group is important when creating and using human resources.: Methods: Using data from the nationwide China Health and ... ...

    Abstract Objective: China's middle-aged and older population is a rich source of human capital. Therefore, considering the health of this group is important when creating and using human resources.
    Methods: Using data from the nationwide China Health and Retirement Longitudinal Study (CHARLS) 2018 baseline survey of 19,000 adults ages 45 years and older, this study was an objective investigation of the effects of work on the physical and mental health of middle-aged and older adults. We conducted several types of analyses using details of participants' lifestyles and demographic characteristics (living environment, education, financial level, and access to medical services) with
    Results: Six primary outcomes were identified: (1) Employment positively affects both the physical and mental health of middle-aged and older people; (2) Employment can influence the physical and mental health of middle-aged and older people through income, cognitive level, and social support networks; (3) Compared to non-self-employment, self-employment dramatically worsens physical health but has no apparent detrimental effects on mental health. Compared to non-agricultural employment, agricultural labor affects both physical and mental health. (4) Employment has more positive physical and mental health effects in Individuals with higher rather than lower levels of education. (5) Employment opportunities in the eastern region are more likely to promote better physical health than those in the central and western regions of China, although the effects on mental health are negative. (6) When considering groups at different ages of the lifespan, the 60-65-year-old group, who are just entering retirement probably benefit more from continuing work.
    Conclusion: We provide some recommendations to encourage middle-aged and older people to work and utilize their experience, which will enhance their physical and mental well-being and help them in realize their own value and social integration.
    MeSH term(s) Middle Aged ; Humans ; Aged ; Mental Health ; Longitudinal Studies ; Employment ; Health Status ; China
    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2024.1322398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Analysis of compression damage pattern and strength influencing factors in graphite-tailing-filled soilbags

    Jian Gao / Changbo Du / Zhan Xu / Fu Yi

    Scientific Reports, Vol 14, Iss 1, Pp 1-

    2024  Volume 19

    Abstract: Abstract To realize the resourceful use of soilbags filled with graphite tailings, their load-bearing and deformation characteristics must be fully understood. In this study, the following results were obtained by performing geometric testing of water- ... ...

    Abstract Abstract To realize the resourceful use of soilbags filled with graphite tailings, their load-bearing and deformation characteristics must be fully understood. In this study, the following results were obtained by performing geometric testing of water-filled sealing bags and uniaxial compression tests of soilbags filled with graphite tailings. The volume of the soilbag expressed in rectangular form was approximately 0.773 times the actual volume. The types of compression damage to soilbags can be defined as surface damage and overall damage. The surface damage load increases with decreasing filling density and decreases with decreasing soilbag size. Moreover, the higher the tensile capacity of the soilbag material and the lower the friction between the soilbags, the greater the surface damage load. The overall damage load increased with an increase in the tensile strength of the soilbag material and decreased with an increase in the degree of filling; the overall damage load was greater for large-sized soilbags at high degrees of filling. Thus, the existing theoretical calculation method cannot accurately calculate the damage load of soilbags filled with graphite tailings, and the test results deviate from the theoretical calculation results, with the latter showing an increasing damage load with a decreasing filling degree.
    Keywords Medicine ; R ; Science ; Q
    Subject code 621 ; 600
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Association between sex and efficacy of immune checkpoint inhibitors: a systematic review and meta-analysis.

    Lai, Jianxiong / Kuang, Xiaohong / Fu, Yi / Li, Jian

    Immunotherapy

    2024  Volume 16, Issue 7, Page(s) 481–495

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Male ; Humans ; Female ; Immune Checkpoint Inhibitors/therapeutic use ; B7-H1 Antigen ; Neoplasms/drug therapy ; Lung Neoplasms/drug therapy
    Chemical Substances Immune Checkpoint Inhibitors ; B7-H1 Antigen
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2495964-9
    ISSN 1750-7448 ; 1750-743X
    ISSN (online) 1750-7448
    ISSN 1750-743X
    DOI 10.2217/imt-2023-0307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Experimental study on dynamic characteristics of tailings under different consolidation conditions

    Changbo Du / Xinqi Jiang / Laigui Wang / Fu Yi / Ben Niu

    Scientific Reports, Vol 14, Iss 1, Pp 1-

    2024  Volume 13

    Abstract: Abstract The dynamic stability of tailing ponds depend largely on the dynamic characteristics of tailings sand. To explore the dynamic characteristics of tailings sand under different consolidation conditions, consolidated undrained triaxial tests under ... ...

    Abstract Abstract The dynamic stability of tailing ponds depend largely on the dynamic characteristics of tailings sand. To explore the dynamic characteristics of tailings sand under different consolidation conditions, consolidated undrained triaxial tests under different dry densities, consolidation ratios and containing pressures, the dynamic shear stress, liquefaction stress ratio, dynamic strength index, dynamic pore water pressure, dynamic modulus, and damping ratio of tailings sand under different consolidation conditions were analyzed. The dynamic shear stress linearly changed with the number of failure vibrations. The liquefaction stress ratio increases with an increase in consolidation ratio, conforming to the quadratic polynomial of the origin. With an increase in failure vibration times, the dynamic internal friction angle decreases gradually. Under different failure vibration times, the dynamic internal friction angle increases with an increase in consolidation ratio and dry density. An exponential function model of dynamic pore pressure growth suitable for equal pressure and bias consolidation conditions is proposed, and the fitting effect is favorable. The dynamic shear modulus ratio decreases with an increase in dynamic shear strain; the damping ratio increases with an increase in dynamic shear strain. The research results can provide a theoretical reference for seismic liquefaction of tailings dams in high-intensity seismic areas.
    Keywords Medicine ; R ; Science ; Q
    Subject code 690
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: [Research Progress of Transmembrane Protein Abnormality in Non-Hodgkin's Lymphoma --Review].

    Fu, Yi-Xian / Li, Fei

    Zhongguo shi yan xue ye xue za zhi

    2022  Volume 30, Issue 5, Page(s) 1617–1621

    Abstract: Transmembrane protein, also known as integral membrane protein, can be distributed in the lipid bilayer or across the entire membrane, and it plays an important role in cell signal transduction. It has been discovered that multiple transmembrane proteins ...

    Abstract Transmembrane protein, also known as integral membrane protein, can be distributed in the lipid bilayer or across the entire membrane, and it plays an important role in cell signal transduction. It has been discovered that multiple transmembrane proteins are involved in the regulation of tumor signals. Recent studies have revealed that the abnormal expression of some transmembrane protein is closely related to the occurrence, development and prognosis of non-Hodgkin's lymphoma (NHL), including programmed cell death protein 1 (PD-1), TMEM30A, NOTCH1, TOLL-like receptor (TLR), sphingosine-1-phosphate receptor, TRAIL, etc. The study on these transmembrane proteins and related genes has important clinical significance for the treatment and prognosis of NHL, and it may become a new therapeutic target. At present, there have been some research results in this field at home and abroad. This article reviewed the research progress of transmembrane protein that has inhibitory effects on NHL in recent years.
    MeSH term(s) Humans ; Lipid Bilayers ; Lymphoma, Non-Hodgkin/therapy ; Prognosis ; Programmed Cell Death 1 Receptor ; Sphingosine-1-Phosphate Receptors
    Chemical Substances Lipid Bilayers ; Programmed Cell Death 1 Receptor ; Sphingosine-1-Phosphate Receptors
    Language Chinese
    Publishing date 2022-10-08
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2404306-0
    ISSN 1009-2137
    ISSN 1009-2137
    DOI 10.19746/j.cnki.issn.1009-2137.2022.05.050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Cerebral Amyloid Angiopathy: An Undeniable Small Vessel Disease.

    Wang, Litao / Liu, Qiong / Yue, Dongqi / Liu, Jun / Fu, Yi

    Journal of stroke

    2024  Volume 26, Issue 1, Page(s) 1–12

    Abstract: Cerebral amyloid angiopathy (CAA) has been proven to be the most common pathological change in cerebral small vessel disease except arteriosclerosis. In recent years, with the discovery of imaging technology and new imaging markers, the diagnostic rate ... ...

    Abstract Cerebral amyloid angiopathy (CAA) has been proven to be the most common pathological change in cerebral small vessel disease except arteriosclerosis. In recent years, with the discovery of imaging technology and new imaging markers, the diagnostic rate of CAA has greatly improved. CAA plays an important role in non-hypertensive cerebral hemorrhage and cognitive decline. This review comprehensively describes the etiology, epidemiology, pathophysiological mechanisms, clinical features, imaging manifestations, imaging markers, diagnostic criteria, and treatment of CAA to facilitate its diagnosis and treatment and reduce mortality.
    Language English
    Publishing date 2024-01-30
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2814366-8
    ISSN 2287-6405 ; 2287-6391
    ISSN (online) 2287-6405
    ISSN 2287-6391
    DOI 10.5853/jos.2023.01942
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Extracellular Matrix Interactome in Modulating Vascular Homeostasis and Remodeling.

    Fu, Yi / Zhou, Yuan / Wang, Kai / Li, Zhuofan / Kong, Wei

    Circulation research

    2024  Volume 134, Issue 7, Page(s) 931–949

    Abstract: The ECM (extracellular matrix) is a major component of the vascular microenvironment that modulates vascular homeostasis. ECM proteins include collagens, elastin, noncollagen glycoproteins, and proteoglycans/glycosaminoglycans. ECM proteins form complex ... ...

    Abstract The ECM (extracellular matrix) is a major component of the vascular microenvironment that modulates vascular homeostasis. ECM proteins include collagens, elastin, noncollagen glycoproteins, and proteoglycans/glycosaminoglycans. ECM proteins form complex matrix structures, such as the basal lamina and collagen and elastin fibers, through direct interactions or lysyl oxidase-mediated cross-linking. Moreover, ECM proteins directly interact with cell surface receptors or extracellular secreted molecules, exerting matricellular and matricrine modulation, respectively. In addition, extracellular proteases degrade or cleave matrix proteins, thereby contributing to ECM turnover. These interactions constitute the ECM interactome network, which is essential for maintaining vascular homeostasis and preventing pathological vascular remodeling. The current review mainly focuses on endogenous matrix proteins in blood vessels and discusses the interaction of these matrix proteins with other ECM proteins, cell surface receptors, cytokines, complement and coagulation factors, and their potential roles in maintaining vascular homeostasis and preventing pathological remodeling.
    MeSH term(s) Extracellular Matrix/metabolism ; Extracellular Matrix Proteins/metabolism ; Collagen/metabolism ; Elastin/metabolism ; Homeostasis ; Receptors, Cell Surface/metabolism
    Chemical Substances Extracellular Matrix Proteins ; Collagen (9007-34-5) ; Elastin (9007-58-3) ; Receptors, Cell Surface
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.123.324055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Proliferative verrucous leukoplakia: Report of a case and literature review.

    Dou, Chun-Bo / Fu, Yi-Hui / Yu, Zi-Li / Jia, Jun

    Oral oncology

    2024  Volume 150, Page(s) 106720

    MeSH term(s) Humans ; Leukoplakia, Oral/diagnosis ; Mouth Neoplasms ; Cell Transformation, Neoplastic ; Carcinoma, Verrucous
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Review ; Case Reports ; Letter
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2024.106720
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  9. Article ; Online: Isolated transthyretin valvular amyloidosis.

    Fu, Yi-Tsang / Kuo, Ling / Yu, Wen-Chung

    European heart journal

    2023  Volume 44, Issue 29, Page(s) 2789

    MeSH term(s) Humans ; Prealbumin/genetics ; Amyloid Neuropathies, Familial/complications ; Amyloid Neuropathies, Familial/diagnosis
    Chemical Substances Prealbumin
    Language English
    Publishing date 2023-06-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Response of the nitrogen processing bacterial community to water level fluctuation and nitrate availability in an intact marsh soil column.

    Shan, Yuanqi / Fu, Yi / Wang, Lei / Yao, Yunlong

    Environmental science and pollution research international

    2023  Volume 30, Issue 52, Page(s) 111947–111957

    Abstract: Wetlands are known to experience fluctuations in water levels and receive exogenous nitrogen inputs that affect various organisms, including soil microorganisms. To study the impact of these factors on microbial diversity, we collected intact soil ... ...

    Abstract Wetlands are known to experience fluctuations in water levels and receive exogenous nitrogen inputs that affect various organisms, including soil microorganisms. To study the impact of these factors on microbial diversity, we collected intact soil columns from a Phragmites australis-dominated site in the Qixing River National Nature Reserve in Northeast China. In a laboratory experiment, we simulated water level fluctuations and exogenous nitrogen inputs to the soil columns and examined the associated changes in the relative abundance of 51 bacterial genera involved in nitrogen cycling processes. Our findings revealed that different bacterial genera exhibited varying relative abundances across treatments. Specifically, Massilia showed the highest total relative abundance at the genus level, while Planctomyces had the second highest, and Campylobacter had the lowest abundance. The DESeq2 model, based on negative binomial distribution, revealed that the tags of bacterial genera were significantly correlated with soil depth, but not with water levels or nitrogen concentrations. However, the addition of a 30 mg/L nitrate solution caused a decrease in the relative abundances of bacterial genera with decreasing water levels, while a 60 mg/L concentration of nitrogen resulted in a decrease and then an increase in the relative abundances of bacterial genera with decreasing water levels. Our study provides valuable insights into the response of nitrogen-cycling bacteria to changes in different environmental conditions.
    MeSH term(s) Wetlands ; Nitrates/analysis ; Water ; Soil ; Nitrogen/analysis ; Bacteria
    Chemical Substances Nitrates ; Water (059QF0KO0R) ; Soil ; Nitrogen (N762921K75)
    Language English
    Publishing date 2023-10-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-30020-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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