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Article ; Online: Presumptive hemophagocytic syndrome associated with co-infections with FIV, Toxoplasma gondii, and Candidatus mycoplasma haemominutum in an adult cat.

Fonseca, Joana / Silveira, João / Faísca, Pedro / de Almeida, Pedro Morais

2023 Volume 52, Issue 2, Page(s) 324–333

Abstract: A 9-year-old neutered male cat, previously test-positive for feline immunodeficiency virus (FIV), was presented with an history of vomiting, hyporexia, and weight loss. Panleukopenia was identified on complete blood counts, and bone marrow evaluation ... ...

Abstract	A 9-year-old neutered male cat, previously test-positive for feline immunodeficiency virus (FIV), was presented with an history of vomiting, hyporexia, and weight loss. Panleukopenia was identified on complete blood counts, and bone marrow evaluation revealed ineffective granulocytic hyperplasia and rare neutro-, erythro-, and rubriphagocytosis. Prednisolone was initiated with no response, and progression to pancytopenia occurred. On abdominal ultrasonographic examination, splenomegaly was present. PCR testing was positive for Candidatus Mycoplasma haemominutum and IgG antibodies against Toxoplasma gondii were detected (titer 1:2560). Treatment with antibiotics, feline recombinant interferon-ω, chlorambucil, mycophenolate, and raltegravir was implemented with no clinical improvement, and splenectomy was performed. Cytologic evaluation of splenic aspirates revealed exuberant neutro-, erythro-, and rubriphagocytosis. Histopathology of the spleen also showed many erythrophagocytic macrophages with no evidence of malignancy, and a diagnosis of hemophagocytic syndrome (HS) was made. The WBC count and hematocrit reached reference values 1 day and 3 months, respectively, after splenectomy. The cat was treated with cyclosporine and lomustine. Disease progression led to the development of septic hepatitis, and the cat was euthanized. To our knowledge, this is the first case of presumptive HS in cats that might have been associated with FIV, Toxoplasma gondii, and Candidatus Mycoplasma haemominutum co-infection.
MeSH term(s)	Animals ; Cats ; Male ; Immunodeficiency Virus, Feline ; Toxoplasma ; Lymphohistiocytosis, Hemophagocytic/complications ; Lymphohistiocytosis, Hemophagocytic/diagnosis ; Lymphohistiocytosis, Hemophagocytic/veterinary ; Coinfection/diagnosis ; Coinfection/veterinary ; Mycoplasma ; Mycoplasma Infections/complications ; Mycoplasma Infections/diagnosis ; Mycoplasma Infections/veterinary ; Cat Diseases/diagnosis
Language	English
Publishing date	2023-03-28
Publishing country	United States
Document type	Case Reports
ZDB-ID	2114702-4
ISSN	1939-165X ; 0275-6382
ISSN (online)	1939-165X
ISSN	0275-6382
DOI	10.1111/vcp.13205
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Article: The Histo-CLEM Workflow for tissues of model organisms.

Sousa, Ana Laura / Rodrigues Lóios, Joana / Faísca, Pedro / Tranfield, Erin M

Methods in cell biology

2021 Volume 162, Page(s) 13–37

Abstract: Bridging from the macrostructure to the nanostructure of tissues is often technically challenging. To try to solve this, we developed a flexible CLEM workflow that can be applied to the analysis of tissues from diverse model organisms across various ... ...

Abstract	Bridging from the macrostructure to the nanostructure of tissues is often technically challenging. To try to solve this, we developed a flexible CLEM workflow that can be applied to the analysis of tissues from diverse model organisms across various length scales. The Histo-CLEM Workflow combines three main microscopy techniques, namely histology, light microscopy and electron microscopy. Herein, all the steps of the Histo-CLEM Workflow are explained in detail to enable the adaptation of the method to tissue particularities and biological questions. The preparation and visualization of mice nerve fibers is shown as an application example of the presented Histo-CLEM Workflow.
MeSH term(s)	Animals ; Mice ; Microscopy, Electron ; Microscopy, Fluorescence ; Workflow
Language	English
Publishing date	2021-02-18
Publishing country	United States
Document type	Journal Article
ISSN	0091-679X
ISSN	0091-679X
DOI	10.1016/bs.mcb.2020.12.001
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Article: Current Insights and Progress in the Clinical Management of Head and Neck Cancer.

Amaral, Mariana Neves / Faísca, Pedro / Ferreira, Hugo Alexandre / Gaspar, Maria Manuela / Reis, Catarina Pinto

Cancers

2022 Volume 14, Issue 24

Abstract: Head and neck cancer (HNC), also known as the cancer that can affect the structures between the dura mater and the pleura, is the 6th most common type of cancer. This heterogeneous group of malignancies is usually treated with a combination of surgery ... ...

Abstract	Head and neck cancer (HNC), also known as the cancer that can affect the structures between the dura mater and the pleura, is the 6th most common type of cancer. This heterogeneous group of malignancies is usually treated with a combination of surgery and radio- and chemotherapy, depending on if the disease is localized or at an advanced stage. However, most HNC patients are diagnosed at an advanced stage, resulting in the death of half of these patients. Thus, the prognosis of advanced or recurrent/metastatic HNC, especially HNC squamous cell carcinoma (HNSCC), is notably poorer than the prognosis of patients diagnosed with localized HNC. This review explores the epidemiology and etiologic factors of HNC, the histopathology of this heterogeneous cancer, and the diagnosis methods and treatment approaches currently available. Moreover, special interest is given to the novel therapies used to treat HNC subtypes with worse prognosis, exploring immunotherapies and targeted/multi-targeted drugs undergoing clinical trials, as well as light-based therapies (i.e., photodynamic and photothermal therapies).
Language	English
Publishing date	2022-12-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14246079
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Article ; Online: Pessimistic cognitive bias is associated with enhanced reproductive investment in female zebrafish.

Espigares, Felipe / Alvarado, María V / Faísca, Pedro / Abad-Tortosa, Diana / Oliveira, Rui F

Biology letters

2022 Volume 18, Issue 12, Page(s) 20220232

Abstract: Optimistic and pessimistic cognitive biases have been described in many animals and are related to the perceived valence of the environment. We, therefore, hypothesize that such cognitive bias can be adaptive depending on environmental conditions. In ... ...

Abstract	Optimistic and pessimistic cognitive biases have been described in many animals and are related to the perceived valence of the environment. We, therefore, hypothesize that such cognitive bias can be adaptive depending on environmental conditions. In reward-rich environments, an optimistic bias would be favoured, whereas in harsh environments, a pessimistic one would thrive. Here, we empirically investigated the potential adaptive value of such bias using zebrafish as a model. We first phenotyped female zebrafish in an optimistic/pessimistic axis using a previously validated judgement bias assay. Optimistic and pessimistic females were then exposed to an unpredictable chronic stress protocol for 17 days, after which fish were euthanized and the sectional area of the different ovarian structures was quantified in both undisturbed and stressed groups. Our results show that zebrafish ovarian development responded to chronic stress, and that judgement bias impacted the relative area of the vitellogenic developmental stage, with pessimists showing higher vitellogenic areas as compared with optimists. These results suggest that pessimism maximizes reproductive investment, through increased vitellogenesis, indicating a relationship between cognitive bias and life-history organismal decisions.
MeSH term(s)	Animals ; Female ; Zebrafish ; Pessimism/psychology ; Judgment ; Cognition ; Bias
Language	English
Publishing date	2022-12-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2135022-X
ISSN	1744-957X ; 1744-9561
ISSN (online)	1744-957X
ISSN	1744-9561
DOI	10.1098/rsbl.2022.0232
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Article ; Online: Nanoformulation of Seaweed

Pinto, Sofia / Gaspar, Maria Manuela / Ascensão, Lia / Faísca, Pedro / Reis, Catarina Pinto / Pacheco, Rita

Marine drugs

2022 Volume 20, Issue 10

Abstract: Natural products, especially those derived from seaweeds, are starting to be seen as effective against various diseases, such as cardiovascular diseases (CVDs). This study aimed to design a novel oral formulation of bovine albumin serum nanoparticles ( ... ...

Abstract	Natural products, especially those derived from seaweeds, are starting to be seen as effective against various diseases, such as cardiovascular diseases (CVDs). This study aimed to design a novel oral formulation of bovine albumin serum nanoparticles (BSA NPs) loaded with an extract of
MeSH term(s)	Cattle ; Humans ; Rats ; Animals ; Seaweed ; Serum Albumin, Bovine ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Caco-2 Cells ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/prevention & control ; Hypercholesterolemia ; Rats, Wistar ; Phaeophyceae/metabolism ; Nanoparticles ; Oxidoreductases/metabolism ; Biological Products/metabolism ; Coenzyme A/metabolism ; Drug Carriers
Chemical Substances	Serum Albumin, Bovine (27432CM55Q) ; Antioxidants ; Oxidoreductases (EC 1.-) ; Biological Products ; Coenzyme A (SAA04E81UX) ; Drug Carriers
Language	English
Publishing date	2022-09-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175190-0
ISSN	1660-3397 ; 1660-3397
ISSN (online)	1660-3397
ISSN	1660-3397
DOI	10.3390/md20100608
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Article: Feline calicivirus and natural killer cells: A study of its relationship in chronic gingivostomatitis.

Fontes, Ana C / Vieira, Maria C / Oliveira, Marcela / Lourenço, Lígia / Viegas, Carlos / Faísca, Pedro / Seixas, Fernanda / Requicha, João F / Pires, Maria A

Veterinary world

2023 Volume 16, Issue 8, Page(s) 1708–1713

Abstract: Background and aims: Feline chronic gingivostomatitis (FCGS) is a frequent chronic inflammatory condition in the oral cavity with an etiopathogenesis not completely identified. This study aimed to contribute to the knowledge of FCGS by identifying the ... ...

Abstract	Background and aims: Feline chronic gingivostomatitis (FCGS) is a frequent chronic inflammatory condition in the oral cavity with an etiopathogenesis not completely identified. This study aimed to contribute to the knowledge of FCGS by identifying the presence of feline calicivirus (FCV) antigens and natural killer (NK) cells and comparing them. Materials and methods: Forty biopsies from the oral mucosa of cats diagnosed with chronic gingivostomatitis were subjected to immunohistochemical techniques to evaluate cells with FCV antigens and NK cells positive for CD56. Results: NK cells were identified in all samples, with an average of 725.3 ± 409.1 cells. Regarding FCV, it was identified in 18 out of 30 samples (60%), with a different number of cells with virus in between the analyzed cases. In all cases, the number of cells infected with FCV was lower than the number of NK cells present in the same samples, but there was no statistical association between them. Conclusion: This preliminary study shows that NK cells are present in gingivostomatitis lesions not exclusively caused by FCV-stimulus, as only 60% of all cases were positive for this virus, but other antigens should be considered in the etiology of FCGS.
Language	English
Publishing date	2023-08-24
Publishing country	India
Document type	Journal Article
ZDB-ID	2456277-4
ISSN	2231-0916 ; 0972-8988
ISSN (online)	2231-0916
ISSN	0972-8988
DOI	10.14202/vetworld.2023.1708-1713
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Article ; Online: Stereology in Grading and Prognosis of Canine Cutaneous Mast Cell Tumors

Casanova, Mafalda / Branco, Sandra / Veiga, Inês Berenguer / Barros, André / Faísca, Pedro

Veterinary Pathology. 2021 May, v. 58, no. 3 p.483-490

2021

Abstract: Canine cutaneous mast cell tumors (ccMCTs) are currently graded according to Patnaik and Kiupel grading schemes. The qualitative and semiquantitative parameters applied in these schemes may lead to inter- and intraobserver variability. This study ... ...

Abstract	Canine cutaneous mast cell tumors (ccMCTs) are currently graded according to Patnaik and Kiupel grading schemes. The qualitative and semiquantitative parameters applied in these schemes may lead to inter- and intraobserver variability. This study investigates the prognostic value of volume-weighted mean nuclear volume (vv¯), a stereological estimation that provides information about nuclear size and its variability. vv¯ of 55 ccMCTs was estimated using the “point-sampled intercept” method and compared with histological grade and clinical outcome. The clinical history of dogs treated with surgical excision alone was available for 30 ccMCTs. Statistical differences in vv¯ were found between grade II (x¯ = 115 ± 29 µm³) and grade III ccMCTs (x ¯= 197 ± 63 µm³), as well as between low-grade (x ¯= 113 ± 28 µm³) and high-grade ccMCTs (x¯ = 184 ± 63 µm³). An optimal cutoff value of vv¯ ≥ 150 µm³ and vv¯ ≥ 140 µm³ was determined for grade III and high-grade ccMCTs, respectively. In terms of prognosis, vv¯ was not able to predict the clinical outcome in 42% of the cases; however, cases with vv¯ <125 µm³ had a favorable outcome. These results indicate that, despite having limited prognostic value when used as a solitary parameter, vv¯ is highly reproducible and is associated with histological grade as well as with benign behavior.
Keywords	animal pathology ; dogs ; excision ; histology ; mast cells ; prognosis ; mast cell tumor ; mean nuclear volume ; skin ; stereology ; histological grading ; surgical pathology
Language	English
Dates of publication	2021-05
Size	p. 483-490.
Publishing place	SAGE Publications
Document type	Article ; Online
Note	NAL-AP-2-clean
ZDB-ID	188012-3
ISSN	1544-2217 ; 0300-9858
ISSN (online)	1544-2217
ISSN	0300-9858
DOI	10.1177/0300985820985138
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Stereology in Grading and Prognosis of Canine Cutaneous Mast Cell Tumors.

Casanova, Mafalda / Branco, Sandra / Veiga, Inês Berenguer / Barros, André / Faísca, Pedro

Veterinary pathology

2021 Volume 58, Issue 3, Page(s) 483–490

Abstract	Canine cutaneous mast cell tumors (ccMCTs) are currently graded according to Patnaik and Kiupel grading schemes. The qualitative and semiquantitative parameters applied in these schemes may lead to inter- and intraobserver variability. This study investigates the prognostic value of volume-weighted mean nuclear volume (
MeSH term(s)	Animals ; Cell Nucleus ; Dog Diseases/diagnosis ; Dogs ; Mast Cells ; Neoplasms/veterinary ; Observer Variation ; Prognosis ; Skin Neoplasms/diagnosis ; Skin Neoplasms/veterinary
Language	English
Publishing date	2021-02-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	188012-3
ISSN	1544-2217 ; 0300-9858
ISSN (online)	1544-2217
ISSN	0300-9858
DOI	10.1177/0300985820985138
Database	MEDical Literature Analysis and Retrieval System OnLINE

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bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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Article: Feline oral cavity lesions diagnosed by histopathology: a 6-year retrospective study in Portugal

Falcão, Filipa / Faísca, Pedro / Viegas, Inês / de Oliveira, Joana Tavares / Requicha, João Filipe

Journal of feline medicine and surgery. 2020 Oct., v. 22, no. 10

2020

Abstract: The aim of this study was to analyse the frequency of oral cavity lesions in cats, their anatomical location and histological diagnosis, and the effect of life stage, breed and sex on different diagnoses. For this purpose, a retrospective study ... ...

Abstract	The aim of this study was to analyse the frequency of oral cavity lesions in cats, their anatomical location and histological diagnosis, and the effect of life stage, breed and sex on different diagnoses. For this purpose, a retrospective study comprising 297 feline oral cavity lesions was performed over a 6-year period between 2010 and 2015. Histopathological records from the DNAtech Pathology Laboratory (Lisbon, Portugal) were analysed. The incidence of oral disease was higher in male cats (n = 173; 58.4%), mature adults (ranging from 7 to 10 years old [n = 88; 33.0%]) and in the European Shorthair breed (n = 206; 73.6%). The gingiva was the site where oral lesions were most commonly found, with 128 samples (43.1%). Incisional biopsies were used to obtain the majority of samples (n = 256; 86.2%), while excisional biopsies and punch biopsies were performed in 36 (12.1%) and five (1.7%) cases, respectively. Inflammatory and neoplastic lesions accounted for 187 (63%) and 110 (37%) of the studied cases, respectively. Malignancies were found in >80% of neoplastic cases. Feline chronic gingivostomatitis was the most common histological diagnosis (n = 116; 39.1%), followed by squamous cell carcinoma (n = 49; 16.5%) and eosinophilic granuloma complex (n = 33; 11.1%). The present work, involving a large series of samples of feline oral cavity lesions, from numerous geographically scattered practices and all examined at a reference veterinary pathology laboratory, adds important new understanding of the epidemiology of feline oral disease.
Keywords	adults ; animal pathology ; biopsy ; cats ; epidemiology ; frequency ; gingiva ; granuloma ; histology ; histopathology ; incidence ; laboratories ; males ; medicine ; mouth diseases ; retrospective studies ; sampling ; squamous cell carcinoma ; Portugal
Language	English
Dates of publication	2020-10
Size	p. 977-983.
Publishing place	SAGE Publications
Document type	Article
Note	NAL-light
ZDB-ID	2049047-1
ISSN	1532-2750 ; 1098-612X
ISSN (online)	1532-2750
ISSN	1098-612X
DOI	10.1177/1098612X19900033
Database	NAL-Catalogue (AGRICOLA)

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Article: Microtomographic characterization of calcifications in canine mammary tumours

Reis, Joana / Oliveira, Teresa / Pereira, Alfredo / Infante, Paulo / Leal, Nuno / Faísca, Pedro

Veterinary and comparative oncology. 2020 Sept., v. 18, no. 3

2020

Abstract: The present work describes the microtomographic characterization of macro‐ and microcalcifications present in excised canine mammary glands. In human breast cancer, microcalcifications are highly relevant for diagnosis and prognosis, often being the sole ...

Abstract	The present work describes the microtomographic characterization of macro‐ and microcalcifications present in excised canine mammary glands. In human breast cancer, microcalcifications are highly relevant for diagnosis and prognosis, often being the sole element determining biopsy. Canine mammary tumours are considered a model for human breast cancer, but the morphological features of calcifications had still to be studied in this species. The objective of this research is to contribute to the characterization of the mineralization features of the canine mammary gland. In the present study, the excised mammary glands of 33 bitches underwent fluoroscopic examination. In 30 of the samples, the presence of calcification was suspected, and multiple biopsies were taken of these areas. Biopsy fragments underwent microtomographic scanning. Microcalcifications were found in non‐neoplastic glandular tissue, benign and malign lesions, as it is known to happen in humans. Qualitative evaluation regarding morphology of the imaged calcifications showed similarities to breast cancer findings, based on the BI‐RADS 2013 classification, such as pleomorphism and shape. No differences in the quantitative morphological parameters of volume, surface, surface/volume, SMI and structure thickness were found when macrocalcifications were considered. However, although significant differences existed in these parameters between microcalcifications from malignant canine mammary tumours and the two other groups, none were found between non‐neoplastic and benign tumours. Findings further support the use of this spontaneous animal model for the study of human breast cancer, considering how clinically relevant microcalcifications are in humans.
Keywords	animal models ; biopsy ; breast neoplasms ; calcification ; humans ; mammary glands ; mineralization ; prognosis
Language	English
Dates of publication	2020-09
Size	p. 281-291.
Publishing place	Blackwell Publishing Ltd
Document type	Article
Note	NAL-AP-2-clean ; JOURNAL ARTICLE
ZDB-ID	2129634-0
ISSN	1476-5829 ; 1476-5810
ISSN (online)	1476-5829
ISSN	1476-5810
DOI	10.1111/vco.12545
Database	NAL-Catalogue (AGRICOLA)

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