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Article ; Online: Violence against nurses in the emergency department: an observational study.

Chazel, Muriel / Alonso, Sandrine / Price, Jane / Kabani, Sarah / Demattei, Christophe / Fabbro-Peray, Pascale

2023 Volume 13, Issue 4, Page(s) e067354

Abstract: Objective: This study aimed to evaluate the number and risk factors of violent events encountered in the emergency department. An observation grid was developed following interviews with emergency department staff to target the most pertinent ... ...

Abstract	Objective: This study aimed to evaluate the number and risk factors of violent events encountered in the emergency department. An observation grid was developed following interviews with emergency department staff to target the most pertinent information to collect in a prospective study design. Design: Observational study. Setting: Emergency department of a tertiary hospital in France. Outcome measures: Number of violent events occurring during a single shift, recorded over 6 months by two observers. Information collected included time and date of incident; number of male/female staff; number of patients and accompaniers present in the service and the waiting room and length of staff debriefing. Perpetrator, victim and patient information were collected. Victims were followed-up 72 hours later. Results: Eighty-two periods were observed between November 2015 and April 2016 recording 35 violent incidents affecting 37 perpetrators and 48 victims, equally distributed over the days of the week and months of the year. The median interval until violence was 0 [0-96] min from entry. Eight (23%) events were officially reported, with two (6%) resulting in charges being pressed. No risk factors were significantly associated with violent incidents in multivariate analysis, although there was a tendency towards significance for fewer senior female doctors present (p=0.0787) and a resulting longer debriefing session (p=0.0712). Conclusions: We confirm the high rate of violence in the emergency department and poor level of official reporting. Strategies should be implemented to anticipate and reduce incidence and encourage reporting by affected staff. Trial registration number: NCT02116439.
MeSH term(s)	Humans ; Male ; Female ; Prospective Studies ; Violence ; Emergency Service, Hospital ; Aggression ; Causality ; Workplace Violence
Language	English
Publishing date	2023-04-04
Publishing country	England
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-067354
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Article ; Online: Response to the Comment on "Meta-analysis and Systematic Review of the Use of a Prosthetic Mesh for Prevention of Parastomal Hernia".

Prudhomme, Michel / Fabbro-Peray, Pascale / Occean, Bob V / Bertrand, Martin M

Annals of surgery

2021 Volume 274, Issue 6, Page(s) e912–e913

MeSH term(s)	Hernia, Ventral/prevention & control ; Hernia, Ventral/surgery ; Humans ; Incisional Hernia/etiology ; Incisional Hernia/prevention & control ; Surgical Mesh
Language	English
Publishing date	2021-05-20
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	340-2
ISSN	1528-1140 ; 0003-4932
ISSN (online)	1528-1140
ISSN	0003-4932
DOI	10.1097/SLA.0000000000004944
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Article ; Online: Third-generation cognitive behavioral therapy versus treatment-as-usual for attention deficit and hyperactivity disorder: a multicenter randomized controlled trial.

Crouzet, Laetitia / Gramond, Anne / Suehs, Carey / Fabbro-Peray, Pascale / Abbar, Mocrane / Lopez-Castroman, Jorge

Trials

2022 Volume 23, Issue 1, Page(s) 83

Abstract: Background: This study aims to compare improvements in attention deficit and hyperactivity disorder (ADHD) symptom severity between a group of ADHD children and parents undergoing a new therapeutic program based on third-generation cognitive behavioral ... ...

Abstract	Background: This study aims to compare improvements in attention deficit and hyperactivity disorder (ADHD) symptom severity between a group of ADHD children and parents undergoing a new therapeutic program based on third-generation cognitive behavioral therapy (Hyper-mCBT) and a similar group undergoing treatment-as-usual with the Barkley program. Methods: Two hundred forty-eight children diagnosed with ADHD will be randomly assigned to either a Hyper-mCBT program or a Barkley program. This is a multicenter randomized (1:1), 2 parallel-group, superiority trial with evaluator blinding and stratification according to center and methylphenidate treatment. The Hyper-mCBT program consists in a series of 16 simultaneous-but-separate therapy sessions for parents and for children. Discussion: More effective psychotherapeutic approaches are needed for ADHD children. Pharmacotherapy seems to be more effective in reducing ADHD symptoms but it is not always helpful, it carries side effects, and it is rejected by many parents/professionals. Results for psychotherapy programs for ADHD are inconsistent although several studies have shown clinical improvements. This trial will substantiate encouraging preliminary results of an innovative psychotherapy program for both parents and children. Trial registration: ClinicalTrials.gov NCT03437772 . Registered on February 19, 2018. Sponsor number: PHRC-N/2016/JLC-01. RCB identification: 2017-A01349-44.
MeSH term(s)	Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/therapy ; Child ; Cognitive Behavioral Therapy ; Humans ; Methylphenidate/adverse effects ; Parents ; Psychotherapy
Chemical Substances	Methylphenidate (207ZZ9QZ49)
Language	English
Publishing date	2022-01-28
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-021-05983-2
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Article ; Online: Incidence of obstetric anal sphincter injuries following breech compared to cephalic vaginal births.

Leborne, Perrine / de Tayrac, Renaud / Zemmache, Zakarya / Serrand, Chris / Fabbro-Peray, Pascale / Allegre, Lucie / Vintejoux, Emmanuelle

BMC pregnancy and childbirth

2023 Volume 23, Issue 1, Page(s) 317

Abstract: Introduction: Obstetric anal sphincter injuries (OASIs) at the time of childbirth can lead to serious consequences including anal incontinence, dyspareunia, pain and rectovaginal fistula. These types of lesions and their incidence have been well studied ...

Abstract	Introduction: Obstetric anal sphincter injuries (OASIs) at the time of childbirth can lead to serious consequences including anal incontinence, dyspareunia, pain and rectovaginal fistula. These types of lesions and their incidence have been well studied after cephalic presentation deliveries, but no publications have specifically addressed this issue in the context of vaginal breech delivery. The goal of our study was to evaluate the incidence of OASIs following breech deliveries and compare it with cephalic presentation births. Methods: This was a retrospective cohort study involving 670 women. Of these, 224 and 446 had a vaginal birth of a fetus in the breech (breech group) and cephalic (cephalic group) presentations respectively. Both groups were matched for birthweight (± 200 g), date of delivery (± 2 years) and vaginal parity. Main outcome of interest was to evaluate the incidence of OASIs following breech vaginal birth compared to cephalic vaginal births. Secondary endpoints were the incidence of intact perineum or first-degree tear, second-degree perineal tear and rates of episiotomies in each group. Results: There was no statistically significant difference in OASIs incidence between the breech and cephalic groups (0.9% vs. 1.1%; RR 0.802 (0.157; 4.101); p = 0.31). There were more episiotomies in the breech group (12.5% vs. 5.4%, p = 0.0012) and the rate of intact or first-degree perineum was similar in both groups (74.1% vs. 75.3%, p = 0.7291). A sub-analysis excluding patients with episiotomy and history of OASIs did not show any statistically significant difference either. Conclusion: We did not demonstrate a significant difference in the incidence of obstetric anal sphincter injuries between women who had a breech vaginal birth compared to cephalic.
MeSH term(s)	Pregnancy ; Humans ; Female ; Retrospective Studies ; Anal Canal/injuries ; Incidence ; Risk Factors ; Parturition ; Delivery, Obstetric/adverse effects ; Episiotomy/adverse effects ; Lacerations/epidemiology ; Lacerations/etiology ; Perineum/injuries ; Obstetric Labor Complications/epidemiology ; Obstetric Labor Complications/etiology
Language	English
Publishing date	2023-05-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2059869-5
ISSN	1471-2393 ; 1471-2393
ISSN (online)	1471-2393
ISSN	1471-2393
DOI	10.1186/s12884-023-05595-5
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Article ; Online: Post-traumatic stress disorder, anxiety, depression and burnout in nursing home staff in South France during the COVID-19 pandemic.

Conejero, Ismael / Petrier, Melissa / Fabbro Peray, Pascale / Voisin, Christelle / Courtet, Philippe / Potier, Hugo / Elotmani, Loubna / Lafont, Brigitte / Lefrant, Jean-Yves / Lopez Castroman, Jorge / Arbus, Christophe / Blain, Hubert

Translational psychiatry

2023 Volume 13, Issue 1, Page(s) 205

Abstract: The high mortality rate in nursing homes during the COVID-19 pandemic may be linked to psychological disorders in staff. Hence, we assessed the prevalence and associated factors of probable post-traumatic stress disorder (PTSD), anxiety, depression, and ... ...

Abstract	The high mortality rate in nursing homes during the COVID-19 pandemic may be linked to psychological disorders in staff. Hence, we assessed the prevalence and associated factors of probable post-traumatic stress disorder (PTSD), anxiety, depression, and burnout of nursing home staff during the COVID-19 pandemic in a cross-sectional study including 66 randomly selected nursing homes in southern France. 537 of the contacted 3 821 nursing home workers (14.0%) responded between April and October 2021. We collected information on center organization, severity of COVID-19 exposure, and socio-demographic information in an online survey. The prevalence of probable PTSD (PCL-5), anxiety and depressive disorders (Hospital Anxiety Depression Scale) and the sub-scores of burnout syndrome (Maslach Burnout Inventory Human Services Survey for Medical Personnel) were assessed. Probable PTSD was reported in 115/537 responders (21.4% (95% CI [18.0%-24.9%])). After adjustment, low-level exposure to COVID-19 in nursing home residents (AOR, 0.5; 95% CI [0.3-0.9]), fear of managing COVID-19 residents (AOR, 3.5; 95% CI [1.9-6.4]), conflicts with residents (AOR, 2.3; 95% CI, [1.2-4.4]), conflicts with colleagues (AOR, 3.6; 95% CI [1.7-8.6]), cancellation of leave (AOR, 4.8; 95% CI [2.0-11.7]) and temporary worker employment (AOR, 3.4; 95% CI [1.7-6.9]) were associated with higher prevalence of probable PTSD. The prevalence of probable anxiety and depression were 28.8% (95% CI [24.9%-32.7%]) and 10.4% (95% CI [7.8%-13.1%]), respectively. Psychological disorders were observed in nearly one third of nursing home workers during the COVID-19 pandemic. Hence, continuous surveys and preventive measures are needed in this particularly at-risk population.
MeSH term(s)	Humans ; Stress Disorders, Post-Traumatic/epidemiology ; Stress Disorders, Post-Traumatic/psychology ; COVID-19/epidemiology ; Depression/epidemiology ; Cross-Sectional Studies ; Pandemics ; Anxiety/epidemiology ; Burnout, Professional/epidemiology ; Nursing Homes
Language	English
Publishing date	2023-06-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2609311-X
ISSN	2158-3188 ; 2158-3188
ISSN (online)	2158-3188
ISSN	2158-3188
DOI	10.1038/s41398-023-02488-1
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Article ; Online: Meta-analysis and Systematic Review of the Use of a Prosthetic Mesh for Prevention of Parastomal Hernia.

Prudhomme, Michel / Fabbro-Peray, Pascale / Rullier, Eric / Occean, Bob V / Bertrand, Martin M

Annals of surgery

2020 Volume 274, Issue 1, Page(s) 20–28

Abstract: Objective: The primary endpoint of this meta-analysis was the PSH rate at 1 year of follow-up with or without the use of a mesh.: Summary of background data: European guidelines currently recommend the use of a mesh at the time of a stoma formation ... ...

Abstract	Objective: The primary endpoint of this meta-analysis was the PSH rate at 1 year of follow-up with or without the use of a mesh. Summary of background data: European guidelines currently recommend the use of a mesh at the time of a stoma formation for the prevention of PSH. These recommendations are based on the RCT and meta-analyses published before 2017. More recently 2 large RCT found no benefit in the mesh group. We investigated whether these latest results could change the conclusion of a meta-analysis. Methods: We conducted a comprehensive literature search and analyzed RCT investigating the use of a mesh to prevent PSH formation. All studies including end colostomies were included in the qualitative analysis no matter the surgical technique or the type of mesh. All studies with a limited risk of bias and presenting with usable data were used in the quantitative analysis. Results: There is a large heterogeneity among the studies, in terms of position of the mesh, surgical technique, and diagnostic method for the PSH.No statistically significant difference was found on the PSH rate at 1 or 2 years between the mesh and non-mesh groups. Conclusions: Based on this meta-analysis including the latest RCT on the prevention of PSH, the use of a mesh should not be recommended.
MeSH term(s)	Hernia, Ventral/prevention & control ; Humans ; Incisional Hernia/prevention & control ; Postoperative Complications/prevention & control ; Prolapse ; Reoperation ; Surgical Mesh ; Surgical Stomas/adverse effects ; Surgical Wound Infection ; Treatment Outcome
Language	English
Publishing date	2020-11-19
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	340-2
ISSN	1528-1140 ; 0003-4932
ISSN (online)	1528-1140
ISSN	0003-4932
DOI	10.1097/SLA.0000000000004704
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Article ; Online: Assessment of All-Cause Cancer Incidence Among Individuals With Preeclampsia or Eclampsia During First Pregnancy.

Serrand, Chris / Mura, Thibault / Fabbro-Peray, Pascale / Seni, Gilles / Mousty, Ève / Boudemaghe, Thierry / Gris, Jean-Christophe

JAMA network open

2021 Volume 4, Issue 6, Page(s) e2114486

Abstract: Importance: Preeclampsia or eclampsia (preeclampsia/eclampsia) during pregnancy induces major physiological changes and may be associated with specific cancer occurrences in later life. The current data regarding the association between preeclampsia/ ... ...

Abstract	Importance: Preeclampsia or eclampsia (preeclampsia/eclampsia) during pregnancy induces major physiological changes and may be associated with specific cancer occurrences in later life. The current data regarding the association between preeclampsia/eclampsia and cancer are heterogeneous, and cancer risk after preeclampsia/eclampsia could be different depending on the organ. These uncertainties warrant reexamination of the association between preeclampsia/eclampsia and the risk of cancer overall and by specific cancer type. Objective: To evaluate the risk of cancer, overall and by type, after preeclampsia/eclampsia during a first pregnancy. Design, setting, and participants: This retrospective cohort study used data from the French hospital discharge database to identify all female individuals who had a pregnancy-associated hospitalization between January 1, 2010, and December 31, 2019. To allow a minimum of 2 years for the detection of medical history, individuals with a first detected pregnancy before January 1, 2012, were excluded, as were those with a cancer-associated hospitalization before or during their first detected pregnancy. Exposures, comorbidities, and occurrences of cancer were evaluated using data from the medico-administrative registers of hospitalizations in private and public French hospitals. Cox proportional hazards models were used to analyze cancer risk according to the occurrence of preeclampsia/eclampsia during first pregnancy. Exposures: Preeclampsia/eclampsia-associated hospitalization during the first detected pregnancy. Main outcomes and measures: The primary outcome was the incidence of cancer, including myelodysplastic or myeloproliferative diseases, after a first pregnancy with and without preeclampsia/eclampsia. Results: After exclusions, a total of 4 322 970 female individuals (mean [SD] age at first detected pregnancy, 29.6 [6.2] years) with and without preeclampsia/eclampsia during their first pregnancy were included. Of those, 45 523 individuals (1.1%) were diagnosed with preeclampsia/eclampsia during their first detected pregnancy. The maximum follow-up was 8 years, during which 29 173 individuals (0.7%) were diagnosed with cancer. No significant difference in overall cancer incidence was found between those with and without preeclampsia/eclampsia during their first pregnancy (adjusted hazard ratio [AHR], 0.94; 95% CI, 0.84-1.05). Preeclampsia/eclampsia was associated with an increase in the risk of myelodysplastic syndromes or myeloproliferative diseases (AHR, 2.43; 95% CI, 1.46-4.06) and kidney cancer (AHR, 2.19; 95% CI, 1.09-4.42) and a decrease in the risk of breast cancer (AHR, 0.79; 95% CI, 0.62-0.99) and cervical cancer (AHR, 0.75; 95% CI, 0.58-0.96). Conclusions and relevance: In this study, a history of preeclampsia/eclampsia during first pregnancy was associated with an increase in the incidence of myelodysplastic or myeloproliferative diseases and kidney cancer and a decrease in the incidence of cervical and breast cancers. These associations might reflect an underlying common factor among preeclampsia/eclampsia and these pathologies and/or an association between preeclampsia/eclampsia and the development of these cancers.
MeSH term(s)	Adolescent ; Adult ; Child ; Cohort Studies ; Correlation of Data ; Female ; Humans ; Incidence ; Middle Aged ; Neoplasms/diagnosis ; Neoplasms/epidemiology ; Pre-Eclampsia/diagnosis ; Pre-Eclampsia/epidemiology ; Pregnancy ; Proportional Hazards Models ; Retrospective Studies
Language	English
Publishing date	2021-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2021.14486
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Article ; Online: Impact on quality of life 3 years after diagnosis of prostate cancer patients below 75 at diagnosis: an observational case-control study.

Houédé, Nadine / Rébillard, Xavier / Bouvet, Sophie / Kabani, Sarah / Fabbro-Peray, Pascale / Trétarre, Brigitte / Ménégaux, Florence

BMC cancer

2020 Volume 20, Issue 1, Page(s) 757

Abstract: Background: Prostate cancer patients are known to suffer from poor sexual and urinary long-term side-effects following treatment, potentially impacting quality of life. The purpose of our study was to compare health-related quality of life at 3 years ... ...

Abstract	Background: Prostate cancer patients are known to suffer from poor sexual and urinary long-term side-effects following treatment, potentially impacting quality of life. The purpose of our study was to compare health-related quality of life at 3 years between prostate cancer patients and healthy controls according to key life-style characteristics. Secondary objectives were to compare urological dysfunction, sexual function, anxiety and depression. Methods: Multicentric, case-control, observational prospective, open, follow-up study including 819 prostate cancer patients < 75 years old from the EPICAP cohort, newly diagnosed from 1 December 2011 to 31 March 2014 and 879 healthy controls. Participants were excluded if they experienced a relapse. Controls from the same geographical region were age-matched and were excluded if they were diagnosed with prostate cancer. Patients received one of the following treatments: active surveillance (AS), radical prostatectomy (RP), external beam radiotherapy (EBRT), High-intensity Focused Ultrasound (HIFU), chemotherapy (CT), or androgen deprivation therapy (ADT) as appropriate. The primary outcome was the quality of life as evaluated by the QLQ-C30 questionnaire. Scores were analyzed by multivariate analysis to adjust for predefined socio-demographic confounding effects. Results: In total, 564 participants were included (mean age 67.9 years): 376 patients and 188 controls. Treatment breakdown was: 258 underwent RP, 90 received EBRT, 52 brachytherapy or HIFU, 15 CT, 26 ADT and 61 AS. There was no difference in median global quality of life between patients and controls (94.87 vs 94.15, p = 0.71). Multivariate analysis showed poorer social functioning in patients (24.3% vs. 16.3%, p = 0.0209), more dyspnea (22% vs. 12.4%, p = 0.0078), and yet less current pain (23% vs 33%, p = 0.0151). Conclusions: Global health status score at 3 years after diagnosis was similar between patients and controls, though patients showed a significantly worse social functioning. Prostate cancer diagnosis per se does not seem to impact the quality of life of patients < 75 years at diagnosis. However, the therapeutic option that will be chosen following diagnosis should be carefully discussed with the medical staff in terms of benefit-risk ratios as it could have a long-term impact on urinary or erectile dysfunction. Trial registration: clinicaltrials.gov, NCT02854982 . Registered 4 August 2016, retrospectively registered.
MeSH term(s)	Aged ; Androgen Antagonists/therapeutic use ; Antineoplastic Agents/therapeutic use ; Case-Control Studies ; Cohort Studies ; Erectile Dysfunction/etiology ; Extracorporeal Shockwave Therapy/statistics & numerical data ; Health Surveys/statistics & numerical data ; Humans ; Male ; Middle Aged ; Prospective Studies ; Prostatectomy/statistics & numerical data ; Prostatic Neoplasms/complications ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/psychology ; Prostatic Neoplasms/therapy ; Quality of Life ; Radiotherapy/statistics & numerical data ; Surveys and Questionnaires ; Time Factors ; Watchful Waiting/statistics & numerical data
Chemical Substances	Androgen Antagonists ; Antineoplastic Agents
Language	English
Publishing date	2020-08-12
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Observational Study
ISSN	1471-2407
ISSN (online)	1471-2407
DOI	10.1186/s12885-020-07244-y
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Article ; Online: Correction to: The French glioblastoma biobank (FGB): a national clinicobiological database.

Clavreul, Anne / Soulard, Gwénaëlle / Lemée, Jean-Michel / Rigot, Marion / Fabbro-Peray, Pascale / Bauchet, Luc / Figarella-Branger, Dominique / Menei, Philippe

Journal of translational medicine

2020 Volume 18, Issue 1, Page(s) 181

Abstract: An amendment to this paper has been published and can be accessed via the original article. ...

Abstract	An amendment to this paper has been published and can be accessed via the original article.
Language	English
Publishing date	2020-04-30
Publishing country	England
Document type	Journal Article ; Published Erratum
ISSN	1479-5876
ISSN (online)	1479-5876
DOI	10.1186/s12967-020-02345-5
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Article ; Online: Systematic review and meta-analysis on the impact of lung cancer screening by low-dose computed tomography.

Sadate, Alexandre / Occean, Bob V / Beregi, Jean-Paul / Hamard, Aymeric / Addala, Takieddine / de Forges, Hélène / Fabbro-Peray, Pascale / Frandon, Julien

European journal of cancer (Oxford, England : 1990)

2020 Volume 134, Page(s) 107–114

Abstract: Introduction: Lung cancer (LC) has the highest cancer mortality worldwide with poor prognosis. Screening with low-dose computed tomography (LDCT) in populations highly exposed to tobacco has been proposed to improve LC prognosis. Our objective was to ... ...

Abstract	Introduction: Lung cancer (LC) has the highest cancer mortality worldwide with poor prognosis. Screening with low-dose computed tomography (LDCT) in populations highly exposed to tobacco has been proposed to improve LC prognosis. Our objective was to perform a systematic review and meta-analysis to evaluate the efficacy of screening by LDCT compared with any other intervention in populations who reported tobacco consumption for more than 15 years on LC and overall mortality. Methods: We searched randomised controlled trials (RCTs) studying screening by LDCT compared with any other intervention in a population who reported an average smoking history greater than 15 pack-years from inception until the 19th February 2018 using Medline and Cochrane Library databases. Publication selection and data extraction were made independently by two double-blind reviewers. Results: Seven RCTs were included in the meta-analysis which corresponds to 84,558 participants. A significant relative reduction of LC-specific mortality of 17% (risk ratio [RR] = 0.83, 95% confidence interval [CI]: 0.76-0.91) and a relative reduction of overall mortality of 4% (RR = 0.96, 95% CI: 0.92-1.00) was observed in the screening group compared with the control group. Conclusion: In populations highly exposed to tobacco, screening by LDCT reduces lung cancer mortality.
MeSH term(s)	Early Detection of Cancer/methods ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/diagnostic imaging ; Prognosis ; Randomized Controlled Trials as Topic ; Survival Rate ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2020-06-02
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	82061-1
ISSN	1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
ISSN (online)	1879-0852
ISSN	0277-5379 ; 0959-8049 ; 0964-1947
DOI	10.1016/j.ejca.2020.04.035
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